LOCUS       NM_017296               5527 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus potassium inwardly-rectifying channel, subfamily
            J, member 2 (Kcnj2), mRNA.
ACCESSION   NM_017296 XM_006247567
VERSION     NM_017296.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5527)
  AUTHORS   Cao,N., Aikeremu,N., Shi,W.Y., Tang,X.C., Gao,R.J., Kong,L.J.,
            Zhang,J.R., Qin,W.J., Zhang,A.M., Ma,K.T., Li,L. and Si,J.Q.
  TITLE     Inhibition of KIR2.1 decreases pulmonary artery smooth muscle cell
            proliferation and migration
  JOURNAL   Int J Mol Med 50 (3) (2022)
   PUBMED   35856410
  REMARK    GeneRIF: Inhibition of KIR2.1 decreases pulmonary artery smooth
            muscle cell proliferation and migration.
REFERENCE   2  (bases 1 to 5527)
  AUTHORS   Cui,X., Li,X., He,Y., Yu,J., Dong,N. and Zhao,R.C.
  TITLE     Slight up-regulation of Kir2.1 channel promotes endothelial
            progenitor cells to transdifferentiate into a pericyte phenotype by
            Akt/mTOR/Snail pathway
  JOURNAL   J Cell Mol Med 25 (21), 10088-10100 (2021)
   PUBMED   34592781
  REMARK    GeneRIF: Slight up-regulation of Kir2.1 channel promotes
            endothelial progenitor cells to transdifferentiate into a pericyte
            phenotype by Akt/mTOR/Snail pathway.
REFERENCE   3  (bases 1 to 5527)
  AUTHORS   Li,J., He,Y., Bu,H., Wang,M., Yu,J., Li,L., Li,H., Zhang,X., Cui,X.
            and Cheng,M.
  TITLE     Oscillating shear stress mediates mesenchymal transdifferentiation
            of EPCs by the Kir2.1 channel
  JOURNAL   Heart Vessels 35 (10), 1473-1482 (2020)
   PUBMED   32449050
  REMARK    GeneRIF: Oscillating shear stress mediates mesenchymal
            transdifferentiation of EPCs by the Kir2.1 channel.
REFERENCE   4  (bases 1 to 5527)
  AUTHORS   Shimaoka,T., Wang,Y., Morishima,M., Miyamoto,S. and Ono,K.
  TITLE     Magnesium Deficiency Causes Transcriptional Downregulation of
            Kir2.1 and Kv4.2 Channels in Cardiomyocytes Resulting in QT
            Interval Prolongation
  JOURNAL   Circ J 84 (8), 1244-1253 (2020)
   PUBMED   32554946
  REMARK    GeneRIF: Magnesium Deficiency Causes Transcriptional Downregulation
            of Kir2.1 and Kv4.2 Channels in Cardiomyocytes Resulting in QT
            Interval Prolongation.
REFERENCE   5  (bases 1 to 5527)
  AUTHORS   Sengupta,S., Rothenberg,K.E., Li,H., Hoffman,B.D. and Bursac,N.
  TITLE     Altering integrin engagement regulates membrane localization of
            Kir2.1 channels
  JOURNAL   J Cell Sci 132 (17) (2019)
   PUBMED   31391240
  REMARK    GeneRIF: Altering integrin engagement regulates membrane
            localization of Kir2.1 channels.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5527)
  AUTHORS   Plaster,N.M., Tawil,R., Tristani-Firouzi,M., Canun,S.,
            Bendahhou,S., Tsunoda,A., Donaldson,M.R., Iannaccone,S.T.,
            Brunt,E., Barohn,R., Clark,J., Deymeer,F., George,A.L. Jr.,
            Fish,F.A., Hahn,A., Nitu,A., Ozdemir,C., Serdaroglu,P.,
            Subramony,S.H., Wolfe,G., Fu,Y.H. and Ptacek,L.J.
  TITLE     Mutations in Kir2.1 cause the developmental and episodic electrical
            phenotypes of Andersen's syndrome
  JOURNAL   Cell 105 (4), 511-519 (2001)
   PUBMED   11371347
REFERENCE   7  (bases 1 to 5527)
  AUTHORS   Rae,J.L. and Shepard,A.R.
  TITLE     Inwardly rectifying potassium channels in lens epithelium are from
            the IRK1 (Kir 2.1) family
  JOURNAL   Exp Eye Res 66 (3), 347-359 (1998)
   PUBMED   9533862
REFERENCE   8  (bases 1 to 5527)
  AUTHORS   Huang,C.L., Feng,S. and Hilgemann,D.W.
  TITLE     Direct activation of inward rectifier potassium channels by PIP2
            and its stabilization by Gbetagamma
  JOURNAL   Nature 391 (6669), 803-806 (1998)
   PUBMED   9486652
REFERENCE   9  (bases 1 to 5527)
  AUTHORS   Wischmeyer,E., Lentes,K.U. and Karschin,A.
  TITLE     Physiological and molecular characterization of an IRK-type inward
            rectifier K+ channel in a tumour mast cell line
  JOURNAL   Pflugers Arch 429 (6), 809-819 (1995)
   PUBMED   7603835
REFERENCE   10 (bases 1 to 5527)
  AUTHORS   Stanfield,P.R., Davies,N.W., Shelton,P.A., Khan,I.A., Brammar,W.J.,
            Standen,N.B. and Conley,E.C.
  TITLE     The intrinsic gating of inward rectifier K+ channels expressed from
            the murine IRK1 gene depends on voltage, K+ and Mg2+
  JOURNAL   J Physiol 475 (1), 1-7 (1994)
   PUBMED   8189383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Oct 24, 2022 this sequence version replaced
            XM_006247567.4, NM_017296.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.821157.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               JAXUCZ010000010.1  96560225-96560405
            182-5527            JAXUCZ010000010.1  96565443-96570788
FEATURES             Location/Qualifiers
     source          1..5527
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..5527
                     /gene="Kcnj2"
                     /gene_synonym="Kir2.1"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 2"
                     /db_xref="GeneID:29712"
                     /db_xref="RGD:61968"
     exon            1..181
                     /gene="Kcnj2"
                     /gene_synonym="Kir2.1"
                     /inference="alignment:Splign:2.1.0"
     exon            182..5527
                     /gene="Kcnj2"
                     /gene_synonym="Kir2.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..1688
                     /gene="Kcnj2"
                     /gene_synonym="Kir2.1"
                     /note="RBL-IRK1; potassium voltage-gated channel subfamily
                     J member 2; inward rectifier K(+) channel Kir2.1;
                     potassium channel, inwardly rectifying subfamily J member
                     2; IRK-1"
                     /codon_start=1
                     /product="inward rectifier potassium channel 2"
                     /protein_id="NP_058992.1"
                     /db_xref="GeneID:29712"
                     /db_xref="RGD:61968"
                     /translation="MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCR
                     SRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCV
                     FWLIALLHGDLDASKESKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFM
                     VVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLR
                     KSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDED
                     SPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEK
                     HCYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEDSEN
                     GVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI"
ORIGIN      
        1 aggctatcgc agagcgcact ggagccctgg ccagcgcgca gccttcccgg cgccggcaag
       61 cagggtcttg ggaattctca cttgcttcgg ctcactctct ttcacaaaaa ccactggatc
      121 ttacatgctt ctgtaacccc cacttccact ccatgtcccc atgatcctgt gccagcaaca
      181 ggacaagttc tctggatgtc agctgagtta ctaagttagc tctgctggtc aaaagaaccc
      241 cgaggttctt ggaagcatct atctctcctc attaaaaaaa aaaagaaaaa aacatttttt
      301 tttgctgtgt cttcaccgaa cattcaaaac tgtttcttca aagggttttg caaaaactca
      361 gactgttttc taaagcagaa acactggcgt ccacagcgga agcaatgggc agtgtgcgta
      421 caaaccgcta cagcatcgtc tcttcggagg aagacggcat gaagctggcc accatggccg
      481 tcgccaatgg ctttgggaat ggcaagagta aagtccatac ccgacaacag tgcaggagcc
      541 gctttgtgaa gaaagacggg cattgcaacg ttcagtttat caacgtggga gagaaaggac
      601 agaggtacct ggcggacatc tttactacct gtgtggacat ccgctggcgg tggatgctgg
      661 taatcttctg cctcgcattc gtgctctcct ggctgttctt tggctgtgtg ttttggttga
      721 tagctctgct ccacggggat ctggatgctt ctaaagagag caaagcgtgt gtgtctgagg
      781 tcaacagctt cacggctgcc ttcctcttct ccattgagac ccagacaacc atcggctatg
      841 gtttcaggtg tgttacagac gagtgcccga ttgctgtttt catggtggta ttccagtcaa
      901 tcgtgggctg catcatcgac gccttcatca ttggtgcagt catggcgaag atggcgaagc
      961 caaagaagag gaatgagact ctggtcttca gccacaacgc tgtgattgcc atgagggacg
     1021 gcaaactctg cttgatgtgg agagtgggca accttcgcaa gagccacctt gtggaagctc
     1081 atgtccgggc acagcttctc aaatctagga tcacttcaga aggggagtac atccccttgg
     1141 accagataga catcaacgtt ggtttcgata gcggaatcga ccgtatattt ctagtgtccc
     1201 caatcactat tgtccatgaa atagacgaag acagcccttt atatgacttg agtaagcagg
     1261 acattgacaa tgcagacttt gaaatcgttg tcatcctgga aggcatggtg gaggccactg
     1321 ccatgacaac gcaatgccgg agttcatatc tggccaatga gattctctgg ggtcaccgct
     1381 acgagccggt gctctttgaa gagaagcatt gctataaagt agactattca agattccata
     1441 agacttacga agtacctaac actccccttt gtagtgccag agacttagca gagaagaaat
     1501 acatcctctc aaatgcaaat tcattttgct atgaaaatga agttgcccta acaagcaaag
     1561 aggaagagga cagtgagaac ggagttccag agagcacaag tacggactca cctcctggca
     1621 tagatctcca caaccaggcg agcgtgcctc tagagcccag gcctttaagg cgagaatcgg
     1681 agatatgact ggccgattct gtctttggaa tatttacttc ttcgctacac agtctgatgt
     1741 tggtcagaga tccgagacag ttatacagac ggtggtactg gcccagaggt gggtgaaagc
     1801 aggcagccac aagagactaa ggctagcaca aaggtttcaa gaaaagactg taagctggat
     1861 gactgaagta aaaagcgctt tgcaggcctc cgagagaccc gaaggcacat atctgttgca
     1921 gaataagtta tggggttttt aatgtattgt tttgtgtttt tacaaaactt gaatatgcag
     1981 gcaagcctca gtttgggtac atgacttacc tggatagctt ctctttaggg ggaacaagga
     2041 tgattttaat ggcataacat aggcaagact ctgccttaat tttttttgaa aagctgctaa
     2101 ctacatgaac acaaactgta tttttgttgc agtgtagttt atcttttaca taacgttaaa
     2161 atgtcagtgt tgagcattat cgcaagtgca cggtgtgctt caaagcgtca agtatttggc
     2221 tattgactgc caaaatggga gcctgatttt ctgaggccag taatttcttt gctaaaattg
     2281 atatctctcc tctctctctc tctctctctc tctctctctc tctctctctc tctcattaca
     2341 taataacatt atgtaacact agccaaatgg tagcctctgg gttttatagt tttcttttcc
     2401 aggatgctaa taggttatct caaattttca gttagacaac cttaaatgaa taccaaagat
     2461 aatgcacact ttctttcttt ctttctttct ttctttcttt ctttctttct ttctttcttt
     2521 cttttttctt ttgcacgtgg aggttatatt ttttaaaaga aacaaagccc catgggcttg
     2581 tcttggaaga tgtggaacag tcgattcatt ttgtactaca gtctgaaaag aacaccaaag
     2641 tctgatcaat gtagtgtgtt tttcaagtct gtccttttgt gcatctttct tatttggggg
     2701 gggggggcaa gagggaagca agggtcataa ttacatatgc actatacaaa tctttctttc
     2761 cctgataggt agtgctagtc aagctaatgt actcaaaggg ggtgggggag agagagagag
     2821 agagagagag agagagagag agagagagtt gcttggactt ttctgagctt ttctttcttt
     2881 gcacattcca aagtttattc cataagatca gatcttggtt gaactttgtt ggtaacctgg
     2941 caccctccag tcacccagca gcgaagatga acagatttca aattttgcag ctgagtcata
     3001 gccttgactg ccaggacatt tctagctcag tgtcacatta agaaagatat ctggcctcta
     3061 ggcttgtcct tttgaggtct ctgcacggag acagagagag agagagagag agagagagag
     3121 agagagagag agagagagag agaactcgag ccacttcaat gtgactatcc actttacagg
     3181 ggggagagga aagttgcttt tttcatgaca gatgataaga gggactgttt cagtatttta
     3241 ggtcttagtg agccatataa aagaacataa ttataagtta atgagttaag agtttaaagg
     3301 gttatttctc tctctgtaaa tgctcatgat taatgtgagc tggtcattgt ctcttggaaa
     3361 agtctcagag caggttgcta aggacatgct attttctaga ggcctcttct atctattcac
     3421 ctgcctttat agaagcgtct ctccccaccc ccactctagc tcagtaatgc aattctccct
     3481 ccctttctct tggtttttaa tgtcctctac ttataaaccc tagggctgct aattttccct
     3541 ttcagttggc gtctcaaaaa tcaactctct aatggtatta acaccctaat atgccattaa
     3601 caatcagctt tgttctagaa tcatgtattt catttcagtt gttgtttgtg tcagtctgtg
     3661 gcttgtgagc ctccgtgtct ggatgcagtg cctgtaagaa acagtgacag tttctgctgt
     3721 tttcaactgt ctaagtcaat ggatttgaaa actgttggca ttatgggaat caagggagaa
     3781 gtgctgagaa agtggttctt attgtccatc caggtttgaa ggcaaggttg caagttgctt
     3841 aaaagagtca gtggggttgg ggacagaggg gagtcacaga agagaaaaca gactggcttt
     3901 ggaccgtgtg aggctatgga aggcttcaga tgctgctatt aaggtgattt gcaaaggaaa
     3961 gtcatcaaac caaagagtat tcagtggaat gtaaatcaaa tgaaggtgca gtagagagtg
     4021 ggggaggggt gacaacccag actgacccca aacacatagc gctaaccact taaaaagact
     4081 tgagtcattg gaaaaagggg ggggggggta cagagacaag gaaagtgtga gggcaatctt
     4141 tcaatttgtt gcttaacaag aagaaaccat ctaaaatttc tggtgcatag gtttgttttt
     4201 cgttcgtttg ttttcgtccg tccgttcgtt cgttcgttcg tttttctttt tgttttccaa
     4261 gaaaattttt tttgcaggag ctacattttt aaagtgtaca ttttataaag tttatcagat
     4321 attttcatat ttaaagccaa atgtaaatat aagtctgtaa aggaaaaaaa aagtacccta
     4381 agaggtataa ctacccgcag tgagttctga tagctagcac ctataatgct accggttagc
     4441 atggttttag ctgagactac cagccttttg aggttcgatt cagtatgttt cttctgttat
     4501 ttatttcagc atggactgtt cctttgagag ctctttgtag ttattagcat cttaatagtt
     4561 acaagcttta aacggctttc tgttgtgttc tgccaagagc caagacatag gtaatgcatg
     4621 gcatctctcc ctgcatttgt accttcagaa tctctgtctt tatcgactgg gcctccagga
     4681 ctagtgcaca cacctgccac tagtatgcag atggggggac tcaccttgaa catctggggt
     4741 tcgtccccag gtgccagttg cttctgtgct gcgagcaaat ccctctagga tgtattccct
     4801 tttaaagaat gtttgcccat atctgagtgg gcattatatt tttttggaag gggggaggaa
     4861 tagattcctg gttattctat ttttaaataa aaaggtagac aaactgaatt ctattttgat
     4921 tattgagaaa ggaatagttt tctatccctc taagagtata cttgaatcag acatttttag
     4981 aatgtcatat agcactgtag tcatttctaa atccctagag aagtttgttt gactcctttc
     5041 ctgttctgtt gatgcaccat cccttttctt tcacttcctt tctccctata gcttccttcc
     5101 ctaaatctcg atgtgtctct gatgaccttg gttccccaaa gatcttcccc ttgcggataa
     5161 caaacgccag cttttaactt ataatcggcc accccataaa aacaaaatgc tcatctcgag
     5221 gggtgggtta agctccttat cactctgatg tcaaggtgga aggtataaaa gtgttgcatt
     5281 accatatccc ctcccacaac cttcagcaaa ctagagtttc tttcctgaga atgttaggtt
     5341 tcagctctgg gctctggcga gttgaacgtt cctagccttt gacaatcacg atagttatta
     5401 tttttttccc atttgccatc tttttgtatc taaagtcttc ctattgtact gcacaaacca
     5461 tgggttgtat atatttttta tatattatgt cttattttat tatttctaaa taaaaattga
     5521 aaataaa
//
