LOCUS       NM_053314               1770 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus potassium inwardly-rectifying channel, subfamily
            J, member 16 (Kcnj16), mRNA.
ACCESSION   NM_053314
VERSION     NM_053314.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1770)
  AUTHORS   Xu,B., Levchenko,V., Bohovyk,R., Ahrari,A., Geurts,A.M., Sency,V.,
            Xin,B., Wang,H. and Staruschenko,A.
  TITLE     Characterization of a novel variant in KCNJ16, encoding Kir5.1
            channel
  JOURNAL   Physiol Rep 12 (20), e70083 (2024)
   PUBMED   39414394
  REMARK    GeneRIF: Characterization of a novel variant in KCNJ16, encoding
            Kir5.1 channel.
REFERENCE   2  (bases 1 to 1770)
  AUTHORS   Manis,A.D., Cook-Snyder,D.R., Duffy,E., Osmani,W.A., Eilbes,M.,
            Dillard,M., Palygin,O., Staruschenko,A. and Hodges,M.R.
  TITLE     Repeated seizures lead to progressive ventilatory dysfunction in
            SSKcnj16-/- rats
  JOURNAL   J Appl Physiol (1985) 135 (4), 872-885 (2023)
   PUBMED   37535709
  REMARK    GeneRIF: Repeated seizures lead to progressive ventilatory
            dysfunction in SS[Kcnj16-/-] rats.
REFERENCE   3  (bases 1 to 1770)
  AUTHORS   Manis,A.D., Palygin,O., Isaeva,E., Levchenko,V., LaViolette,P.S.,
            Pavlov,T.S., Hodges,M.R. and Staruschenko,A.
  TITLE     Kcnj16 knockout produces audiogenic seizures in the Dahl
            salt-sensitive rat
  JOURNAL   JCI Insight 6 (1), 143251 (2021)
   PUBMED   33232300
  REMARK    GeneRIF: Kcnj16 knockout produces audiogenic seizures in the Dahl
            salt-sensitive rat.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1770)
  AUTHORS   Manis,A.D., Palygin,O., Khedr,S., Levchenko,V., Hodges,M.R. and
            Staruschenko,A.
  TITLE     Relationship between the renin-angiotensin-aldosterone system and
            renal Kir5.1 channels
  JOURNAL   Clin Sci (Lond) 133 (24), 2449-2461 (2019)
   PUBMED   31799617
  REMARK    GeneRIF: Knockout of Kcnj16 markedly altered RAAS regulation and
            function, suggesting Kir5.1 as a key regulator of the
            renin-angiotensin-aldosterone system , particularly when exposed to
            changes in dietary sodium and potassium content.
REFERENCE   5  (bases 1 to 1770)
  AUTHORS   Puissant,M.M., Muere,C., Levchenko,V., Manis,A.D., Martino,P.,
            Forster,H.V., Palygin,O., Staruschenko,A. and Hodges,M.R.
  TITLE     Genetic mutation of Kcnj16 identifies Kir5.1-containing channels as
            key regulators of acute and chronic pH homeostasis
  JOURNAL   FASEB J 33 (4), 5067-5075 (2019)
   PUBMED   30605394
REFERENCE   6  (bases 1 to 1770)
  AUTHORS   Hibino,H., Higashi-Shingai,K., Fujita,A., Iwai,K., Ishii,M. and
            Kurachi,Y.
  TITLE     Expression of an inwardly rectifying K+ channel, Kir5.1, in
            specific types of fibrocytes in the cochlear lateral wall suggests
            its functional importance in the establishment of endocochlear
            potential
  JOURNAL   Eur J Neurosci 19 (1), 76-84 (2004)
   PUBMED   14750965
  REMARK    GeneRIF: Specific immunoreactivity for Kir5.1 was detected in
            fibrocytes of the cochlear spiral ligament and spiral limbus, all
            of which are directly involved in K+ circulation.
REFERENCE   7  (bases 1 to 1770)
  AUTHORS   Konstas,A.A., Korbmacher,C. and Tucker,S.J.
  TITLE     Identification of domains that control the heteromeric assembly of
            Kir5.1/Kir4.0 potassium channels
  JOURNAL   Am J Physiol Cell Physiol 284 (4), C910-C917 (2003)
   PUBMED   12456399
  REMARK    GeneRIF: examined the heteromeric assembly of Kir5.1 with other Kir
            subunits and have shown that this subunit exhibits a highly
            selective interaction with members of the Kir4.0 subfamily and does
            not physically associate with other Kir subunits
REFERENCE   8  (bases 1 to 1770)
  AUTHORS   Tanemoto,M., Kittaka,N., Inanobe,A. and Kurachi,Y.
  TITLE     In vivo formation of a proton-sensitive K+ channel by heteromeric
            subunit assembly of Kir5.1 with Kir4.1
  JOURNAL   J Physiol 525 Pt 3 (Pt 3), 587-592 (2000)
   PUBMED   10856114
REFERENCE   9  (bases 1 to 1770)
  AUTHORS   Tucker,S.J., Imbrici,P., Salvatore,L., D'Adamo,M.C. and Pessia,M.
  TITLE     pH dependence of the inwardly rectifying potassium channel, Kir5.1,
            and localization in renal tubular epithelia
  JOURNAL   J Biol Chem 275 (22), 16404-16407 (2000)
   PUBMED   10764726
REFERENCE   10 (bases 1 to 1770)
  AUTHORS   Bond,C.T., Pessia,M., Xia,X.M., Lagrutta,A., Kavanaugh,M.P. and
            Adelman,J.P.
  TITLE     Cloning and expression of a family of inward rectifier potassium
            channels
  JOURNAL   Recept Channels 2 (3), 183-191 (1994)
   PUBMED   7874445
  REMARK    Erratum:[Receptors Channels 1994;2(4):following 350]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053314.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC078776.1, SRR26360181.1338535.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1770              JAXUCZ010000010.1  96517324-96519093
FEATURES             Location/Qualifiers
     source          1..1770
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1770
                     /gene="Kcnj16"
                     /gene_synonym="Kir5.1"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 16"
                     /db_xref="GeneID:29719"
                     /db_xref="RGD:61824"
     exon            1..1770
                     /gene="Kcnj16"
                     /gene_synonym="Kir5.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1302
                     /gene="Kcnj16"
                     /gene_synonym="Kir5.1"
                     /note="BIR9; inward rectifier K(+) channel Kir5.1;
                     potassium channel, inwardly rectifying subfamily J member
                     16; potassium voltage-gated channel subfamily J member 16"
                     /codon_start=1
                     /product="inward rectifier potassium channel 16"
                     /protein_id="NP_445766.2"
                     /db_xref="GeneID:29719"
                     /db_xref="RGD:61824"
                     /translation="MSYYGSSYRIVNVDSKYPGYPPEHAIAEKRRARRRLLHKDGSCN
                     VYFKHIFGEWGSYMVDIFTTLVDTKWRHMFVIFSLSYILSWLIFGSIFWLIALHHGDL
                     LSDPDITPCVDNVHSFTAAFLFSLETQTTIGYGYRCVTEECSVAVLTVILQSILSCII
                     NTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRA
                     QLLRYSEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNF
                     EILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFHDVLEVKRKYYKVNCLQFEGSVEV
                     YAPFCSAKQLDWKDQQLNNLEKTSPARGSCTSDTNTRRRSFSAVAMVSSCENPEETSL
                     SPQDECKEVPYQKALLTLNRISMESQM"
ORIGIN      
        1 ctgactcctt tggatgccct aaagaccaaa aaaaaaaaaa gaatgagcta ttacggaagt
       61 agctaccgga ttgtcaacgt ggactccaaa tatccaggct atcctccaga gcatgccata
      121 gccgagaaga gaagagcgag gaggcgcctg ctccacaaag atggcagctg taacgtgtac
      181 tttaaacaca tttttggaga atgggggagc tacatggttg atatattcac cactcttgtg
      241 gataccaagt ggcgccatat gtttgtaata ttttctttgt cttacattct ctcctggttg
      301 atattcggct ccatattttg gctcatagcc cttcatcacg gagacctatt aagcgatcca
      361 gacatcaccc cgtgcgtgga caacgtgcat tcatttacgg cggcgttttt attctccctt
      421 gagacccaaa ccaccatcgg gtacggttac cgttgtgtca cggaagaatg ctctgtggcc
      481 gtgctgacgg tcatccttca gtccatcctg agctgcatca taaacacctt catcattggg
      541 gcagccttgg caaagatggc gaccgcccgg aagcgagccc agaccatccg cttcagctat
      601 ttcgcactca tcggcatgag agacgggaag ctttgcctca tgtggcgcat aggtgacttc
      661 cgacccaacc atgtggtgga gggcacggtg agagcccaac ttctgcgcta ttcagaagac
      721 agcgaagggc ggatgacgat ggcgtttaaa gacctcaaac tcgtcaatga ccagataatc
      781 ctggtaacgc cagtgaccat tgtccatgaa attgaccacg agagtcctct gtatgccctt
      841 gaccgcaagg cagtggccaa agataatttc gagattctgg tgacatttat ttatactggt
      901 gactctactg ggacatccca ccagtccaga agttcctacg tccccagaga aattctctgg
      961 ggacacaggt ttcatgatgt attggaagtg aagagaaagt actacaaggt aaactgcttg
     1021 cagtttgagg gaagcgtgga agtctacgcc cccttttgca gtgccaaaca actggactgg
     1081 aaggaccaac agctcaacaa cttggagaaa acgtcccctg cccgaggatc ctgcacctcg
     1141 gacaccaaca ccaggaggag atccttcagc gcagttgcca tggtgagcag ctgtgagaac
     1201 ccagaggaga ccagcctgtc cccacaagat gagtgtaagg aggtccccta tcagaaagcc
     1261 ctcctgactt taaacaggat ctccatggaa tcccagatgt agccctcctc tctgaccctt
     1321 acctgaaggc cctgagctgc aagcacgatt tcttaacaaa atgttagttc tgtaatttgc
     1381 agcgggaaca gaaagcagag ccagttaaac ttggcataga atcatttgaa agttccacag
     1441 ttttctaata tgaaaattcg gcttccgtag cagagtttgt attagggaag cgattaagaa
     1501 gcctaattga ttacaattaa tctcattact gcgcatgctt gtgtctcctc ttgaaggtga
     1561 gataattagg agtatgtgtg aggggagggg agaagaggct gatagactag ataaaaatag
     1621 agaaaccggt aagctagata tttgcatata aattaattaa ttatggaatg aggacttata
     1681 acaatatctt atctcctaag cacaacagat gagataaacg cctcagctta ggagcgttgt
     1741 gataagtaaa taaaatccag cctggtttga
//
