LOCUS       NM_133426               1586 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel modifier
            subfamily G member 3 (Kcng3), transcript variant 1, mRNA.
ACCESSION   NM_133426
VERSION     NM_133426.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1586)
  AUTHORS   Mederos Y Schnitzler,M., Rinne,S., Skrobek,L., Renigunta,V.,
            Schlichthorl,G., Derst,C., Gudermann,T., Daut,J. and
            Preisig-Muller,R.
  TITLE     Mutation of histidine 105 in the T1 domain of the potassium channel
            Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4
  JOURNAL   J Biol Chem 284 (7), 4695-4704 (2009)
   PUBMED   19074135
  REMARK    GeneRIF: Mutation of histidine 105 in the T1 domain of the
            potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and
            Kv6.4.
REFERENCE   2  (bases 1 to 1586)
  AUTHORS   Vega-Saenz de Miera,E.C.
  TITLE     Modification of Kv2.1 K+ currents by the silent Kv10 subunits
  JOURNAL   Brain Res Mol Brain Res 123 (1-2), 91-103 (2004)
   PUBMED   15046870
REFERENCE   3  (bases 1 to 1586)
  AUTHORS   Ottschytsch,N., Raes,A., Van Hoorick,D. and Snyders,D.J.
  TITLE     Obligatory heterotetramerization of three previously
            uncharacterized Kv channel alpha-subunits identified in the human
            genome
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7986-7991 (2002)
   PUBMED   12060745
REFERENCE   4  (bases 1 to 1586)
  AUTHORS   Sano,Y., Mochizuki,S., Miyake,A., Kitada,C., Inamura,K., Yokoi,H.,
            Nozawa,K., Matsushime,H. and Furuichi,K.
  TITLE     Molecular cloning and characterization of Kv6.3, a novel modulatory
            subunit for voltage-gated K(+) channel Kv2.1
  JOURNAL   FEBS Lett 512 (1-3), 230-234 (2002)
   PUBMED   11852086
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF454550.1.
            
            On Oct 4, 2005 this sequence version replaced NM_133426.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF454550.1, AB070605.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1586              AF454550.1         185-1770
FEATURES             Location/Qualifiers
     source          1..1586
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..1586
                     /gene="Kcng3"
                     /gene_synonym="Kv10.1; Kv6.3"
                     /note="potassium voltage-gated channel modifier subfamily
                     G member 3"
                     /db_xref="GeneID:171011"
                     /db_xref="RGD:628832"
     exon            1..698
                     /gene="Kcng3"
                     /gene_synonym="Kv10.1; Kv6.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1344
                     /gene="Kcng3"
                     /gene_synonym="Kv10.1; Kv6.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potassium voltage-gated channel, subfamily G, memeber 3;
                     potassium voltage-gated channel, subfamily G, member 3;
                     voltage-gated potassium channel subunit Kv6.3;
                     voltage-gated potassium channel subunit Kv10.1; potassium
                     channel, voltage gated modifier subfamily G, member 3;
                     voltage-gated potassium channel 6.3; voltage-gated
                     potassium channel regulatory subunit KCNG3"
                     /codon_start=1
                     /product="voltage-gated potassium channel regulatory
                     subunit KCNG3 isoform 1"
                     /protein_id="NP_596917.2"
                     /db_xref="GeneID:171011"
                     /db_xref="RGD:628832"
                     /translation="MTFGRGGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSE
                     RDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWG
                     LEGAHLEYCCQRRLDDRMSDTHTFHAAEELGREQPRPTGPEAAPSRRWLERMRRTFEE
                     PTSSLAAQILASVSVVFVIVSMVVLCASTLPDWRAAAADNRSLDDRSRYSASPGREPS
                     GIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENS
                     QLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIF
                     SALSQLLEHGLDLETSNKDFASIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVV
                     SGIVLLALPITFIYHSFVQCYHELKFRSARYSRSLSAEFLN"
     exon            699..1586
                     /gene="Kcng3"
                     /gene_synonym="Kv10.1; Kv6.3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccccgtgc gcgcggcggg caggcccccg gggcggccag ccatgacctt cgggcgcggc
       61 ggggcggcct cggtggtgct gaacgtgggc ggcgcccggt actcgctgtc ccgggagctg
      121 ctcaaggact tcccgctgcg ccgtgtgagc cggctgcacg gctgccgctc ggagcgcgac
      181 gtgctcgagg tgtgcgacga ctacgaccgg gagcgcaacg agtacttctt cgaccggcac
      241 tcggaggcct tcggcttcat cctgctgtac gtgcgcggcc acgggaagct gcgcttcgcg
      301 ccgcggatgt gcgagctctc cttctacaac gagatgatct actggggcct ggagggcgcg
      361 cacctggagt actgctgcca gcgccgccta gacgaccgca tgtccgacac ccacaccttc
      421 cacgcggcag aggagctggg ccgcgagcag cctcgtccca ccgggcccga ggcggctccc
      481 tcccggcgct ggctggagcg catgcggcgg accttcgagg agcccacgtc gtcgctggcc
      541 gcgcagatcc tggccagcgt gtccgtggtg ttcgtgatcg tgtctatggt ggtgctgtgc
      601 gccagcacgc tgccggactg gcgcgcggcg gccgccgaca accgcagtct ggatgaccgg
      661 agcaggtact ccgccagccc tgggagggag ccctccggga taattgaagc tatctgcata
      721 ggctggttca ccgcggagtg catcgtgcgg ttcatcgtct ccaaaaacaa gtgtgagttt
      781 gtcaagagac ccctgaacat catcgactta ctggcaatca ccccctatta catctccgtg
      841 ctgatgacag tgtttacagg cgagaactct caactccaga gggctggggt caccctgagg
      901 gtcctccgaa tgatgcggat cttctgggtg attaagcttg cccggcactt catcggcctg
      961 cagaccctgg gcttgactct caagcgatgc taccgagaga tggttatgtt gctcgtcttc
     1021 atctgtgttg ctatggcgat cttcagtgca ctctctcagc tccttgagca cgggttggac
     1081 ttggagacgt ccaacaagga ctttgccagc atccccgctg cctgctggtg ggtgattatc
     1141 tctatgacta cagtgggcta tggagacatg tatcctatca cagtgcctgg aaggattctt
     1201 ggaggagttt gtgttgtcag tgggatcgtt ctgttggcat tacctatcac tttcatctac
     1261 catagctttg tgcagtgcta ccacgagctc aagtttagat cggctcgata tagtaggagc
     1321 ctctccgctg agttcctgaa ttaatgggtt gcaaatcagt ccttgggcac acttcatctg
     1381 gtagagtcga cactacttct tattcacgtg tttctccctg ggtgagcgct acatggcatt
     1441 gtcctcctgt tggaagggtg acattatcct tcccagctga agggatagaa cagtttactt
     1501 acagagtagt caagactggg accacacaca caggacagtg acaggagaga gaacgctagg
     1561 gcctggtctt attcggtctc gtggcc
//
