LOCUS       NM_031742               7486 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily H
            member 1 (Kcnh1), mRNA.
ACCESSION   NM_031742 XM_006250491
VERSION     NM_031742.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7486)
  AUTHORS   Fang,Y.C., Fu,S.J., Hsu,P.H., Chang,P.T., Huang,J.J., Chiu,Y.C.,
            Liao,Y.F., Jow,G.M., Tang,C.Y. and Jeng,C.J.
  TITLE     Identification of MKRN1 as a second E3 ligase for Eag1 potassium
            channels reveals regulation via differential degradation
  JOURNAL   J Biol Chem 296, 100484 (2021)
   PUBMED   33647316
  REMARK    GeneRIF: Identification of MKRN1 as a second E3 ligase for Eag1
            potassium channels reveals regulation via differential degradation.
REFERENCE   2  (bases 1 to 7486)
  AUTHORS   Whicher,J.R. and MacKinnon,R.
  TITLE     Regulation of Eag1 gating by its intracellular domains
  JOURNAL   Elife 8, e49188 (2019)
   PUBMED   31490124
  REMARK    GeneRIF: The authors demonstrate that the Eag1 intracellular
            domains are not required for voltage-dependent gating but likely
            interact with the transmembrane voltage sensors to modulate gating.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7486)
  AUTHORS   Lorinczi,E., Helliwell,M., Finch,A., Stansfeld,P.J., Davies,N.W.,
            Mahaut-Smith,M., Muskett,F.W. and Mitcheson,J.S.
  TITLE     Calmodulin Regulates Human Ether a Go-Go 1 (hEAG1) Potassium
            Channels through Interactions of the Eag Domain with the Cyclic
            Nucleotide Binding Homology Domain
  JOURNAL   J Biol Chem 291 (34), 17907-17918 (2016)
   PUBMED   27325704
REFERENCE   4  (bases 1 to 7486)
  AUTHORS   Whicher,J.R. and MacKinnon,R.
  TITLE     Structure of the voltage-gated K channel Eag1 reveals an
            alternative voltage sensing mechanism
  JOURNAL   Science 353 (6300), 664-669 (2016)
   PUBMED   27516594
  REMARK    GeneRIF: this study determined the single-particle cryo-electron
            microscopy structure of mammalian K(v)10.1, or Eag1, bound to the
            channel inhibitor calmodulin, at 3.78 angstrom resolution.
REFERENCE   5  (bases 1 to 7486)
  AUTHORS   Han,B., He,K., Cai,C., Tang,Y., Yang,L., Heinemann,S.H., Hoshi,T.
            and Hou,S.
  TITLE     Human EAG channels are directly modulated by PIP2 as revealed by
            electrophysiological and optical interference investigations
  JOURNAL   Sci Rep 6, 23417 (2016)
   PUBMED   27005320
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7486)
  AUTHORS   Piros,E.T., Shen,L. and Huang,X.Y.
  TITLE     Purification of an EH domain-binding protein from rat brain that
            modulates the gating of the rat ether-a-go-go channel
  JOURNAL   J Biol Chem 274 (47), 33677-33683 (1999)
   PUBMED   10559257
REFERENCE   7  (bases 1 to 7486)
  AUTHORS   Hoshi,N., Takahashi,H., Shahidullah,M., Yokoyama,S. and
            Higashida,H.
  TITLE     KCR1, a membrane protein that facilitates functional expression of
            non-inactivating K+ currents associates with rat EAG
            voltage-dependent K+ channels
  JOURNAL   J Biol Chem 273 (36), 23080-23085 (1998)
   PUBMED   9722534
REFERENCE   8  (bases 1 to 7486)
  AUTHORS   Ludwig,J., Owen,D. and Pongs,O.
  TITLE     Carboxy-terminal domain mediates assembly of the voltage-gated rat
            ether-a-go-go potassium channel
  JOURNAL   EMBO J 16 (21), 6337-6345 (1997)
   PUBMED   9400421
REFERENCE   9  (bases 1 to 7486)
  AUTHORS   Stansfeld,C.E., Roper,J., Ludwig,J., Weseloh,R.M., Marsh,S.J.,
            Brown,D.A. and Pongs,O.
  TITLE     Elevation of intracellular calcium by muscarinic receptor
            activation induces a block of voltage-activated rat ether-a-go-go
            channels in a stably transfected cell line
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9910-9914 (1996)
   PUBMED   8790430
REFERENCE   10 (bases 1 to 7486)
  AUTHORS   Ludwig,J., Terlau,H., Wunder,F., Bruggemann,A., Pardo,L.A.,
            Marquardt,A., Stuhmer,W. and Pongs,O.
  TITLE     Functional expression of a rat homologue of the voltage gated
            either a go-go potassium channel reveals differences in selectivity
            and activation kinetics between the Drosophila channel and its
            mammalian counterpart
  JOURNAL   EMBO J 13 (19), 4451-4458 (1994)
   PUBMED   7925287
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On or before Apr 5, 2021 this sequence version replaced
            XM_006250491.4, NM_031742.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.45826.1,
                                           SRR26643298.53166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               JAXUCZ010000013.1  106253216-106253500
            286-409             JAXUCZ010000013.1  106280749-106280872
            410-516             JAXUCZ010000013.1  106284268-106284374
            517-645             JAXUCZ010000013.1  106296656-106296784
            646-764             JAXUCZ010000013.1  106301361-106301479
            765-1157            JAXUCZ010000013.1  106332462-106332854
            1158-1587           JAXUCZ010000013.1  106391679-106392108
            1588-1787           JAXUCZ010000013.1  106462053-106462252
            1788-2040           JAXUCZ010000013.1  106467672-106467924
            2041-2237           JAXUCZ010000013.1  106483197-106483393
            2238-7486           JAXUCZ010000013.1  106550464-106555712
FEATURES             Location/Qualifiers
     source          1..7486
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..7486
                     /gene="Kcnh1"
                     /note="potassium voltage-gated channel subfamily H member
                     1"
                     /db_xref="GeneID:65198"
                     /db_xref="RGD:68398"
     exon            1..285
                     /gene="Kcnh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..3095
                     /gene="Kcnh1"
                     /note="EAG1; r-eag; ether-a-go-go potassium channel 1;
                     voltage-gated potassium channel subunit Kv10.1; EAG
                     channel 1; potassium voltage-gated channel, subfamily H
                     (eag-related), member 1; potassium channel, voltage gated
                     eag related subfamily H, member 1"
                     /codon_start=1
                     /product="voltage-gated delayed rectifier potassium
                     channel KCNH1"
                     /protein_id="NP_113930.1"
                     /db_xref="GeneID:65198"
                     /db_xref="RGD:68398"
                     /translation="MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVY
                     SNDGFCKLSGYHRAEVMQKSSACSFMYGELTDKDTVEKVRQTFENYEMNSFEILMYKK
                     NRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTS
                     SRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKT
                     TWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGP
                     AGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRL
                     GRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWL
                     YQLALDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEK
                     IFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSER
                     VMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRAL
                     AMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKE
                     ATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRK
                     ISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVE
                     KGNALTDHTSANHSLVKASVVTVRESPATPVSFQAASTSTVSDHAKLHAPGSECLGPK
                     AGGGDPAKRKGWARFKDACGKGEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSG
                     ITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVKHELKEDIKALN
                     AKMTSIEKQLSEILRILMSRGSSQSPQDTCEVSRPQSPESDRDIFGAS"
     exon            286..409
                     /gene="Kcnh1"
                     /inference="alignment:Splign:2.1.0"
     exon            410..516
                     /gene="Kcnh1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..645
                     /gene="Kcnh1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..764
                     /gene="Kcnh1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..1157
                     /gene="Kcnh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1587
                     /gene="Kcnh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1787
                     /gene="Kcnh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..2040
                     /gene="Kcnh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2237
                     /gene="Kcnh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..7486
                     /gene="Kcnh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgagcgc acacccgggc gggccgcagc ggagaggtgc ggagcgcagc gaaggcggca
       61 gcgggagcta gccgccgccc ctgcgctccg gggctgcggg gcgcatgggg cgcgtggagc
      121 cgggaacact cgcgggttgc gcacccggcc gcctgctgcg gtgagacacg gcgccggacg
      181 cccccagagc cccagcagta gggaggatga ccatggctgg cggccggcgg ggactagtgg
      241 ccccgcagaa cacatttctg gagaacatcg tgcggcggtc caacgacact aattttgtgt
      301 tggggaatgc ccagatcgtg gactggccca tcgtgtacag caatgatgga ttctgcaagc
      361 tgtctggcta ccaccgagcg gaagtgatgc aaaagagtag cgcctgcagt tttatgtatg
      421 gagagctgac cgacaaggac acggttgaaa aggttcgcca gacctttgag aactacgaga
      481 tgaactcctt cgaaattctg atgtacaaga agaacaggac acctgtgtgg ttttttgtga
      541 agatcgctcc aatcaggaac gaacaggata aagtggttct gttcctttgc actttcagtg
      601 acataacggc attcaagcag cccattgagg acgactcctg caaaggttgg gggaagtttg
      661 ctcgactgac gagagctctg acaagcagca ggggagtcct gcagcagctg gcccccagtg
      721 tgcagaaggg tgagaatgtt cacaagcact cgcgcctggc agaggtcctg cagctgggtt
      781 cagacatcct cccccagtac aagcaagagg cgccaaagac accccctcac atcatcctac
      841 actactgtgt ctttaagacc acatgggatt ggatcatctt gatcctgacc ttctacacag
      901 ccatcctggt cccttacaac gtctccttta aaaccaggca gaataacgtg gcctggctgg
      961 tggtggacag catcgtggat gtcatctttt tggtggacat tgtcttgaat tttcacacca
     1021 cctttgtcgg gccagcgggg gaagtgatct ctgaccccaa acttatccgc atgaactacc
     1081 tgaagacgtg gtttgtgatc gaccttctct cctgtttgcc atatgacgtc atcaacgctt
     1141 ttgagaacgt ggatgagggc atcagcagcc tgttcagttc tctgaaagtc gtgcggctgc
     1201 tccgtctcgg acgagtggcc cgcaagctgg accattatat cgagtacgga gcggcggtac
     1261 tggtcctgct ggtgtgcgtg ttcgggctgg ctgcccactg gatggcctgc atctggtaca
     1321 gcattgggga ctatgagatc tttgatgaag acaccaagac catccgtaac aacagctggc
     1381 tctaccaact ggcattggac attggcactc cataccagtt taatgggtct ggttcgggga
     1441 agtgggaagg cgggccaagc aagaactccg tatacatttc ctcgctgtac ttcaccatga
     1501 caagtctcac cagtgtgggc tttggtaaca tcgccccatc cacagacatc gagaagatct
     1561 tcgccgtagc catcatgatg attggctccc ttctgtatgc caccatcttt gggaatgtga
     1621 cgaccatttt ccagcagatg tatgccaaca ccaacaggta tcatgagatg ctcaacagcg
     1681 tccgggattt cctgaagctc taccaggtgc ccaaggggct gagcgagcgg gtcatggact
     1741 acattgtgtc tacctggtcc atgtcccgcg gcatcgacac ggagaaggtc ctgcaaatct
     1801 gccccaagga catgcgagct gacatttgcg tacacctgaa ccgaaaagtg ttcaaagaac
     1861 accccgcctt ccggctggcc agcgatggtt gcctgagggc cttggccatg gagttccaga
     1921 cagtacactg cgccccaggg gacctcatct atcacgccgg ggagagtgtg gacagcctct
     1981 gcttcgtggt ctcgggctcc ctggaggtga tccaggatga tgaggtggtg gccatcctag
     2041 ggaaaggaga tgtgtttggg gatgttttct ggaaggaggc tacccttgca cagtcctgcg
     2101 ctaatgtccg ggccttgacc tactgtgacc tgcacgtgat caagagggat gccctgcaga
     2161 aagtgctaga attctacaca gccttctccc actccttctc ccggaacctg attctcacct
     2221 acaatctgag gaagaggatt gtgttccgga agatcagcga cgtgaaacga gaagaagagg
     2281 agaggatgaa acggaagaac gaggcccccc ttatcctgcc tcctgaccac cctgtcagga
     2341 ggctcttcca aaggttccgc cagcagaaag aagccaggct ggcagccgag agaggtggcc
     2401 gggacctgga tgacctggat gtagagaagg gcaatgccct cacggaccat acctcagcca
     2461 accacagcct ggtgaaggcc agtgtggtca cggtgcgtga gagtcccgcc acgcctgtgt
     2521 ccttccaggc agcctccacc tccacagtgt cagaccacgc caagctgcat gcaccgggat
     2581 ctgagtgcct aggtcccaag gcaggcggtg gcgaccctgc caagcgcaaa ggctgggccc
     2641 ggttcaaaga tgcctgtggg aagggtgagg attggaacaa ggtgtccaag gcagagtcca
     2701 tggagacgct tcccgagagg acaaaggcat cgggcgaggc cacgctgaag aagacagact
     2761 cctgtgacag tggaatcacc aagagtgacc tgcgcttgga caatgtgggt gaggccagga
     2821 gtccccagga ccggagcccc atcttggccg aggtcaagca ttctttctac cccatccccg
     2881 agcagacact gcaggccaca gtgctggagg tgaagcatga gctgaaggaa gacatcaagg
     2941 ccttgaatgc caaaatgacc tccattgaga agcagctgtc tgagatcctc aggatactca
     3001 tgtccagagg gtcctcccag tctccgcagg acacgtgtga ggtctccagg ccccagtccc
     3061 cagagtcaga cagagacatt tttggggcaa gctgagagga tcatttcaaa acaaacaaac
     3121 aaaaaaatca aagacaaaag cctgccccct gcccctgaca cttcctaccg caccaaacac
     3181 atgaccaaca actttcaaac tgggcttttt ctgacaagaa gtcaaagtca gaccaagtga
     3241 cttaggtgtg cctgcgtggt ctctggaaaa cataagaggg aacatggcaa ggaaccctac
     3301 catgcaagat ggcagctgtg ttgggctagc cattgacagt tgttgaagaa ggggcattac
     3361 atccatcgaa agagcatttc ctctaacatg ttttaccaat gtgatatttt taaagggtta
     3421 aaactaccag gtaagggcag cagccatgta gagaccggtg gaagaaccct gaaaaccttt
     3481 cacaaataga ctacactggg cttctttacc aagacccctg aagaccacag caggcacagg
     3541 acttctgggc attcaccacc ctcaagtagc cctgtctgac accacctgtt tttctactct
     3601 cgtcttttgt aacaagctcg tgatagggga gcttgacggg ctggaagaac ctttccactc
     3661 taacggtaga ggtgaagcat cgggtgctgt gcgtggacac gcaggctggg cccctcaggt
     3721 ttccttgccc agaagaggtg aggcaagagt aagggctgga gagggccctg caggggctct
     3781 gagtgggttc tgttgcatgg tccaacgcct gctcctgtgg acggttggtg tggaagctcc
     3841 ctaaccccag gggaccctct ggagctgcac caccttacag gcctcatgac acgagctcct
     3901 ctccttctcc cttaacctac cttttcctaa gcttgtccat ggctttcctc agggtgtagg
     3961 gcatcgaccg gaaggggcag gcgcccagta ttgatttcct aacaaagcag acacacatac
     4021 aacctcaaaa aaatgattgt agcaagtact aggtttctat tttgattctc atggggattt
     4081 ctgtccaatg catggggtca ttagaggacc tgtgggagcc acacttagcc ttatttgaaa
     4141 gccaacctat ttcctactct aaaaataatg gcaggaccat gataattctc ttcttaggga
     4201 gctggagaaa aacaataaaa cattggtttt caaaatatct cagtaatgag ctggaggatg
     4261 tgacagtgga actatggcct gggagaagga gggggctcgg agccatggtc acggggccac
     4321 ctccgtgcca tccaaattcc cacatcatgg tgctcaggga cactcgctgc ctcgatcact
     4381 tgaggacagg ttgtttgttc ttccttcaat ggcgtgagac aggacggagg aactggctca
     4441 ggtgcatacc tggccggatg tcaggggtgt aactctgcca ttgagcctag aaggtcagct
     4501 ctacagtgag atttgagaga gcagttggga caacaagtga catgggcacc tctgcttagc
     4561 tttgcttggc tgttgcaatt cagaatgtca gcctctttag ggaacctgac actcaagacc
     4621 tgttctacca aagatactta ctgttctgct tggtggctat ggcacatgct gggacttgat
     4681 cccagacagc cctgggacgt caagggtgta cagacatgta gcttttcatg caatgcatag
     4741 gggctggttc atggcatccc taggccaaga catggcagaa ttcaaagaca cccactgatg
     4801 accatgggta aaactaggcc tgcagtctct tgagctgctg ccaaacacca cttagaacag
     4861 agactgtgaa gtgctgtcgc atatgccagc tgcccctgaa tgtctcacaa ggccactcct
     4921 cacatatact tattagccta aagtcaaggg actgctcagc ttaggctaga tggacctcac
     4981 tgccatgcaa cactcggcct cagaagcact tgctcctaga gatctttctg gaactctctg
     5041 ggatttaatg gccctctagc cagctataga gcagagaccc cactgctcct tgactgagct
     5101 ctgtctgagg agggggtaaa cctccttatg gtgtatctcc ctatcttagg gattcagatg
     5161 ctggggttca ggtaaaccca cccttgtgac aggacaggtg acagataaag cttctggctg
     5221 ctctctgggg tcagtgcaca tgaggttgaa gtcccattag actgaggtcc ataccctgga
     5281 aggggtatag ctctgcccat cttggggttc taggttgtct ggggcttcgg ttccttctgg
     5341 tgacagtgaa gaactgaggg tggcttctag tttcctccat ttcttcagca gttttgctag
     5401 gattgccttc tccgaaacaa attttaaatg aaccaaccca tgtctcttta ctgtcatggc
     5461 atgcgctggg ccggaggcag gtcttgagca aggaccacag gacgtggata cacagcctgc
     5521 accttccggc tttagctgtt acctggtggt tgaggagaga ctgggaaaca aagagttacc
     5581 atgtgcagac tgaacacgga gatttcagat gaattatgct tcgagacact ttgtcctttt
     5641 tggggggggg gggacaaaca cacagtgtgg tgcaccactg tctggtaagt gctggctacc
     5701 tggtctctct aagcgagctt ctgtggatgt catctgtagt gaagtgccgc ttcccagcgg
     5761 ctatcctgac aggtgactga tggactgctc tcttcctgag ggtgtgggca tcagatccaa
     5821 aatatcagtc aatgttctgg ctgtggtggg catgctgcct catcagcctt gccctcccag
     5881 ggcagtggca ggttcctcca cggggcatgt gacagccttt gcgttgctgt gatctcgcat
     5941 ggccaacccc acttctctgc ttactgctgg agcggggctc aagtgttttg gctgctggag
     6001 gtccaagtta ggcctttgtt tatgctaggg atgagctctg ccactgaatg atacctcagg
     6061 ctccccattt ctcgcttcca tgtcttgttc tctggttcct agggtcctgt tttagcctcc
     6121 acctcttaga gtctctgctg ctttaacagc agggataatt gggcaagggg tagaaacaca
     6181 ccaccacccc accatccgca ggcttcagcc tccgtatcct tcagtggaag gagagaatat
     6241 taagccaaaa tgctgggtgt gtccaggttg gaacagggac tgagtgaact ctccagaaat
     6301 accagtcaga gacagacatc tctctgtgac actgacatct cacaggtata ctctgtgggc
     6361 tctcaggagc cccggtgaag gtacatgtcg tagatgtaca cgcaactaat tgtattttgt
     6421 tttgcaataa agatgtttag ccttaagacc cttgagtgga agtccagctg ccgtgggggt
     6481 gccagtaccc ctttttaccc catctccttg tgccacttag gaaagagacc tgcctaaatt
     6541 cactccggcc cttggacacc ctctcctacc taaaggtccc tgtcgctgtt gctgctccat
     6601 gtactgcctt ctctctcgct tcaataaaaa actatcctca ccagctcctg tgctctcttc
     6661 ccggaggagt cctcagtgtc cttgaagcac cgaccctaag cttccaagaa aggaccattt
     6721 cccacccaag gtgttgttgg tgtggagaca cgtaccttgc cacctctcac acagttcaaa
     6781 ggagtcagcg tgaatttacc tgcagcttaa aggtctgtct caaaagtgaa acgccagtct
     6841 tcatgctagt gtatctgaac ctttcaagga ggtctggaat ttcctgcggg agccagacct
     6901 ggtgggggcg tctccacctg ccacttgacc ttccttagag ccactgactc tacacctgtg
     6961 acttccgagt catcccatcg acccattagt ccttgagaag ttcacagctc tcctttcaga
     7021 agacagaccg cttctcggta aggacgcagc gtgccctacc gtactccccc gtgagtgtag
     7081 cctcttatta ttcagatgct gtatttcggc atcagttgga gactgtccac attcaagttg
     7141 caaggacatt catactcatg agcagttcgt catcccgggg cttctcatac gaacgctctc
     7201 cgtcaaatcc tgccaaatcc tttatcggga tttttttttt gtttgtttct tttccctctg
     7261 tccgaatgag catgaataaa caagtgagaa ggaaccaagg ctatttttgt ggtcagccga
     7321 ggatgctgcc aagagctccc ctgtgtggct gtgtggatgt ggagaacatg tgggcactcc
     7381 acggatgata cccccttttc ttgacatttt taaacaagca caaatgatat ttgtaaaaaa
     7441 aaagtttaat tttatttatt atggtaataa actattttat acgtga
//
