LOCUS       NM_022235               1205 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily E
            regulatory subunit 3 (Kcne3), mRNA.
ACCESSION   NM_022235 XM_346557 XM_347357
VERSION     NM_022235.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1205)
  AUTHORS   Nakajima,T., Wu,J., Kaneko,Y., Ashihara,T., Ohno,S., Irie,T.,
            Ding,W.G., Matsuura,H., Kurabayashi,M. and Horie,M.
  TITLE     KCNE3 T4A as the genetic basis of Brugada-pattern electrocardiogram
  JOURNAL   Circ J 76 (12), 2763-2772 (2012)
   PUBMED   22987075
REFERENCE   2  (bases 1 to 1205)
  AUTHORS   Alzamora,R., O'Mahony,F., Bustos,V., Rapetti-Mauss,R., Urbach,V.,
            Cid,L.P., Sepulveda,F.V. and Harvey,B.J.
  TITLE     Sexual dimorphism and oestrogen regulation of KCNE3 expression
            modulates the functional properties of KCNQ1 K channels
  JOURNAL   J Physiol 589 (Pt 21), 5091-5107 (2011)
   PUBMED   21911611
REFERENCE   3  (bases 1 to 1205)
  AUTHORS   Roura-Ferrer,M., Sole,L., Oliveras,A., Dahan,R., Bielanska,J.,
            Villarroel,A., Comes,N. and Felipe,A.
  TITLE     Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface
            targeting
  JOURNAL   J Cell Physiol 225 (3), 692-700 (2010)
   PUBMED   20533308
REFERENCE   4  (bases 1 to 1205)
  AUTHORS   Lewis,A., McCrossan,Z.A. and Abbott,G.W.
  TITLE     MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel
            gating
  JOURNAL   J Biol Chem 279 (9), 7884-7892 (2004)
   PUBMED   14679187
REFERENCE   5  (bases 1 to 1205)
  AUTHORS   McCrossan,Z.A., Lewis,A., Panaghie,G., Jordan,P.N., Christini,D.J.,
            Lerner,D.J. and Abbott,G.W.
  TITLE     MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels
            in mammalian brain
  JOURNAL   J Neurosci 23 (22), 8077-8091 (2003)
   PUBMED   12954870
REFERENCE   6  (bases 1 to 1205)
  AUTHORS   Boucherot,A., Schreiber,R. and Kunzelmann,K.
  TITLE     Regulation and properties of KCNQ1 (K(V)LQT1) and impact of the
            cystic fibrosis transmembrane conductance regulator
  JOURNAL   J Membr Biol 182 (1), 39-47 (2001)
   PUBMED   11426298
REFERENCE   7  (bases 1 to 1205)
  AUTHORS   Abbott,G.W., Butler,M.H., Bendahhou,S., Dalakas,M.C., Ptacek,L.J.
            and Goldstein,S.A.
  TITLE     MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is
            associated with periodic paralysis
  JOURNAL   Cell 104 (2), 217-231 (2001)
   PUBMED   11207363
REFERENCE   8  (bases 1 to 1205)
  AUTHORS   Kunzelmann,K., Hubner,M., Schreiber,R., Levy-Holzman,R., Garty,H.,
            Bleich,M., Warth,R., Slavik,M., von Hahn,T. and Greger,R.
  TITLE     Cloning and function of the rat colonic epithelial K+ channel
            KVLQT1
  JOURNAL   J Membr Biol 179 (2), 155-164 (2001)
   PUBMED   11220365
REFERENCE   9  (bases 1 to 1205)
  AUTHORS   Schroeder,B.C., Waldegger,S., Fehr,S., Bleich,M., Warth,R.,
            Greger,R. and Jentsch,T.J.
  TITLE     A constitutively open potassium channel formed by KCNQ1 and KCNE3
  JOURNAL   Nature 403 (6766), 196-199 (2000)
   PUBMED   10646604
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086406.1.
            
            On Nov 22, 2004 this sequence version replaced NM_022235.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086406.1, CO402261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1205
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1205
                     /gene="Kcne3"
                     /gene_synonym="MiRP2"
                     /note="potassium voltage-gated channel subfamily E
                     regulatory subunit 3"
                     /db_xref="GeneID:63883"
                     /db_xref="RGD:621384"
     exon            1..57
                     /gene="Kcne3"
                     /gene_synonym="MiRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            58..1158
                     /gene="Kcne3"
                     /gene_synonym="MiRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..421
                     /gene="Kcne3"
                     /gene_synonym="MiRP2"
                     /note="potassium channel subunit beta MiRP2; minimum
                     potassium ion channel-related peptide 2; potassium
                     voltage-gated channel, Isk-related subfamily, gene 3;
                     mink-related peptide 2; potassium voltage-gated channel,
                     Isk-related subfamily, member 3; potassium voltage-gated
                     channel, Isk-related family, member 3; potassium channel,
                     voltage-gated Isk-related subfamily E regulatory beta
                     subunit 3; potassium channel, voltage gated subfamily E
                     regulatory beta subunit 3"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily E
                     member 3"
                     /protein_id="NP_071571.1"
                     /db_xref="GeneID:63883"
                     /db_xref="RGD:621384"
                     /translation="METSNGTETWYKSLHAVLKALNTTLHSHLLCRPGPGPGSGTGPD
                     NQTEDHRASLPGRNDNSYMYILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHVYIKN
                     RVSMI"
ORIGIN      
        1 cactgagcgc cgctgggcat cactgcagtg ctcaccggag acagatcgca gagtcagatc
       61 acattccagc tcttcccata cctcgatttc tgttgctatg gagacttcca acgggactga
      121 gacctggtac aagagcctcc acgctgtgct aaaggctctg aacacaaccc ttcacagtca
      181 cttgctctgc cggcctgggc cagggccagg gtcaggaaca gggccagaca atcaaacaga
      241 ggatcatcgg gctagccttc ccggccgtaa tgacaactcc tacatgtata ttctttttgt
      301 catgttccta ttcgctgtca ctgtgggcag tctcatcctg ggatataccc gttcacgcaa
      361 agtggacaaa cgtagtgacc cctatcatgt gtacatcaaa aaccgtgtgt ctatgatctg
      421 atgtgaggtg cctgaggaca atggaagatt atgatgtctg aggattgtct tcttgggtct
      481 ccggaactca tctcgaccct atcaagccac agtacctctg tctatacaag atcaacgaga
      541 aattggtaag agagttaggt catcactggg accagagaag aggggctgat aggcctggtc
      601 ttctggatga gacatttttc tagacacaga tgcgcattat aaactcagag cccgtgagca
      661 cacatataaa agtatggaca accaacaagt aggagaggaa gctgtggtga agggaaatgg
      721 agcaggaaaa tgctctggaa atataatctt ttaatgtatg atctttaaca tgagagatct
      781 tgataaaaca gagaatgcta cttacttgta tcgattcaaa gtttgttctt taaatagcct
      841 taatatttgt gggttttgcc tcatctgcca agaaaacgga acaagtccta tgactggaat
      901 ccaggaactc tggtcatttc ttctaggact tttcaatccc acgtcgggta agatccaggc
      961 cagaagaaca ttcggccgag cacaatgatg catgtctaca attgtagtgc tcaagaggct
     1021 gagtggggag gatcatttga gttcaagagt tcaagaccag actactcaag ctctatcttg
     1081 gaagggactt ggtgggggct gttgagaaat atcttacttt tacaaatatt accaaagaca
     1141 cgtcactgtg ctaacgtaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1201 aaaaa
//
