LOCUS       NM_031358               3051 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus potassium inwardly-rectifying channel, subfamily
            J, member 11 (Kcnj11), mRNA.
ACCESSION   NM_031358
VERSION     NM_031358.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3051)
  AUTHORS   Li,Y., Ba,M., Du,Y., Xia,C., Tan,S., Ng,K.P. and Ma,G.
  TITLE     Abeta1-42 increases the expression of neural KATP subunits
            Kir6.2/SUR1 via the NF-kappaB, p38 MAPK and PKC signal pathways in
            rat primary cholinergic neurons
  JOURNAL   Hum Exp Toxicol 38 (6), 665-674 (2019)
   PUBMED   30868916
  REMARK    GeneRIF: Our findings suggest that the NF-kappaB, p38 MAPK, and PKC
            signal pathways are partially involved in the upregulation of KATP
            subunits Kir6.2/SUR1 expression induced by Abeta1-42 cytotoxicity
            in neurons, which supports a potential theoretical basis of
            targeting these signal pathways in the treatment of Alzheimer's
            disease.
REFERENCE   2  (bases 1 to 3051)
  AUTHORS   Wang,X. and Fitts,R.H.
  TITLE     Effects of regular exercise on ventricular myocyte biomechanics and
            KATP channel function
  JOURNAL   Am J Physiol Heart Circ Physiol 315 (4), H885-H896 (2018)
   PUBMED   30074836
  REMARK    GeneRIF: Up-regulation of the KATP channel accelerates
            repolarization and shortens action potential duration during stress
            and exercise.
REFERENCE   3  (bases 1 to 3051)
  AUTHORS   Cooper,P.E., McClenaghan,C., Chen,X., Stary-Weinzinger,A. and
            Nichols,C.G.
  TITLE     Conserved functional consequences of disease-associated mutations
            in the slide helix of Kir6.1 and Kir6.2 subunits of the
            ATP-sensitive potassium channel
  JOURNAL   J Biol Chem 292 (42), 17387-17398 (2017)
   PUBMED   28842488
  REMARK    GeneRIF: both Kir6.1(V65M) and Kir6.2(V64M) mutations essentially
            abolish high-affinity sensitivity to the KATP blocker glibenclamide
            in both intact cells and excised patches. This raises the
            possibility that, at least for some CS mutations, sulfonylurea
            therapy may not prove to be successful and highlights the need for
            detailed pharmacogenomic analyses of CS mutations.
REFERENCE   4  (bases 1 to 3051)
  AUTHORS   Feng,Y., Liu,J., Wang,M., Liu,M., Shi,L., Yuan,W., Ye,J., Hu,D. and
            Wan,J.
  TITLE     The E23K variant of the Kir6.2 subunit of the ATP-sensitive
            potassium channel increases susceptibility to ventricular
            arrhythmia in response to ischemia in rats
  JOURNAL   Int J Cardiol 232, 192-198 (2017)
   PUBMED   28082085
  REMARK    GeneRIF: The E23K variant of the KATP channel increased the
            susceptibility to ventricular arrhythmia under acute ischemia
            stress.
REFERENCE   5  (bases 1 to 3051)
  AUTHORS   Martin,G.M., Yoshioka,C., Rex,E.A., Fay,J.F., Xie,Q., Whorton,M.R.,
            Chen,J.Z. and Shyng,S.L.
  TITLE     Cryo-EM structure of the ATP-sensitive potassium channel
            illuminates mechanisms of assembly and gating
  JOURNAL   Elife 6, e24149 (2017)
   PUBMED   28092267
  REMARK    GeneRIF: Intricate interactions between TMD0, the loop following
            TMD0, and Kir6.2 near the proposed PIP2 binding site, and where ATP
            density is observed, suggest SUR1 may contribute to ATP and PIP2
            binding to enhance Kir6.2 sensitivity to both.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3051)
  AUTHORS   Moritz,W., Leech,C.A., Ferrer,J. and Habener,J.F.
  TITLE     Regulated expression of adenosine triphosphate-sensitive potassium
            channel subunits in pancreatic beta-cells
  JOURNAL   Endocrinology 142 (1), 129-138 (2001)
   PUBMED   11145575
REFERENCE   7  (bases 1 to 3051)
  AUTHORS   Thomas,P., Ye,Y. and Lightner,E.
  TITLE     Mutation of the pancreatic islet inward rectifier Kir6.2 also leads
            to familial persistent hyperinsulinemic hypoglycemia of infancy
  JOURNAL   Hum Mol Genet 5 (11), 1809-1812 (1996)
   PUBMED   8923010
REFERENCE   8  (bases 1 to 3051)
  AUTHORS   Isomoto,S., Kondo,C., Yamada,M., Matsumoto,S., Higashiguchi,O.,
            Horio,Y., Matsuzawa,Y. and Kurachi,Y.
  TITLE     A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth
            muscle type ATP-sensitive K+ channel
  JOURNAL   J Biol Chem 271 (40), 24321-24324 (1996)
   PUBMED   8798681
REFERENCE   9  (bases 1 to 3051)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P., Wang,C.Z., Aguilar-Bryan,L.,
            Bryan,J. and Seino,S.
  TITLE     A family of sulfonylurea receptors determines the pharmacological
            properties of ATP-sensitive K+ channels
  JOURNAL   Neuron 16 (5), 1011-1017 (1996)
   PUBMED   8630239
REFERENCE   10 (bases 1 to 3051)
  AUTHORS   Tokuyama,Y., Fan,Z., Furuta,H., Makielski,J.C., Polonsky,K.S.,
            Bell,G.I. and Yano,H.
  TITLE     Rat inwardly rectifying potassium channel Kir6.2: cloning
            electrophysiological characterization, and decreased expression in
            pancreatic islets of male Zucker diabetic fatty rats
  JOURNAL   Biochem Biophys Res Commun 220 (3), 532-538 (1996)
   PUBMED   8607800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D61687.1, D86039.1, AB043638.1, BF565039.1 and AW527189.1.
            
            On Feb 11, 2005 this sequence version replaced NM_031358.2.
            
            Sequence Note: This RefSeq record was created using sequences from
            two different strains, W and Sprague-Dawley, because no single
            transcript from the same strain was available for the full length
            of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1466              D61687.1           9-1474
            1467-1761           D86039.1           1767-2061
            1762-1848           AB043638.1         1529-1615
            1849-2564           D86039.1           2149-2864
            2565-2782           BF565039.1         66-283
            2783-3051           AW527189.1         1-269               c
FEATURES             Location/Qualifiers
     source          1..3051
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3051
                     /gene="Kcnj11"
                     /gene_synonym="Kir6.2"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 11"
                     /db_xref="GeneID:83535"
                     /db_xref="RGD:69247"
     exon            1..3034
                     /gene="Kcnj11"
                     /gene_synonym="Kir6.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1409
                     /gene="Kcnj11"
                     /gene_synonym="Kir6.2"
                     /note="BIR; inward rectifier K(+) channel Kir6.2;
                     potassium channel, inwardly rectifying subfamily J member
                     11; potassium voltage-gated channel subfamily J member 11"
                     /codon_start=1
                     /product="ATP-sensitive inward rectifier potassium channel
                     11"
                     /protein_id="NP_112648.2"
                     /db_xref="GeneID:83535"
                     /db_xref="RGD:69247"
                     /translation="MLSRKGIIPEEYVLTRLAEDPTEPRYRTRERRARFVSKKGNCNV
                     AHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMVWWLIAFAHGDLAP
                     GEGTNVPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMIN
                     AIMLGCIFMKTAQAHRRAETLIFSKHAVITLRHGRLCFMLRVGDLRKSMIISATIHMQ
                     VVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDSNSPLYDLAPSDLH
                     HHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFG
                     NTVKVPTPLCTARQLDEDRSLLDALTLASSRGPLRKRSVAVAKAKPKFSISPDSLS"
     polyA_site      3034
                     /gene="Kcnj11"
                     /gene_synonym="Kir6.2"
ORIGIN      
        1 ccagggccag gtagagtaca ggctgggtca ggggctcagt aagcaatgag cagggggcgt
       61 cggcatctga agctagtata aaaagaaaca gaaccagctg gggggcatat cagtccagag
      121 gttggtgcaa gcttgaggag agggctcaga gagggggacc ctacaaagag gccctaggcc
      181 aagccagtgt agtgcctccc ccatggggga aaccccttcc tggggccaac ggagccatgc
      241 tgtcccgaaa gggcattatc cctgaggaat atgtgctgac ccggctggca gaggacccta
      301 cagagcccag gtaccgtact cgggagagga gggcccgctt cgtgtccaag aaaggcaact
      361 gcaacgtcgc ccacaagaac atccgagagc agggccgctt cctgcaagat gtgttcacca
      421 cgctggtgga cctcaagtgg ccccacacgc tgctcatttt caccatgtcc ttcctgtgca
      481 gctggctgct cttcgccatg gtctggtggc tcatcgcctt tgcccacggt gacttggccc
      541 ccggagaggg caccaatgtg ccctgcgtca caagcatcca ctccttttcg tctgccttcc
      601 ttttctccat cgaggtccag gtgaccattg gtttcggcgg gcgcatggtg acagaggaat
      661 gtcccctggc catccttatt ctgatcgtgc agaatatcgt agggctaatg atcaacgcca
      721 tcatgctggg ctgcatcttc atgaaaacgg cacaggccca tcggcgggca gaaaccctca
      781 tcttcagcaa gcatgccgtg atcaccctgc gacatggccg cctgtgcttc atgcttcgcg
      841 taggggacct ccgaaaaagc atgatcatta gcgccaccat tcatatgcag gtggtgcgca
      901 agaccaccag cccggagggc gaggttgtgc ctctccacca ggtggacatc cccatggaga
      961 acggtgtggg tggtaacagc atctttctgg tggccccact catcatctac cacgtcatcg
     1021 actccaacag cccgctctac gacctggctc ctagtgacct gcaccaccac caggacctgg
     1081 agatcattgt catcttggaa ggtgtggtag aaaccacagg cattaccacc caggcccgca
     1141 cctcctatct ggctgacgag attctgtggg ggcagcgttt tgtccccatc gtggccgagg
     1201 aggatggccg ctattctgtg gactactcca aattcgggaa caccgttaaa gtgcccacac
     1261 cactctgcac agcccgccag cttgatgagg accgcagcct gctggatgcc ctgaccctcg
     1321 cctcgtcgcg agggcccctg cgcaagcgca gtgtggctgt ggcaaaggcc aagcccaagt
     1381 ttagcatctc tccggattcc ttgtcctgag ttgcggtccc tcaggccccc actcacttag
     1441 gtgggcacat ggaaagtgaa gtacggtatg tagagtgctg gggtgcgagc ccctcggcca
     1501 gatgagggtc tggcgtggga caagaccctc cttggctcag cctccccgcc gctgtgtgcc
     1561 tggggtgtta caagatactt gtcactatgc tatttctggc cccagcagga gcctgtaccg
     1621 ggttattttt gttcctgctc ctcccgggct cagctcagga ctggcttacc ctatgtccct
     1681 gcccaacgat ggggaggcta tagaaggttc aggggtccta aagctaaggt ctggaaggaa
     1741 gccagtcttg gtcctccacg attcatcctg ccacaagcag gcaggtaatt gggcaaaagc
     1801 agcccccaag ttgggagcct attgctgttt ctgtagccac taagaaatac ctggccaggc
     1861 cccagccctg ttcgtgccac gctaaagaat cctgccagcc agggaggagg tgggtgtcag
     1921 agcgtgggag ctgaggggcc cacacagcca cgacaggata agtttaccta ggctctcctc
     1981 catatggccg gcttatgaga gaaaggggga caagaaggag gcaaatgatt ggagaccttg
     2041 atggtcccgt tcagacgcgt gtctctgtcc tctacccttg actccagcct tctgcagaga
     2101 gagtggggac tgctgccctg ttttgtcccc cggagaggct gggaagtggg gcattgggca
     2161 aacactgaga tacctggctg agaggccgaa aagggtcctg tgagtgccat acaagatcta
     2221 cttcaggcaa aactctgctc ttggctcccc atgggcagct gtcactttgt ctgggggaca
     2281 ctggtgggta gcaatgcctt gtctaggttg tcagaaaaag aaatattgga aagttcaccc
     2341 tggtgaggga aagggaggtc tccaaggcaa aaggcccttg ggcttgacct gagcccggac
     2401 tctcagagca gtgtagtgtc ctcgcccaga accccactgg cccgtcgtca ataaagcctc
     2461 ccatctgtga cctgaactct gggcttttct tgctggggag gcagtgggca tgccactggg
     2521 gggaaaaggc actgtcagag tctgccacct agcatggccc ggcaggcaag aggccagaaa
     2581 agctacttag actagctcct ccgtttccct cacctcagga ggccatcatc cttccacctc
     2641 aggttccacc ccccccccac tctcagtctg tctggccaac tccaccattt gacatccacc
     2701 agacatcata gtcaagggcc tgggctgtct cctgactctg ctggaaggct gaggtgccca
     2761 tggggagggg gagggaggct gtaggcctca ggggtattga ttggctcaaa tcctggctcc
     2821 agctgaacca ccctgtgacc cggttgtctc gcccatgtta atagtcccta cctcattagg
     2881 ttgagcaggt gaaaacacat gtatacttgc ttcggaagtg cctggtctgt acacaagtgc
     2941 tcaataaatg tcaaccgtcg tgatcgctgc tgagctagcc atgtgatggg aaaactaaac
     3001 ctaagacaaa aaaaaaaaag atgtttttac actgaaaaaa aaaaaaaaaa a
//
