LOCUS       NM_001101003             616 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily E
            regulatory subunit 5 (Kcne5), mRNA.
ACCESSION   NM_001101003 XM_001060695
VERSION     NM_001101003.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 616)
  AUTHORS   Ohno S, Zankov DP, Ding WG, Itoh H, Makiyama T, Doi T, Shizuta S,
            Hattori T, Miyamoto A, Naiki N, Hancox JC, Matsuura H and Horie M.
  TITLE     KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome
            and idiopathic ventricular fibrillation
  JOURNAL   Circ Arrhythm Electrophysiol 4 (3), 352-361 (2011)
   PUBMED   21493962
REFERENCE   2  (bases 1 to 616)
  AUTHORS   Roura-Ferrer M, Sole L, Oliveras A, Dahan R, Bielanska J,
            Villarroel A, Comes N and Felipe A.
  TITLE     Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface
            targeting
  JOURNAL   J Cell Physiol 225 (3), 692-700 (2010)
   PUBMED   20533308
REFERENCE   3  (bases 1 to 616)
  AUTHORS   Ravn LS, Aizawa Y, Pollevick GD, Hofman-Bang J, Cordeiro JM, Dixen
            U, Jensen G, Wu Y, Burashnikov E, Haunso S, Guerchicoff A, Hu D,
            Svendsen JH, Christiansen M and Antzelevitch C.
  TITLE     Gain of function in IKs secondary to a mutation in KCNE5 associated
            with atrial fibrillation
  JOURNAL   Heart Rhythm 5 (3), 427-435 (2008)
   PUBMED   18313602
REFERENCE   4  (bases 1 to 616)
  AUTHORS   Angelo K, Jespersen T, Grunnet M, Nielsen MS, Klaerke DA and Olesen
            SP.
  TITLE     KCNE5 induces time- and voltage-dependent modulation of the KCNQ1
            current
  JOURNAL   Biophys J 83 (4), 1997-2006 (2002)
   PUBMED   12324418
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF535526.1.
            
            On Aug 13, 2007 this sequence version replaced XM_001060695.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: EF535526.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..616
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq33"
     gene            1..616
                     /gene="Kcne5"
                     /gene_synonym="Kcne1l"
                     /note="potassium voltage-gated channel subfamily E
                     regulatory subunit 5"
                     /db_xref="GeneID:681190"
                     /db_xref="RGD:1583501"
     exon            1..616
                     /gene="Kcne5"
                     /gene_synonym="Kcne1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..500
                     /gene="Kcne5"
                     /gene_synonym="Kcne1l"
                     /note="voltage-gated potassium channel accessory subunit
                     5; potassium channel, voltage-gated Isk-related subfamily
                     E regulatory beta subunit 5; potassium voltage-gated
                     channel subfamily E member 1-like protein; potassium
                     voltage-gated channel, Isk-related family, member 1-like;
                     KCNE1-like; potassium channel, voltage gated subfamily E
                     regulatory beta subunit 5"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily E
                     regulatory beta subunit 5"
                     /protein_id="NP_001094473.1"
                     /db_xref="GeneID:681190"
                     /db_xref="RGD:1583501"
                     /translation="MNCSESQRLQTLLNRLLLELHHRGNASGLGVGSGPSMGMGVVPD
                     PFVGREATSAKGNDAYLYILLIMIFYACLAGGLILAYTRSRKLVEAKDEPPLACVAEQ
                     EWVPTAVASADPENGQGLLGEGSHQLAPGALPALAQCAERV"
ORIGIN      
        1 ttgcttcccc ttgtccaggg ggaaaggtca acggcgtcct ggagcctccg tgccactctc
       61 caacagccat gaactgcagc gagagccaac ggctgcaaac cctcttgaac cgcttgctgc
      121 tggagctgca tcatcgtggc aacgccagcg gcctcggtgt cggatccggc ccgagcatgg
      181 gcatgggggt cgtccctgac cctttcgtgg gccgtgaggc gaccagcgcc aagggtaacg
      241 atgcttatct ctacatccta ctcatcatga tcttctatgc ttgcctagcc ggaggcctca
      301 tcctggccta cactcgctcc cgcaagctcg tcgaggccaa ggatgagcca cccctggcct
      361 gtgttgccga gcaggaatgg gtccccaccg ccgtcgcatc tgctgacccg gagaatggcc
      421 agggcttgct gggtgagggc agccaccagc tcgcaccagg ggctctgcct gcattggccc
      481 agtgcgctga gagggtctag attcgctgcc ctcctcattt tgtttatatc tgggcctggc
      541 tcccgcgttt ttattgcctt tccaaagctt gctttaccag aggcccagaa gatgatgagc
      601 ggtcagaacc cttcaa
//
