LOCUS       NM_032462                818 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel interacting
            protein 3 (Kcnip3), mRNA.
ACCESSION   NM_032462
VERSION     NM_032462.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 818)
  AUTHORS   Ismail,C.A.N., Suppian,R., Ab Aziz,C.B. and Long,I.
  TITLE     Ifenprodil Reduced Expression of Activated Microglia, BDNF and
            DREAM Proteins in the Spinal Cord Following Formalin Injection
            During the Early Stage of Painful Diabetic Neuropathy in Rats
  JOURNAL   J Mol Neurosci 71 (2), 379-393 (2021)
   PUBMED   32671697
  REMARK    GeneRIF: Ifenprodil Reduced Expression of Activated Microglia, BDNF
            and DREAM Proteins in the Spinal Cord Following Formalin Injection
            During the Early Stage of Painful Diabetic Neuropathy in Rats.
REFERENCE   2  (bases 1 to 818)
  AUTHORS   Formisano,L., Laudati,G., Guida,N., Mascolo,L., Serani,A.,
            Cuomo,O., Cantile,M., Boscia,F., Molinaro,P., Anzilotti,S.,
            Pizzorusso,V., Di Renzo,G., Pignataro,G. and Annunziato,L.
  TITLE     HDAC4 and HDAC5 form a complex with DREAM that epigenetically
            down-regulates NCX3 gene and its pharmacological inhibition reduces
            neuronal stroke damage
  JOURNAL   J Cereb Blood Flow Metab 40 (10), 2081-2097 (2020)
   PUBMED   31696766
  REMARK    GeneRIF: HDAC4 and HDAC5 form a complex with DREAM that
            epigenetically down-regulates NCX3 gene and its pharmacological
            inhibition reduces neuronal stroke damage.
REFERENCE   3  (bases 1 to 818)
  AUTHORS   Tian,N.X., Xu,Y., Yang,J.Y., Li,L., Sun,X.H., Wang,Y. and Zhang,Y.
  TITLE     KChIP3 N-Terminal 31-50 Fragment Mediates Its Association with
            TRPV1 and Alleviates Inflammatory Hyperalgesia in Rats
  JOURNAL   J Neurosci 38 (7), 1756-1773 (2018)
   PUBMED   29335353
  REMARK    GeneRIF: The KChIP3-TRPV1 interaction reduces the surface
            localization of TRPV1 and thus alleviates heat hyperalgesia and
            gait alterations induced by peripheral inflammation
REFERENCE   4  (bases 1 to 818)
  AUTHORS   Qian,J., Lv,M. and Zhang,W.
  TITLE     The function of DREAM gene mediated by NF-kB signal pathway in the
            pathogenesis of osteosarcoma
  JOURNAL   J BUON 22 (4), 1068-1072 (2017)
   PUBMED   28952229
  REMARK    GeneRIF: NF-kB signal pathway promoted the expression of DREAM
            gene.
REFERENCE   5  (bases 1 to 818)
  AUTHORS   Siran,R., Ahmad,A.H., Abdul Aziz,C.B. and Ismail,Z.
  TITLE     REM sleep deprivation induces changes of down regulatory antagonist
            modulator (DREAM) expression in the ventrobasal thalamic nuclei of
            sprague-dawley rats
  JOURNAL   J Physiol Biochem 70 (4), 877-889 (2014)
   PUBMED   25218926
  REMARK    GeneRIF: DREAM expression and REM sleep deprivation, as well as
            sleep recovery, are linked which may indicate potential involvement
            of DREAM in REM sleep-induced changes in gene expression,
            specifically in nociceptive processing.
REFERENCE   6  (bases 1 to 818)
  AUTHORS   Leclerc,G.M., Leclerc,G.J., Shorte,S.L., Stephen Frawley,L. and
            Boockfor,F.R.
  TITLE     Cloning and mRNA expression of the Ca2+-binding DREAM protein in
            the pituitary
  JOURNAL   Gen Comp Endocrinol 129 (1), 45-55 (2002)
   PUBMED   12409095
  REMARK    GeneRIF: Findings of DREAM expression in the pituitary in a manner
            specific to pituitary endocrine cell type raises the possibility
            that this protein may play a role in determining specific pituitary
            cell function.[DREAM protein]
REFERENCE   7  (bases 1 to 818)
  AUTHORS   Takimoto,K., Yang,E.K. and Conforti,L.
  TITLE     Palmitoylation of KChIP splicing variants is required for efficient
            cell surface expression of Kv4.3 channels
  JOURNAL   J Biol Chem 277 (30), 26904-26911 (2002)
   PUBMED   12006572
REFERENCE   8  (bases 1 to 818)
  AUTHORS   Cheng,H.Y., Pitcher,G.M., Laviolette,S.R., Whishaw,I.Q., Tong,K.I.,
            Kockeritz,L.K., Wada,T., Joza,N.A., Crackower,M., Goncalves,J.,
            Sarosi,I., Woodgett,J.R., Oliveira-dos-Santos,A.J., Ikura,M., van
            der Kooy,D., Salter,M.W. and Penninger,J.M.
  TITLE     DREAM is a critical transcriptional repressor for pain modulation
  JOURNAL   Cell 108 (1), 31-43 (2002)
   PUBMED   11792319
REFERENCE   9  (bases 1 to 818)
  AUTHORS   Ohya,S., Morohashi,Y., Muraki,K., Tomita,T., Watanabe,M.,
            Iwatsubo,T. and Imaizumi,Y.
  TITLE     Molecular cloning and expression of the novel splice variants of
            K(+) channel-interacting protein 2
  JOURNAL   Biochem Biophys Res Commun 282 (1), 96-102 (2001)
   PUBMED   11263977
REFERENCE   10 (bases 1 to 818)
  AUTHORS   An,W.F., Bowlby,M.R., Betty,M., Cao,J., Ling,H.P., Mendoza,G.,
            Hinson,J.W., Mattsson,K.I., Strassle,B.W., Trimmer,J.S. and
            Rhodes,K.J.
  TITLE     Modulation of A-type potassium channels by a family of calcium
            sensors
  JOURNAL   Nature 403 (6769), 553-556 (2000)
   PUBMED   10676964
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF297118.1.
            
            On Aug 30, 2012 this sequence version replaced NM_032462.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF297118.1, AB043892.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-818               AF297118.1         3-820
FEATURES             Location/Qualifiers
     source          1..818
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="CD IGS"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..818
                     /gene="Kcnip3"
                     /gene_synonym="Csen; Dream; rKChIP3"
                     /note="potassium voltage-gated channel interacting protein
                     3"
                     /db_xref="GeneID:65199"
                     /db_xref="RGD:70888"
     exon            1..36
                     /gene="Kcnip3"
                     /gene_synonym="Csen; Dream; rKChIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..792
                     /gene="Kcnip3"
                     /gene_synonym="Csen; Dream; rKChIP3"
                     /note="calsenilin, presenilin-binding protein, EF hand
                     transcription factor; A-type potassium channel modulating
                     protein 3; downstream regulatory element-antagonist
                     modulator; KChIP3; DRE-antagonist modulator; kv
                     channel-interacting protein 3; A-type potassium channel
                     modulatory protein 3; Kv channel interacting protein 3,
                     calsenilin"
                     /codon_start=1
                     /product="calsenilin"
                     /protein_id="NP_115851.1"
                     /db_xref="GeneID:65199"
                     /db_xref="RGD:70888"
                     /translation="MQRTKEAMKASDGSLLGDPGRIPLSKREGIKWQRPRFTRQALMR
                     CCLIKWILSSAAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKN
                     ECPTGLVDEDTFKLIYSQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLR
                     GTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILRKDAPLEHVERF
                     FQKMDRNQDGVVTIDEFLETCQKDENIMSSMQLFENVI"
     exon            37..202
                     /gene="Kcnip3"
                     /gene_synonym="Csen; Dream; rKChIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            203..327
                     /gene="Kcnip3"
                     /gene_synonym="Csen; Dream; rKChIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            328..397
                     /gene="Kcnip3"
                     /gene_synonym="Csen; Dream; rKChIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            398..468
                     /gene="Kcnip3"
                     /gene_synonym="Csen; Dream; rKChIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            469..576
                     /gene="Kcnip3"
                     /gene_synonym="Csen; Dream; rKChIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            577..681
                     /gene="Kcnip3"
                     /gene_synonym="Csen; Dream; rKChIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            682..744
                     /gene="Kcnip3"
                     /gene_synonym="Csen; Dream; rKChIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            745..818
                     /gene="Kcnip3"
                     /gene_synonym="Csen; Dream; rKChIP3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtcccttt cagcagccga gatgcagagg accaaggaag caatgaaggc atcggatggc
       61 agcctcctgg gagaccctgg gcgcataccg ctgagcaaga gggaaggcat caagtggcag
      121 aggccacggt tcacccgcca ggccctgatg cgttgctgct taatcaagtg gatcctgtcc
      181 agtgctgccc cacaaggctc agacagcagt gacagtgaac tggagttgtc cacggtgcgc
      241 catcagccag agggcttgga ccagctacag gcccaaacca agttcaccaa gaaggagctg
      301 cagtccctgt accgaggctt caagaacgaa tgtcccacgg gcctggtcga tgaagatacc
      361 ttcaaactca tttattccca gttcttcccc cagggagatg ccaccaccta tgcacacttc
      421 ctcttcaatg ccttcgatgc tgatgggaac ggggccatcc actttgagga ctttgtggtt
      481 gggctctcca tcctgcttcg agggaccgtc catgagaagc tcaagtgggc cttcaatctc
      541 tacgacatca acaaggacgg ttacatcacc aaagaggaga tgctggccat catgaagtcc
      601 atctacgaca tgatgggccg ccacacctac cctatcctgc gaaaggacgc acctctggag
      661 catgtggaga ggttcttcca gaaaatggac aggaaccagg atggagtagt gactattgat
      721 gaatttctgg agacttgtca gaaggacgag aacatcatga gctccatgca gctgtttgag
      781 aacgtcatct aggacatgta ggaggggacc ctgggtgg
//
