LOCUS       NM_053630               3746 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily H
            member 4 (Kcnh4), mRNA.
ACCESSION   NM_053630
VERSION     NM_053630.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3746)
  AUTHORS   Saganich,M.J., Machado,E. and Rudy,B.
  TITLE     Differential expression of genes encoding subthreshold-operating
            voltage-gated K+ channels in brain
  JOURNAL   J Neurosci 21 (13), 4609-4624 (2001)
   PUBMED   11425889
REFERENCE   2  (bases 1 to 3746)
  AUTHORS   Miyake,A., Mochizuki,S., Yokoi,H., Kohda,M. and Furuichi,K.
  TITLE     New ether-a-go-go K(+) channel family members localized in human
            telencephalon
  JOURNAL   J Biol Chem 274 (35), 25018-25025 (1999)
   PUBMED   10455180
REFERENCE   3  (bases 1 to 3746)
  AUTHORS   Engeland,B., Neu,A., Ludwig,J., Roeper,J. and Pongs,O.
  TITLE     Cloning and functional expression of rat ether-a-go-go-like K+
            channel genes
  JOURNAL   J Physiol 513 (Pt 3) (Pt 3), 647-654 (1998)
   PUBMED   9824707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 5, 2020 this sequence version replaced NM_053630.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB022699.1, AJ007628.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               JAXUCZ010000010.1  86188258-86188476   c
            220-453             JAXUCZ010000010.1  86186313-86186546   c
            454-600             JAXUCZ010000010.1  86185859-86186005   c
            601-728             JAXUCZ010000010.1  86185636-86185763   c
            729-972             JAXUCZ010000010.1  86184485-86184728   c
            973-1130            JAXUCZ010000010.1  86183890-86184047   c
            1131-1338           JAXUCZ010000010.1  86180599-86180806   c
            1339-1533           JAXUCZ010000010.1  86178358-86178552   c
            1534-1733           JAXUCZ010000010.1  86177750-86177949   c
            1734-1983           JAXUCZ010000010.1  86175898-86176147   c
            1984-2222           JAXUCZ010000010.1  86175099-86175337   c
            2223-2261           JAXUCZ010000010.1  86174512-86174550   c
            2262-2614           JAXUCZ010000010.1  86173963-86174315   c
            2615-2721           JAXUCZ010000010.1  86173595-86173701   c
            2722-2798           JAXUCZ010000010.1  86172695-86172771   c
            2799-3509           JAXUCZ010000010.1  86169935-86170645   c
            3510-3746           JAXUCZ010000010.1  86168644-86168880   c
FEATURES             Location/Qualifiers
     source          1..3746
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..3746
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /note="potassium voltage-gated channel subfamily H member
                     4"
                     /db_xref="GeneID:114032"
                     /db_xref="RGD:621415"
     exon            1..219
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..3194
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /note="rElk1; ELK channel 1; brain-specific eag-like
                     channel 2; ether-a-go-go-like potassium channel 1;
                     voltage-gated potassium channel subunit Kv12.3; potassium
                     voltage-gated channel, subfamily H (eag-related), member
                     4; potassium channel, voltage gated eag related subfamily
                     H, member 4"
                     /codon_start=1
                     /product="voltage-gated delayed rectifier potassium
                     channel KCNH4"
                     /protein_id="NP_446082.2"
                     /db_xref="GeneID:114032"
                     /db_xref="RGD:621415"
                     /translation="MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGPRGFPIVY
                     CSDGFCELTGYGRTEVMQKTCSCRFLYGPETSEPALQRLQKALEGHQEHRAEICFYRK
                     DGSAFWCLLDMMPIKNEMGEVVLFLFSFKDISQSGGPGLGSPGIHGDNNHENSLGRRG
                     ASSRLRSTRRQNRTVLHRLTGHFGRRDQGSVKANSNVFEPKPSVPEYKVASVGGSRCL
                     LLHYSIPKAVWDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAVEMLFIL
                     DIILNFRTTYVSQSGQVVSAPRSIGLHYLATWFFVDLIAALPFDLLYVFNITVTSLVH
                     LLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACVWYVIGRREMEAND
                     PLLWDIGWLHELGKRLEEPYVNGSAGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTD
                     AEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPL
                     KQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAASRGCLR
                     ALSLHIKTSFCAPGEFLLRRGDALQAHYYVCSGSLEVLRDNTVLAILGKGDLIGADIP
                     ELGQEPGAGAGCVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYVAAFRAGLPRDL
                     TFNLRQGSENNGLGRFSRSPRLSQARSDTLGSSSDKTLPSITETEGGMEPGAGSKPRR
                     PLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPTPSPALAGRGSSPSLHGPPR
                     GSAAWKPPQLLTPPLGTFGPPDLSPRIVDGIEDSSNTAEAPTFRFSKRPEPTRTRSQA
                     PLSGPRLSRELATEAAEEVKEKVCRLNQEISRLNQEVSQLSRELRQVMGLLQARLGPP
                     SHPPDSTWLPDLPCPHQRPPCISPHMSGPPPGLQNTTLAVVHCPASVGTVEIGATPSE
                     LRSSMVPPFPSEPDPLGPSPVPEASPLTPSLLKHSFQSGSDTFH"
     exon            220..453
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..600
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            601..728
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..972
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1130
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1338
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1533
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1733
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1983
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2222
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2261
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2614
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2721
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2798
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..3509
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
     exon            3510..3746
                     /gene="Kcnh4"
                     /gene_synonym="Bec2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcacaca ggcagcggcg gcgagaggag gggaggaggc aggccggcgc atggggcgcc
       61 ccggccccgc cggtagcgcg ccccctccgg ccaggccgcg ctgaacgcag cccgcgcaac
      121 gcctcgaatt cgtacccggg gccatgccgg tcatgaaggg gttgctggcc ccgcaaaaca
      181 cctttctgga caccatcgcc actcgctttg acggcacgca cagcaacttt cttctggcca
      241 atgcccaggg cccacggggt tttcccatcg tctactgctc tgacggcttc tgtgagctca
      301 caggctacgg ccgcaccgag gtcatgcaga aaacctgtag ctgccggttc ctctatggcc
      361 cagagaccag tgagccggcc ttgcaacggt tacaaaaagc cctggagggc caccaagaac
      421 acagagctga aatctgcttt taccgaaagg atggctcggc cttttggtgt cttctggaca
      481 tgatgcccat caaaaatgag atgggagagg ttgtgctttt cctattttcc tttaaggaca
      541 tctctcagag tggaggccca ggacttggct caccagggat ccatggggac aataatcatg
      601 aaaactccct tgggaggaga ggagctagct caagacttag gtccacgagg aggcagaacc
      661 ggacagttct acaccggttg actggccact ttggtcgccg ggaccaggga agcgtgaaag
      721 ccaatagtaa cgtgtttgag ccaaagccat cagtgcctga gtacaaagtg gcctccgtgg
      781 ggggctcccg ctgcctgctc ctccactaca gcatccccaa ggctgtctgg gacggtctca
      841 tccttctcgc tacgttctac gtcgcggtca ccgtccctta caacgtctgc ttcgctggtg
      901 atgacgacac ccccatcacg tcccgacaca cccttgtcag tgacatcgct gtggagatgc
      961 tcttcatcct ggacatcatc ttgaacttcc gcaccaccta cgtgtcccag tcgggccagg
     1021 tggtttctgc tcctcggtcc attggcctcc actacctggc cacctggttc ttcgtggacc
     1081 tcattgctgc tttgcccttt gacctgctgt atgtcttcaa catcactgtg acctcgctgg
     1141 tacatctgct gaaaaccgtg cggctcctgc ggttgctgag gctgctgcag aagctagagc
     1201 ggtactctca gtgcagcgcg gtggtgctca cgctgctcat gtccgtcttt gcactccttg
     1261 cccactggat ggcctgcgtc tggtatgtca tcgggcgccg ggagatggag gccaatgacc
     1321 cgctgctctg ggacattggt tggttgcatg agctgggtaa gcggctggag gagccttatg
     1381 tcaatggctc ggccggtgga ccatctcggc gcagtgccta catcgccgcg ctgtacttca
     1441 cgctgagcag cctcaccagt gtaggcttcg gcaacgtttg tgccaacact gacgctgaga
     1501 agatcttctc catctgcacg atgctcatag gcgcgctgat gcacgcggtg gtgtttggga
     1561 atgtcacagc catcatccag cgcatgtact cccgacgctc gctctaccac agccgcatga
     1621 aggatctcaa ggacttcatc cgagtgcatc gtctgccccg cccactcaag cagcgcatgc
     1681 tcgagtactt ccagactaca tgggccgtca acagcggcat cgatgccaac gagttactgc
     1741 gtgacttccc ggatgagctg cgagctgaca tcgccatgca cctgaatcgg gagatcctgc
     1801 agctgccttt gtttggagca gcaagcaggg gctgccttcg tgccctctcc ctgcacatca
     1861 agacctcatt ttgtgctcct ggggagttcc tgctacgccg tggggatgcc ctgcaggcac
     1921 actactatgt ctgctctggc tctcttgagg tgctccgaga caacacggtg ctggccatcc
     1981 ttggaaaggg ggacttgatt ggggcagaca tccctgagtt ggggcaggag cctggggcag
     2041 gggcaggctg cgtgctgaag accagcgctg atgtgaaagc actgacttac tgcggcctgc
     2101 agcagctgag cagccgaggg ctggccgagg tccttcggtt gtatccggaa tatgtggctg
     2161 ccttcagggc tggcctaccc cgggacctaa ccttcaacct gcgccaaggc tctgaaaaca
     2221 atggcctcgg ccgcttctca cgttctcctc gactctccca ggcacgctcc gacactcttg
     2281 gttcctcctc agacaagact ctgccatcca tcacagaaac cgagggtggc atggagcctg
     2341 gggctggttc caagccccgt cggcccctcc tgctgcccaa cctcagtcca gcacgacctc
     2401 gggggtccct ggtcagcctt ttgggcgaag agctgccccc attctcagcc cttgtctcct
     2461 ctccttccct gtccccaact ccttcccctg ccctggctgg ccggggttca agtccctccc
     2521 tgcacgggcc ccccaggggc tctgctgcct ggaagccccc ccagctcctc acccccccac
     2581 tgggaacatt tggacctccg gacctcagtc cccggatcgt ggatggcatt gaggactcca
     2641 gtaacacagc tgaggctcct acattccggt tcagcaagag gccggagccc accagaaccc
     2701 gttcacaggc tcccctttca ggccctaggc tcagccggga actggccaca gaggcagcag
     2761 aggaggtgaa ggaaaaggtc tgcaggctga accaagagat ttccagactc aaccaggaag
     2821 tgtctcagct gagccgggag cttcgccaag tgatgggcct cttacaggcc aggctgggtc
     2881 ccccaagtca cccacctgac tccacttggc tcccagacct tccttgtccc catcagagac
     2941 cgccatgcat ctctcctcat atgtctggac ctccacctgg tctccagaat actacacttg
     3001 ctgtagtcca ctgtccagcc agtgttggga cagtggagat aggggccacc ccctcagagc
     3061 tgaggtcttc catggtgcca ccctttccct cagaacctga tcctcttgga ccctctccag
     3121 tgccagaggc ttctcctctg accccaagcc tcctgaagca cagcttccag tctgggtcag
     3181 acacattcca ctgaccctgg ccttgggccc aggcctgtct ggggtgggct taattacctg
     3241 ccatccaggg aggagctggg ctccttggcc tcttgccttg gggtcagcag ctgccagctg
     3301 gtctggttgg ctctggattc tctggacttt ttaacaatga gtggccacat ctaaccccgt
     3361 tccattttct aaaccatccc ccccacccgt cctactcttg tgggagggga gtcacctgaa
     3421 gccgtggaat ccagcaggca tgaaatggac catggtgcct tgttgggcta cgcagaggag
     3481 atgtcttact ttctccccac gacttggagg ctgtcatgca aggtggtccc ttctgctgcc
     3541 agcagctcaa agcattctag ctttaccctt ctgcagttcc cacctccaaa catcagtcat
     3601 atctgccccc ctccctccca acatggtctc gacctcaatg aggatctggg caactcacaa
     3661 accctctctg gtttccagct cccctttctc actaaacacc ccaggctcac ttttggatag
     3721 aaaataaatc catatatttt tgtaga
//
