LOCUS       NM_145095               3739 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily H
            member 8 (Kcnh8), mRNA.
ACCESSION   NM_145095 XM_234523
VERSION     NM_145095.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3739)
  AUTHORS   Ono,A., Hirooka,K., Nakano,Y., Nitta,E., Nishiyama,A. and
            Tsujikawa,A.
  TITLE     Gene expression changes in the retina after systemic administration
            of aldosterone
  JOURNAL   Jpn J Ophthalmol 62 (4), 499-507 (2018)
   PUBMED   29713904
REFERENCE   2  (bases 1 to 3739)
  AUTHORS   Martin,S., Lino de Oliveira,C., Mello de Queiroz,F., Pardo,L.A.,
            Stuhmer,W. and Del Bel,E.
  TITLE     Eag1 potassium channel immunohistochemistry in the CNS of adult rat
            and selected regions of human brain
  JOURNAL   Neuroscience 155 (3), 833-844 (2008)
   PUBMED   18650019
  REMARK    GeneRIF: The results indicate that Eag1 protein expression greatly
            overlaps with mRNA distribution in rat.
REFERENCE   3  (bases 1 to 3739)
  AUTHORS   Zhang,C., Kavurma,M.M., Lai,A. and Khachigian,L.M.
  TITLE     Ets-1 protects vascular smooth muscle cells from undergoing
            apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and and
            inducible p21WAF1/Cip: ETS-1 regulates basal and inducible
            p21WAF1/Cip1 transcription via distinct cis-acting elements in the
            p21WAF/Cip1 promoter
  JOURNAL   J Biol Chem 278 (30), 27903-27909 (2003)
   PUBMED   12740370
REFERENCE   4  (bases 1 to 3739)
  AUTHORS   Saganich,M.J., Machado,E. and Rudy,B.
  TITLE     Differential expression of genes encoding subthreshold-operating
            voltage-gated K+ channels in brain
  JOURNAL   J Neurosci 21 (13), 4609-4624 (2001)
   PUBMED   11425889
REFERENCE   5  (bases 1 to 3739)
  AUTHORS   Wulfsen,I., Hauber,H.P., Schiemann,D., Bauer,C.K. and Schwarz,J.R.
  TITLE     Expression of mRNA for voltage-dependent and inward-rectifying K
            channels in GH3/B6 cells and rat pituitary
  JOURNAL   J Neuroendocrinol 12 (3), 263-272 (2000)
   PUBMED   10718922
REFERENCE   6  (bases 1 to 3739)
  AUTHORS   Engeland,B., Neu,A., Ludwig,J., Roeper,J. and Pongs,O.
  TITLE     Cloning and functional expression of rat ether-a-go-go-like K+
            channel genes
  JOURNAL   J Physiol 513 (Pt 3) (Pt 3), 647-654 (1998)
   PUBMED   9824707
REFERENCE   7  (bases 1 to 3739)
  AUTHORS   Shi,W., Wang,H.S., Pan,Z., Wymore,R.S., Cohen,I.S., McKinnon,D. and
            Dixon,J.E.
  TITLE     Cloning of a mammalian elk potassium channel gene and EAG mRNA
            distribution in rat sympathetic ganglia
  JOURNAL   J Physiol 511 (Pt 3) (Pt 3), 675-682 (1998)
   PUBMED   9714851
REFERENCE   8  (bases 1 to 3739)
  AUTHORS   Bellacosa,A., Datta,K., Bear,S.E., Patriotis,C., Lazo,P.A.,
            Copeland,N.G., Jenkins,N.A. and Tsichlis,P.N.
  TITLE     Effects of provirus integration in the Tpl-1/Ets-1 locus in Moloney
            murine leukemia virus-induced rat T-cell lymphomas: levels of
            expression, polyadenylation, transcriptional initiation, and
            differential splicing of the Ets-1 mRNA
  JOURNAL   J Virol 68 (4), 2320-2330 (1994)
   PUBMED   8139017
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF061957.1.
            
            On Feb 4, 2015 this sequence version replaced NM_145095.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF061957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345238, SAMN09345329
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3739              AF061957.1         5-3743
FEATURES             Location/Qualifiers
     source          1..3739
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..3739
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /note="potassium voltage-gated channel subfamily H member
                     8"
                     /db_xref="GeneID:246325"
                     /db_xref="RGD:2549"
     exon            1..124
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..3357
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /note="ether-a-go-go-like potassium channel 1; ELK channel
                     3; voltage-gated potassium channel subunit Kv12.1;
                     ether-a-go-go-like potassium channel 3; potassium channel,
                     voltage gated eag related subfamily H, member 8; potassium
                     voltage-gated channel, subfamily H (eag-related), member
                     8"
                     /codon_start=1
                     /product="voltage-gated delayed rectifier potassium
                     channel KCNH8"
                     /protein_id="NP_659563.1"
                     /db_xref="GeneID:246325"
                     /db_xref="RGD:2549"
                     /translation="MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVY
                     CSDGFCELAGFARTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKVEFKGEIMFYKK
                     NGAPFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKITSEDKKEDRAKGRSRAGSHF
                     DSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFS
                     TFKAGWDWLILLATFYVAVTVPYNVCFIGNEDLSTTRSTTVSDIAVEILFIIDIILNF
                     RTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVR
                     LLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEV
                     GWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIF
                     SICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRML
                     EYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLH
                     IKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQV
                     IKTNADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVI
                     SRLSNKSTVPQAEPKGNGSIKKRLPSIVEDEEEEEVEEEETTSLSPIYTRGSSVSHSK
                     KTGSSKSYLGLSLKQLTSGTVPFHSPIRVSSANSPKTKQEADPPNHGTRKEKNLKVQL
                     CSLGTAGTPELSPRIVDGIEDGNSSEETQTFDFGSEQIRPEPRISPSLGESEIGAAFL
                     FIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRSIMQLLENILSPQQPSQFCSLHPTS
                     ICPSRESFQTRVSWSAHQPCLHLQANGAHLYHGNVTSDIWSVDPSLVGSNPQRTEAHE
                     QSPVDSELHHSPNLAYSPSHCQVIQEGHLQFLRCISPHSDTTLTPLQSISATLSSSVC
                     SSSETSLHLVLPSRSEEGSITHGPVSSFSLENLPGSWDREGMMSASTEPLENFPVEVV
                     TSTADVKDSKAINV"
     exon            125..358
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     exon            359..490
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     exon            491..618
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     exon            619..859
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1017
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1225
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1423
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1623
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1873
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2088
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2127
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2483
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2590
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2667
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..3739
                     /gene="Kcnh8"
                     /gene_synonym="Elk1; ELK3; Ets-1; RELK3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccttgtgg acaaactttg atggggaatt tcacacagcg ctggaaaaat gccggttatg
       61 aaaggattgc tggcgccaca gaacaccttc ctggacacta ttgccacccg tttcgacgga
      121 acacatagca acttcatcct ggccaatgcc caagtggcaa aaggtttccc catagtctac
      181 tgttcagatg gcttctgtga gctggctggg tttgctcgaa ctgaagtcat gcagaagagt
      241 tgcagctgca agtttctgtt tggggtggag accaacgagc agctgatgct tcagatcgaa
      301 aagtccctgg aggagaaggt agagttcaaa ggagaaatta tgttctacaa gaagaatggg
      361 gctccatttt ggtgcctgtt ggatatcgtt cctataaaga atgagaaagg agatgtggtc
      421 cttttcctgg cctcattcaa agatataaca gacacgaaag tgaagattac ttcagaagat
      481 aaaaaagaag acagagccaa aggaagatca agagcaggga gccacttcga ctcagcccgc
      541 agacggagcc gagcagtcct ttatcacatc tcaggacacc tgcaaagaag agaaaagaac
      601 aaattgaaaa taaataataa cgtgtttgta gataaaccgg cgtttccaga gtataaggtt
      661 tccgatgcaa aaaagtccaa gttcatcctg ctgcacttca gcacttttaa agctggctgg
      721 gactggctca ttttgctggc aacgttttat gttgctgtga cagtccctta caacgtgtgc
      781 ttcattggca atgaggatct gtccacaact cggagcacaa cggtcagtga catcgctgtg
      841 gagattctct tcattataga tattattcta aatttccgaa caacttatgt cagcaagtct
      901 ggccaagtta tctttgaagc gagatccatt tgcatccact acgtcaccac ctggttcatc
      961 attgatctga ttgctgccct gccctttgac ctcctgtatg ctttcaatgt cacagtggtg
     1021 tccctcgtac atcttctgaa gactgttcgg ctgctccgtc ttttgcgcct cctgcagaag
     1081 ctggaccgtt attctcagca cagcacaatt gtcctcaccc tgctcatgtc catgtttgct
     1141 ctccttgcac actggatggc atgtatctgg tatgtcattg gaaaaatgga gagggaggac
     1201 aacagccttc tcaagtggga agtcggttgg cttcacgagc tgggaaagag actggaatct
     1261 ccgtactacg gcaacaacac gctgggcggc ccgtccatcc gcagtgccta tatcgcagcc
     1321 ttgtacttca ctctcagcag cctcaccagc gtgggatttg ggaatgtgtc cgctaacacg
     1381 gatgcagaga agatcttctc catctgtacc atgttgattg gagccctgat gcatgccttg
     1441 gtatttggga atgtgactgc catcatacag agaatgtact ctagatggag cctgtaccat
     1501 actagaacca aggacctaaa ggacttcatc cgtgtgcatc acctgcccca gcaactcaag
     1561 cagaggatgc ttgagtactt tcagacaact tggtctgtca acaatggaat agattcaaat
     1621 gagcttttga aagactttcc agatgagctg cgctctgaca tcacaatgca tctgaacaag
     1681 gagatcttac agctgtccct gtttgaatgt gctagccggg gctgcctcag gtctctgtct
     1741 ctccatatta aaacctcatt ctgtgcccca ggagagtatc tgctgcgcca gggagatgcg
     1801 ttgcaggcca tctacttcgt gtgctcaggc tctatggagg ttcttaaaga cagcatggtg
     1861 ttggctattc tagggaaggg ggatttaatt ggagcaaatt tatcaattaa agaccaagtg
     1921 atcaagacca acgctgacgt gaaggctctg acctactgtg atctacagtg catcatcctg
     1981 aaaggtctct ttgaggtgct gggcctttac ccagagtacg cacacaaatt cgtagaagac
     2041 atccagcacg acctcacata caaccttcga gaaggtcatg agagtgatgt aatatcaaga
     2101 ttatcgaaca aatctacagt cccacaggca gagcccaagg ggaatggaag catcaagaag
     2161 agactcccat ccattgtgga agatgaggaa gaggaggaag tggaggaaga ggagaccacc
     2221 tccctttctc ccatctacac aaggggatcc tctgtttcac acagcaaaaa gactggaagc
     2281 agtaagagct atctaggttt gagcttaaag caactgacct caggaacagt tccattccac
     2341 tcacctatca gagtctccag tgccaactcc cctaaaacca agcaggaagc tgacccacct
     2401 aaccatggca cacggaaaga gaagaatctg aaagttcagc tctgcagcct gggtactgct
     2461 ggaaccccag agctcagtcc gaggattgtc gatggaattg aagatggcaa cagcagtgag
     2521 gaaactcaga cttttgattt tggctctgaa caaatcaggc cagagcccag gatttcccct
     2581 tcccttggag aatcagagat tggagctgcg tttctgttca tcaaggctga agaaaccaag
     2641 cagcagataa acaagctcaa cagtgaggtc acaacattga ctcaggaggt ctcccagcta
     2701 gggaaagata tgagaagcat catgcaactt ctggaaaaca tcttgtcacc tcagcagcca
     2761 tcacaatttt gttctctgca tcccacttca atctgtcctt ccagagaaag tttccagact
     2821 agggtgagct ggagtgctca ccagccttgc ctacacttgc aggcaaatgg agcacatctt
     2881 taccatggca atgtcacctc tgacatctgg agtgtcgacc cctccttggt gggcagcaac
     2941 cctcaacgaa ctgaagctca tgagcaaagt ccagtagata gtgaactgca tcattctcca
     3001 aacctggctt attccccctc tcactgccag gttatccaag aaggccactt gcagttccta
     3061 aggtgcatct cccctcattc agataccaca ctgacacctt tgcagtccat ctcagccact
     3121 ctctcatcct ctgtgtgctc ctcatcagaa acatccttgc acctcgttct cccaagtagg
     3181 tcagaggagg gcagcatcac tcatggacct gtgagttctt tcagtttgga aaacttacca
     3241 ggatcttggg accgagaagg aatgatgtca gcctctacag aacccttgga gaactttcca
     3301 gtagaagttg tcacaagcac agcggatgta aaagacagca aagccataaa cgtataatat
     3361 cagcacataa gggcagcttt caatgccaaa tccactgctg catgacagct ctagtttgcc
     3421 tttgtggctt ctagcaggtg tggagcctga gcaaagttag gaattctgca ggaaagaggg
     3481 caaggggcca gtaaaaggca gagccacctc tatactgtag caaacaattt ctagatcgta
     3541 gaagcataaa accttttctg tacaggtatt aacttactgg tctgattgac agactttggt
     3601 aacaatccta tgacccagag ggtctgagca gatagaaacc ccagacaaag agtttgggga
     3661 ttagttttgt cataagtgga tttttttgtg aagtgcagca aaggtttttt ttcctgagtg
     3721 cctggttgtc attcctgaa
//
