LOCUS       NM_017023               2999 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus potassium inwardly-rectifying channel, subfamily
            J, member 1 (Kcnj1), transcript variant 1, mRNA.
ACCESSION   NM_017023
VERSION     NM_017023.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2999)
  AUTHORS   O'Donnell,B.M., Mackie,T.D., Subramanya,A.R. and Brodsky,J.L.
  TITLE     Endoplasmic reticulum-associated degradation of the renal potassium
            channel, ROMK, leads to type II Bartter syndrome
  JOURNAL   J Biol Chem 292 (31), 12813-12827 (2017)
   PUBMED   28630040
  REMARK    GeneRIF: Data suggest underlying pathology for some patients with
            type II Bartter syndrome is linked to stability of ROMK1 in ERAD
            pathway; using a yeast expression system, cells can be rescued by
            wild-type (rat) ROMK1 but not by ROMK1 containing any one of four
            mutations found in (human) type II Bartter syndrome; mutant ROMKs
            are significantly less stable than wild-type ROMK. (ERAD =
            endoplasmic reticulum-associated degradation)
REFERENCE   2  (bases 1 to 2999)
  AUTHORS   Araujo,M., Welch,W.J., Zhou,X., Sullivan,K., Walsh,S., Pasternak,A.
            and Wilcox,C.S.
  TITLE     Inhibition of ROMK blocks macula densa tubuloglomerular feedback
            yet causes renal vasoconstriction in anesthetized rats
  JOURNAL   Am J Physiol Renal Physiol 312 (6), F1120-F1127 (2017)
   PUBMED   28228405
  REMARK    GeneRIF: Blockade of ROMK or Na(+)-K(+)-2Cl(-) transport inhibits
            tubuloglomerular feedback yet increases renal vascular resistance.
            The renal vasoconstriction was independent of volume depletion,
            blood pressure, TGF, or proximal tubule hydrostatic pressure.
REFERENCE   3  (bases 1 to 2999)
  AUTHORS   Smoot,B., Kober,K.M., Paul,S.M., Levine,J.D., Abrams,G.,
            Mastick,J., Topp,K., Conley,Y.P. and Miaskowski,C.A.
  TITLE     Potassium Channel Candidate Genes Predict the Development of
            Secondary Lymphedema Following Breast Cancer Surgery
  JOURNAL   Nurs Res 66 (2), 85-94 (2017)
   PUBMED   28252570
  REMARK    GeneRIF: These preliminary findings suggest that K channel genes
            play a role in the development of secondary lymphedema
REFERENCE   4  (bases 1 to 2999)
  AUTHORS   Bollepalli,M.K., Fowler,P.W., Rapedius,M., Shang,L., Sansom,M.S.,
            Tucker,S.J. and Baukrowitz,T.
  TITLE     State-dependent network connectivity determines gating in a K+
            channel
  JOURNAL   Structure 22 (7), 1037-1046 (2014)
   PUBMED   24980796
  REMARK    GeneRIF: Data indicate that mutations in kir1.1 potassium channel
            preferentially increase pH sensitivity.
REFERENCE   5  (bases 1 to 2999)
  AUTHORS   Hu,J., Qiu,S., Yang,F., Cao,Z., Li,W. and Wu,Y.
  TITLE     Unique mechanism of the interaction between honey bee toxin TPNQ
            and rKir1.1 potassium channel explored by computational
            simulations: insights into the relative insensitivity of channel
            towards animal toxins
  JOURNAL   PLoS One 8 (7), e67213 (2013)
   PUBMED   23874410
  REMARK    GeneRIF: The TPNQ toxin-rKir1.1 channel complex structure not only
            revealed their unique interaction mechanism, but also elucidate the
            relative insensitivity of rKir1.1 channel towards animal toxins.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2999)
  AUTHORS   Beesley,A.H., Ortega,B. and White,S.J.
  TITLE     Splicing of a retained intron within ROMK K+ channel RNA generates
            a novel set of isoforms in rat kidney
  JOURNAL   Am J Physiol 276 (3), C585-C592 (1999)
   PUBMED   10069985
REFERENCE   7  (bases 1 to 2999)
  AUTHORS   Derst,C., Konrad,M., Kockerling,A., Karolyi,L., Deschenes,G.,
            Daut,J., Karschin,A. and Seyberth,H.W.
  TITLE     Mutations in the ROMK gene in antenatal Bartter syndrome are
            associated with impaired K+ channel function
  JOURNAL   Biochem Biophys Res Commun 230 (3), 641-645 (1997)
   PUBMED   9015377
REFERENCE   8  (bases 1 to 2999)
  AUTHORS   Boim,M.A., Ho,K., Shuck,M.E., Bienkowski,M.J., Block,J.H.,
            Slightom,J.L., Yang,Y., Brenner,B.M. and Hebert,S.C.
  TITLE     ROMK inwardly rectifying ATP-sensitive K+ channel. II. Cloning and
            distribution of alternative forms
  JOURNAL   Am J Physiol 268 (6 Pt 2), F1132-F1140 (1995)
   PUBMED   7611454
REFERENCE   9  (bases 1 to 2999)
  AUTHORS   Zhou,H., Tate,S.S. and Palmer,L.G.
  TITLE     Primary structure and functional properties of an epithelial K
            channel
  JOURNAL   Am J Physiol 266 (3 Pt 1), C809-C824 (1994)
   PUBMED   8166245
REFERENCE   10 (bases 1 to 2999)
  AUTHORS   Ho,K., Nichols,C.G., Lederer,W.J., Lytton,J., Vassilev,P.M.,
            Kanazirska,M.V. and Hebert,S.C.
  TITLE     Cloning and expression of an inwardly rectifying ATP-regulated
            potassium channel
  JOURNAL   Nature 362 (6415), 31-38 (1993)
   PUBMED   7680431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jun 9, 2015 this sequence version replaced NM_017023.1.
            
            Transcript Variant: This variant (1, also known as ROMK1)
            represents the longest transcript and encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X72341.1, SRR26643287.19760.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984041 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               JAXUCZ010000008.1  39061641-39061825
            186-2999            JAXUCZ010000008.1  39063902-39066715
FEATURES             Location/Qualifiers
     source          1..2999
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q21"
     gene            1..2999
                     /gene="Kcnj1"
                     /gene_synonym="KAB-1; Kcnj; Kcnj1_v1; Kcnj1_v3; kir1.1;
                     ROMK1; ROMK2; ROMK3"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 1"
                     /db_xref="GeneID:24521"
                     /db_xref="RGD:2957"
     exon            1..185
                     /gene="Kcnj1"
                     /gene_synonym="KAB-1; Kcnj; Kcnj1_v1; Kcnj1_v3; kir1.1;
                     ROMK1; ROMK2; ROMK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1325
                     /gene="Kcnj1"
                     /gene_synonym="KAB-1; Kcnj; Kcnj1_v1; Kcnj1_v3; kir1.1;
                     ROMK1; ROMK2; ROMK3"
                     /note="isoform 1 is encoded by transcript variant 1; K+
                     channel protein; ATP-sensitive inward rectifier potassium
                     channel 1; ATP-regulated potassium channel ROM-K;
                     potassium channel, inwardly rectifying subfamily J member
                     1; inward rectifier K(+) channel Kir1.1"
                     /codon_start=1
                     /product="ATP-sensitive inward rectifier potassium channel
                     1 isoform 1"
                     /protein_id="NP_058719.2"
                     /db_xref="GeneID:24521"
                     /db_xref="RGD:2957"
                     /translation="MGASERSVFRVLIRALTERMFKHLRRWFVTHIFGRSRQRARLVS
                     KEGRCNIEFGNVDAQSRFIFFVDIWTTVLDLKWRYKMTVFITAFLGSWFLFGLLWYVV
                     AYVHKDLPEFYPPDNRTPCVENINGMTSAFLFSLETQVTIGYGFRFVTEQCATAIFLL
                     IFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRK
                     SLLIGSHIYGKLLKTTITPEGETIILDQTNINFVVDAGNENLFFISPLTIYHIIDHNS
                     PFFHMAAETLSQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFVPIVSKTKE
                     GKYRVDFHNFGKTVEVETPHCAMCLYNEKDARARMKRGYDNPNFVLSEVDETDDTQM"
     exon            186..2999
                     /gene="Kcnj1"
                     /gene_synonym="KAB-1; Kcnj; Kcnj1_v1; Kcnj1_v3; kir1.1;
                     ROMK1; ROMK2; ROMK3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caatcacaca actccactcg agttagccat tgaaagccaa tgcaagtaaa tgtcattcca
       61 aagcttaaga ttcattaagg tgggcctaaa agaagacagc tgctgtgcag acaacgtcga
      121 acaagcacca cttgcttgct ttgcccagca tgggcgcttc ggaacggagt gtgttcagag
      181 tgctgatcag ggcactgaca gaaaggatgt tcaaacacct ccgaagatgg tttgtcactc
      241 acatatttgg gcgttcccgg caacgggcaa ggctggtctc taaagaagga agatgtaaca
      301 tcgagtttgg caatgtggat gcacagtcaa ggtttatatt ctttgtggac atctggacaa
      361 ctgtgctgga cctgaaatgg aggtacaaaa tgaccgtgtt catcacagcc ttcttgggga
      421 gttggttcct ctttggtctc ctgtggtatg tcgtagcgta tgttcataag gacctcccag
      481 agttctaccc gcctgacaac cgcactcctt gtgtggagaa cattaatggc atgacttcag
      541 cctttctgtt ttctctagag actcaagtga ccataggtta cggattcagg tttgtgacag
      601 aacagtgcgc cactgccatt ttcctgctta tcttccaatc tattcttgga gtgatcatca
      661 attccttcat gtgtggtgcc attttagcca agatctctag acctaaaaaa cgtgctaaaa
      721 ccattacgtt cagcaagaat gcggtgatca gcaagcgtgg cgggaagctc tgcctcctca
      781 tccgagtggc caatcttagg aagagccttc tgattggcag ccacatatat ggcaagcttc
      841 taaagacaac catcactcct gaaggcgaga ccatcatttt ggatcagacc aacatcaact
      901 ttgtcgtcga cgctggcaat gaaaatttgt tcttcatatc cccactgacg atctaccaca
      961 ttattgacca caacagccct ttcttccaca tggcagcaga aactctttcc caacaggact
     1021 ttgagctggt ggtcttttta gatggcacag tggaatccac cagtgcaacc tgccaggtcc
     1081 gcacgtcata cgtcccagag gaggtacttt ggggctaccg tttcgttcct attgtgtcca
     1141 agaccaagga agggaaatac cgagtggatt ttcataactt cggtaagaca gtggaagtgg
     1201 agacccctca ctgtgccatg tgcctctata atgagaaaga tgccagggcc aggatgaaga
     1261 gaggctatga caaccctaac tttgtcttgt cagaagttga tgaaacggac gacacccaga
     1321 tgtagcagtg gcttttccac ctacaaaaag cctcccaagg acctaagggt tgactgtgtt
     1381 cagaagcatc tgacgggggt ctgaaagcag gatgagaaca tgcgaaatct gctagcacag
     1441 tcacccctga accccagggc tatggttcta caagacacat agctctataa ggctgcatac
     1501 ggtgcatgca tgtgaatgaa actgtggaag ccaaaggggc ccacttggat tctcactatg
     1561 actgtgtaag ttcatatcgt gttgatggaa acaaagtcat tcaaggacaa aacttaggag
     1621 ctttagaaag cttcaggaac tagccacatt tcctgtttga ttctatggat gagaaagatg
     1681 ccatttttat cttaaagtag acttctatca atggaaaatc tgccctctgc gttgggaagt
     1741 gagccagcca atcagtgaca ataagagact gtcatacaaa gaatcagtaa agactctaac
     1801 cttctcaagc tctggtgttt gaagcctttg tctgagtctg ggtccatgct tcagaagggg
     1861 taaggtgaca tccactgact gtacctctct gaacacaagg tacagaagaa caggaagccc
     1921 caatcaactt cataatcaac ccagatgctg cagcccatac agaatttggc ctgaatgatt
     1981 tcctgtggag cattaaatgg aggccaagtc cactctttag atattaaatg aatattcttt
     2041 tgcaaaggag aatgagttga aagtgttgga gagactgaag ggatgactct gtaatgaagg
     2101 cctgggtctg gaccgccagt aaccacatac aaagcctgac ttagtagcag tcagtactcc
     2161 tactggggag gtggagatag gaggatgtct ctggtttgct gggcagctga atgggtgatg
     2221 cccaagttca atgagagact aaagagggtg aaggggctgg agagaagatt ctggttaaaa
     2281 gtgccgtggc cgctcttcca gagaacctaa gtttggttct tggcacggta cttgataact
     2341 atctataact ccagtttcag ggcatctgaa tatcttttct ggcatccatg agcatcaggt
     2401 gcacagatat acatgcaagc aaaacaccgt acacatacaa ttaaaaaaac aaggtagaga
     2461 atgactgaag aagaatctta cgttaacttc tgatctacac acacacacac acacacacac
     2521 acacacacac acacacacac ggcatagtga tgtttgtttc aatattcaat ggataggttc
     2581 tggggctaca ggtctggtaa aagaggtttt aatccttcct ctttcaagat ggtaccgagg
     2641 aatgggaaag cagtgagcct ggaagagggt gtagtgctaa cacaccctct tcttgtgtcc
     2701 ttgtgtttct ctgcccggtg gttgaactga gattctaggt atggaggaag aaggaataag
     2761 atacagagtc acagtcaggg tgttgctgct ttcttgtctc tgagggccat tcctgtgtct
     2821 tccaaaggga acaagttagc aggagaactt ctttggagga aggttctagt gtgaacgtct
     2881 tgtttcttca tttccatacc tgtatcattc caaattcacc ttgaaaaaaa aagtagagtt
     2941 caaagctgct caaagatcaa aatttttttg gtatgtgatt aataaatttc tgaaaccgt
//
