LOCUS       NM_053937               3382 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily H
            member 6 (Kcnh6), mRNA.
ACCESSION   NM_053937
VERSION     NM_053937.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3382)
  AUTHORS   Jang,S.W., Srinivasan,R., Jones,E.A., Sun,G., Keles,S., Krueger,C.,
            Chang,L.W., Nagarajan,R. and Svaren,J.
  TITLE     Locus-wide identification of Egr2/Krox20 regulatory targets in
            myelin genes
  JOURNAL   J Neurochem 115 (6), 1409-1420 (2010)
   PUBMED   21044070
  REMARK    GeneRIF: Erg2 was found to bind to promoters of several lipid
            biosynthesis genes during the formation of lipid-rich myelin.
REFERENCE   2  (bases 1 to 3382)
  AUTHORS   Hirdes,W., Schweizer,M., Schuricht,K.S., Guddat,S.S., Wulfsen,I.,
            Bauer,C.K. and Schwarz,J.R.
  TITLE     Fast erg K+ currents in rat embryonic serotonergic neurones
  JOURNAL   J Physiol 564 (Pt 1), 33-49 (2005)
   PUBMED   15677682
REFERENCE   3  (bases 1 to 3382)
  AUTHORS   Ohya,S., Asakura,K., Muraki,K., Watanabe,M. and Imaizumi,Y.
  TITLE     Molecular and functional characterization of ERG, KCNQ, and KCNE
            subtypes in rat stomach smooth muscle
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 282 (2), G277-G287 (2002)
   PUBMED   11804849
REFERENCE   4  (bases 1 to 3382)
  AUTHORS   Saganich,M.J., Machado,E. and Rudy,B.
  TITLE     Differential expression of genes encoding subthreshold-operating
            voltage-gated K+ channels in brain
  JOURNAL   J Neurosci 21 (13), 4609-4624 (2001)
   PUBMED   11425889
REFERENCE   5  (bases 1 to 3382)
  AUTHORS   Wimmers,S., Wulfsen,I., Bauer,C.K. and Schwarz,J.R.
  TITLE     Erg1, erg2 and erg3 K channel subunits are able to form
            heteromultimers
  JOURNAL   Pflugers Arch 441 (4), 450-455 (2001)
   PUBMED   11212207
REFERENCE   6  (bases 1 to 3382)
  AUTHORS   Wulfsen,I., Hauber,H.P., Schiemann,D., Bauer,C.K. and Schwarz,J.R.
  TITLE     Expression of mRNA for voltage-dependent and inward-rectifying K
            channels in GH3/B6 cells and rat pituitary
  JOURNAL   J Neuroendocrinol 12 (3), 263-272 (2000)
   PUBMED   10718922
REFERENCE   7  (bases 1 to 3382)
  AUTHORS   Shi,W., Wymore,R.S., Wang,H.S., Pan,Z., Cohen,I.S., McKinnon,D. and
            Dixon,J.E.
  TITLE     Identification of two nervous system-specific members of the erg
            potassium channel gene family
  JOURNAL   J Neurosci 17 (24), 9423-9432 (1997)
   PUBMED   9390998
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF016192.1.
            
            [WARNING] On Oct 8, 2024 this sequence was replaced by NM_053937.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF016192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132302, SAMD00155317
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..3382
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /note="potassium voltage-gated channel subfamily H member
                     6"
                     /db_xref="GeneID:116745"
                     /db_xref="RGD:620304"
     exon            1..108
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2885
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /note="eag-related protein 2; ether-a-go-go-related
                     protein 2; potassium channel, voltage gated eag related
                     subfamily H, member 6; ether-a-go-go-related gene
                     potassium channel 2; voltage-gated potassium channel
                     subunit Kv11.2; ERG-2; Eag-related gene member 2;
                     potassium voltage-gated channel, subfamily H
                     (eag-related), member 6"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily H
                     member 6"
                     /protein_id="NP_446389.1"
                     /db_xref="GeneID:116745"
                     /db_xref="RGD:620304"
                     /translation="MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYC
                     NDGFCELFGYSRVEVMQRPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKD
                     ASSFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKSSSRSLTQRLLSHSFLGSEGSH
                     SRPSGQGPGPGRGKYRTVSQIPQFTLNFVEFNLEKHRSGSTTEIEIIAPHKVVERTQN
                     VTEKVTQVLSLGADVLPEYKLQAPRIHRGTILHYSPFKAVWDWLILLLVIYTAVFTPY
                     SAAFLLSDQDESQRGTCGYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHP
                     RRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDR
                     YSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEPKIGWLDSLGAQLGKQYNG
                     SDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIF
                     GNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMN
                     AVLKGFPECLQADICLHLHRALLQHCPAFRGASKGCLRALAVKFKTTHAPPGDTLVHL
                     GDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPASLHARPGKSSADVRALTYCDL
                     HKIHRADLLEVLDMYPAFADTFWNKLEVTFNLRDADGGLQSTPRQAPGHQDPQGFFLN
                     DSQSGAAPSLSISDTSALWPELLQQMPPSPPNPRQDLDCWHRELGFKLEQLQAQMNRL
                     ESRVSSDLSRILQLLQHPQGRPSYILGASASSDLASFPETSVTRSSESTLLVGHVPSA
                     QTLSYGDLDDHIQTPRNFSPRTPHVAMAMDKTLVPSSEQEQPGGLLSPLASPLRPLEV
                     PGLGGSRFPSLPEHLSSVPKQLEFQRHGSDPGFTRS"
     exon            109..339
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            340..501
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            502..707
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..1133
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1533
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1733
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1986
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2180
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2265
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2422
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2603
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..3382
                     /gene="Kcnh6"
                     /gene_synonym="Erg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtaactcc cagcaagtgc tgttacagaa agatgccagt ccgcaggggc cacgttgctc
       61 cccaaaacac ttacttggac accatcatcc gcaagtttga aggccagagt cggaagttcc
      121 tgattgccaa tgcgcagatg gagaactgtg ccatcattta ctgcaacgat ggcttctgcg
      181 aactctttgg ctactcccgt gtggaggtga tgcagcggcc ctgtacttgt gatttcctca
      241 cgggcccgaa cactccaagc agtgctgtgt cccgcttggc tcaggccctg ctcggggctg
      301 aagagtgcaa ggtggacatc ctctactatc gcaaggacgc ctccagcttc cgctgcctgg
      361 tggatgtggt ccccgtgaag aatgaggacg gggcagtcat catgtttatc ctcaatttcg
      421 aggacctggc ccagctcctg gccaaaagca gcagccgcag cctgacccaa cggttgttgt
      481 cacacagctt cctgggttct gagggctctc acagcaggcc gagtggacag gggcctggcc
      541 caggcagggg caaatacaga accgtcagcc agattccgca gttcacactc aacttcgtgg
      601 agttcaacct ggagaagcac cgctcaggct ccaccacgga gattgagatc atcgctccgc
      661 acaaggtggt ggagcggaca cagaatgtca ctgaaaaagt cacccaggtc ctgtccctag
      721 gtgcagatgt gctgccagag tacaagctac aagcaccgcg tatccaccga ggcaccattc
      781 tgcactacag ccccttcaag gccgtgtggg actggctaat cttgctctta gtcatctata
      841 cagcggtctt cacgccctac tctgccgcct ttctactcag cgaccaggac gaatcacagc
      901 gcggtacctg tggctatacc tgcagcccgc tcaccgtggt ggacctcatc gtggatatca
      961 tgtttgtcgt ggacatcgtc atcaacttcc gaaccaccta cgtcaacact aatgatgagg
     1021 tggtcagcca cccacgacgc atcgctgtcc actatttcaa gggctggttc ctcattgaca
     1081 tggtggctgc catccccttt gacctgctta tcttccgcac tggctcagat gagaccacca
     1141 ccttgattgg gttactgaag acggcgcgcc tcctgcggct ggtgcgcgtg gcccggaagc
     1201 tggaccgcta ttctgaatac ggggccgcgg tactcttcct gctcatgtgt actttcgcgc
     1261 tcattgcgca ctggctggcc tgtatctggt acgccatcgg caacgtggag cgaccctact
     1321 tggagcccaa gatcggctgg ctggacagcc tgggtgcaca gcttggcaag cagtataatg
     1381 gcagcgaccc agcctcagga ccctctgtcc aggacaagta tgtcaccgcc ctctacttca
     1441 ccttcagcag ccttaccagt gtgggcttcg gcaacgtgtc acccaacacc aactctgaga
     1501 aggtcttctc tatctgcgtc atgctcattg gctcccttat gtacgccagc atctttggca
     1561 acgtgtcggc catcatccaa cgcctgtact cgggcactgc ccgctaccac acgcagatgc
     1621 tgcgtgtcaa ggagttcatc cgcttccacc agatccccaa cccactgcgg cagcgcctgg
     1681 aagagtattt ccagcacgcc tggtcctaca ccaacggcat tgacatgaac gcggtgctga
     1741 agggcttccc tgagtgcctg caggcggaca tctgcctgca cctgcaccgc gctctgctgc
     1801 agcactgccc cgccttccgg ggcgccagca aggggtgcct gcgcgcgctc gcggtcaagt
     1861 tcaagaccac gcacgcgccg cctggggaca cgctggtgca cctgggcgac gtgctctcca
     1921 cgctctactt catctcccgc ggctccatcg agatcctgcg cgatgatgtg gtcgtggcca
     1981 ttctagggaa gaatgacatc tttggggagc ctgccagtct tcatgccagg ccaggcaaat
     2041 ctagcgcaga tgtgcgcgcc ctgacctact gcgacctgca taagatccat cgagcagacc
     2101 tgctggaggt gctggacatg taccctgcct ttgcagacac cttctggaat aagctggagg
     2161 tcaccttcaa cctgcgggac gcagatgggg gtctccagtc aacaccccga caggccccag
     2221 gccaccaaga cccccaaggc ttcttcctca atgacagtca gtcaggtgcc gccccttcct
     2281 tgagcatttc agacacatct gcactttggc ctgaattgct acagcaaatg cccccaagtc
     2341 ccccaaaccc acgacaggac ctggattgct ggcatcggga gctaggcttt aagttagaac
     2401 agctccaagc ccagatgaac agattggagt cccgtgtgtc atcagacctc agccgcatcc
     2461 tacagctgct tcagcacccg cagggtcgcc ccagctacat cttgggagcc tctgcctcca
     2521 gtgacctggc ctcatttcct gaaacttcag tgactcggag ttcagagtct acgcttctgg
     2581 tgggacatgt gccctctgct cagaccctaa gctacggtga cttggacgac catattcaga
     2641 cacccaggaa tttctccccc aggacacctc acgtggccat ggcaatggac aaaactctgg
     2701 tgccatcctc agaacaagag caacctgggg gtctcctgtc acctctagcc tcacctctgc
     2761 gtcccctgga agtaccggga ctgggtggtt cccgcttccc ctccctccct gaacacctca
     2821 gctcagttcc caagcagcta gagttccaga gacacggttc cgatcctgga ttcacaagga
     2881 gttagggcct ttagacccca gggtaaaagc taccatgagg gaatttaagt acagtgaggt
     2941 gagagttaag cccccttcgg gggagggcca ggcagctctc ccataaaact ctgaaaacca
     3001 tttcctcaga gaaactgtag accgctgagc cagtgaccag gatgatctga gcaaagaggc
     3061 tcaggacttg gcccgggctc cttgggaccc ctgtagtcag caagccaggc agaggtttgc
     3121 tcagaggtag cttacaggat gccagtggag aatacagatg cttcagatct ctgggagggt
     3181 cttgcttggg gccgcatgtg gttggctccc agctcagaac caccttctgc ctcaaaagcc
     3241 cagacccaag gccaggtttg accagacctt taccaaaagc ctctacctaa tatggctgga
     3301 attagaggtg tcctctgtgg tggacataaa agacagggag ctgcagccct cagcccctct
     3361 tcccctgaga ctctcataac ag
//
