LOCUS       NM_133321               1486 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus potassium inwardly-rectifying channel, subfamily
            J, member 15 (Kcnj15), mRNA.
ACCESSION   NM_133321
VERSION     NM_133321.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1486)
  AUTHORS   Okamoto,K., Iwasaki,N., Doi,K., Noiri,E., Iwamoto,Y., Uchigata,Y.,
            Fujita,T. and Tokunaga,K.
  TITLE     Inhibition of glucose-stimulated insulin secretion by KCNJ15, a
            newly identified susceptibility gene for type 2 diabetes
  JOURNAL   Diabetes 61 (7), 1734-1741 (2012)
   PUBMED   22566534
  REMARK    GeneRIF: It was shown that downregulation of Kcnj15 leads to
            increased insulin secretion in vitro and in vivo. The mechanism for
            regulating insulin secretion inolved a calcium-sensiong receptor.
REFERENCE   2  (bases 1 to 1486)
  AUTHORS   Earley,S. and Resta,T.C.
  TITLE     Estradiol attenuates hypoxia-induced pulmonary endothelin-1 gene
            expression
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 283 (1), L86-L93 (2002)
   PUBMED   12060564
REFERENCE   3  (bases 1 to 1486)
  AUTHORS   Hill,C.E., Briggs,M.M., Liu,J. and Magtanong,L.
  TITLE     Cloning, expression, and localization of a rat hepatocyte inwardly
            rectifying potassium channel
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 282 (2), G233-G240 (2002)
   PUBMED   11804844
REFERENCE   4  (bases 1 to 1486)
  AUTHORS   Pearson,W.L., Dourado,M., Schreiber,M., Salkoff,L. and Nichols,C.G.
  TITLE     Expression of a functional Kir4 family inward rectifier K+ channel
            from a gene cloned from mouse liver
  JOURNAL   J Physiol 514 (Pt 3) (Pt 3), 639-653 (1999)
   PUBMED   9882736
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY028455.1.
            
            [WARNING] On Oct 10, 2024 this sequence was replaced by
            NM_133321.3.
            
            On Aug 31, 2012 this sequence version replaced NM_133321.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY028455.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1486              AY028455.1         2-1487
FEATURES             Location/Qualifiers
     source          1..1486
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..1486
                     /gene="Kcnj15"
                     /gene_synonym="Kir4.2"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 15"
                     /db_xref="GeneID:170847"
                     /db_xref="RGD:621662"
     exon            1..103
                     /gene="Kcnj15"
                     /gene_synonym="Kir4.2"
                     /inference="alignment:Splign:2.1.0"
     exon            104..189
                     /gene="Kcnj15"
                     /gene_synonym="Kir4.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1337
                     /gene="Kcnj15"
                     /gene_synonym="Kir4.2"
                     /note="inward rectifier K(+) channel Kir4.2; potassium
                     channel, inwardly rectifying subfamily J member 15;
                     potassium voltage-gated channel subfamily J member 15"
                     /codon_start=1
                     /product="ATP-sensitive inward rectifier potassium channel
                     15"
                     /protein_id="NP_579855.1"
                     /db_xref="GeneID:170847"
                     /db_xref="RGD:621662"
                     /translation="MVARWVKGSEDAPLALQKIPDLQSGPRSLRMEAIHIGMSSAPLV
                     KHSNGVGLKAHRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAA
                     TFVMTWFLFGVVYYAIAFIHGDLELGESNSNHTPCIMKVDSLTGAFLFSLESQTTIGY
                     GVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVISK
                     QNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESP
                     FLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEE
                     IYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQKLEEQYRQEDQRE
                     RELRSLLLQQSNV"
     exon            190..1486
                     /gene="Kcnj15"
                     /gene_synonym="Kir4.2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaaaccagg ctcctggatt tgaccaactg ggacatgtct gagagtaaat gattccacag
       61 atttggctgt ggcagagtgt ggaaagtttc tcagctggac actgccatag cacagcccca
      121 tggtagccag gtgggtgaag gggagcgagg acgcgccact tgccctgcag aagattcctg
      181 acctacagag tggtccaagg agcctgagga tggaggccat tcacattggc atgtccagtg
      241 ccccactggt gaagcacagc aatggggttg gactcaaagc ccacaggccc cgagtcatgt
      301 cgaagagtgg acacagcaat gtgagaattg acaaggtaga cggtatctat ttgctctacc
      361 tccaggactt gtggacgaca gtcatcgaca tgaagtggag atataagctc accctgtttg
      421 ctgccacctt tgtgatgacc tggtttcttt ttggggtggt ctactatgcc atagctttta
      481 ttcatggcga tttagaactc ggggaatcta attctaacca cacgccctgc attatgaaag
      541 tggattccct cacaggggca ttcctctttt ccttggagtc tcagacaacc attggctatg
      601 gggtccgttc catcacagag gagtgtcccc acgctatctt cctcttggtt gcccaactgg
      661 tcatcaccac cttgattgaa atcttcatta ctggaacctt cctggccaag attgcaagac
      721 ccaaaaagcg agccgagacc attaagttca gccactgcgc cgtcatcagc aagcagaatg
      781 ggaagctatg cctggtcatc caggtggcta acatgaggaa gagtctcttg attcagtgcc
      841 agctttccgg aaaactcctc cagacacatg ttaccaaaga gggagagcgc attctcctca
      901 accaggctac tgtcaaattc cacgtggact cctcttccga gagtcccttt ctcatcctgc
      961 ctatgacctt ctaccatgtg ttggatgaga cgagccccct gcgggacctc acaccccaga
     1021 acctaaagga aaaggagttt gaattggtgg tgcttctcaa tgccaccgtg gaatccacca
     1081 gcgcagtctg ccagagccga acgtcttaca tcccagagga gatctactgg ggctttgagt
     1141 ttgtgcctgt ggtttctctc tccaaaaatg gaaagtatgt ggctgatttc agtcaatttg
     1201 agcagatccg gaagagcccg gattgtacct tctactgtgc ggattctgag aaacagaagc
     1261 ttgaagagca gtacaggcag gaggaccaga gggaacgtga gctgaggagc cttctactgc
     1321 agcagagcaa cgtctgaccc cggccggcct ctgggcatct cctaaccagg gctcttctca
     1381 aaagcaacgg ctgccatgaa catgggatgg gtggccctgc tcccaagcca cacagacgtc
     1441 catggccatc ttcctctttg ctatggtggc taaacaagca tttctg
//
