LOCUS       NM_053981               2283 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus potassium inwardly-rectifying channel, subfamily
            J, member 12 (Kcnj12), mRNA.
ACCESSION   NM_053981
VERSION     NM_053981.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2283)
  AUTHORS   Seyler,C., Scherer,D., Kopple,C., Kulzer,M., Korkmaz,S.,
            Xynogalos,P., Thomas,D., Kaya,Z., Scholz,E., Backs,J., Karle,C.,
            Katus,H.A. and Zitron,E.
  TITLE     Role of plasma membrane-associated AKAPs for the regulation of
            cardiac IK1 current by protein kinase A
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 390 (5), 493-503 (2017)
   PUBMED   28331977
  REMARK    GeneRIF: Report coupling of cardiac Kir2.1 and Kir2.2 subunits with
            the plasma membrane-bound AKAPs 15 and 79. Cardiac
            membrane-associated AKAPs are a functionally essential part of the
            regulatory cascade determining IK1 current function.
REFERENCE   2  (bases 1 to 2283)
  AUTHORS   Matamoros,M., Perez-Hernandez,M., Guerrero-Serna,G., Amoros,I.,
            Barana,A., Nunez,M., Ponce-Balbuena,D., Sacristan,S., Gomez,R.,
            Tamargo,J., Caballero,R., Jalife,J. and Delpon,E.
  TITLE     Nav1.5 N-terminal domain binding to alpha1-syntrophin increases
            membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels
  JOURNAL   Cardiovasc Res 110 (2), 279-290 (2016)
   PUBMED   26786162
  REMARK    GeneRIF: Nav1.5 N-terminal domain binding to alpha1-syntrophin
            increases membrane density of human Kir2.1, Kir2.2 and Nav1.5
            channels
REFERENCE   3  (bases 1 to 2283)
  AUTHORS   Murata,Y., Yasaka,T., Takano,M. and Ishihara,K.
  TITLE     Neuronal and glial expression of inward rectifier potassium channel
            subunits Kir2.x in rat dorsal root ganglion and spinal cord
  JOURNAL   Neurosci Lett 617, 59-65 (2016)
   PUBMED   26854211
  REMARK    GeneRIF: Kir2 channels composed of Kir2.1-2.3 subunits are
            expressed in neuronal and glial cells in the DRG and spinal cord,
            contributing to sensory transduction and motor control.
REFERENCE   4  (bases 1 to 2283)
  AUTHORS   Li,J., Blankenship,M.L. and Baccei,M.L.
  TITLE     Inward-rectifying potassium (Kir) channels regulate pacemaker
            activity in spinal nociceptive circuits during early life
  JOURNAL   J Neurosci 33 (8), 3352-3362 (2013)
   PUBMED   23426663
  REMARK    GeneRIF: Immunohistochemical analysis reveals the expression of
            Kir2.1, Kir2.2, and Kir2.3 within spontaneously bursting neurons
            that regulate the level of pacemaker activity within the developing
            superficial dorsal horn.
REFERENCE   5  (bases 1 to 2283)
  AUTHORS   Hansen,S.B., Tao,X. and MacKinnon,R.
  TITLE     Structural basis of PIP2 activation of the classical inward
            rectifier K+ channel Kir2.2
  JOURNAL   Nature 477 (7365), 495-498 (2011)
   PUBMED   21874019
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2283)
  AUTHORS   Chwalisz,W.T., Koelsch,B.U., Kindler-Rohrborn,A., Hedrich,H.J. and
            Wedekind,D.
  TITLE     The circling behavior of the deafblind LEW-ci2 rat is linked to a
            segment of RNO10 containing Myo15 and Kcnj12
  JOURNAL   Mamm Genome 14 (9), 620-627 (2003)
   PUBMED   14629112
  REMARK    GeneRIF: Myo15 and Kcnj12 can be regarded as candidate genes for
            the deafblind phenotype of the LEW-ci2 rat.
REFERENCE   7  (bases 1 to 2283)
  AUTHORS   Pruss,H., Wenzel,M., Eulitz,D., Thomzig,A., Karschin,A. and
            Veh,R.W.
  TITLE     Kir2 potassium channels in rat striatum are strategically localized
            to control basal ganglia function
  JOURNAL   Brain Res Mol Brain Res 110 (2), 203-219 (2003)
   PUBMED   12591157
REFERENCE   8  (bases 1 to 2283)
  AUTHORS   Chen,L., Kawano,T., Bajic,S., Kaziro,Y., Itoh,H., Art,J.J.,
            Nakajima,Y. and Nakajima,S.
  TITLE     A glutamate residue at the C terminus regulates activity of inward
            rectifier K+ channels: implication for Andersen's syndrome
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 8430-8435 (2002)
   PUBMED   12034888
REFERENCE   9  (bases 1 to 2283)
  AUTHORS   Leonoudakis,D., Mailliard,W., Wingerd,K., Clegg,D. and
            Vandenberg,C.
  TITLE     Inward rectifier potassium channel Kir2.2 is associated with
            synapse-associated protein SAP97
  JOURNAL   J Cell Sci 114 (Pt 5), 987-998 (2001)
   PUBMED   11181181
REFERENCE   10 (bases 1 to 2283)
  AUTHORS   Koyama,H., Morishige,K., Takahashi,N., Zanelli,J.S., Fass,D.N. and
            Kurachi,Y.
  TITLE     Molecular cloning, functional expression and localization of a
            novel inward rectifier potassium channel in the rat brain
  JOURNAL   FEBS Lett 341 (2-3), 303-307 (1994)
   PUBMED   8137958
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC127487.1.
            
            On Nov 13, 2006 this sequence version replaced NM_053981.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127487.1, DY319566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2283
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2283
                     /gene="Kcnj12"
                     /gene_synonym="IRK2; Kir2.1; Kir2.2"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 12"
                     /db_xref="GeneID:117052"
                     /db_xref="RGD:621660"
     exon            1..276
                     /gene="Kcnj12"
                     /gene_synonym="IRK2; Kir2.1; Kir2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..2260
                     /gene="Kcnj12"
                     /gene_synonym="IRK2; Kir2.1; Kir2.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..1616
                     /gene="Kcnj12"
                     /gene_synonym="IRK2; Kir2.1; Kir2.2"
                     /note="inward rectifier K(+) channel Kir2.2; potassium
                     channel, inwardly rectifying subfamily J member 12; IRK-2;
                     potassium voltage-gated channel subfamily J member 12"
                     /codon_start=1
                     /product="ATP-sensitive inward rectifier potassium channel
                     12"
                     /protein_id="NP_446433.2"
                     /db_xref="GeneID:117052"
                     /db_xref="RGD:621660"
                     /translation="MTAASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRN
                     RFVKKNGQCNIEFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIF
                     WVIAVAHGDLEPAEGRGRTPCVLQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVF
                     MVVAQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNL
                     RKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDE
                     ASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEE
                     KNQYKIDYSHFHKTYEVPSTPRCSAKDLVENKFLLPSANSFCYENELAFLSRDEEDEV
                     ATDRDGRSPQPEHDFDRLQASSGALERPYRRESEI"
ORIGIN      
        1 gtcgcgggac tgagcgacag aagccagcgg caagcccgga gcgagagccg agtggctggg
       61 ggcgccgtct gggcgtgcgc ccccgaccca tggctggctg gtggcaccca gcgcccggga
      121 gcgacgcgcc cctcggcgtg gagcgctccc aggggctgcg ctgaggcggc ggcggcaacg
      181 gtggcaatgc agccagcgca gcggcggccg ggacccggaa cggccgcgcg gagcttggag
      241 gacgcgggac gcgccgcgcc ccggccactg accgagaagt gcccccgcct ggagtcagcc
      301 tgggggcagg ccagggtcca ccagaccccg ggatgaccgc agccagtcgg gccaacccct
      361 acagcatcgt atcatcagag gaggacgggc tgcacctggt taccatgtca ggcgccaacg
      421 gttttggcaa tggcaaggtg catacacggc gccggtgccg caaccgcttt gtcaagaaga
      481 acggtcagtg caacattgaa ttcgccaaca tggatgagaa gtcacagcgc tacctggctg
      541 acatgtttac cacatgtgtg gatatccgct ggcgctacat gctgctcatc ttctctctgg
      601 cctttcttgc ctcctggttg ctgttcggca tcatcttctg ggtcattgcg gtcgcccacg
      661 gagacctgga gccggctgag ggccgcggcc gtacaccctg tgtgctacag gtccatggct
      721 ttatggcagc ctttctcttc tccattgaga cgcagaccac cattggctac gggctacgat
      781 gcgtgactga agagtgccca gtggctgtct tcatggtggt ggctcagtcc attgtgggct
      841 gcatcattga ctccttcatg atcggcgcca tcatggccaa gatggcgcgg cccaagaagc
      901 gagcacagac tctgcttttc agccacaatg ccgtggtggc tctgcgtgac ggcaagctct
      961 gcctcatgtg gcgcgtgggc aacctgcgca agagccacat cgtagaggcc cacgtgcgag
     1021 cccagctcat caagcccagg gtcacagaag agggtgagta catcccactg gaccagattg
     1081 acattgacgt tggctttgac aagggcctgg atcgtatctt cctagtatcg cccatcacca
     1141 tcttgcacga gattgatgag gccagcccac tgtttggcat tagccgtcag gacctcgaga
     1201 cggacgactt tgagatcgtg gtcatcctgg aaggcatggt agaggccaca gccatgacca
     1261 cccaggctcg cagttcctac ctggccaacg agatcctctg gggtcatcgc tttgagccag
     1321 tgctcttcga agagaagaac cagtacaaga ttgactactc acacttccac aagacctatg
     1381 aggtgccatc tacaccccgc tgcagcgcca aggacctggt ggagaacaag ttccttctgc
     1441 ccagtgccaa ctctttctgc tatgagaatg agctagcctt cctgagccga gatgaggagg
     1501 atgaggtggc tacagaccgg gatggccgca gccctcagcc tgagcatgac tttgacaggc
     1561 tgcaggccag cagtggtgcc cttgagcggc cctacagacg ggagtcagag atttgagtgc
     1621 ccttggctta gatgcagcac caccctgacc acgataggtt ccatgtccct tggggacctg
     1681 tgtttgagca gagcaggccg aatgccttgg gtcacagact cagtaacatc ttagtctttt
     1741 tcatgttttc ttgcaatagc ttgggaaagt tggcaggagg gtggatggcc agaatgacca
     1801 gctcatggcc tcggaggctg atgtatacac acgggcaagg aagtgatttc ttggggtagg
     1861 gttgtacagg agttggggac tctgctggag gcctcgggag caggtcctag ccatggtggg
     1921 agaaggctgt gtatgtacac ttcattggtt tttaatttgg gcaagactgt ttacaaacaa
     1981 aaacaaaaac aaaaaaaccc acaaaacaca agaaaacact aacaggtggt tcaattttta
     2041 aaattcatgg tgtagggaca gctggaatat tctactcagc gctgcgaagc aatcagttgt
     2101 atggagaccc ctgaaggttc tcagaggtcg ggtttctccc tcacgtgggc cagggccctg
     2161 caagttgtca ttcttaagga tggatcaggc agtttgtgac catgttacga tcctaataaa
     2221 gtatctgggt gtctctgggg gtggggccca ctagggtgaa aaaaaaaaaa aaaaaaaaaa
     2281 aaa
//
