LOCUS       NM_017108               3715 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily H
            member 3 (Kcnh3), mRNA.
ACCESSION   NM_017108 XM_001063471
VERSION     NM_017108.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3715)
  AUTHORS   Wulfsen,I., Hauber,H.P., Schiemann,D., Bauer,C.K. and Schwarz,J.R.
  TITLE     Expression of mRNA for voltage-dependent and inward-rectifying K
            channels in GH3/B6 cells and rat pituitary
  JOURNAL   J Neuroendocrinol 12 (3), 263-272 (2000)
   PUBMED   10718922
REFERENCE   2  (bases 1 to 3715)
  AUTHORS   Miyake,A., Mochizuki,S., Yokoi,H., Kohda,M. and Furuichi,K.
  TITLE     New ether-a-go-go K(+) channel family members localized in human
            telencephalon
  JOURNAL   J Biol Chem 274 (35), 25018-25025 (1999)
   PUBMED   10455180
REFERENCE   3  (bases 1 to 3715)
  AUTHORS   Engeland,B., Neu,A., Ludwig,J., Roeper,J. and Pongs,O.
  TITLE     Cloning and functional expression of rat ether-a-go-go-like K+
            channel genes
  JOURNAL   J Physiol 513 (Pt 3) (Pt 3), 647-654 (1998)
   PUBMED   9824707
REFERENCE   4  (bases 1 to 3715)
  AUTHORS   Shi,W., Wang,H.S., Pan,Z., Wymore,R.S., Cohen,I.S., McKinnon,D. and
            Dixon,J.E.
  TITLE     Cloning of a mammalian elk potassium channel gene and EAG mRNA
            distribution in rat sympathetic ganglia
  JOURNAL   J Physiol 511 (Pt 3) (Pt 3), 675-682 (1998)
   PUBMED   9714851
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB022697.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001063471.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB022697.1, AJ007627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3715
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..3715
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /note="potassium voltage-gated channel subfamily H member
                     3"
                     /db_xref="GeneID:27150"
                     /db_xref="RGD:71070"
     exon            1..231
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..3419
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /note="rElk2; ELK channel 2; brain-specific eag-like
                     channel 1; ether-a-go-go-like potassium channel 2;
                     voltage-gated potassium channel subunit Kv12.2; potassium
                     voltage-gated channel, subfamily H (eag-related), member
                     3; potassium channel, voltage gated eag related subfamily
                     H, member 3"
                     /codon_start=1
                     /product="voltage-gated inwardly rectifying potassium
                     channel KCNH3"
                     /protein_id="NP_058804.1"
                     /db_xref="GeneID:27150"
                     /db_xref="RGD:71070"
                     /translation="MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVY
                     CSDGFCDLTGFSRAEVMQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRK
                     SGLPFWCLLDVIPIKNEKGEVALFLVSHKDISETKNRGGPDNWKERGGGRRRYGRAGS
                     KGFNANRRRSRAVLYHLSGHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILL
                     HCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDI
                     VLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYVGAHLL
                     KTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQQEIENSESE
                     LPEIGWLQELARRLETPYYLVSRSPDGGNSSGQSENCSSSGGGSEANGTGLELLGGPS
                     LRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQ
                     RMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPD
                     ELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYF
                     VCSGSMEVLKGGTVLAILGKGDLIGCELPQREQVVKANADVKGLTYCVLQCLQLAGLH
                     ESLALYPEFAPRFSRGLRGELSYNLGAGGVSAEVDTSSLSGDNTLMSTLEEKETDGEQ
                     GHTISPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPSRAGVLKPEA
                     GPSAHPRTLDGLQLPPMPWNVPPDLSPRVVDGIEDGCGSDQHKFSFRVGQSGPECSSS
                     PSPGTESGLLTVPLVPSEARNTDTLDKLRQAVTELSEQVLQMREGLQSLRQAVQLILV
                     PQGEGQCPRVSGEGPCPATASGLLQPLRVDTGASSYCLQPPAGSVLSGTWPHPRPGHP
                     PPLMAPWPWGPPASQSSPWPRATALWTSTSDSEPPGSGDLCSEPSTPASPPPPEEGAR
                     TGTPAPVSQAEATSTGEPPPGSGGRALPWDPHSLEMVLIGCHGPGSVQWTQEEGTGV"
     exon            232..465
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
     exon            466..600
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
     exon            601..734
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
     exon            735..978
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1136
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1344
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1632
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1832
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..2082
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2300
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2632
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2739
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2816
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..3715
                     /gene="Kcnh3"
                     /gene_synonym="Bec1; Elk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctggggc ctacgaacct gggccgggca tagccccccg acggctactc tagggggcgc
       61 ggggcccggc ggggggcggc cgagccaggc gccctccccc ggcgctgagt ccccgcgccc
      121 cggagggatg gggcgggcgg tccccgccgc ctaagatgcc ggccatgcgg gggctccttg
      181 cgccgcagaa caccttcctg gacaccatcg ccacccgctt cgacgggacg cacagtaact
      241 tcgtcctggg caacgcccag gtggcagggc tcttccctgt ggtctactgc tccgatggct
      301 tctgtgacct cacgggtttc tccagagctg aggtcatgca gcgaggctgt gcctgctcct
      361 tcctctatgg gccagacacc agtgagttgg tccgccaaca gatccgaaaa gccctggatg
      421 agcacaaaga attcaaggct gaactgatcc tgtaccggaa gagcgggctt ccattctggt
      481 gtctcctgga tgtgatacct ataaaaaacg agaaggggga ggtggccctc ttcctggtct
      541 ctcacaagga catcagtgag accaagaacc gaggaggccc tgacaactgg aaggagagag
      601 gtggtggccg acgcagatat ggtcgggcag gatccaaagg ctttaatgcc aatcggaggc
      661 gcagccgggc ggttctctac cacctctctg gtcacctgca gaaacaaccc aagggcaagc
      721 acaaactcaa taagggtgtg tttggagaga agccaaattt gcccgaatat aaagtcgctg
      781 ctatccggaa gtcacccttt atcctgctgc actgtggggc tctgagagcc acctgggatg
      841 gcttcatcct gctcgccacg ctctacgtgg ctgtcactgt gccatacagc gtgtgtgtga
      901 gcacagcacg ggagcccagt gctgcccgtg gcccacctag tgtctgtgac ctggccgtgg
      961 aagtcctctt catcttagat attgtgctga attttcgtac tacatttgtg tccaagtcag
     1021 gccaggtggt attcgcccca aagtccattt gcctccacta cgtcaccacc tggttcctgc
     1081 tggatgtcat agcagcactg ccctttgacc tactacatgc cttcaaggtc aatgtgtacg
     1141 ttggggctca cctactgaag accgtgcggc tgcttcggct gctgcgccta ctaccaagac
     1201 tggaccggta ctctcagtat agcgctgttg tgctcacctt gctcatggct gtgtttgccc
     1261 tgctcgccca ctgggtggcc tgcgtttggt tctacatcgg ccagcaagag attgagaaca
     1321 gcgagtcaga gctgcctgag atcggctggc tgcaggagct ggcacgcagg ctggagacgc
     1381 cctattacct ggtgagccgg agtccagatg gagggaacag ctctggccag agtgaaaact
     1441 gcagtagcag tggcggcggc agcgaagcca acgggactgg gctggagctg ctgggtggcc
     1501 catccctacg cagcgcctac atcacctcct tgtacttcgc gctcagcagt ctcaccagtg
     1561 tgggcttcgg caatgtgtcc gctaacacag acactgagaa gattttctcc atctgcacca
     1621 tgcttattgg agctctgatg catgcagtgg tgtttgggaa tgtgacagcc atcatccagc
     1681 gcatgtacgc tcgccgcttt ctgtaccaca gccgcacccg tgacctgcga gactacattc
     1741 gcatccaccg catccccaag cccctcaagc agcgcatgct cgagtacttc caagccacct
     1801 gggccgtgaa caacggcatc gataccactg agctgctgca gagccttccg gatgagcttc
     1861 gagcagacat cgccatgcac ctgcacaagg aggtcctgca gctgccattg ttcgaggcag
     1921 cgagccgtgg ctgcctgcgg gcactgtctc tggccctgag gcccgccttc tgcacgccgg
     1981 gcgagtacct cattcaccaa ggcgatgctc tccaggctct ctactttgtg tgctcaggtt
     2041 ccatggaggt cctcaaaggt ggcaccgtcc tcgccattct agggaagggt gacctgatcg
     2101 gctgtgagct gccccagcga gagcaagtag tgaaggccaa tgccgacgta aaggggctga
     2161 catactgcgt cctacagtgc ctgcagctgg ctgggctgca cgagagcctc gcactgtacc
     2221 ctgagtttgc cccacgcttt agccgtggcc tccgagggga gctcagctac aacctgggag
     2281 ctggaggagt gtctgcagag gtggatacca gctcactgag tggtgacaac accctcatgt
     2341 ccacactgga ggagaaggag acagatgggg agcaaggaca cacgatctca ccagccccag
     2401 cagatgagcc ctccagcccc ctgctgtcac ctggctgtac ctcctcctcc tcagcggcca
     2461 aactactctc cccacgtcga actgcacccc ggccgaggct gggtggcaga gggcggccaa
     2521 gtagggcagg ggttttgaag cctgaggctg gtccttctgc tcatccacgg acacttgatg
     2581 ggttgcagct gccccccatg ccatggaatg tacctccaga cctgagcccc agggtcgtag
     2641 atggcattga ggatggctgc ggctctgacc agcacaagtt ctctttccgg gtgggtcagt
     2701 ctggcccaga atgtagcagc agcccctccc caggaacaga gagtggcctg ctcactgtcc
     2761 ccttggtgcc cagtgaggca agaaacacag acacactgga caagctacgg caggcggtga
     2821 cggagctgtc tgaacaggtg ctgcagatgc gagagggact gcagtcactt cgccaggctg
     2881 tgcagctcat cctggtgccc caaggggaag gccagtgtcc ccgggtatca ggagaggggc
     2941 catgcccagc cactgcctct gggctcctac aacccctgcg tgtggacact ggggcatcat
     3001 cctactgcct gcagccccca gcaggttcag tcttgagtgg gacctggcct cacccccgtc
     3061 cagggcatcc ccctcccctc atggcaccct ggccctgggg ccccccagca tctcagagct
     3121 ccccctggcc tcgagccaca gctttatgga cctccacctc agactcagag ccccctggct
     3181 ctggagacct ctgctctgag cccagcaccc cagcctcacc ccctcctcct gaggaaggag
     3241 ctaggactgg gactcctgca cctgtgagcc aggctgaggc taccagtact ggagagcccc
     3301 ctccggggtc agggggccga gccttgccct gggatcccca cagcctagag atggtgctca
     3361 tcggctgcca tggccctggc tcggtccagt ggacccagga ggagggcaca ggagtctgac
     3421 cacaggcagg gagaggggtt ctgcaaacac ccgccacctg ctgaccgccc agcctcacag
     3481 ggctgccctc tggctcaggg cagggaacct aaggaaggag gagggtgagc tggagcctca
     3541 ggccccaggc cagggatcca cgggttctgc tccactgacc tgacccaatg ggggcagagg
     3601 cctgaggacg aggaggggtt ctgccattcc ttgcatgtgc ccatctccac tgtcctctgt
     3661 cctcatgttt tttatattaa aaaacataaa aaaaaaccaa taaagaaact acttt
//
