LOCUS       NM_031610               1827 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus potassium inwardly-rectifying channel, subfamily
            J, member 3 (Kcnj3), mRNA.
ACCESSION   NM_031610
VERSION     NM_031610.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1827)
  AUTHORS   Baculis,B.C., Weiss,A.C., Pang,W., Jeong,H.G., Lee,J.H., Liu,D.C.,
            Tsai,N.P. and Chung,H.J.
  TITLE     Prolonged seizure activity causes caspase dependent cleavage and
            dysfunction of G-protein activated inwardly rectifying potassium
            channels
  JOURNAL   Sci Rep 7 (1), 12313 (2017)
   PUBMED   28951616
  REMARK    GeneRIF: Study is first to show direct cleavage of GIRK1 and GIRK2
            subunits by caspase-3, with cleavage sites in GIRK1 (387ECLD390)
            and GIRK2 (349YEVD352) and suggests the possible role of caspase-3
            mediated down-regulation of GIRK channel function and expression in
            hippocampal neuronal injury during prolonged epileptic seizures.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1827)
  AUTHORS   Li,Y., Fu,X., Zhang,Z. and Yu,B.
  TITLE     Knockdown of cardiac Kir3.1 gene with siRNA can improve bradycardia
            in an experimental sinus bradycardia rat model
  JOURNAL   Mol Cell Biochem 429 (1-2), 103-111 (2017)
   PUBMED   28205094
  REMARK    GeneRIF: Study provides evidence that Kir3.1 is involved in the
            pathogenesis of sinus bradycardia since its ihibition with siRNA
            can reverse the sinus bradycardia.
REFERENCE   3  (bases 1 to 1827)
  AUTHORS   Kramer,P.F. and Williams,J.T.
  TITLE     Calcium Release from Stores Inhibits GIRK
  JOURNAL   Cell Rep 17 (12), 3246-3255 (2016)
   PUBMED   28009293
  REMARK    GeneRIF: Transient activation of mGluRs decreased the GIRK current
            evoked by GABAB and D2 receptors, although less efficaciously for
            D2.
REFERENCE   4  (bases 1 to 1827)
  AUTHORS   Montalbano,A., Corradetti,R. and Mlinar,B.
  TITLE     Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled
            GIRK Channels in Rat Dorsal Raphe 5-HT Neurons
  JOURNAL   PLoS One 10 (10), e0140369 (2015)
   PUBMED   26460748
  REMARK    GeneRIF: inwardly rectifying K+ channels coupled to 5-HT1A
            autoreceptors display pharmacological properties generally expected
            for neuronal GIRK channels, but different from GIRK1-GIRK2
            heteromers
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1827)
  AUTHORS   Lyu,C., Mulder,J., Barde,S., Sahlholm,K., Zeberg,H., Nilsson,J.,
            Arhem,P., Hokfelt,T., Fried,K. and Shi,T.J.
  TITLE     G protein-gated inwardly rectifying potassium channel subunits 1
            and 2 are down-regulated in rat dorsal root ganglion neurons and
            spinal cord after peripheral axotomy
  JOURNAL   Mol Pain 11, 44 (2015)
   PUBMED   26199148
  REMARK    GeneRIF: Fourteen days after axotomy, GIRK1 and GIRK2 were
            down-regulated in DRG neurons at the mRNA and protein levels.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1827)
  AUTHORS   Karschin,C., Dissmann,E., Stuhmer,W. and Karschin,A.
  TITLE     IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are
            differentially expressed in the adult rat brain
  JOURNAL   J Neurosci 16 (11), 3559-3570 (1996)
   PUBMED   8642402
REFERENCE   7  (bases 1 to 1827)
  AUTHORS   Slesinger,P.A., Reuveny,E., Jan,Y.N. and Jan,L.Y.
  TITLE     Identification of structural elements involved in G protein gating
            of the GIRK1 potassium channel
  JOURNAL   Neuron 15 (5), 1145-1156 (1995)
   PUBMED   7576657
REFERENCE   8  (bases 1 to 1827)
  AUTHORS   DePaoli,A.M., Bell,G.I. and Stoffel,M.
  TITLE     G protein-activated inwardly rectifying potassium channel
            (GIRK1/KGA) mRNA in adult rat heart and brain by in situ
            hybridization histochemistry
  JOURNAL   Mol Cell Neurosci 5 (6), 515-522 (1994)
   PUBMED   7704424
REFERENCE   9  (bases 1 to 1827)
  AUTHORS   Dascal,N., Schreibmayer,W., Lim,N.F., Wang,W., Chavkin,C.,
            DiMagno,L., Labarca,C., Kieffer,B.L., Gaveriaux-Ruff,C.,
            Trollinger,D. et al.
  TITLE     Atrial G protein-activated K+ channel: expression cloning and
            molecular properties
  JOURNAL   Proc Natl Acad Sci U S A 90 (21), 10235-10239 (1993)
   PUBMED   8234283
REFERENCE   10 (bases 1 to 1827)
  AUTHORS   Kubo,Y., Reuveny,E., Slesinger,P.A., Jan,Y.N. and Jan,L.Y.
  TITLE     Primary structure and functional expression of a rat
            G-protein-coupled muscarinic potassium channel
  JOURNAL   Nature 364 (6440), 802-806 (1993)
   PUBMED   8355805
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L25264.1.
            
            On Jun 10, 2007 this sequence version replaced NM_031610.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L25264.1, U09243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1827
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..1827
                     /gene="Kcnj3"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 3"
                     /db_xref="GeneID:50599"
                     /db_xref="RGD:2958"
     exon            1..760
                     /gene="Kcnj3"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1564
                     /gene="Kcnj3"
                     /note="KGA; KGB1; GIRK1; inward rectifier K(+) channel
                     Kir3.1; potassium channel, inwardly rectifying subfamily J
                     member 3; GIRK-1; potassium channel inwarding rectifying
                     channel subfamily J member 3; potassium channel subunit
                     Kir3.1 type 3 delta; potassium voltage-gated channel
                     subfamily J member 3"
                     /codon_start=1
                     /product="G protein-activated inward rectifier potassium
                     channel 1"
                     /protein_id="NP_113798.1"
                     /db_xref="GeneID:50599"
                     /db_xref="RGD:2958"
                     /translation="MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQGPQQQLVPKKKRQ
                     RFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMW
                     WVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGII
                     LFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNL
                     RNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDA
                     KSPFYDLSQRSMQTEQFEVVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLE
                     EGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGL
                     DDISTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEK
                     LVSKTTKMLSDPMSQSVADLPPKLQKMAGGPTRMEGNLPAKLRKMNSDRFT"
     exon            761..977
                     /gene="Kcnj3"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1827
                     /gene="Kcnj3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgcttgg ctcctgcgcc tccgcttcgt gtttgaatct ggatctcccc tccgtattat
       61 gtctgcactc cgaaggaaat ttggggacga ttaccaggta gtgaccactt cgtccagcgg
      121 ttcgggcttg cagccccagg ggccaggaca gggcccacag cagcagcttg tacccaagaa
      181 gaaacggcag cggttcgtgg acaagaacgg tcggtgcaat gtgcagcacg gcaacctggg
      241 cagcgagacc agtcgctacc tttccgacct cttcactacc ctggtggatc tcaagtggcg
      301 ttggaacctc tttatcttca tcctcaccta caccgtggcc tggctcttca tggcgtccat
      361 gtggtgggtg atcgcttata cccggggcga cctgaacaaa gcccatgtcg gcaactacac
      421 tccctgtgtg gccaatgtct ataacttccc ctctgccttc cttttcttca tcgagaccga
      481 ggccaccatc ggctatggct accgctacat caccgacaag tgccccgagg gcatcatcct
      541 tttccttttc cagtccatcc ttggctccat cgtggacgct ttcctcatcg gctgcatgtt
      601 catcaagatg tcccagccca aaaagcgcgc cgagaccctc atgtttagcg agcatgcggt
      661 tatttccatg agggacggaa aactcactct catgttccgg gtgggcaacc tgcgcaacag
      721 ccacatggtc tccgcgcaga tccgctgcaa gctgctcaaa tctcggcaga cacctgaggg
      781 tgagtttcta ccccttgacc aacttgaact ggatgtaggt tttagtacag gggcagatca
      841 actttttctt gtgtcccctc tcaccatttg ccacgtgatt gatgccaaaa gcccctttta
      901 tgacctatcc cagcgaagca tgcaaactga acagttcgag gtggtcgtca tcctggaagg
      961 catcgtggaa accacaggga tgacttgtca agctcgaaca tcatacaccg aagatgaagt
     1021 tctttggggt catcgttttt tccctgtaat ttctttagaa gaaggattct ttaaagtcga
     1081 ttactcccag ttccatgcaa cctttgaagt ccccacccct ccgtacagtg tgaaagagca
     1141 ggaagaaatg cttctcatgt cttccccttt aatagcacca gccataacca acagcaaaga
     1201 aagacacaat tctgtggagt gcttagatgg actagatgac attagcacaa aacttccatc
     1261 gaagctgcag aaaattacgg ggagagaaga ctttcccaaa aaactcctga ggatgagttc
     1321 tacaacttca gaaaaagcct atagtttggg tgatttgccc atgaaactcc aacgaataag
     1381 ttcggttcct ggcaactctg aagaaaaact ggtatctaaa accaccaaga tgttatcaga
     1441 tcccatgagc cagtctgtgg ccgatttgcc accgaagctt caaaagatgg ctggaggacc
     1501 taccaggatg gaagggaatc ttccagccaa actaagaaaa atgaactctg accgcttcac
     1561 atagcaaaac accccattag gcattatttc atgttttgat ttagttttag tccaatattt
     1621 ggctgataag ataatcctcc ccgggaaatc tgagaggtct atcccagtct ggcaaattca
     1681 tcagaggact cttcattgaa gtgttgttac tgtgttgaac atgagttaca aagggaggac
     1741 atcataagaa agctaatagt tggcatgtat tatcacatca agcatgcaat aatgtgcaaa
     1801 ttttgcattt agttttctgg catgatt
//
