LOCUS       NM_020094               2370 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel interacting
            protein 2 (Kcnip2), transcript variant a, mRNA.
ACCESSION   NM_020094 NM_001034005
VERSION     NM_020094.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2370)
  AUTHORS   Murthy,A., Workman,S.W., Jiang,M., Hu,J., Sifa,I., Bernas,T.,
            Tang,W., Deschenes,I. and Tseng,G.N.
  TITLE     Dynamic palmitoylation regulates trafficking of K channel
            interacting protein 2 (KChIP2) across multiple subcellular
            compartments in cardiac myocytes
  JOURNAL   J Mol Cell Cardiol 135, 1-9 (2019)
   PUBMED   31362018
  REMARK    GeneRIF: acute stress in a rat model of cardiac
            arrest/resuscitation induced changes in native KChIP2 resembling
            those of KChIP2 depalmitoylation, promoting KChIP2 nuclear entry.
REFERENCE   2  (bases 1 to 2370)
  AUTHORS   Liu,W., Wang,G., Zhang,C., Ding,W., Cheng,W., Luo,Y., Wei,C. and
            Liu,J.
  TITLE     MG53, A Novel Regulator of KChIP2 and Ito,f, Plays a Critical Role
            in Electrophysiological Remodeling in Cardiac Hypertrophy
  JOURNAL   Circulation 139 (18), 2142-2156 (2019)
   PUBMED   30760025
  REMARK    GeneRIF: These findings establish MG53 as a novel regulator of
            KChIP2 and Ito,f by modulating NF-kappaB activity and reveal its
            critical role in electrophysiological remodeling in cardiac
            hypertrophy.
REFERENCE   3  (bases 1 to 2370)
  AUTHORS   Panama,B.K., Korogyi,A.S., Aschar-Sobbi,R., Oh,Y., Gray,C.B.,
            Gang,H., Brown,J.H., Kirshenbaum,L.A. and Backx,P.H.
  TITLE     Reductions in the Cardiac Transient Outward K+ Current Ito Caused
            by Chronic beta-Adrenergic Receptor Stimulation Are Partly Rescued
            by Inhibition of Nuclear Factor kappaB
  JOURNAL   J Biol Chem 291 (8), 4156-4165 (2016)
   PUBMED   26742842
  REMARK    GeneRIF: mRNA and KChIP2 promoter data suggest that the ISO-induced
            Ito,f reductions are, in part, mediated through reduced KChIP2
            transcription caused by NF-kappaB activation.
REFERENCE   4  (bases 1 to 2370)
  AUTHORS   Sato,T., Kobayashi,T., Kuno,A., Miki,T., Tanno,M., Kouzu,H.,
            Itoh,T., Ishikawa,S., Kojima,T., Miura,T. and Tohse,N.
  TITLE     Type 2 diabetes induces subendocardium-predominant reduction in
            transient outward K+ current with downregulation of Kv4.2 and
            KChIP2
  JOURNAL   Am J Physiol Heart Circ Physiol 306 (7), H1054-H1065 (2014)
   PUBMED   24486512
  REMARK    GeneRIF: Type 2 diabetes induces Endo-predominant prolongation of
            the action potential duration via a reduction of the fast component
            of Ito recovery from inactivation and reduced steady-state Ito, in
            which downregulation of Kv4.2 and KChIP2 may be involved.
REFERENCE   5  (bases 1 to 2370)
  AUTHORS   Rainnie,D.G., Hazra,R., Dabrowska,J., Guo,J.D., Li,C.C., Dewitt,S.
            and Muly,E.C.
  TITLE     Distribution and functional expression of Kv4 family alpha subunits
            and associated KChIP beta subunits in the bed nucleus of the stria
            terminalis
  JOURNAL   J Comp Neurol 522 (3), 609-625 (2014)
   PUBMED   24037673
  REMARK    GeneRIF: This study demonistrared that the expression and function
            of KCHIP2 channels in neurons of the rat bed nucleus of the stria
            terminalis.
REFERENCE   6  (bases 1 to 2370)
  AUTHORS   Takimoto,K., Yang,E.K. and Conforti,L.
  TITLE     Palmitoylation of KChIP splicing variants is required for efficient
            cell surface expression of Kv4.3 channels
  JOURNAL   J Biol Chem 277 (30), 26904-26911 (2002)
   PUBMED   12006572
  REMARK    GeneRIF: palmitoylation of the KChIP auxiliary subunits controls
            plasma membrane localization of their associated channels
REFERENCE   7  (bases 1 to 2370)
  AUTHORS   Kuo,H.C., Cheng,C.F., Clark,R.B., Lin,J.J., Lin,J.L., Hoshijima,M.,
            Nguyen-Tran,V.T., Gu,Y., Ikeda,Y., Chu,P.H., Ross,J., Giles,W.R.
            and Chien,K.R.
  TITLE     A defect in the Kv channel-interacting protein 2 (KChIP2) gene
            leads to a complete loss of I(to) and confers susceptibility to
            ventricular tachycardia
  JOURNAL   Cell 107 (6), 801-813 (2001)
   PUBMED   11747815
REFERENCE   8  (bases 1 to 2370)
  AUTHORS   Bahring,R., Dannenberg,J., Peters,H.C., Leicher,T., Pongs,O. and
            Isbrandt,D.
  TITLE     Conserved Kv4 N-terminal domain critical for effects of Kv
            channel-interacting protein 2.2 on channel expression and gating
  JOURNAL   J Biol Chem 276 (26), 23888-23894 (2001)
   PUBMED   11287421
REFERENCE   9  (bases 1 to 2370)
  AUTHORS   Ohya,S., Morohashi,Y., Muraki,K., Tomita,T., Watanabe,M.,
            Iwatsubo,T. and Imaizumi,Y.
  TITLE     Molecular cloning and expression of the novel splice variants of
            K(+) channel-interacting protein 2
  JOURNAL   Biochem Biophys Res Commun 282 (1), 96-102 (2001)
   PUBMED   11263977
REFERENCE   10 (bases 1 to 2370)
  AUTHORS   An,W.F., Bowlby,M.R., Betty,M., Cao,J., Ling,H.P., Mendoza,G.,
            Hinson,J.W., Mattsson,K.I., Strassle,B.W., Trimmer,J.S. and
            Rhodes,K.J.
  TITLE     Modulation of A-type potassium channels by a family of calcium
            sensors
  JOURNAL   Nature 403 (6769), 553-556 (2000)
   PUBMED   10676964
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085905.1, AF269283.1 and CK226309.1.
            
            On or before May 11, 2012 this sequence version replaced
            NM_001034005.1, NM_020094.1.
            
            Transcript Variant: This variant (a) represents the longest
            transcript and encodes the longest protein (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF269283.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               BC085905.1         1-240
            241-1022            AF269283.1         19-800
            1023-2272           BC085905.1         873-2122
            2273-2345           CK226309.1         433-505
            2346-2370           BC085905.1         2196-2220
FEATURES             Location/Qualifiers
     source          1..2370
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..2370
                     /gene="Kcnip2"
                     /gene_synonym="Kchip2"
                     /note="potassium voltage-gated channel interacting protein
                     2"
                     /db_xref="GeneID:56817"
                     /db_xref="RGD:70887"
     exon            1..295
                     /gene="Kcnip2"
                     /gene_synonym="Kchip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1035
                     /gene="Kcnip2"
                     /gene_synonym="Kchip2"
                     /note="isoform a is encoded by transcript variant a;
                     potassium channel auxiliary subunit KCHIP2; A-type
                     potassium channel modulatory protein 2; Kv
                     channel-interacting protein 2; Kv channel-interacting
                     protein 2-like; A-type potassium channel modulatory
                     protein KCNIP2"
                     /codon_start=1
                     /product="A-type potassium channel modulatory protein
                     KCNIP2 isoform a"
                     /protein_id="NP_064479.2"
                     /db_xref="GeneID:56817"
                     /db_xref="RGD:70887"
                     /translation="MRGQGRKESLSESRDLDGSYDQLTGHPPGPSKKALKQRFLKLLP
                     CCGPQALPSVSETLAAPASLRPHRPRPLDPDSVEDEFELSTVCHRPEGLEQLQEQTKF
                     TRRELQVLYRGFKNECPSGIVNEENFKQIYSQFFPQGDSSNYATFLFNAFDTNHDGSV
                     SFEDFVAGLSVILRGTIDDRLSWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYP
                     ALREEAPREHVESFFQKMDRNKDGVVTIEEFIESCQQDENIMRSMQLFDNVI"
     exon            296..391
                     /gene="Kcnip2"
                     /gene_synonym="Kchip2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..445
                     /gene="Kcnip2"
                     /gene_synonym="Kchip2"
                     /inference="alignment:Splign:2.1.0"
     exon            446..570
                     /gene="Kcnip2"
                     /gene_synonym="Kchip2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..640
                     /gene="Kcnip2"
                     /gene_synonym="Kchip2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..711
                     /gene="Kcnip2"
                     /gene_synonym="Kchip2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..819
                     /gene="Kcnip2"
                     /gene_synonym="Kchip2"
                     /inference="alignment:Splign:2.1.0"
     exon            820..924
                     /gene="Kcnip2"
                     /gene_synonym="Kchip2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..987
                     /gene="Kcnip2"
                     /gene_synonym="Kchip2"
                     /inference="alignment:Splign:2.1.0"
     exon            988..2346
                     /gene="Kcnip2"
                     /gene_synonym="Kchip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccgctct cacttgctgc ccaaggctcc tgctcctgcc ccaggactct gaggtgggcc
       61 ctaaaaccca gcgctctcta aagaaaagcc ttgccagccc ctactcccgg cccccaaccc
      121 cagcaggtcg ctgcgccgcc aggggggcgc tgtgtgagcg ccctattctg gccacccggc
      181 gccccctccc acggcccagg cgggagcggg gcgccggggg ccatgcgggg ccaaggcaga
      241 aaggagagtt tgtccgaatc ccgagatctg gacggctcct atgaccagct tacgggccac
      301 cctccagggc ccagtaaaaa agccctgaag cagcgtttcc tcaagctgct gccgtgctgc
      361 gggccccaag ccctgccctc agtcagtgaa acattagctg ccccagcctc cctccgcccc
      421 cacagacccc gcccgctgga cccagacagc gtagaggatg agtttgaatt atccacggtg
      481 tgtcaccgac ctgagggcct ggaacaactc caggaacaga ccaagttcac acgcagagag
      541 ctgcaggtcc tgtaccgagg cttcaagaac gaatgcccca gtgggattgt caacgaggag
      601 aacttcaagc agatttattc tcagttcttt ccccaaggag actccagcaa ctatgctact
      661 tttctcttca atgcctttga caccaaccac gatggctctg tcagttttga ggactttgtg
      721 gctggtttgt cggtgattct tcgggggacc atagatgata gactgagctg ggctttcaac
      781 ttatatgacc tcaacaagga cggctgtatc acaaaggagg aaatgcttga cattatgaag
      841 tccatctatg acatgatggg caagtacaca taccctgccc tccgggagga ggccccaaga
      901 gaacacgtgg agagcttctt ccagaagatg gacaggaaca aggacggcgt ggtgaccatc
      961 gaggaattca tcgagtcttg tcaacaggac gagaacatca tgaggtccat gcagctcttt
     1021 gataatgtca tctagctccc cagggagagg ggttagtgtg tcctagggtg accaggctgt
     1081 agtcctagtc cagacgaacc taaccctctc tctccaggcc tgtcctcatc ttacctgtac
     1141 cctgggggct gtagggattc aatatcctgg ggcttcagta gtccagatcc ctgagctaag
     1201 tcacaaaagt aggcaagagt aggcaagcta aatctggggg cttcccaacc cccgacagct
     1261 ctcacccctt ctcaactgat acctagtgct gaggacaccc ctggtgtagg gaccaagtgg
     1321 ttctccactt tctagtccca ctctagaaac cacattagac agaaggtctc ctgctatggt
     1381 gctttcccca tccctaatct cttagatttt cctcaagact cccttctcag agaacacgct
     1441 ctgtccatgt ccccagctgg cttctcagcc tagcctttga gggccctgtg gggaggcggg
     1501 gacaagaaag cagaaaagtc ttggccccga gccagtggtt aggtcctagg aattggctgg
     1561 agtggaggcc agaaagcctg ggcagatgat gagagcccag ctgggctgtc actgcaggtt
     1621 ccagggccta cagccctggg tcagcagagt atgagttccc agactttcca gaaggtcctt
     1681 agcaatgtcc cagaaattca ccatacactt ctcagtgtct taggagggcc cgggatccag
     1741 atgtctggtt catccctgaa tcctctccct ccttcttgct cgtatggtgg gagtggtggc
     1801 caggggaaga tgagtggtgt cccggatgat gcctgtcaag gtcccacctc ccctccggct
     1861 gttctcatga cagctgtttg gttctccatg acccctatct agatgtagag gcatggagtg
     1921 agtcagggat ttcccgaact tgagttttac cactcctcct agtggctgcc ttaggggaat
     1981 gggaagaacc cagtgtgggg gcacccatta gaatctttgc ccggttcctc acaatgccct
     2041 agggtcccct agggtacccg ctccctctgt ttagtctacc cagagatgct cctgagctca
     2101 cctagagggt agggacggta ggctccaggt ccaacctctc caggtcagca ccctgccatg
     2161 ctgctgctcc tcattaacaa acctgcttgt ctcctcctgc gccccttctc agtcagccag
     2221 ggtctgaggg gaagggcctc ccgtttcccc atccgtcaga catggttgac tgctttgcat
     2281 tttgggctct tctatctatt ttgtaaaata agacatcaga tccaataaaa cacacggcta
     2341 tgcacaaaaa aaaaaaaaaa aaaaaaaaaa
//
