LOCUS       NM_053608               1268 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus potassium inwardly-rectifying channel, subfamily
            J, member 13 (Kcnj13), mRNA.
ACCESSION   NM_053608
VERSION     NM_053608.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1268)
  AUTHORS   Zietara,A., Palygin,O., Levchenko,V., Dissanayake,L.V.,
            Klemens,C.A., Geurts,A., Denton,J.S. and Staruschenko,A.
  TITLE     Kir7.1 knockdown and inhibition alter renal electrolyte handling
            but not the development of hypertension in Dahl salt-sensitive rats
  JOURNAL   Am J Physiol Renal Physiol 325 (2), F177-F187 (2023)
   PUBMED   37318990
  REMARK    GeneRIF: Kir7.1 knockdown and inhibition alter renal electrolyte
            handling but not the development of hypertension in Dahl
            salt-sensitive rats.
REFERENCE   2  (bases 1 to 1268)
  AUTHORS   Villanueva,S., Burgos,J., Lopez-Cayuqueo,K.I., Lai,K.M.,
            Valenzuela,D.M., Cid,L.P. and Sepulveda,F.V.
  TITLE     Cleft Palate, Moderate Lung Developmental Retardation and Early
            Postnatal Lethality in Mice Deficient in the Kir7.1 Inwardly
            Rectifying K+ Channel
  JOURNAL   PLoS One 10 (9), e0139284 (2015)
   PUBMED   26402555
  REMARK    GeneRIF: Kir7.1 is expressed in epithelial cells all along the
            respiratory tree.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1268)
  AUTHORS   Zhang,W., Zhang,X., Wang,H., Sharma,A.K., Edwards,A.O. and
            Hughes,B.A.
  TITLE     Characterization of the R162W Kir7.1 mutation associated with
            snowflake vitreoretinopathy
  JOURNAL   Am J Physiol Cell Physiol 304 (5), C440-C449 (2013)
   PUBMED   23255580
  REMARK    GeneRIF: Mutant subunits did not alter Kir7.1 channel selectivity.
REFERENCE   4  (bases 1 to 1268)
  AUTHORS   Tateno,T., Nakamura,N., Hirata,Y. and Hirose,S.
  TITLE     Role of C-terminus of Kir7.1 potassium channel in cell-surface
            expression
  JOURNAL   Cell Biol Int 30 (3), 270-277 (2006)
   PUBMED   16406822
  REMARK    GeneRIF: results suggest that the C-terminal length plays an
            important role in the plasma-membrane localization of Kir7.1
REFERENCE   5  (bases 1 to 1268)
  AUTHORS   Dong,K., Tang,L.Q., MacGregor,G.G., Leng,Q. and Hebert,S.C.
  TITLE     Novel nucleotide-binding sites in ATP-sensitive potassium channels
            formed at gating interfaces
  JOURNAL   EMBO J 24 (7), 1318-1329 (2005)
   PUBMED   15775962
REFERENCE   6  (bases 1 to 1268)
  AUTHORS   Suzuki,Y., Yasuoka,Y., Shimohama,T., Nishikitani,M., Nakamura,N.,
            Hirose,S. and Kawahara,K.
  TITLE     Expression of the K+ channel Kir7.1 in the developing rat kidney:
            role in K+ excretion
  JOURNAL   Kidney Int 63 (3), 969-975 (2003)
   PUBMED   12631077
  REMARK    GeneRIF: Kir7.1 is involved in the development of renal K+
            excretion between 14 and 21 days after birth under the condition of
            K+ overload.
REFERENCE   7  (bases 1 to 1268)
  AUTHORS   Doring,F. and Karschin,A.
  TITLE     Genomic structure and promoter analysis of the rat kir7.1 potassium
            channel gene (Kcnj13)
  JOURNAL   FEBS Lett 483 (2-3), 93-98 (2000)
   PUBMED   11042260
REFERENCE   8  (bases 1 to 1268)
  AUTHORS   Nakamura,N., Suzuki,Y., Ikeda,Y., Notoya,M. and Hirose,S.
  TITLE     Complex structure and regulation of expression of the rat gene for
            inward rectifier potassium channel Kir7.1
  JOURNAL   J Biol Chem 275 (36), 28276-28284 (2000)
   PUBMED   10871613
REFERENCE   9  (bases 1 to 1268)
  AUTHORS   Nakamura,N., Suzuki,Y., Sakuta,H., Ookata,K., Kawahara,K. and
            Hirose,S.
  TITLE     Inwardly rectifying K+ channel Kir7.1 is highly expressed in
            thyroid follicular cells, intestinal epithelial cells and choroid
            plexus epithelial cells: implication for a functional coupling with
            Na+,K+-ATPase
  JOURNAL   Biochem J 342 (Pt 2) (Pt 2), 329-336 (1999)
   PUBMED   10455019
REFERENCE   10 (bases 1 to 1268)
  AUTHORS   Doring,F., Derst,C., Wischmeyer,E., Karschin,C.,
            Schneggenburger,R., Daut,J. and Karschin,A.
  TITLE     The epithelial inward rectifier channel Kir7.1 displays unusual K+
            permeation properties
  JOURNAL   J Neurosci 18 (21), 8625-8636 (1998)
   PUBMED   9786970
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB013890.1.
            
            On Oct 11, 2005 this sequence version replaced NM_053608.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV213333.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1268              AB013890.1         9-1276
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..1268
                     /gene="Kcnj13"
                     /gene_synonym="Kir7.1"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 13"
                     /db_xref="GeneID:94341"
                     /db_xref="RGD:621661"
     exon            1..101
                     /gene="Kcnj13"
                     /gene_synonym="Kir7.1"
                     /inference="alignment:Splign:2.1.0"
     exon            102..577
                     /gene="Kcnj13"
                     /gene_synonym="Kir7.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1200
                     /gene="Kcnj13"
                     /gene_synonym="Kir7.1"
                     /note="inward rectifier K(+) channel Kir7.1; potassium
                     channel, inwardly rectifying subfamily J member 13;
                     potassium voltage-gated channel subfamily J member 13"
                     /codon_start=1
                     /product="inward rectifier potassium channel 13"
                     /protein_id="NP_446060.1"
                     /db_xref="GeneID:94341"
                     /db_xref="RGD:621661"
                     /translation="MDSRNCKVNAPLLSQRYRRMVTKDGHSTLQMDGAQRGLVYLRDA
                     WGILMDMRWRWMMLVFSASFVVHWLVFAVLWYAVAEMNGDLEIDHDVPPENHTICVKH
                     ITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKI
                     ARPKNRAFSIRFTDLAVVAHKDGKPNLIFQVANTRPSPLTSVRVSAVLYQERENGELY
                     QTSVDFHLDGISSEECPFFIFPLTYYHTITPSSPLATLLQHETPSHFELVVFLSAMQE
                     GTGEICQRRTSYLPSEIMLHHRFAALMTRGSKGEYQVKMENFDKTVPEHPTPVVSKSP
                     HRTDLDIHINGQSIDNFQIAETGLTE"
     exon            578..1257
                     /gene="Kcnj13"
                     /gene_synonym="Kir7.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctacaaacga cactgcaggt taaaactacc tggccaaaaa gacaagagtc tgctagcttc
       61 cttaagacct tccttggtag gctgatccca caaaagaact gagaaacaca gcctgagatg
      121 gacagcagga attgtaaagt taatgctcct ctcctaagtc aaagataccg gaggatggtc
      181 acaaaagatg gccacagcac acttcaaatg gatggtgctc aaagaggtct tgtgtatctt
      241 cgggatgcat ggggaatcct aatggacatg cgctggcgct ggatgatgct ggtcttttct
      301 gcttctttcg ttgtccactg gcttgttttt gcagtcctct ggtatgctgt agctgagatg
      361 aatggtgatc tggaaataga ccacgacgtc ccgcctgaaa accacactat ctgtgtgaag
      421 cacatcacca gtttcacagc tgcgttctcc ttctctctgg agacacaact tacaatcggc
      481 tatggcacca tgttccccag tggggactgt ccaagtgcaa tcgccttact tgccatacaa
      541 atgctcctag gcctcatgct agaggccttt atcacaggtg cctttgtggc gaagattgca
      601 cggccaaaaa atagagcttt ctcaatccga ttcacagact tagcagttgt agctcacaaa
      661 gatggcaaac ctaatcttat cttccaagtg gccaacaccc ggcccagccc tctgaccagc
      721 gttcgggtct ctgctgtact ctatcaggaa agagaaaatg gtgaactcta ccagaccagt
      781 gtggacttcc accttgatgg catcagttct gaggaatgtc cattcttcat cttcccgcta
      841 acctattatc atactatcac accatcaagt cctctagcta ccctgctcca gcatgagact
      901 ccttcacact ttgaattagt tgtgttcctc tcagcaatgc aagaaggcac tggggaaatc
      961 tgccaaagga ggacatccta cctaccctct gagatcatgt tacatcaccg atttgcagct
     1021 ctaatgactc gaggttccaa aggtgagtat caagtcaaga tggagaattt tgacaagact
     1081 gttcctgaac atccaactcc tgtggtctct aagagtccac ataggactga cctagatatt
     1141 catatcaatg gacaaagcat tgacaatttt cagattgctg aaacagggct gacagaataa
     1201 gactcatcta catcatccta cttcttaatg tattaaatat atgcagccag ctatgcaaaa
     1261 aaaaaaaa
//
