LOCUS       NM_053949               3889 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily H
            member 2 (Kcnh2), mRNA.
ACCESSION   NM_053949
VERSION     NM_053949.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3889)
  AUTHORS   Hu,S., Li,Z., Liu,H., Cao,W., Meng,Y., Liu,C., He,S., Lin,Q.,
            Shang,M., Lin,F., Yi,N., Wang,H., Sachinidis,A., Ying,Q., Li,L. and
            Peng,L.
  TITLE     Kcnh2 deletion is associated with rat embryonic development defects
            via destruction of KCNH2-integrin beta1 complex
  JOURNAL   Int J Mol Med 53 (2) (2024)
   PUBMED   38063256
  REMARK    GeneRIF: Kcnh2 deletion is associated with rat embryonic
            development defects via destruction of KCNH2-integrin beta1
            complex.
REFERENCE   2  (bases 1 to 3889)
  AUTHORS   Xu,W., Dahlke,S.P., Sung,M., Samal,B., Emery,A.C., Elkahloun,A. and
            Eiden,L.E.
  TITLE     ERK-dependent induction of the immediate-early gene Egr1 and the
            late gene Gpr50 contribute to two distinct phases of PACAP Gs-GPCR
            signaling for neuritogenesis
  JOURNAL   J Neuroendocrinol 34 (9), e13182 (2022)
   PUBMED   35841324
  REMARK    GeneRIF: ERK-dependent induction of the immediate-early gene Egr1
            and the late gene Gpr50 contribute to two distinct phases of PACAP
            Gs-GPCR signaling for neuritogenesis.
REFERENCE   3  (bases 1 to 3889)
  AUTHORS   Wang,D., Liu,C., Liu,H., Meng,Y., Lin,F., Gu,Y., Wang,H., Shang,M.,
            Tong,C., Sachinidis,A., Ying,Q., Li,L. and Peng,L.
  TITLE     ERG1 plays an essential role in rat cardiomyocyte fate decision by
            mediating AKT signaling
  JOURNAL   Stem Cells 39 (4), 443-457 (2021)
   PUBMED   33426760
  REMARK    GeneRIF: ERG1 plays an essential role in rat cardiomyocyte fate
            decision by mediating AKT signaling.
REFERENCE   4  (bases 1 to 3889)
  AUTHORS   Li,Z., Meng,Y., Liu,C., Liu,H., Cao,W., Tong,C., Lu,M., Li,L. and
            Peng,L.
  TITLE     Kcnh2 mediates FAK/AKT-FOXO3A pathway to attenuate sepsis-induced
            cardiac dysfunction
  JOURNAL   Cell Prolif 54 (2), e12962 (2021)
   PUBMED   33263944
  REMARK    GeneRIF: Kcnh2 mediates FAK/AKT-FOXO3A pathway to attenuate
            sepsis-induced cardiac dysfunction.
REFERENCE   5  (bases 1 to 3889)
  AUTHORS   Hajimirzaei,N., Khalili,N.P., Boroumand,B., Safari,F.,
            Pourhosseini,A., Judi-Chelan,R. and Tavakoli,F.
  TITLE     Comparative Study of the Effect of Macrolide Antibiotics
            Erythromycin, Clarithromycin, and Azithromycin on the ERG1 Gene
            Expression in H9c2 Cardiomyoblast Cells
  JOURNAL   Drug Res (Stuttg) 70 (8), 341-347 (2020)
   PUBMED   32559772
  REMARK    GeneRIF: Comparative Study of the Effect of Macrolide Antibiotics
            Erythromycin, Clarithromycin, and Azithromycin on the ERG1 Gene
            Expression in H9c2 Cardiomyoblast Cells.
REFERENCE   6  (bases 1 to 3889)
  AUTHORS   Li,X., Xu,J. and Li,M.
  TITLE     The human delta1261 mutation of the HERG potassium channel results
            in a truncated protein that contains a subunit interaction domain
            and decreases the channel expression
  JOURNAL   J Biol Chem 272 (2), 705-708 (1997)
   PUBMED   8995352
REFERENCE   7  (bases 1 to 3889)
  AUTHORS   Smith,P.L., Baukrowitz,T. and Yellen,G.
  TITLE     The inward rectification mechanism of the HERG cardiac potassium
            channel
  JOURNAL   Nature 379 (6568), 833-836 (1996)
   PUBMED   8587608
REFERENCE   8  (bases 1 to 3889)
  AUTHORS   Trudeau,M.C., Warmke,J.W., Ganetzky,B. and Robertson,G.A.
  TITLE     HERG, a human inward rectifier in the voltage-gated potassium
            channel family
  JOURNAL   Science 269 (5220), 92-95 (1995)
   PUBMED   7604285
  REMARK    Erratum:[Science. 1996 May 24;272(5265):1087.. PMID: 8638148]
REFERENCE   9  (bases 1 to 3889)
  AUTHORS   Sanguinetti,M.C., Jiang,C., Curran,M.E. and Keating,M.T.
  TITLE     A mechanistic link between an inherited and an acquired cardiac
            arrhythmia: HERG encodes the IKr potassium channel
  JOURNAL   Cell 81 (2), 299-307 (1995)
   PUBMED   7736582
REFERENCE   10 (bases 1 to 3889)
  AUTHORS   Curran,M.E., Splawski,I., Timothy,K.W., Vincent,G.M., Green,E.D.
            and Keating,M.T.
  TITLE     A molecular basis for cardiac arrhythmia: HERG mutations cause long
            QT syndrome
  JOURNAL   Cell 80 (5), 795-803 (1995)
   PUBMED   7889573
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Z96106.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z96106.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3889
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..3889
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /note="potassium voltage-gated channel subfamily H member
                     2"
                     /db_xref="GeneID:117018"
                     /db_xref="RGD:621414"
     CDS             1..3492
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /note="RERG; r-ERG; eag-related protein 1;
                     ether-a-go-go-related protein 1; ether-a-go-go-related
                     gene potassium channel 1; voltage-gated potassium channel
                     subunit Kv11.1; potassium channel, voltage gated eag
                     related subfamily H, member 2; ERG-1; potassium
                     voltage-gated channel, subfamily H (eag-related), member
                     2"
                     /codon_start=1
                     /product="voltage-gated inwardly rectifying potassium
                     channel KCNH2"
                     /protein_id="NP_446401.1"
                     /db_xref="GeneID:117018"
                     /db_xref="RGD:621414"
                     /translation="MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYC
                     NDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKD
                     GSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPSTSWLASGRA
                     KTFRLKLPALLALTARESPMRTGSTGSPGAPGAVVVDVDLTPAAPSSESLALDEVSAM
                     DNHVAGLGPAEERRALVGPASASPVASIPGPHPSPRAQSLNPDASGSSCSLARTRSRE
                     SCASVRRASSADDIEAMRAGALPLPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISK
                     IPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKL
                     QAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAPDCGYA
                     CQPLAVVDLLVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAI
                     PFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWL
                     ACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSL
                     TSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV
                     REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQ
                     HCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV
                     AILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWS
                     SLEITFNLRDTNMIPGSPSSAELESGFNRQRKRKLSFRRRTDKDTEQPGEVSALGQGP
                     ARVGPGPSCRGQPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGDSP
                     GGEPLTEDGEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPAPSLLNIP
                     LSSPGRRSRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTP
                     GPGPTSTSPLLPVGPVPTLTLDSLSQVSQFVAFEELPAGAPELPQDGPTRRLSLPGQL
                     GALTSQPLHRHGSDPGS"
     exon            1..76
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
     exon            77..307
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..472
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..922
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1134
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1563
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1951
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2151
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2404
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2598
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2698
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2977
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3164
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3342
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3881
                     /gene="Kcnh2"
                     /gene_synonym="ERG1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccggtgc ggaggggcca cgtcgcgccg cagaacacct tcctcgacac catcatccgc
       61 aagtttgagg gccagagccg caagttcatc atcgctaacg ctcgtgtaga gaactgcgcc
      121 gtcatctact gcaacgacgg cttctgcgaa ctgtgcggct actctcgggc cgaggtgatg
      181 cagcggccct gcacctgcga tttcctgcat gggccgcgca cgcagcgccg tgccgccgcg
      241 cagatcgcgc aggccctgct gggcgcggag gagcgcaaag tggagatcgc cttctaccgg
      301 aaagatggga gctgcttcct gtgtttggtg gatgtggtgc ccgtgaagaa tgaggatggg
      361 gctgtcatca tgtttatcct caactttgaa gtggtgatgg agaaggacat ggtagggtcg
      421 ccagctcatg acaccaatca cagggggccc tctaccagct ggctagcttc tggccgggcc
      481 aagaccttcc gcctgaagct gcctgccttg ttggcactga ctgccaggga atcgcccatg
      541 cggacaggaa gcacgggcag tcctggagcc cccggggcag tggtggtgga tgtggacctg
      601 acgccggcag cacccagcag tgagtccctg gccttggatg aggtttctgc catggacaac
      661 catgtggctg gacttgggcc tgcagaagag aggcgagcac tggtgggccc agcgtctgct
      721 tcaccggtag ccagcatccc aggccctcac ccgtcccctc gagctcagag ccttaaccct
      781 gacgcctctg gttccagctg cagtctggcc cgaacacgct cacgggagag ctgcgctagt
      841 gtgcgccggg cgtcttccgc agatgacatc gaggcaatgc gggctggggc gctgcccctc
      901 ccgccccgac atgctagtac aggggccatg caccccctgc gcagtggcct gcttaactcc
      961 acctcagact ctgacctcgt gcgctaccga accattagca agatacccca aatcaccctc
     1021 aactttgtgg acctcaaagg cgaccctttc ctggcttcac ccaccagtga ccgggaaatc
     1081 atagcaccca agataaaaga gcggacccac aatgtcaccg agaaggtcac ccaggtcctg
     1141 tccttgggag ccgatgtgct tcctgaatat aagctgcagg ccccaagaat acaccgctgg
     1201 accatcctac actacagccc cttcaaggca gtgtgggact ggctcattct gctgctggtc
     1261 atctacacag ccgtcttcac accgtactcg gctgccttcc tgctgaagga gactgaagat
     1321 gggtcccaag cccctgactg cggctatgcc tgccagcctc tggctgtagt ggacctcctc
     1381 gtggacatca tgttcattgt ggacatcctt atcaatttcc gcaccaccta cgttaacgcc
     1441 aatgaagagg tggtcagcca tcctggccgc atcgctgtgc actacttcaa gggctggttc
     1501 ctcatcgaca tggtggctgc catccccttc gacctgctca tctttggctc tggctctgag
     1561 gagctcatcg gactgctgaa aactgccagg ctgctgcggc tggtgcgagt ggctcggaag
     1621 ctggaccgct actcggagta tggggcagca gtgctcttcc tgctcatgtg caccttcgcg
     1681 ctcattgcac actggttggc ctgcatctgg tacgccatcg gcaacatgga acagcctcac
     1741 atggactcac acattggctg gctgcacaac ttgggcgacc agatcggcaa gccctacaac
     1801 agcagcggcc tgggaggccc ctccatcaag gacaagtacg tcacagcgct ctacttcacc
     1861 ttcagcagcc tcaccagcgt gggctttggc aatgtctctc ccaacaccaa ctcagaaaag
     1921 atcttctcca tctgtgtcat gctcattggc tccctcatgt atgccagcat cttcggcaac
     1981 gtgtccgcca tcatccagcg gctgtactcg ggcacggccc gctaccacac acagatgctc
     2041 cgggtgcggg agtttatccg cttccatcag attcccaacc cgctacgcca gcgcctcgag
     2101 gagtacttcc agcacgcttg gtcctacacc aacggcatcg acatgaatgc ggtgctgaag
     2161 ggtttccccg agtgcctgca ggctgacatc tgcctacatc taaaccgctc actgctgcag
     2221 cactgcaaac cattccgagg ggccactaaa ggctgcctga gggccctggc catgaaattc
     2281 aagaccacac atgcgccacc aggggacacg ctggtgcacg ctggggacct gcttactgcc
     2341 ctctacttca tctccagggg ctccatcgag atcctgcggg gtgatgtcgt ggtggccatc
     2401 ttggggaaga acgacatctt tggagagcct ctgaacctgt atgcacgtcc tgggaagtcc
     2461 aatggggatg tgagggccct cacttactgt gacctgcaca agatccatcg agacgatctg
     2521 ctggaggtgt tggacatgta ccccgagttc tcagaccact tttggtctag cctggagatc
     2581 accttcaacc ttcgagatac caacatgatt cctggctccc ccagcagtgc ggaactagag
     2641 agcggcttca acaggcagcg aaagcgcaaa ctgtccttcc gcaggcgtac tgacaaggac
     2701 acagagcagc caggggaggt gtcagccctg gggcaaggcc ctgcccgagt tgggccaggg
     2761 ccgagttgcc ggggacagcc gggagggcca tggggggaga gcccatccag tggcccttcc
     2821 agcccagaga gcagtgagga tgagggccca ggtcgcagct ccagccccct ccgcctggtg
     2881 cccttctcca gccccaggcc tcccggagac tccccaggtg gggagccttt gacagaggat
     2941 ggagagaaaa gcagtgacac ttgtaatccc ctgtcaggtg ccttctctgg ggtgtccaat
     3001 attttcagct tctgggggga cagtcggggg cgccagtacc aggagctgcc tcgatgccct
     3061 gccccggccc ctagcctcct caacatcccc ttgtctagcc ctggccggcg ttcccggggt
     3121 gacgtggaga gcaggctgga tgcactccag agacagctga acaggctgga aacccggcta
     3181 agtgcagaca tggccactgt cctacagctg ctacagaggc aaatgaccct ggtccctcct
     3241 gcctacagtg ctgtgaccac ccctgggcct ggccccactt ccacgtcccc tttgttgcct
     3301 gtcggccccg tccccactct caccctggac tcgctttctc aggtttccca gttcgtggcg
     3361 tttgaggagc ttcctgcagg agccccagag ctcccccaag atggccccac tcgacgcctc
     3421 tccctgccgg gccagctggg ggccctcacc tcccagcccc tgcacagaca tggctcagat
     3481 ccaggcagtt agtgacgctg cccggtgtgg acacgtggct caccctgggg tcaggggatt
     3541 acctgaccgc tctccttgga gaccctggtt tgaaggggag aacagtgcag gagcacctcc
     3601 tcccccgccc ttgggaccag catctcctcc tgcaataccc tgggccccac tgggaggggc
     3661 aggggcagag ctgggcagtg gacagggggt ctgtggtccc cccactgccc tgggggcatt
     3721 agctggtcta actgcccgga ggcacccggc cctgggcctt aggcacctca aggacttttc
     3781 tgctatttac tgctcttatt gttaaggata ataattaagg atcatatgaa taattaatga
     3841 agatgctgat gactatgaat aataaataat tatcctgagg aaaaaaaaa
//
