LOCUS       NM_212526                629 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily E
            regulatory subunit 4 (Kcne4), mRNA.
ACCESSION   NM_212526 XM_346064
VERSION     NM_212526.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 629)
  AUTHORS   Sole L, Roig SR, Sastre D, Vallejo-Gracia A, Serrano-Albarras A,
            Ferrer-Montiel A, Fernandez-Ballester G, Tamkun MM and Felipe A.
  TITLE     The calmodulin-binding tetraleucine motif of KCNE4 is responsible
            for association with Kv1.3
  JOURNAL   FASEB J 33 (7), 8263-8279 (2019)
   PUBMED   30969795
  REMARK    GeneRIF: experimental data and the in silico structure suggest that
            the KCNE4 interaction hides a forward-trafficking motif within
            Kv1.3 in addition to adding a strong endoplasmic reticulum
            retention signature to the Kv1.3-KCNE4 complex.
REFERENCE   2  (bases 1 to 629)
  AUTHORS   Jepps TA, Carr G, Lundegaard PR, Olesen SP and Greenwood IA.
  TITLE     Fundamental role for the KCNE4 ancillary subunit in Kv7.4
            regulation of arterial tone
  JOURNAL   J Physiol 593 (24), 5325-5340 (2015)
   PUBMED   26503181
  REMARK    GeneRIF: Knockdown of KCNE4 leads to reduced Kv7.4 membrane
            abundance, a depolarized membrane potential and an augmented
            response to vasoconstrictors.
REFERENCE   3  (bases 1 to 629)
  AUTHORS   Vanoye CG, Welch RC, Daniels MA, Manderfield LJ, Tapper AR, Sanders
            CR and George AL Jr.
  TITLE     Distinct subdomains of the KCNQ1 S6 segment determine channel
            modulation by different KCNE subunits
  JOURNAL   J Gen Physiol 134 (3), 207-217 (2009)
   PUBMED   19687231
REFERENCE   4  (bases 1 to 629)
  AUTHORS   Levy DI, Wanderling S, Biemesderfer D and Goldstein SA.
  TITLE     MiRP3 acts as an accessory subunit with the BK potassium channel
  JOURNAL   Am J Physiol Renal Physiol 295 (2), F380-F387 (2008)
   PUBMED   18463315
  REMARK    GeneRIF: MiRP3 (encoded by the KCNE4 gene) plays a role in
            modulation of BK-dependent urinary potassium excretion.
            GeneRIF: Apparent association with BK channel in renal collecting
            duct
REFERENCE   5  (bases 1 to 629)
  AUTHORS   Grunnet M, Rasmussen HB, Hay-Schmidt A, Rosenstierne M, Klaerke DA,
            Olesen SP and Jespersen T.
  TITLE     KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium
            channels
  JOURNAL   Biophys J 85 (3), 1525-1537 (2003)
   PUBMED   12944270
  REMARK    GeneRIF: Mouse studies regarding function of mouse Kcne4 protein
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF512994.1.
            
            On Aug 30, 2004 this sequence version replaced XM_346064.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF512994.1, FQ220973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132268, SAMD00132271
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q34"
     gene            1..629
                     /gene="Kcne4"
                     /note="potassium voltage-gated channel subfamily E
                     regulatory subunit 4"
                     /db_xref="GeneID:367302"
                     /db_xref="RGD:1302957"
     exon            1..50
                     /gene="Kcne4"
                     /inference="alignment:Splign:2.1.0"
     exon            51..629
                     /gene="Kcne4"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..589
                     /gene="Kcne4"
                     /note="minK-related peptide 3; potassium voltage-gated
                     channel, Isk-related subfamily, gene 4; potassium
                     voltage-gated channel, Isk-related family, member 4;
                     potassium channel, voltage-gated Isk-related subfamily E
                     regulatory beta subunit 4; potassium channel, voltage
                     gated subfamily E regulatory beta subunit 4"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily E
                     member 4"
                     /protein_id="NP_997691.1"
                     /db_xref="GeneID:367302"
                     /db_xref="RGD:1302957"
                     /translation="MLRMEPLNSTHPSAAASSSPLESHVSSNSGGNGNEYFYILVVMS
                     FYGIFLIGIMLGYMKSKRREKKSSLLLLYKDEERLWGEAMKPLPMMSGLRSGQVPMML
                     NMLQESVAPALSCTLCSMEGDSVSSESSSPDVHLTIQEEGADEELEETSETPLNESSE
                     GSTENIHQNS"
ORIGIN      
        1 agattcagcc gtttaagagt tccacacttg ggacaaactg tcagcctttg atcccggctg
       61 ggcgagcagc aattcaatgc tgaggatgga gcctctgaat agcacacacc cgagcgctgc
      121 agcttccagc agcccccttg agtcccatgt gtctagtaac agcggtggta atggcaacga
      181 atacttctat attttggtcg ttatgtcctt ctatggcatt ttcttgattg gaatcatgct
      241 gggctacatg aaatccaaga ggcgggagaa gaagtccagc ctcctgctgc tgtacaaaga
      301 tgaggagagg ctgtgggggg aggctatgaa gccgctacct atgatgtccg gcctgaggtc
      361 agggcaggtg cccatgatgc tgaacatgct tcaagagagt gtggcgcctg cgctgtcctg
      421 caccctttgc tctatggaag gggatagtgt gagctccgag tcctcctcgc ctgacgtgca
      481 cctcaccatc caggaagagg gggctgatga ggagcttgag gagacctctg agacgcccct
      541 caatgaaagc agcgaagggt ctacagaaaa catccatcag aattcctagc atccccaggc
      601 ctctggaggt ggctccagaa agctacgct
//
