LOCUS       NM_031602               1438 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus potassium inwardly-rectifying channel, subfamily
            J, member 10 (Kcnj10), mRNA.
ACCESSION   NM_031602
VERSION     NM_031602.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1438)
  AUTHORS   Lu,S., Wang,J., Sun,T., Yan,H., Zou,W., Li,H., Qi,Q. and Sun,M.
  TITLE     [IL-6 promotes the activation of rat astrocytes and down-regulation
            of the expression of Kir4.1 channel]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 38 (4), 316-320 (2022)
   PUBMED   35583060
  REMARK    GeneRIF: [IL-6 promotes the activation of rat astrocytes and
            down-regulation of the expression of Kir4.1 channel].
REFERENCE   2  (bases 1 to 1438)
  AUTHORS   Peric,M., Nikolic,L., Andjus,P.R. and Bataveljic,D.
  TITLE     Dysfunction of oligodendrocyte inwardly rectifying potassium
            channel in a rat model of amyotrophic lateral sclerosis
  JOURNAL   Eur J Neurosci 54 (7), 6339-6354 (2021)
   PUBMED   34510584
  REMARK    GeneRIF: Dysfunction of oligodendrocyte inwardly rectifying
            potassium channel in a rat model of amyotrophic lateral sclerosis.
REFERENCE   3  (bases 1 to 1438)
  AUTHORS   Madadi,A., Wolfart,J., Lange,F., Brehme,H., Linnebacher,M.,
            Brauer,A.U., Buttner,A., Freiman,T., Henker,C., Einsle,A.,
            Rackow,S., Kohling,R., Kirschstein,T. and Muller,S.
  TITLE     Correlation between Kir4.1 expression and barium-sensitive currents
            in rat and human glioma cell lines
  JOURNAL   Neurosci Lett 741, 135481 (2021)
   PUBMED   33161102
  REMARK    GeneRIF: Correlation between Kir4.1 expression and barium-sensitive
            currents in rat and human glioma cell lines.
REFERENCE   4  (bases 1 to 1438)
  AUTHORS   Kinboshi,M., Shimizu,S., Mashimo,T., Serikawa,T., Ito,H., Ikeda,A.,
            Takahashi,R. and Ohno,Y.
  TITLE     Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic
            Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant
            Rats
  JOURNAL   Int J Mol Sci 20 (5), 1013 (2019)
   PUBMED   30813600
  REMARK    GeneRIF: he down-regulation of Kir4.1 channels in astrocytes is
            involved in audiogenic epileptogenesis caused by Lgi1 mutation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1438)
  AUTHORS   Thompson,K., Chen,J., Luo,Q., Xiao,Y., Cummins,T.R. and
            Bhatwadekar,A.D.
  TITLE     Advanced glycation end (AGE) product modification of laminin
            downregulates Kir4.1 in retinal Muller cells
  JOURNAL   PLoS One 13 (2), e0193280 (2018)
   PUBMED   29474462
  REMARK    GeneRIF: studies suggest that AGE-modification of laminin is
            detrimental to Kir4.1 channels. By studying the role of AGEs in
            Kir4.1 channels we have identified a novel mechanism of Muller cell
            dysfunction and its subsequent involvement in Diabetic retinopathy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1438)
  AUTHORS   Kurschner,C. and Yuzaki,M.
  TITLE     Neuronal interleukin-16 (NIL-16): a dual function PDZ domain
            protein
  JOURNAL   J Neurosci 19 (18), 7770-7780 (1999)
   PUBMED   10479680
REFERENCE   7  (bases 1 to 1438)
  AUTHORS   Kurschner,C., Mermelstein,P.G., Holden,W.T. and Surmeier,D.J.
  TITLE     CIPP, a novel multivalent PDZ domain protein, selectively interacts
            with Kir4.0 family members, NMDA receptor subunits, neurexins, and
            neuroligins
  JOURNAL   Mol Cell Neurosci 11 (3), 161-172 (1998)
   PUBMED   9647694
REFERENCE   8  (bases 1 to 1438)
  AUTHORS   Bredt,D.S., Wang,T.L., Cohen,N.A., Guggino,W.B. and Snyder,S.H.
  TITLE     Cloning and expression of two brain-specific inwardly rectifying
            potassium channels
  JOURNAL   Proc Natl Acad Sci U S A 92 (15), 6753-6757 (1995)
   PUBMED   7624316
REFERENCE   9  (bases 1 to 1438)
  AUTHORS   Takumi,T., Ishii,T., Horio,Y., Morishige,K., Takahashi,N.,
            Yamada,M., Yamashita,T., Kiyama,H., Sohmiya,K., Nakanishi,S. et al.
  TITLE     A novel ATP-dependent inward rectifier potassium channel expressed
            predominantly in glial cells
  JOURNAL   J Biol Chem 270 (27), 16339-16346 (1995)
   PUBMED   7608203
REFERENCE   10 (bases 1 to 1438)
  AUTHORS   Bond,C.T., Pessia,M., Xia,X.M., Lagrutta,A., Kavanaugh,M.P. and
            Adelman,J.P.
  TITLE     Cloning and expression of a family of inward rectifier potassium
            channels
  JOURNAL   Recept Channels 2 (3), 183-191 (1994)
   PUBMED   7874445
  REMARK    Erratum:[Receptors Channels 1994;2(4):following 350]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Apr 28, 2015 this sequence version replaced NM_031602.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U27558.1, X86818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000013.1  87334510-87334643
            135-1438            JAXUCZ010000013.1  87362711-87364014
FEATURES             Location/Qualifiers
     source          1..1438
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1438
                     /gene="Kcnj10"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 10"
                     /db_xref="GeneID:29718"
                     /db_xref="RGD:61822"
     exon            1..134
                     /gene="Kcnj10"
                     /inference="alignment:Splign:2.1.0"
     exon            135..1438
                     /gene="Kcnj10"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1274
                     /gene="Kcnj10"
                     /note="BIR10; BIRK1; kir4.1; brain-specific inwardly
                     rectifying K(+) channel 1; ATP-sensitive inward rectifier
                     potassium channel KAB-2; potassium channel, inwardly
                     rectifying subfamily J member 10; inward rectifier K(+)
                     channel Kir4.1; potassium voltage-gated channel subfamily
                     J member 10"
                     /codon_start=1
                     /product="ATP-sensitive inward rectifier potassium channel
                     10"
                     /protein_id="NP_113790.2"
                     /db_xref="GeneID:29718"
                     /db_xref="RGD:61822"
                     /translation="MTSVAKVYYSQTTQTESRPLVAPGIRRRRVLTKDGRSNVRMEHI
                     ADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELGPP
                     ANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIF
                     ITGTFLAKIARPKKRAETIRFSQHAVVAYHNGKLCLMIRVANMRKSLLIGCQVTGKLL
                     QTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGD
                     FELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYVADFSLFDQVV
                     KVASPGGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVRISNV"
ORIGIN      
        1 gattccagct gggggtttaa gagtcttggc cctggcagtg gcacagctcc gctcgccact
       61 cctgcccgcc agtctcttca tctgtcccac taccccagga ttcatcagag cagccactcc
      121 acctctgtgc caagatgaca tcagttgcca aggtctatta cagccagacg acgcagacag
      181 agagccggcc cctagtggct ccaggaatac gtcggaggag ggtcctgaca aaagatggcc
      241 ggagcaacgt gagaatggag catattgctg acaagcgttt cctctacctc aaggatctat
      301 ggacgacctt cattgacatg cagtggcgct acaagcttct gctcttctcg gcaacctttg
      361 caggcacttg gttcctcttt ggcgtggtgt ggtatctggt cgctgtggcc cacggggacc
      421 tgttggagct gggacctcct gccaaccaca cgccctgtgt ggtgcaggtg cacacactta
      481 ctggggcctt cctcttctcc ctcgaatccc agaccaccat tggctatggc ttccgctaca
      541 tcagcgagga atgccctctg gccattgtgc ttctcattgc acagctcgtg ctcaccacca
      601 ttctggaaat cttcatcacc ggaaccttcc ttgcaaagat tgcccggcca aagaagaggg
      661 ctgagacgat ccgtttcagc cagcatgcgg ttgtggctta ccacaacggg aagctttgcc
      721 tcatgatccg ggtggccaac atgcgtaaga gtctcctcat tgggtgccag gtgacaggca
      781 aactgcttca aacccaccag acaaaggagg gtgagaatat tcggctcaac caggtcaatg
      841 tgactttcca agtagacaca gcctctgata gcccctttct cattctaccc ctgactttct
      901 accatgtggt agatgagacc agccccttga aagatctccc cctccgcagc ggggagggtg
      961 acttcgagct cgtgctgatc ctaagtggga cggtggagtc caccagcgcc acctgtcaag
     1021 ttcgcacttc ctatctaccg gaggagatcc tctggggcta cgagttcaca cctgctatct
     1081 cactgtcagc cagtggcaaa tacgtggctg acttcagcct ttttgaccag gttgtgaaag
     1141 tggcgtcccc cggtggtctc cgagatagca ccgtacgtta tggagaccca gaaaagctca
     1201 agttggagga gtcattaaga gagcaagctg aaaaggaagg cagtgccctt agtgtgcgca
     1261 ttagtaacgt ctgacatcct gttctctcct cctcagccct ctggcctttt cctctcccag
     1321 tgtcctggga aaaggatact atctgggttc gctggagagc cctggaagta cccatcctct
     1381 actttccctt aacccggtgg cctatgagca gtctaggcct gctggagtcc tactcttt
//
