LOCUS       NM_181365               1289 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel interacting
            protein 4 (Kcnip4), mRNA.
ACCESSION   NM_181365
VERSION     NM_181365.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1289)
  AUTHORS   Su,Z.J., Wang,X.Y., Zhou,C. and Chai,Z.
  TITLE     Down-regulation of miR-3068-3p enhances kcnip4-regulated A-type
            potassium current to protect against glutamate-induced
            excitotoxicity
  JOURNAL   J Neurochem 153 (5), 617-630 (2020)
   PUBMED   31792968
  REMARK    GeneRIF: Down-regulation of miR-3068-3p enhances kcnip4-regulated
            A-type potassium current to protect against glutamate-induced
            excitotoxicity.
REFERENCE   2  (bases 1 to 1289)
  AUTHORS   Kitazawa,M., Kubo,Y. and Nakajo,K.
  TITLE     The stoichiometry and biophysical properties of the Kv4 potassium
            channel complex with K+ channel-interacting protein (KChIP)
            subunits are variable, depending on the relative expression level
  JOURNAL   J Biol Chem 289 (25), 17597-17609 (2014)
   PUBMED   24811166
  REMARK    GeneRIF: Subunit counting by single-molecule imaging revealed that
            the bound number of KChIP4 in each Kv4.2.KChIP4 complex was
            dependent on the expression level of KChIP4.
REFERENCE   3  (bases 1 to 1289)
  AUTHORS   Rainnie,D.G., Hazra,R., Dabrowska,J., Guo,J.D., Li,C.C., Dewitt,S.
            and Muly,E.C.
  TITLE     Distribution and functional expression of Kv4 family alpha subunits
            and associated KChIP beta subunits in the bed nucleus of the stria
            terminalis
  JOURNAL   J Comp Neurol 522 (3), 609-625 (2014)
   PUBMED   24037673
  REMARK    GeneRIF: This study demonistrared that the expression and function
            of KCHIP4 channels in neurons of the rat bed nucleus of the stria
            terminalis.
REFERENCE   4  (bases 1 to 1289)
  AUTHORS   Norris,A.J., Foeger,N.C. and Nerbonne,J.M.
  TITLE     Interdependent roles for accessory KChIP2, KChIP3, and KChIP4
            subunits in the generation of Kv4-encoded IA channels in cortical
            pyramidal neurons
  JOURNAL   J Neurosci 30 (41), 13644-13655 (2010)
   PUBMED   20943905
REFERENCE   5  (bases 1 to 1289)
  AUTHORS   McCue,H.V., Haynes,L.P. and Burgoyne,R.D.
  TITLE     The diversity of calcium sensor proteins in the regulation of
            neuronal function
  JOURNAL   Cold Spring Harb Perspect Biol 2 (8), a004085 (2010)
   PUBMED   20668007
  REMARK    Review article
REFERENCE   6  (bases 1 to 1289)
  AUTHORS   Rhodes,K.J., Carroll,K.I., Sung,M.A., Doliveira,L.C.,
            Monaghan,M.M., Burke,S.L., Strassle,B.W., Buchwalder,L.,
            Menegola,M., Cao,J., An,W.F. and Trimmer,J.S.
  TITLE     KChIPs and Kv4 alpha subunits as integral components of A-type
            potassium channels in mammalian brain
  JOURNAL   J Neurosci 24 (36), 7903-7915 (2004)
   PUBMED   15356203
  REMARK    GeneRIF: KChIP4 coassociates with Kv4 subunits in hippocampal
            membranes, confirming that the KChIPs are tightly associated with
            Kv4 subunits in native brain A-type channel complexes which may
            play a major role as modulators of somatodendritic excitability.
REFERENCE   7  (bases 1 to 1289)
  AUTHORS   Shibata,R., Misonou,H., Campomanes,C.R., Anderson,A.E.,
            Schrader,L.A., Doliveira,L.C., Carroll,K.I., Sweatt,J.D.,
            Rhodes,K.J. and Trimmer,J.S.
  TITLE     A fundamental role for KChIPs in determining the molecular
            properties and trafficking of Kv4.2 potassium channels
  JOURNAL   J Biol Chem 278 (38), 36445-36454 (2003)
   PUBMED   12829703
  REMARK    GeneRIF: KChIP4a isoform, which exhibits unique effects on Kv4
            channel gating negatively influences the impact of other KChIPs
REFERENCE   8  (bases 1 to 1289)
  AUTHORS   Morohashi,Y., Hatano,N., Ohya,S., Takikawa,R., Watabiki,T.,
            Takasugi,N., Imaizumi,Y., Tomita,T. and Iwatsubo,T.
  TITLE     Molecular cloning and characterization of CALP/KChIP4, a novel
            EF-hand protein interacting with presenilin 2 and voltage-gated
            potassium channel subunit Kv4
  JOURNAL   J Biol Chem 277 (17), 14965-14975 (2002)
   PUBMED   11847232
REFERENCE   9  (bases 1 to 1289)
  AUTHORS   Holmqvist,M.H., Cao,J., Hernandez-Pineda,R., Jacobson,M.D.,
            Carroll,K.I., Sung,M.A., Betty,M., Ge,P., Gilbride,K.J.,
            Brown,M.E., Jurman,M.E., Lawson,D., Silos-Santiago,I., Xie,Y.,
            Covarrubias,M., Rhodes,K.J., Distefano,P.S. and An,W.F.
  TITLE     Elimination of fast inactivation in Kv4 A-type potassium channels
            by an auxiliary subunit domain
  JOURNAL   Proc Natl Acad Sci U S A 99 (2), 1035-1040 (2002)
   PUBMED   11805342
REFERENCE   10 (bases 1 to 1289)
  AUTHORS   Rosati,B., Pan,Z., Lypen,S., Wang,H.S., Cohen,I., Dixon,J.E. and
            McKinnon,D.
  TITLE     Regulation of KChIP2 potassium channel beta subunit gene expression
            underlies the gradient of transient outward current in canine and
            human ventricle
  JOURNAL   J Physiol 533 (Pt 1), 119-125 (2001)
   PUBMED   11351020
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF345444.1.
            
            [WARNING] On Oct 10, 2024 this sequence was replaced by
            NM_181365.3.
            
            On Jun 3, 2003 this sequence version replaced NM_181365.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF345444.1, AF453245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1289
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q11"
     gene            1..1289
                     /gene="Kcnip4"
                     /gene_synonym="Kchip4"
                     /note="potassium voltage-gated channel interacting protein
                     4"
                     /db_xref="GeneID:259243"
                     /db_xref="RGD:708539"
     exon            1..438
                     /gene="Kcnip4"
                     /gene_synonym="Kchip4"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..1130
                     /gene="Kcnip4"
                     /gene_synonym="Kchip4"
                     /note="potassium channel-interacting protein 4; A-type
                     potassium channel modulatory protein 4; Kv channel
                     interacting protein 4"
                     /codon_start=1
                     /product="Kv channel-interacting protein 4"
                     /protein_id="NP_852030.1"
                     /db_xref="GeneID:259243"
                     /db_xref="RGD:708539"
                     /translation="MNVRRVESISAQLEEASSTGGFLYAQNNTKRSIKERLMKLLPCS
                     AAKTSSPAIQNSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGV
                     VNEETFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEK
                     LNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDK
                     NKDGVVTIDEFIESCQKDENIMRSMQLFENVI"
     exon            439..540
                     /gene="Kcnip4"
                     /gene_synonym="Kchip4"
                     /inference="alignment:Splign:2.1.0"
     exon            541..665
                     /gene="Kcnip4"
                     /gene_synonym="Kchip4"
                     /inference="alignment:Splign:2.1.0"
     exon            666..735
                     /gene="Kcnip4"
                     /gene_synonym="Kchip4"
                     /inference="alignment:Splign:2.1.0"
     exon            736..806
                     /gene="Kcnip4"
                     /gene_synonym="Kchip4"
                     /inference="alignment:Splign:2.1.0"
     exon            807..914
                     /gene="Kcnip4"
                     /gene_synonym="Kchip4"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1019
                     /gene="Kcnip4"
                     /gene_synonym="Kchip4"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1082
                     /gene="Kcnip4"
                     /gene_synonym="Kchip4"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1289
                     /gene="Kcnip4"
                     /gene_synonym="Kchip4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcctccac ttcctccttt agtgacttgg cagcaggtgg caggggaggt gccaagcgtg
       61 ccaggggcgg ggggcgcccc gctctgtctg gcggtacagc gctccgggct tctcggcggc
      121 gggtgtcctg gcccccacca cccgcgtagc tctgctaccc agcgtggcac agcgcccccg
      181 gcgccccccg ccggcctcct tctgcacctg cagcggctcc gcgcgccctg cccgccgcca
      241 ccgccgccgc ctccagctcc cagcgccttg gtcgcccagg acagagtggc tgtgcgctcc
      301 ggtggcggac ccctcgccag acgcccctgg gtcagtggac tctaagagtg tcgctccagc
      361 atctatcatc cctaaagatg aacgtgagaa gggtggaaag catctcggct cagctggagg
      421 aggcgagctc cacaggcggt ttcctctacg ctcagaacaa caccaagcgc agcattaaag
      481 agcggctcat gaagctcttg ccctgctcag ctgccaaaac gtcgtctcct gctattcaaa
      541 acagtgtgga agatgaactg gagatggcca ctgtcaggca ccggcctgaa gccctggagc
      601 tgctggaggc ccagagcaaa ttcaccaaga aagagcttca gatcctttac agaggattta
      661 agaatgaatg ccccagtggt gttgttaatg aagaaacctt caaggagatt tactcgcagt
      721 tcttcccaca gggagactcc accacatatg cacattttct cttcaatgca ttcgacacgg
      781 accacaatgg agctgtgagc tttgaggatt tcatcaaagg tctttccatt ttgcttcgag
      841 ggacagtaca agaaaaactg aactgggcat ttaatttgta tgacataaac aaagatggct
      901 acatcactaa agaggaaatg ctggacataa tgaaagcaat ttacgacatg atggggaaat
      961 gcacataccc tgtcctcaag gaagatgctc cccgacagca cgtggagaca tttttccaga
     1021 agatggacaa gaataaagat ggtgtcgtta ccatagacga gttcattgaa agttgccaaa
     1081 aagatgaaaa cataatgcgc tccatgcagc tctttgaaaa tgtgatctag actgtcggtg
     1141 ccttgaccgg aggcaaatgt ggacgactac acacgagttg aagccaccat ttctagcata
     1201 gattgctcag ctttacactg aggcatatta tgcaaacagc tttgttttaa tataaagacc
     1261 cccgcgccca aatttaagtt ttccagtta
//
