LOCUS       NM_133610               3505 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily H
            member 5 (Kcnh5), mRNA.
ACCESSION   NM_133610
VERSION     NM_133610.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3505)
  AUTHORS   Yu,L., Liu,Y., Xia,J., Feng,S. and Chen,F.
  TITLE     KCNH5 deletion increases autism susceptibility by regulating
            neuronal growth through Akt/mTOR signaling pathway
  JOURNAL   Behav Brain Res 470, 115069 (2024)
   PUBMED   38797494
  REMARK    GeneRIF: KCNH5 deletion increases autism susceptibility by
            regulating neuronal growth through Akt/mTOR signaling pathway.
REFERENCE   2  (bases 1 to 3505)
  AUTHORS   Lin,T.F., Lin,I.W., Chen,S.C., Wu,H.H., Yang,C.S., Fang,H.Y.,
            Chiu,M.M. and Jeng,C.J.
  TITLE     The subfamily-specific assembly of Eag and Erg K+ channels is
            determined by both the amino and the carboxyl recognition domains
  JOURNAL   J Biol Chem 289 (33), 22815-22834 (2014)
   PUBMED   25008323
REFERENCE   3  (bases 1 to 3505)
  AUTHORS   Chuang,C.C., Jow,G.M., Lin,H.M., Weng,Y.H., Hu,J.H., Peng,Y.J.,
            Chiu,Y.C., Chiu,M.M. and Jeng,C.J.
  TITLE     The punctate localization of rat Eag1 K+ channels is conferred by
            the proximal post-CNBHD region
  JOURNAL   BMC Neurosci 15, 23 (2014)
   PUBMED   24495567
  REMARK    GeneRIF: Our findings suggest that Eag1 and Eag2 K+ channels may
            modulate membrane excitability in both the dendrosomatic and the
            axonal compartments and that Eag1 may additionally regulate
            neurotransmitter release and postsynaptic signaling
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3505)
  AUTHORS   Huang,X., Dubuc,A.M., Hashizume,R., Berg,J., He,Y., Wang,J.,
            Chiang,C., Cooper,M.K., Northcott,P.A., Taylor,M.D., Barnes,M.J.,
            Tihan,T., Chen,J., Hackett,C.S., Weiss,W.A., James,C.D.,
            Rowitch,D.H., Shuman,M.A., Jan,Y.N. and Jan,L.Y.
  TITLE     Voltage-gated potassium channel EAG2 controls mitotic entry and
            tumor growth in medulloblastoma via regulating cell volume dynamics
  JOURNAL   Genes Dev 26 (16), 1780-1796 (2012)
   PUBMED   22855790
REFERENCE   5  (bases 1 to 3505)
  AUTHORS   Martin,S., Lino-de-Oliveira,C., Joca,S.R., Weffort de Oliveira,R.,
            Echeverry,M.B., Da Silva,C.A., Pardo,L., Stuhmer,W. and Bel,E.D.
  TITLE     Eag 1, Eag 2 and Kcnn3 gene brain expression of isolated reared
            rats
  JOURNAL   Genes Brain Behav 9 (8), 918-924 (2010)
   PUBMED   20662937
  REMARK    GeneRIF: Isolation rearing changes the expression of Eag2 potassium
            channel in the midbrain, striatum, cortex, hippocampus and
            olfactory bult; and reduces exploratory activity in the center of
            an open field.
REFERENCE   6  (bases 1 to 3505)
  AUTHORS   Jow,G.M. and Jeng,C.J.
  TITLE     Differential localization of rat Eag1 and Eag2 potassium channels
            in the retina
  JOURNAL   Neurosci Lett 431 (1), 12-16 (2008)
   PUBMED   18063306
  REMARK    GeneRIF: Compared to rEag2, rEag1 expression encompasses a
            significantly broader range of the somatodendritic compartment of
            the retinal ganglion cell.
REFERENCE   7  (bases 1 to 3505)
  AUTHORS   Jeng,C.J., Chang,C.C. and Tang,C.Y.
  TITLE     Differential localization of rat Eag1 and Eag2 K+ channels in
            hippocampal neurons
  JOURNAL   Neuroreport 16 (3), 229-233 (2005)
   PUBMED   15706225
  REMARK    GeneRIF: Immunofluorescence studies using markers for different
            compartments of neurons demonstrated a differential expression
            pattern of rEag1 and rEag2 K channels in the somatodendritic
            region.
REFERENCE   8  (bases 1 to 3505)
  AUTHORS   Ludwig,J., Weseloh,R., Karschin,C., Liu,Q., Netzer,R., Engeland,B.,
            Stansfeld,C. and Pongs,O.
  TITLE     Cloning and functional expression of rat eag2, a new member of the
            ether-a-go-go family of potassium channels and comparison of its
            distribution with that of eag1
  JOURNAL   Mol Cell Neurosci 16 (1), 59-70 (2000)
   PUBMED   10882483
REFERENCE   9  (bases 1 to 3505)
  AUTHORS   Saganich,M.J., Vega-Saenz de Miera,E., Nadal,M.S., Baker,H.,
            Coetzee,W.A. and Rudy,B.
  TITLE     Cloning of components of a novel subthreshold-activating K(+)
            channel with a unique pattern of expression in the cerebral cortex
  JOURNAL   J Neurosci 19 (24), 10789-10802 (1999)
   PUBMED   10594062
REFERENCE   10 (bases 1 to 3505)
  AUTHORS   Shi,W., Wang,H.S., Pan,Z., Wymore,R.S., Cohen,I.S., McKinnon,D. and
            Dixon,J.E.
  TITLE     Cloning of a mammalian elk potassium channel gene and EAG mRNA
            distribution in rat sympathetic ganglia
  JOURNAL   J Physiol 511 (Pt 3) (Pt 3), 675-682 (1998)
   PUBMED   9714851
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ250280.1.
            
            On Aug 30, 2012 this sequence version replaced NM_133610.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ250280.1, AF185637.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3505              AJ250280.1         3-3507
FEATURES             Location/Qualifiers
     source          1..3505
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..3505
                     /gene="Kcnh5"
                     /gene_synonym="Eag2"
                     /note="potassium voltage-gated channel subfamily H member
                     5"
                     /db_xref="GeneID:171146"
                     /db_xref="RGD:621417"
     exon            1..339
                     /gene="Kcnh5"
                     /gene_synonym="Eag2"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..3233
                     /gene="Kcnh5"
                     /gene_synonym="Eag2"
                     /function="voltage-gated potassium channel"
                     /note="rEAG2; ether-a-go-go potassium channel 2;
                     voltage-gated potassium channel subunit Kv10.2; potassium
                     voltage-gated channel, subfamily H (eag-related), member
                     5; potassium channel, voltage gated eag related subfamily
                     H, member 5"
                     /codon_start=1
                     /product="voltage-gated delayed rectifier potassium
                     channel KCNH5"
                     /protein_id="NP_598294.1"
                     /db_xref="GeneID:171146"
                     /db_xref="RGD:621417"
                     /translation="MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSN
                     DGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNR
                     TPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSR
                     SVLQQLTPMNKTETVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWD
                     WVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGE
                     VISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV
                     ARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQL
                     ALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSV
                     AMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDY
                     IVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEF
                     QTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDEEVVAILGKGDVFGDIFWKETTLA
                     HACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDV
                     KKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSAQSDPERSQLQVESRP
                     LQNGASITGTSVVTVSQITPIQTSLAYVKTSETLKQNNRDAMELKPNGGAEPKCLKVN
                     SPIRMKNGNGKGWLRLKNNMGAHEEKKEEWNNVTKAESMGLLSEDPKGSDSENSVTKN
                     PLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPSQADAKHPFYPIPEQALQTTLQEVK
                     HELKEDIQLLSCRMTALEKQVAEILKLLSEKSVPQTSSPKPQIPLQVPPQIPCQDIFS
                     VSRPESPESDKDEINF"
     exon            340..463
                     /gene="Kcnh5"
                     /gene_synonym="Eag2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..570
                     /gene="Kcnh5"
                     /gene_synonym="Eag2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..699
                     /gene="Kcnh5"
                     /gene_synonym="Eag2"
                     /inference="alignment:Splign:2.1.0"
     exon            700..815
                     /gene="Kcnh5"
                     /gene_synonym="Eag2"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1208
                     /gene="Kcnh5"
                     /gene_synonym="Eag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1635
                     /gene="Kcnh5"
                     /gene_synonym="Eag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1835
                     /gene="Kcnh5"
                     /gene_synonym="Eag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2088
                     /gene="Kcnh5"
                     /gene_synonym="Eag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2285
                     /gene="Kcnh5"
                     /gene_synonym="Eag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..3505
                     /gene="Kcnh5"
                     /gene_synonym="Eag2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttccccagc cccgtgtgcg gcaccgccac agtctgggca gcggcggccg ggggagcgct
       61 actaccatga actgcttggt cctccttccc agagctgctc atccgggtcg gactggagac
      121 acactcaggg gaccccgccg ccgccgccgc gccccctttt ctttcggctc catctccact
      181 acctcttcct cttcttcttc caccttttct tcctgcttcc ccccctcccc cgccgcggat
      241 cctggccgct gctttccaga cccaggatgc cggggggcaa gagagggctg gtggctccgc
      301 agaacacatt tttggagaac atcgtcaggc gctccagtga atcaagtttc ttactgggaa
      361 atgcccaaat tgtggactgg cctgtagttt atagtaatga cggattttgt aaactctctg
      421 gatatcatcg agctgacgtc atgcagaaaa gcagcacttg cagttttatg tatggagaac
      481 tgaccgataa gaagaccatt gagaaagtca ggcagacttt tgacaactac gagtcaaact
      541 gttttgaagt tcttctgtat aaaaaaaacc gtacccccgt ttggttttac atgcaaatcg
      601 caccaataag aaacgaacac gagaaggtgg tcttgttcct gtgtacgttc aaggatatca
      661 cgctgttcaa acagcccata gaggatgact caacaaaagg ttggacgaaa tttgcccggt
      721 tgacacgggc tttgacaaac agccggagtg tgttacagca gcttacacca atgaataaaa
      781 cagagacagt ccacaaacat tcaagactgg cagaagttct tcagctggga tcagacatcc
      841 ttcctcagta caaacaagaa gcgccaaaga cgccgccgca catcatctta cattactgtg
      901 ctttcaaaac tacgtgggat tgggtgattt taattcttac cttctacacc gccatcatgg
      961 ttccttacaa cgtttccttc aaaacaaaac agaacaatat cgcctggctg gttctggaca
     1021 gcgtggtgga cgttattttt ctggtggaca tcgttttaaa ctttcacacg acttttgtgg
     1081 ggccgggtgg agaggtcatt tctgacccaa aactcatacg gatgaactat ctgaaaactt
     1141 ggtttgtgat tgatctgctg tcttgtttac cttatgacat catcaatgcc tttgaaaatg
     1201 tggatgaggg aatcagcagt ctcttcagct ctttaaaggt ggtacgcctc ttacgcctgg
     1261 gccgtgttgc taggaaactg gaccattacc tggaatatgg agcagcggtc cttgtgctcc
     1321 tggtatgtgt gtttggactg gttgcccact ggctggcctg catctggtac agcattggag
     1381 actatgaggt cattgatgaa gtcaccaaca ccattcaaat agacagctgg ctctaccagt
     1441 tggccttgag cattgggact ccatatcgct acaataccag tgcagggatc tgggaaggag
     1501 gacccagcaa ggactccctg tatgtgtcct ccctctactt caccatgacg agccttacaa
     1561 ccataggatt tggaaacata gctccgacca cagacgtgga gaagatgttc tcagtggcca
     1621 tgatgatggt cggctctctt ctttatgcaa ctatttttgg aaatgttacc acaattttcc
     1681 agcaaatgta tgccaacacc aaccgttacc atgagatgct gaacaatgtt cgagatttcc
     1741 tgaaattata tcaggtcccg aaaggcctta gtgaacgagt catggattac attgtgtcaa
     1801 cgtggtcaat gtcaaaaggc atcgacacag agaaggtcct ctccatctgc cccaaggaca
     1861 tgagagctga catctgtgtt catctgaacc ggaaggtttt taatgaacat cctgcattcc
     1921 gattggccag cgatggatgt ctgcgtgcct tggcagtgga gttccaaacc attcactgtg
     1981 ctcctgggga cctgatttac catgctggag agagtgtgga cgccctctgc tttgtggtgt
     2041 cagggtcctt ggaggttatc caggatgagg aggtggtggc tatcttaggg aaaggtgatg
     2101 tgtttggaga catcttctgg aaggaaacca cccttgctca tgcatgtgcc aatgtccggg
     2161 ccctgactta ctgtgacctg cacatcatca agagagaagc cttgctcaaa gtccttgact
     2221 tctatacagc atttgcaaac tcattctcca ggaacctcac tctcacttgc aatctaagga
     2281 agcggatcat cttccgtaaa attagtgatg tgaaaaagga ggaggaggag cggcttcgac
     2341 agaagaatga ggtgactctg agcatccccg tggaccaccc agtgaggaag ctcttccaga
     2401 agttcaaaca gcagaaggag ctgaggaacc agggctcagc gcagagcgac cctgagagga
     2461 gccagcttca ggtagagagc cgccctttgc agaatggagc ctccatcaca ggtaccagtg
     2521 tggtcactgt gtcacagatt acccccatcc agacatcgct ggcctatgtg aaaaccagcg
     2581 agactcttaa gcagaacaac cgtgatgcca tggaactgaa gcccaatggt ggtgctgagc
     2641 ccaaatgtct caaggtcaac agccccatca gaatgaaaaa cggaaatggg aaggggtggc
     2701 tgagactgaa gaacaacatg ggggctcacg aggagaaaaa ggaagagtgg aataatgtca
     2761 ccaaagctga gtccatgggg ctgttgtcag aggaccccaa gggcagtgac tcagagaaca
     2821 gtgtgaccaa gaacccctta aggaaaacgg attcttgtga cagtgggatt acaaaaagtg
     2881 accttcgttt ggataaagct ggtgaggccc gaagtcctct agaacacagt cccagccagg
     2941 ctgatgccaa gcatcccttc taccccatcc ccgagcaggc cttacaaacc acactgcagg
     3001 aggtaaaaca tgaactcaaa gaggacatcc agctgctgag ctgcagaatg actgccctgg
     3061 aaaagcaggt ggcagagatt ttaaaactac tctcagagaa aagtgtaccc cagacatctt
     3121 ctccaaaacc ccaaattcca ctccaagtac ctccccaaat accatgtcag gatattttta
     3181 gtgtctcaag gcctgagtca cctgaatctg acaaagatga aatcaacttt taatatatat
     3241 acatatatat acatatatat ttattaatat atttaaaaca gtatatacat ctatatacat
     3301 aagtgtgtat atatagtata tacatatata ttttcacttg ctttcattat gatgaacaca
     3361 atatggattt tgatatgtac atactgcatg tccagctgga ttctggcctg ccaaagacaa
     3421 ttattcaaaa catagatatt gcttgtacat tatgcagttg actgcatgca cactttacat
     3481 ttatttatac tctctattct gtaat
//
