LOCUS       NM_001261387            1653 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel interacting
            protein 1 (Kcnip1), transcript variant 1, mRNA.
ACCESSION   NM_001261387
VERSION     NM_001261387.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1653)
  AUTHORS   Del Pino,J., Frejo,M.T., Baselga,M.J.A., Capo,M.A., Moyano,P.,
            Garcia,J.M. and Diaz,M.J.
  TITLE     Neuroprotective or neurotoxic effects of 4-aminopyridine mediated
            by KChIP1 regulation through adjustment of Kv 4.3 potassium
            channels expression and GABA-mediated transmission in primary
            hippocampal cells
  JOURNAL   Toxicology 333, 107-117 (2015)
   PUBMED   25917026
  REMARK    GeneRIF: KChIP1 plays a neuroprotective role against 4-AP acute
            induced cell death in primary hippocampal cells through regulation
            of Kv 4.3 and GABA transmission but this is lost after long term
            exposure.
REFERENCE   2  (bases 1 to 1653)
  AUTHORS   Rainnie,D.G., Hazra,R., Dabrowska,J., Guo,J.D., Li,C.C., Dewitt,S.
            and Muly,E.C.
  TITLE     Distribution and functional expression of Kv4 family alpha subunits
            and associated KChIP beta subunits in the bed nucleus of the stria
            terminalis
  JOURNAL   J Comp Neurol 522 (3), 609-625 (2014)
   PUBMED   24037673
  REMARK    GeneRIF: This study demonistrared that the expression and function
            of KCHIP1 channels in neurons of the rat bed nucleus of the stria
            terminalis.
REFERENCE   3  (bases 1 to 1653)
  AUTHORS   Dabrowska,J. and Rainnie,D.G.
  TITLE     Expression and distribution of Kv4 potassium channel subunits and
            potassium channel interacting proteins in subpopulations of
            interneurons in the basolateral amygdala
  JOURNAL   Neuroscience 171 (3), 721-733 (2010)
   PUBMED   20849929
  REMARK    GeneRIF: KChIP1 is selectively expressed in BLA interneurons where
            it may function to regulate the activity of A-type potassium
            channels. Hence, KChIP1 might be considered as a specific regulator
            of GABAergic inhibitory circuits in the basolateral amygdala.
REFERENCE   4  (bases 1 to 1653)
  AUTHORS   McCue,H.V., Haynes,L.P. and Burgoyne,R.D.
  TITLE     The diversity of calcium sensor proteins in the regulation of
            neuronal function
  JOURNAL   Cold Spring Harb Perspect Biol 2 (8), a004085 (2010)
   PUBMED   20668007
  REMARK    Review article
REFERENCE   5  (bases 1 to 1653)
  AUTHORS   Van Schijndel,J.E., Van Zweeden,M., Van Loo,K.M. and Martens,G.J.
  TITLE     Gene expression profiling in brain regions of a rat model
            displaying schizophrenia-related features
  JOURNAL   Behav Brain Res 207 (2), 476-479 (2010)
   PUBMED   19896980
  REMARK    GeneRIF: Aph1b and KCnIP1 are significantly differentially
            expressed in a number of brain tissues of a schizophrenia model;
            KCnIP1 is an attractive novel candidate gene that may play a role
            in the complex phenotype
REFERENCE   6  (bases 1 to 1653)
  AUTHORS   Boland,L.M., Jiang,M., Lee,S.Y., Fahrenkrug,S.C., Harnett,M.T. and
            O'Grady,S.M.
  TITLE     Functional properties of a brain-specific NH2-terminally spliced
            modulator of Kv4 channels
  JOURNAL   Am J Physiol Cell Physiol 285 (1), C161-C170 (2003)
   PUBMED   12646414
  REMARK    GeneRIF: The features of KChIP1b modulation of Kv4 channels are
            likely to be conserved in mammals and demonstrate a role for the
            KChIP1 NH2-terminal region in the regulation of closed inactivation
            gating.
REFERENCE   7  (bases 1 to 1653)
  AUTHORS   Hilber,K., Sandtner,W., Kudlacek,O., Schreiner,B., Glaaser,I.,
            Schutz,W., Fozzard,H.A., Dudley,S.C. and Todt,H.
  TITLE     Interaction between fast and ultra-slow inactivation in the
            voltage-gated sodium channel. Does the inactivation gate stabilize
            the channel structure?
  JOURNAL   J Biol Chem 277 (40), 37105-37115 (2002)
   PUBMED   12138168
  REMARK    GeneRIF: hypothesis that occlusion of the inner vestibule of the
            Na(+) channel by the fast inactivation gate inhibits ultra-slow
            inactivation (mu1 sodium channel)
REFERENCE   8  (bases 1 to 1653)
  AUTHORS   Nakamura,T.Y., Nandi,S., Pountney,D.J., Artman,M., Rudy,B. and
            Coetzee,W.A.
  TITLE     Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4
            subfamily members, Kv4.1 and Kv4.2
  JOURNAL   FEBS Lett 499 (3), 205-209 (2001)
   PUBMED   11423117
REFERENCE   9  (bases 1 to 1653)
  AUTHORS   Ohya,S., Morohashi,Y., Muraki,K., Tomita,T., Watanabe,M.,
            Iwatsubo,T. and Imaizumi,Y.
  TITLE     Molecular cloning and expression of the novel splice variants of
            K(+) channel-interacting protein 2
  JOURNAL   Biochem Biophys Res Commun 282 (1), 96-102 (2001)
   PUBMED   11263977
REFERENCE   10 (bases 1 to 1653)
  AUTHORS   An,W.F., Bowlby,M.R., Betty,M., Cao,J., Ling,H.P., Mendoza,G.,
            Hinson,J.W., Mattsson,K.I., Strassle,B.W., Trimmer,J.S. and
            Rhodes,K.J.
  TITLE     Modulation of A-type potassium channels by a family of calcium
            sensors
  JOURNAL   Nature 403 (6769), 553-556 (2000)
   PUBMED   10676964
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760393, SAMEA5760433
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               JAXUCZ010000010.1  19092801-19093025   c
            226-258             JAXUCZ010000010.1  18745163-18745195   c
            259-383             JAXUCZ010000010.1  18740170-18740294   c
            384-453             JAXUCZ010000010.1  18738730-18738799   c
            454-524             JAXUCZ010000010.1  18737409-18737479   c
            525-632             JAXUCZ010000010.1  18736548-18736655   c
            633-737             JAXUCZ010000010.1  18728125-18728229   c
            738-800             JAXUCZ010000010.1  18726738-18726800   c
            801-1653            JAXUCZ010000010.1  18723726-18724578   c
FEATURES             Location/Qualifiers
     source          1..1653
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1653
                     /gene="Kcnip1"
                     /gene_synonym="Kchip1"
                     /note="potassium voltage-gated channel interacting protein
                     1"
                     /db_xref="GeneID:65023"
                     /db_xref="RGD:70886"
     exon            1..225
                     /gene="Kcnip1"
                     /gene_synonym="Kchip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..848
                     /gene="Kcnip1"
                     /gene_synonym="Kchip1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potassium channel-interacting protein 1; A-type potassium
                     channel modulatory protein 1; Kv channel-interacting
                     protein 1; A-type potassium channel modulatory protein
                     KCNIP1"
                     /codon_start=1
                     /product="A-type potassium channel modulatory protein
                     KCNIP1 isoform 1"
                     /protein_id="NP_001248316.1"
                     /db_xref="GeneID:65023"
                     /db_xref="RGD:70886"
                     /translation="MSGCSKRCRLGFVKFAQTIFKLITGTLSKDIAWWYYQYQRDKIE
                     DDLEMTMVCHRPEGLEQLEAQTNFTKRELQVLYRGFKNECPSGVVNEETFKQIYAQFF
                     PHGDASTYAHYLFNAFDTTQTGSVKFEDFVTALSILLRGTVHEKLRWTFNLYDINKDG
                     YINKEEMMDIVKAIYDMMGKYTYPVLKEDTPRQHVDVFFQKMDKNKDGIVTLDEFLES
                     CQEDDNIMRSLQLFQNVM"
     exon            226..258
                     /gene="Kcnip1"
                     /gene_synonym="Kchip1"
                     /inference="alignment:Splign:2.1.0"
     exon            259..383
                     /gene="Kcnip1"
                     /gene_synonym="Kchip1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..453
                     /gene="Kcnip1"
                     /gene_synonym="Kchip1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..524
                     /gene="Kcnip1"
                     /gene_synonym="Kchip1"
                     /inference="alignment:Splign:2.1.0"
     exon            525..632
                     /gene="Kcnip1"
                     /gene_synonym="Kchip1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..737
                     /gene="Kcnip1"
                     /gene_synonym="Kchip1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..800
                     /gene="Kcnip1"
                     /gene_synonym="Kchip1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1653
                     /gene="Kcnip1"
                     /gene_synonym="Kchip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtgccgg agactggttt ctggggtgca tcaatctttc agggttcacc taagcaggct
       61 ccaaggtcca gaggcacgca aggtgcgtac taacccttct gggcgctgac tgcagaacct
      121 gcctcccctc tgccactatg agcggctgct ccaaaagatg cagactcggg ttcgtgaaat
      181 ttgcccagac catctttaaa ctcatcaccg ggaccctcag caaagacatc gcctggtggt
      241 attaccagta tcagagagac aagatcgagg atgatctgga gatgaccatg gtttgccatc
      301 ggcctgaggg actggagcag cttgaggcac agacgaactt caccaagaga gaactgcaag
      361 tcctttaccg gggattcaaa aacgagtgcc ccagtggtgt ggttaacgaa gagacattca
      421 agcagatcta cgctcagttt ttccctcatg gagatgccag cacatacgca cattacctct
      481 tcaatgcctt cgacaccacc cagacaggct ctgtaaagtt cgaggacttt gtgactgctc
      541 tgtcgatttt actgagagga acggtccatg aaaaactgag gtggacgttt aatttgtacg
      601 acatcaataa agacggctac ataaacaaag aggagatgat ggacatagtg aaagccatct
      661 atgacatgat ggggaaatac acctatcctg tgctcaaaga ggacactccc aggcagcacg
      721 tggacgtctt cttccagaaa atggataaaa ataaagatgg cattgtaacg ttagacgaat
      781 ttctcgagtc ctgtcaggag gatgacaaca tcatgaggtc tctacagctg ttccaaaatg
      841 tcatgtaact gaggacactg gccatcctgc tctcagagac actgaaaaac acctcaatgc
      901 cctgatctgc ccttgttcca gttttacaca tcaactctcg ggacagaaat accttttaca
      961 ctttggaaga attctctgct gaagactttc tacaaaacct ggcaccgcgt ggctcagtct
     1021 ctgattgcca actcttcctc cctcctcctc ttgagaggga cgagctgaaa tccgaagttt
     1081 gttttggaag catgcccatc tctccatgct gctgctgccc tgtggaaggc ccctctgctt
     1141 gagcttaaac agtagtgcac agttttctgc gtatacagat ccccaactca ctgcctctaa
     1201 gtcaggcaga ccctgatcaa tctgaaccaa atgtgcacca tcctccgatg gcctcccaag
     1261 ccaatgtgcc tgcttctctt cctctggtgg gaagaaagaa cgctctacag agcacttaga
     1321 gcttaccatg aaaatactgg gagaggcagc aactaacata tgtagaatag gactgaatta
     1381 ttaagcatgg tggtatcaga tgatgcaaac agcccatgtc attttttttc cagaggtagg
     1441 gactaataat tctcccacac tagcacctac gatcatagaa caagtctttt aacacatcca
     1501 ggagggaaac cgctgcccag tggtctatcc cttctctcca tcccctgctc aagcccagca
     1561 ctgcatgtct ctcccggaag gtccagaatg cctgtgaaat gctgtaactt ttataccctg
     1621 ttataatcaa taaacagaac tatttcgtac aca
//
