LOCUS       NM_133603               1744 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily E
            regulatory subunit 2 (Kcne2), mRNA.
ACCESSION   NM_133603
VERSION     NM_133603.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1744)
  AUTHORS   Liu,W.J., Deng,J.X., Wang,G., Gao,K.P., Lin,Z.X., Liu,S.Y.,
            Wang,Y.H. and Liu,J.
  TITLE     Manipulation of KCNE2 expression modulates action potential
            duration and Ito and IK in rat and mouse ventricular myocytes
  JOURNAL   Am J Physiol Heart Circ Physiol 309 (8), H1288-H1302 (2015)
   PUBMED   26297229
  REMARK    GeneRIF: Endogenous KCNE2 in cardiomyocytes is important in
            maintaining cardiac electrical stability mainly by regulating Ito
            and action potential duration.
REFERENCE   2  (bases 1 to 1744)
  AUTHORS   Liu,W., Deng,J., Wang,G., Zhang,C., Luo,X., Yan,D., Su,Q. and
            Liu,J.
  TITLE     KCNE2 modulates cardiac L-type Ca(2+) channel
  JOURNAL   J Mol Cell Cardiol 72, 208-218 (2014)
   PUBMED   24681347
  REMARK    GeneRIF: The KCNE2 mutation R27C may induce familial atrial
            fibrillation partially through enhancing the suppression of Cav1.2
            calcium channel.
REFERENCE   3  (bases 1 to 1744)
  AUTHORS   Sachse,C.C., Kim,Y.H., Agsten,M., Huth,T., Alzheimer,C.,
            Kovacs,D.M. and Kim,D.Y.
  TITLE     BACE1 and presenilin/gamma-secretase regulate proteolytic
            processing of KCNE1 and 2, auxiliary subunits of voltage-gated
            potassium channels
  JOURNAL   FASEB J 27 (6), 2458-2467 (2013)
   PUBMED   23504710
  REMARK    GeneRIF: KCNE1 and KCNE2, auxiliary subunits of voltage-gated
            potassium channels, undergo sequential cleavage mediated by either
            alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 and
            PS/gamma-secretase in cells.
REFERENCE   4  (bases 1 to 1744)
  AUTHORS   Zhang,M., Wang,Y., Jiang,M., Zankov,D.P., Chowdhury,S.,
            Kasirajan,V. and Tseng,G.N.
  TITLE     KCNE2 protein is more abundant in ventricles than in atria and can
            accelerate hERG protein degradation in a phosphorylation-dependent
            manner
  JOURNAL   Am J Physiol Heart Circ Physiol 302 (4), H910-H922 (2012)
   PUBMED   22180649
  REMARK    GeneRIF: KCNE2 can modulate its partner channel function not only
            by altering channel conductance and/or gating kinetics, but also by
            affecting protein stability.
REFERENCE   5  (bases 1 to 1744)
  AUTHORS   Kanda,V.A., Lewis,A., Xu,X. and Abbott,G.W.
  TITLE     KCNE1 and KCNE2 provide a checkpoint governing voltage-gated
            potassium channel alpha-subunit composition
  JOURNAL   Biophys J 101 (6), 1364-1375 (2011)
   PUBMED   21943417
  REMARK    GeneRIF: KCNE1 and KCNE2 suppress currents generated by homomeric
            Kv1.4, Kv3.3, and Kv3.4 channels
REFERENCE   6  (bases 1 to 1744)
  AUTHORS   Jiang,M., Zhang,M., Tang,D.G., Clemo,H.F., Liu,J., Holwitt,D.,
            Kasirajan,V., Pond,A.L., Wettwer,E. and Tseng,G.N.
  TITLE     KCNE2 protein is expressed in ventricles of different species, and
            changes in its expression contribute to electrical remodeling in
            diseased hearts
  JOURNAL   Circulation 109 (14), 1783-1788 (2004)
   PUBMED   15066947
  REMARK    GeneRIF: In aging rat ventricle, KCNE2 may associate with HCN2 and
            enhance its current amplitude. KCNE2 protein is expressed in
            ventricles, and it can play diverse roles in ventricular electrical
            activity under (patho)physiological conditions.
REFERENCE   7  (bases 1 to 1744)
  AUTHORS   Lewis,A., McCrossan,Z.A. and Abbott,G.W.
  TITLE     MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel
            gating
  JOURNAL   J Biol Chem 279 (9), 7884-7892 (2004)
   PUBMED   14679187
REFERENCE   8  (bases 1 to 1744)
  AUTHORS   Ohya,S., Asakura,K., Muraki,K., Watanabe,M. and Imaizumi,Y.
  TITLE     Molecular and functional characterization of ERG, KCNQ, and KCNE
            subtypes in rat stomach smooth muscle
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 282 (2), G277-G287 (2002)
   PUBMED   11804849
REFERENCE   9  (bases 1 to 1744)
  AUTHORS   Yu,H., Wu,J., Potapova,I., Wymore,R.T., Holmes,B., Zuckerman,J.,
            Pan,Z., Wang,H., Shi,W., Robinson,R.B., El-Maghrabi,M.R.,
            Benjamin,W., Dixon,J., McKinnon,D., Cohen,I.S. and Wymore,R.
  TITLE     MinK-related peptide 1: A beta subunit for the HCN ion channel
            subunit family enhances expression and speeds activation
  JOURNAL   Circ Res 88 (12), E84-E87 (2001)
   PUBMED   11420311
REFERENCE   10 (bases 1 to 1744)
  AUTHORS   Abbott,G.W., Sesti,F., Splawski,I., Buck,M.E., Lehmann,M.H.,
            Timothy,K.W., Keating,M.T. and Goldstein,S.A.
  TITLE     MiRP1 forms IKr potassium channels with HERG and is associated with
            cardiac arrhythmia
  JOURNAL   Cell 97 (2), 175-187 (1999)
   PUBMED   10219239
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089778.1.
            
            On Feb 13, 2005 this sequence version replaced NM_133603.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132278, SAMD00132302
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1744
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..1744
                     /gene="Kcne2"
                     /gene_synonym="Mirp1"
                     /note="potassium voltage-gated channel subfamily E
                     regulatory subunit 2"
                     /db_xref="GeneID:171138"
                     /db_xref="RGD:621383"
     exon            1..8
                     /gene="Kcne2"
                     /gene_synonym="Mirp1"
                     /inference="alignment:Splign:2.1.0"
     exon            9..181
                     /gene="Kcne2"
                     /gene_synonym="Mirp1"
                     /inference="alignment:Splign:2.1.0"
     exon            182..1718
                     /gene="Kcne2"
                     /gene_synonym="Mirp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..565
                     /gene="Kcne2"
                     /gene_synonym="Mirp1"
                     /note="potassium channel, voltage-gated Isk-related
                     subfamily E regulatory beta subunit 2; potassium channel
                     subunit beta MiRP1; potassium channel, voltage gated
                     subfamily E regulatory beta subunit 2; minimum potassium
                     ion channel-related peptide 1; potassium voltage-gated
                     channel, Isk-related subfamily, gene 2; minK-related
                     peptide 1; potassium voltage-gated channel, Isk-related
                     family, member 2"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily E
                     member 2"
                     /protein_id="NP_598287.1"
                     /db_xref="GeneID:171138"
                     /db_xref="RGD:621383"
                     /translation="MTTLANLTQTLEDAFKKVFITYMDSWRRNTTAEQQALQARVDAE
                     NFYYVILYLMVMIGMFAFIVVAILVSTVKSKRREHSQDPYHQYIVEDWQQKYRSQILH
                     LEDSKATIHENLGATGFTVSP"
ORIGIN      
        1 gccgcgcgca gcaagcaacc cagctctcag gaggtgctga ctacacccag tgtggacggt
       61 tggctggagg gggactccat ctgtgcagcc gtggggaaat cttcgtccaa tcgtgcgtgg
      121 ggctctttaa tcgtgcagcc gtggagggat atcagcactc ctgtgaggaa tctctcatcc
      181 tcaaggggga aacatgacca ctttagccaa cttgacgcag accctggagg atgccttcaa
      241 aaaggttttc attacttata tggacagctg gaggaggaac acaacagccg aacaacaggc
      301 gctccaggcc agagtggatg ccgagaactt ctactacgtc atcctgtacc tcatggtgat
      361 gatcggcatg ttcgccttca tcgtggtggc catcctggtg agcacggtga agtcgaagcg
      421 gcgggagcac tcccaggacc cgtaccacca gtacatcgtg gaggattggc agcagaagta
      481 taggagtcag atcttgcatc tggaagactc caaggccacc atccatgaga acctgggggc
      541 gacggggttc acagtgtcac cctgataaag aacgagagtc catctgccca ggaaggggtg
      601 cttctgccgc cttgaggccc cacttgccct tgcttggaag aaagctagtt cctctgtgca
      661 gcctggctgg cggtggacgc aggtagcggt ctatctcagt ggtttaggtg agcctggtgg
      721 ggtgagattt atgctgaggg tctcttgttg cttgctaggc aatgtaaatg tcatttaagt
      781 ccattccaat catgagaaca gaggcaaaca tgaagcaacg ggactgggca cgggcagcgg
      841 ggatagaaag cagagagtta caaatctttc aaccttcttt ctcataaaat attagtttga
      901 atgtagcaaa ttcagtttat gagtaagtca aaagtgtcca gacgctgggg tttaaatcta
      961 tctcgggctt gcagaagtga tgggagagca tttactcact gatttatggg cagcgagtcc
     1021 gaggtggtca atgaacaaaa gtgtggggtt attttgcatc tacagctttc ctggtattta
     1081 actgatttgg acatccggac agagcaaaca ctgaaaggac aaataaccca caccagaggc
     1141 atcaaatatt caagagcccc cagtgcaacc caacttattt ttaacttttc aaggaaactt
     1201 aagctttaaa agttctctgg cttgacacag tgtggccttc cttcccaaac atcgtactct
     1261 ttacttggtt ttagatccca tttatagctt attttcacac acatttgaca tgacgcaagc
     1321 tacagaacac cccgctagat atttgctgca agctggacag tggctgctta atcctttgca
     1381 ccacagtgga ggtgctaaag agatgttggt caaaggctac acattttaat ggggctgggg
     1441 atgcacgctc ataacccaac cctcaggaga ctgagggggg aaggactagc tgagggtcca
     1501 agccattcta gacccgttgc cctccaaggt caataaaggt gccttttgtc cttagacact
     1561 gttacctgag aggatagtta ggtatcctta ccacaaaaga gtgactacat gagatgatac
     1621 cttagtcatt ccacaatgtg tatagcttca atatatcatg ttatgtgtgt aatacaatgt
     1681 aagctgtcct ttaaaaaaaa taaagtgaat gctttgcaaa aaaaaaaaaa aaaaaaaaaa
     1741 aaaa
//
