LOCUS       NM_012973                585 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily E
            regulatory subunit 1 (Kcne1), mRNA.
ACCESSION   NM_012973
VERSION     NM_012973.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 585)
  AUTHORS   Braun,C., Parks,X.X., Qudsi,H. and Lopes,C.M.B.
  TITLE     Membrane pools of phosphatidylinositol-4-phosphate regulate
            KCNQ1/KCNE1 membrane expression
  JOURNAL   Commun Biol 4 (1), 1392 (2021)
   PUBMED   34907346
  REMARK    GeneRIF: Membrane pools of phosphatidylinositol-4-phosphate
            regulate KCNQ1/KCNE1 membrane expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 585)
  AUTHORS   Jiang,M., Wang,Y. and Tseng,G.N.
  TITLE     Adult Ventricular Myocytes Segregate KCNQ1 and KCNE1 to Keep the
            IKs Amplitude in Check Until When Larger IKs Is Needed
  JOURNAL   Circ Arrhythm Electrophysiol 10 (6) (2017)
   PUBMED   28611207
  REMARK    GeneRIF: In adult ventricular myocytes, KCNE1 maintains a stable
            presence on the cell surface, whereas KCNQ1 is dynamic in its
            localization. KCNQ1 is largely in an intracellular reservoir under
            basal conditions but can traffic to the cell surface and boost the
            IKs amplitude in response to stress.
REFERENCE   3  (bases 1 to 585)
  AUTHORS   Redina,O.E., Smolenskaya,S.E., Fedoseeva,L.A. and Markel,A.L.
  TITLE     [Differentially expressed genes in the locus associated with
            relative kidney weight and resting blood pressure in hypertensive
            rats of the ISIAH strain]
  JOURNAL   Mol Biol (Mosk) 50 (6), 944-952 (2016)
   PUBMED   28064310
  REMARK    GeneRIF: Six differentially expressed genes (Kcne1, Rcan1, Mx1,
            Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex,
            and three genes (Rcan1, Mx2, and Tmprss2) were identified in the
            renal medulla.
REFERENCE   4  (bases 1 to 585)
  AUTHORS   Li,X., Liu,C., Liang,W., Ye,H., Chen,W., Lin,R., Li,Z., Liu,X. and
            Wu,M.
  TITLE     Millimeter wave promotes the synthesis of extracellular matrix and
            the proliferation of chondrocyte by regulating the voltage-gated K+
            channel
  JOURNAL   J Bone Miner Metab 32 (4), 367-377 (2014)
   PUBMED   24202060
REFERENCE   5  (bases 1 to 585)
  AUTHORS   Bartos,D.C., Giudicessi,J.R., Tester,D.J., Ackerman,M.J., Ohno,S.,
            Horie,M., Gollob,M.H., Burgess,D.E. and Delisle,B.P.
  TITLE     A KCNQ1 mutation contributes to the concealed type 1 long QT
            phenotype by limiting the Kv7.1 channel conformational changes
            associated with protein kinase A phosphorylation
  JOURNAL   Heart Rhythm 11 (3), 459-468 (2014)
   PUBMED   24269949
REFERENCE   6  (bases 1 to 585)
  AUTHORS   Busch,A.E., Varnum,M.D., North,R.A. and Adelman,J.P.
  TITLE     An amino acid mutation in a potassium channel that prevents
            inhibition by protein kinase C
  JOURNAL   Science 255 (5052), 1705-1707 (1992)
   PUBMED   1553557
REFERENCE   7  (bases 1 to 585)
  AUTHORS   Iwai,M., Masu,M., Tsuchida,K., Mori,T., Ohkubo,H. and Nakanishi,S.
  TITLE     Characterization of gene organization and generation of
            heterogeneous mRNA species of rat ISK protein
  JOURNAL   J Biochem 108 (2), 200-206 (1990)
   PUBMED   2229022
REFERENCE   8  (bases 1 to 585)
  AUTHORS   Pragnell,M., Snay,K.J., Trimmer,J.S., MacLusky,N.J., Naftolin,F.,
            Kaczmarek,L.K. and Boyle,M.B.
  TITLE     Estrogen induction of a small, putative K+ channel mRNA in rat
            uterus
  JOURNAL   Neuron 4 (5), 807-812 (1990)
   PUBMED   2344412
REFERENCE   9  (bases 1 to 585)
  AUTHORS   Folander,K., Smith,J.S., Antanavage,J., Bennett,C., Stein,R.B. and
            Swanson,R.
  TITLE     Cloning and expression of the delayed-rectifier IsK channel from
            neonatal rat heart and diethylstilbestrol-primed rat uterus
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 2975-2979 (1990)
   PUBMED   2183220
REFERENCE   10 (bases 1 to 585)
  AUTHORS   Sugimoto,T., Tanabe,Y., Shigemoto,R., Iwai,M., Takumi,T., Ohkubo,H.
            and Nakanishi,S.
  TITLE     Immunohistochemical study of a rat membrane protein which induces a
            selective potassium permeation: its localization in the apical
            membrane portion of epithelial cells
  JOURNAL   J Membr Biol 113 (1), 39-47 (1990)
   PUBMED   2154581
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M22412.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M22412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..585
                     /gene="Kcne1"
                     /gene_synonym="Isk"
                     /note="potassium voltage-gated channel subfamily E
                     regulatory subunit 1"
                     /db_xref="GeneID:25471"
                     /db_xref="RGD:2956"
     exon            1..24
                     /gene="Kcne1"
                     /gene_synonym="Isk"
                     /inference="alignment:Splign:2.1.0"
     exon            25..585
                     /gene="Kcne1"
                     /gene_synonym="Isk"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..456
                     /gene="Kcne1"
                     /gene_synonym="Isk"
                     /note="potassium voltage-gated channel, Isk-related
                     subfamily, member 1; potassium (K+) channel protein,
                     slowly activating (Isk); potassium channel, voltage-gated
                     Isk-related subfamily E regulatory beta subunit 1; delayed
                     rectifier potassium channel subunit IsK; IKs producing
                     slow voltage-gated potassium channel subunit beta Mink;
                     minimal potassium channel; potassium voltage-gated
                     channel, Isk-related family, member 1; mink; potassium
                     voltage-gated channel Shaw-related subfamily member 1;
                     potassium channel, voltage gated subfamily E regulatory
                     beta subunit 1"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily E
                     member 1"
                     /protein_id="NP_037105.1"
                     /db_xref="GeneID:25471"
                     /db_xref="RGD:2956"
                     /translation="MALSNSTTVLPFLASLWQETDEPGGNMSADLARRSQLRDDSKLE
                     ALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKALFQARVLE
                     SFRACYVIENQAAVEQPATHLPELKPLS"
ORIGIN      
        1 cgtccatcca ggtccaggcg tgcagagttt tgctccacat cagggaaacc gtgaagcccc
       61 aggatggccc tgtccaattc cacaactgtt ctgccttttc tggcctcgct gtggcaggaa
      121 acagatgagc cgggtggcaa tatgtcggcg gacttggctc gtaggtccca gctccgagat
      181 gacagcaagc tggaggctct ctatatcctc atggtgctgg gtttcttcgg cttcttcacc
      241 ctgggcatca tgctgagtta catccgatcc aagaagctgg aacactcgca cgaccctttc
      301 aacgtgtaca tcgagtcgga cgcctggcag gagaaaggca aggccctctt ccaggcccgc
      361 gttctggaga gcttcagagc ttgctatgtc attgaaaacc aggcggccgt agaacaacct
      421 gccacacacc ttcctgaact gaagccactg tcatgaaccc catagttaat taatagacaa
      481 gtgataagtg ggtctttcta gtcaaatgcc tgccagtctt tattgtagag gtacccttga
      541 gtttttataa ggggtgagtt aataacacca gttttctgaa attgc
//
