LOCUS       NM_131912               3807 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily H
            member 7 (Kcnh7), mRNA.
ACCESSION   NM_131912
VERSION     NM_131912.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3807)
  AUTHORS   Perry,M. and Sanguinetti,M.C.
  TITLE     A single amino acid difference between ether-a-go-go- related gene
            channel subtypes determines differential sensitivity to a small
            molecule activator
  JOURNAL   Mol Pharmacol 73 (4), 1044-1051 (2008)
   PUBMED   18162604
  REMARK    GeneRIF: The differential sensitivity of hERG1 and rERG3 channels
            to the agonist effect of RPR could be accounted for by a single S5
            residue (Thr556 in hERG1, Ile558 in rERG3).
REFERENCE   2  (bases 1 to 3807)
  AUTHORS   Muhlbauer,E., Bazwinsky,I., Wolgast,S., Klemenz,A. and Peschke,E.
  TITLE     Circadian changes of ether-a-go-go-related-gene (Erg) potassium
            channel transcripts in the rat pancreas and beta-cell
  JOURNAL   Cell Mol Life Sci 64 (6), 768-780 (2007)
   PUBMED   17322986
REFERENCE   3  (bases 1 to 3807)
  AUTHORS   Hirdes,W., Schweizer,M., Schuricht,K.S., Guddat,S.S., Wulfsen,I.,
            Bauer,C.K. and Schwarz,J.R.
  TITLE     Fast erg K+ currents in rat embryonic serotonergic neurones
  JOURNAL   J Physiol 564 (Pt 1), 33-49 (2005)
   PUBMED   15677682
REFERENCE   4  (bases 1 to 3807)
  AUTHORS   Ohya,S., Asakura,K., Muraki,K., Watanabe,M. and Imaizumi,Y.
  TITLE     Molecular and functional characterization of ERG, KCNQ, and KCNE
            subtypes in rat stomach smooth muscle
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 282 (2), G277-G287 (2002)
   PUBMED   11804849
REFERENCE   5  (bases 1 to 3807)
  AUTHORS   Wimmers,S., Wulfsen,I., Bauer,C.K. and Schwarz,J.R.
  TITLE     Erg1, erg2 and erg3 K channel subunits are able to form
            heteromultimers
  JOURNAL   Pflugers Arch 441 (4), 450-455 (2001)
   PUBMED   11212207
REFERENCE   6  (bases 1 to 3807)
  AUTHORS   Wulfsen,I., Hauber,H.P., Schiemann,D., Bauer,C.K. and Schwarz,J.R.
  TITLE     Expression of mRNA for voltage-dependent and inward-rectifying K
            channels in GH3/B6 cells and rat pituitary
  JOURNAL   J Neuroendocrinol 12 (3), 263-272 (2000)
   PUBMED   10718922
REFERENCE   7  (bases 1 to 3807)
  AUTHORS   Shi,W., Wymore,R.S., Wang,H.S., Pan,Z., Cohen,I.S., McKinnon,D. and
            Dixon,J.E.
  TITLE     Identification of two nervous system-specific members of the erg
            potassium channel gene family
  JOURNAL   J Neurosci 17 (24), 9423-9432 (1997)
   PUBMED   9390998
REFERENCE   8  (bases 1 to 3807)
  AUTHORS   Long,R.M., Satoh,H., Martin,B.M., Kimura,S., Gonzalez,F.J. and
            Pohl,L.R.
  TITLE     Rat liver carboxylesterase: cDNA cloning, sequencing, and evidence
            for a multigene family
  JOURNAL   Biochem Biophys Res Commun 156 (2), 866-873 (1988)
   PUBMED   2973315
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF016191.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF016191.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3807
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..3807
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /note="potassium voltage-gated channel subfamily H member
                     7"
                     /db_xref="GeneID:170739"
                     /db_xref="RGD:621112"
     exon            1..258
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..3770
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /note="eag-related protein 3; ether-a-go-go-related
                     protein 3; ether-a-go-go-related gene potassium channel 3;
                     voltage-gated potassium channel subunit Kv11.3; ERG-3;
                     potassium channel erg3; potassium voltage-gated channel,
                     subfamily H (eag-related), member 7; potassium channel,
                     voltage gated eag related subfamily H, member 7"
                     /codon_start=1
                     /product="voltage-gated inwardly rectifying potassium
                     channel KCNH7"
                     /protein_id="NP_571987.1"
                     /db_xref="GeneID:170739"
                     /db_xref="RGD:621112"
                     /translation="MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYC
                     NDGFCEMTGFSRPDVMQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKN
                     GSTFICNTHIIPVKNQEGVAMMFIINFEYVTDEDNAASPERVNPILPVKSVNRKLFGF
                     KFPGLRVLTYRKQSLPQEDPDVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEADDTKA
                     LIQPSQCSPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLTHSRSRESLCSIRRASSV
                     HDIEGFNVHPKNIFRDRHASEDNGRNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQ
                     LTLNFSDVKTEKKNTSPPSSDKTIIAPKVKERTHNVTEKVTQVLSLGADVLPEYKLQT
                     PRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSP
                     LNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAVHYFKGWFLIDMVAAIPFD
                     LLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWL
                     ACIWYAIGNVERPYLTDKIGWLDSLGTQIGKRYNDSDSSSGPSIKDKYVTALYFTFSS
                     LTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLR
                     VKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLL
                     QNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIV
                     VAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFL
                     TNLELTFNLRHESAKSQSINDSEGDTCKLRRRRLSFESEGDKDFSKENSANDADDSTD
                     TIRRYQSSKKHFEEKKSRSSSFISSIDDEQKPLFLGTVDSTPRMVKASRHHGEEAAPP
                     SGRIHTDKRSHSCKDITDTHSWEREHARAQPEECSPSGLQRAAWGISETESDLTYGEV
                     EQRLDLLQEQLNRLESQMTTDIQAILQLLQKQTTVVPPAYSMVTAGAEYQRPILRLLR
                     TSHPRASIKTDRSFSPSSQCPEFLDLEKSKLKSKESLSSGKRLNTASEDNLTSLLKQD
                     SDASSELDPRQRKSYLHPIRHPSLPDSSLSTVGILGLHRHVSDPGLPGK"
     exon            259..489
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     exon            490..645
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     exon            646..1074
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1095
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1310
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1736
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..2136
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2336
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2589
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2795
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2877
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..3141
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3310
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     exon            3311..3503
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3807
                     /gene="Kcnh7"
                     /gene_synonym="erg3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatggattgg acttcggcgg ggaacgcggg tgtctcgaag tggtgctaat ggaaagagat
       61 ttctgctccc caaagaagat gcgctgccac aaagagcggc ttgcgcgccg gcctgggctc
      121 tagcccggga gacatcccgg gagaactccg agctcggagc gctcggcgaa gacccgggca
      181 acatgcctgt tcgcaggggg catgtggcac cgcaaaacac cttcctgggg accatcatac
      241 ggaaatttga agggcagaat aaaaaattta tcattgcaaa tgccagagtg cagaactgtg
      301 ccatcatcta ctgcaatgat ggcttctgtg agatgacagg tttctccagg ccagatgtca
      361 tgcagaagcc atgcacctgc gactttctcc atgggcctga gaccaagagg catgatattg
      421 cccagattgc ccaggcgctg ttggggtcag aggagaggaa agtggaggtc acctactatc
      481 acaagaatgg ttccactttt atttgtaaca ctcacataat cccagtaaag aaccaagagg
      541 gtgtggctat gatgttcatc attaactttg agtatgtgac agatgaagac aatgctgcct
      601 ccccagagag agtcaaccca atattgccag tcaaatctgt aaatcggaaa ctttttgggt
      661 tcaaatttcc tggtctgaga gttctaacat acagaaagca gtccttgccg caggaagacc
      721 cggacgtggt agtcattgat tcttctaagc acagcgatga ctctgtggct atgaagcact
      781 ttaagtctcc cacgaaagaa agctgcagtc cctctgaagc agatgatacg aaggccttga
      841 tacagcctag ccagtgttct cccttagtga acatatcagg acctctggac cattcctctc
      901 ccaaaaggca atgggaccgc ctctaccctg acatgctgca gtcaagttcc caactaacac
      961 actccaggtc aagggagagc ctctgtagca tacggagagc atcttcagtt catgatatag
     1021 aagggttcaa tgtccacccc aagaacatat ttagagatcg acatgccagt gaagacaatg
     1081 gtcgaaatgt caaaggacct ttcaatcata tcaagtcaag cctgttggga tccacatcag
     1141 attcaaacct caacaaatac agcaccatta acaagatccc gcaactcact ctgaactttt
     1201 cagatgtcaa aactgagaaa aagaatactt ccccgccttc ttcagacaaa actattattg
     1261 cacccaaggt taaagagagg acacacaacg tgacagagaa ggtaactcag gttctttctt
     1321 tgggagcaga tgtcttgcca gaatacaagc tgcagacgcc acgcatcaac aaatttacaa
     1381 tattgcacta cagccctttc aaagcagtgt gggattggct cattttactc ctggtcattt
     1441 atactgctat attcaccccc tactcggcag cctttctcct caacgacaga gaggagcaga
     1501 aaagacgaga atgtggctat tcttgtagcc ctttgaatgt ggtagacttg attgtggata
     1561 ttatgtttat tatagacatc ctaataaact tcagaacaac ctatgtaaat cagaacgaag
     1621 aagtggtaag tgatcctgcc aaaatagcag tacactactt caaaggctgg ttcctgattg
     1681 acatggtcgc agccatccct tttgacttgc tgattttcgg atcaggctct gatgagacaa
     1741 caacactaat tggtcttttg aagactgcac gtctcctgcg tcttgtgcgt gtagccagga
     1801 aactggaccg atactcagaa tatggtgccg ctgttctaat gctcttgatg tgcatatttg
     1861 ccctgattgc ccactggctg gcttgcatct ggtatgcgat tgggaatgta gagaggccct
     1921 atctgactga caaaattgga tggttggatt ccttaggaac acaaattggg aaacgttaca
     1981 atgacagtga ctcgagttct ggaccgtcca ttaaagacaa atacgtcacg gcactttact
     2041 ttaccttcag cagtctaacc agtgtaggat ttggaaatgt gtctcctaac accaattcgg
     2101 agaaaatctt ttccatttgt gtcatgttga ttggctctct aatgtatgcg agcatttttg
     2161 ggaatgtttc tgcaattatt caaagactgt actcgggaac tgccaggtac cacatgcaga
     2221 tgctgagagt gaaagagttc attcgcttcc accaaatccc caaccctctg aggcaacggc
     2281 ttgaggagta tttccagcac gcatggacgt acactaacgg cattgacatg aacatggtct
     2341 taaagggatt tccggaatgt ttacaagctg acatttgcct gcatctaaac cagactttgc
     2401 tccaaaactg caaagccttt cgaggagcaa gtaaaggttg cctcagagct ctggcaatga
     2461 agttcaaaac cacccatgcc cctccaggag acaccctggt tcactgtggg gacgtcctaa
     2521 ctgcactgta cttcttatcc agaggctcca ttgaaatcct caaggatgac atagtggtag
     2581 ctattctagg aaaaaatgat atctttggag aaatggttca tctttacgcc aagcctggca
     2641 aatctaatgc agatgtgaga gcgctcacgt attgtgacct gcataagatt cagcgagaag
     2701 acttattaga ggtcttggat atgtatccgg aattttctga tcactttctg acaaatctag
     2761 aactgacttt caacctgaga cacgaaagtg caaagtccca atccataaat gattctgaag
     2821 gggacacctg taagcttcga agaaggagat tgtcctttga aagcgaaggc gacaaagatt
     2881 ttagcaaaga aaacagtgca aatgacgctg acgattccac agatacaata agacgttatc
     2941 agagttccaa gaagcacttc gaagagaaga aaagcagatc gtcttccttt atctcctcca
     3001 tcgatgatga gcaaaagcca ctcttcctgg gaacagtaga ttccactcca agaatggtga
     3061 aagcaagcag gcaccatggt gaagaagcag cgcccccctc aggaagaatt cacacagata
     3121 aaaggagtca ctcctgcaaa gatatcactg acacacacag ctgggaaaga gagcatgccc
     3181 gggctcagcc tgaagaatgc agtccctccg gacttcagag agctgcctgg ggcatctctg
     3241 agaccgaaag cgacctcacc tatggggaag tggagcagag gttagatttg cttcaagagc
     3301 aacttaacag acttgaatcc caaatgacaa cggacatcca ggccatctta cagctcctgc
     3361 agaaacaaac caccgtagtc cctccagcct acagcatggt gaccgcagga gcagagtacc
     3421 agaggcccat cctccgtctg ctgagaacca gtcaccctag agcatccatt aagacagacc
     3481 ggagcttcag cccctcctca caatgtcctg aatttctcga ccttgaaaag tccaaactca
     3541 aatccaaaga atcactgtca agcggaaagc gcctgaacac ggcttcagaa gacaacttga
     3601 cttcactttt aaaacaagac agtgatgcat cgtcagagct tgacccgcgg caaagaaaat
     3661 cttaccttca tcccatccgg catccgtctc tgccagactc ctccctaagc actgtaggga
     3721 tcttgggtct ccataggcat gtttctgatc ctggtcttcc gggaaagtaa ttgttttgta
     3781 ctatttctcc acatccaatg taagtgc
//
