LOCUS       NM_001270962            6818 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily D
            member 3 (Kcnd3), transcript variant 1, mRNA.
ACCESSION   NM_001270962
VERSION     NM_001270962.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6818)
  AUTHORS   Kanda,H., Ling,J., Chang,Y.T., Erol,F., Viatchenko-Karpinski,V.,
            Yamada,A., Noguchi,K. and Gu,J.G.
  TITLE     Kv4.3 Channel Dysfunction Contributes to Trigeminal Neuropathic
            Pain Manifested with Orofacial Cold Hypersensitivity in Rats
  JOURNAL   J Neurosci 41 (10), 2091-2105 (2021)
   PUBMED   33472822
  REMARK    GeneRIF: Kv4.3 Channel Dysfunction Contributes to Trigeminal
            Neuropathic Pain Manifested with Orofacial Cold Hypersensitivity in
            Rats.
REFERENCE   2  (bases 1 to 6818)
  AUTHORS   Tao,B., Liu,Z., Wei,F., Fan,S., Cui,S., Xia,H. and Xu,L.
  TITLE     Over-expression of Kv4.3 gene reverses cardiac remodeling and
            transient-outward K+ current (Ito) reduction via CaMKII inhibition
            in myocardial infarction
  JOURNAL   Biomed Pharmacother 132, 110896 (2020)
   PUBMED   33254430
  REMARK    GeneRIF: Over-expression of Kv4.3 gene reverses cardiac remodeling
            and transient-outward K(+) current (Ito) reduction via CaMKII
            inhibition in myocardial infarction.
REFERENCE   3  (bases 1 to 6818)
  AUTHORS   Alday,A., Ahyayauch,H., Fernandez-Lopez,V., Echeazarra,L.,
            Urrutia,J., Casis,O. and Gallego,M.
  TITLE     CaMKII Modulates the Cardiac Transient Outward K+ Current through
            its Association with Kv4 Channels in Non-Caveolar Membrane Rafts
  JOURNAL   Cell Physiol Biochem 54 (1), 27-39 (2020)
   PUBMED   31935048
  REMARK    GeneRIF: Immunogold staining and electron microscopy of heart
            vibrosections was performed to localize Kv4.2/Kv4.3 and
            Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) proteins.
            Patch-Clamp recordings in control conditions and after lipid raft
            or caveolae disruption show that the CaMKII-Kv4 channel complex
            must associate in non-caveolar lipid rafts to be functional.
REFERENCE   4  (bases 1 to 6818)
  AUTHORS   Wang,Y., Keskanokwong,T. and Cheng,J.
  TITLE     Kv4.3 expression abrogates and reverses norepinephrine-induced
            myocyte hypertrophy by CaMKII inhibition
  JOURNAL   J Mol Cell Cardiol 126, 77-85 (2019)
   PUBMED   30462989
  REMARK    GeneRIF: Kv4.3 reduction is an important mediator in cardiac
            hypertrophy development via excessive CaMKII activation.
REFERENCE   5  (bases 1 to 6818)
  AUTHORS   Viatchenko-Karpinski,V., Ling,J. and Gu,J.G.
  TITLE     Down-regulation of Kv4.3 channels and a-type K+ currents in V2
            trigeminal ganglion neurons of rats following oxaliplatin treatment
  JOURNAL   Mol Pain 14, 1744806917750995 (2018)
   PUBMED   29313436
  REMARK    GeneRIF: down-regulation of Kv4.3 channels mediating A-type K(+)
            (IA) currents currents in nociceptive V2 trigeminal neurons is an
            underlying mechanism of oxaliplatin-induced orofacial neuropathic
            pain.
REFERENCE   6  (bases 1 to 6818)
  AUTHORS   Ohya,S., Tanaka,M., Oku,T., Asai,Y., Watanabe,M., Giles,W.R. and
            Imaizumi,Y.
  TITLE     Molecular cloning and tissue distribution of an alternatively
            spliced variant of an A-type K+ channel alpha-subunit, Kv4.3 in the
            rat
  JOURNAL   FEBS Lett 420 (1), 47-53 (1997)
   PUBMED   9450548
REFERENCE   7  (bases 1 to 6818)
  AUTHORS   Takimoto,K., Li,D., Hershman,K.M., Li,P., Jackson,E.K. and
            Levitan,E.S.
  TITLE     Decreased expression of Kv4.2 and novel Kv4.3 K+ channel subunit
            mRNAs in ventricles of renovascular hypertensive rats
  JOURNAL   Circ Res 81 (4), 533-539 (1997)
   PUBMED   9314834
REFERENCE   8  (bases 1 to 6818)
  AUTHORS   Tsaur,M.L., Chou,C.C., Shih,Y.H. and Wang,H.L.
  TITLE     Cloning, expression and CNS distribution of Kv4.3, an A-type K+
            channel alpha subunit
  JOURNAL   FEBS Lett 400 (2), 215-220 (1997)
   PUBMED   9001401
REFERENCE   9  (bases 1 to 6818)
  AUTHORS   Dixon,J.E., Shi,W., Wang,H.S., McDonald,C., Yu,H., Wymore,R.S.,
            Cohen,I.S. and McKinnon,D.
  TITLE     Role of the Kv4.3 K+ channel in ventricular muscle. A molecular
            correlate for the transient outward current
  JOURNAL   Circ Res 79 (4), 659-668 (1996)
   PUBMED   8831489
  REMARK    Erratum:[Circ Res 1997 Jan;80(1):147]
REFERENCE   10 (bases 1 to 6818)
  AUTHORS   Serodio,P., Vega-Saenz de Miera,E. and Rudy,B.
  TITLE     Cloning of a novel component of A-type K+ channels operating at
            subthreshold potentials with unique expression in heart and brain
  JOURNAL   J Neurophysiol 75 (5), 2174-2179 (1996)
   PUBMED   8734615
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            Transcript Variant: This variant (1, also known as Kv4.3L and
            Kv4.3c) represents the longest transcript and encodes the longest
            isoform (1).
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.8964.1,
                                           SRR26643298.12808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                JAXUCZ010000002.1  195626316-195626333
            19-1198             JAXUCZ010000002.1  195633007-195634186
            1199-1361           JAXUCZ010000002.1  195828104-195828266
            1362-1463           JAXUCZ010000002.1  195834753-195834854
            1464-1553           JAXUCZ010000002.1  195835188-195835277
            1554-1610           JAXUCZ010000002.1  195836703-195836759
            1611-1858           JAXUCZ010000002.1  195837818-195838065
            1859-6818           JAXUCZ010000002.1  195838731-195843690
FEATURES             Location/Qualifiers
     source          1..6818
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..6818
                     /gene="Kcnd3"
                     /gene_synonym="Kv4.3"
                     /note="potassium voltage-gated channel subfamily D member
                     3"
                     /db_xref="GeneID:65195"
                     /db_xref="RGD:68394"
     exon            1..18
                     /gene="Kcnd3"
                     /gene_synonym="Kv4.3"
                     /inference="alignment:Splign:2.1.0"
     exon            19..1198
                     /gene="Kcnd3"
                     /gene_synonym="Kv4.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2060
                     /gene="Kcnd3"
                     /gene_synonym="Kv4.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potassium voltage gated channel, Shal-related family,
                     member 3; voltage-gated potassium channel subunit Kv4.3;
                     potassium channel, voltage-gated Shal-related subfamily D,
                     member 3; potassium voltage-gated channel, Shal-related
                     subfamily, member 3; A-type voltage-gated potassium
                     channel KCND3"
                     /codon_start=1
                     /product="A-type voltage-gated potassium channel KCND3
                     isoform 1"
                     /protein_id="NP_001257891.1"
                     /db_xref="GeneID:65195"
                     /db_xref="RGD:68394"
                     /translation="MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVL
                     NVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGK
                     LHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNESENNQESM
                     PSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPC
                     GERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVM
                     TNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIII
                     FATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGV
                     LVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLL
                     NEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNH
                     EFIDEQMFEQNCMESSMQNYPSTRSPSLSSHSGLTTTCCSRRSKKTTHLPNSNLPATR
                     LRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALT
                     PEGESRPPPASPGPNTNIPSITSNVVKVSAL"
     exon            1199..1361
                     /gene="Kcnd3"
                     /gene_synonym="Kv4.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1463
                     /gene="Kcnd3"
                     /gene_synonym="Kv4.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1553
                     /gene="Kcnd3"
                     /gene_synonym="Kv4.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1610
                     /gene="Kcnd3"
                     /gene_synonym="Kv4.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1858
                     /gene="Kcnd3"
                     /gene_synonym="Kv4.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..6818
                     /gene="Kcnd3"
                     /gene_synonym="Kv4.3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctggctt cggcgaaggg gtcactgaac taactaactc caagctggtg cgtagtgtct
       61 gagcagctac cagcccaaaa gctggagtca ccatggcggc aggagttgca gcctggctgc
      121 cttttgcccg ggctgcggcc attgggtgga tgccagtggc caactgcccc atgcccctag
      181 ctccagccga caagaacaag cggcaagatg agctaatcgt cctcaacgtg agtggccgtc
      241 ggttccagac ctggaggacc actctggagc gctatcccga caccctgctg ggtagcacag
      301 agaaggagtt cttcttcaac gaggacacca aggagtactt ctttgaccgt gacccggaag
      361 tgttccgttg tgtgctcaac ttctaccgca ctgggaagct gcactaccca cgctatgaat
      421 gcatctctgc ctacgacgat gagctggcct tctatggcat cctccctgag atcattggcg
      481 actgctgcta tgaggagtac aaagaccgca agcgggagaa cgctgagcgg ctcatggatg
      541 acaatgagtc tgagaacaac caggagtcca tgccctccct cagcttccgc cagaccatgt
      601 ggcgggcctt cgagaaccca cacaccagca ccctggcact ggtcttctac tacgtgacag
      661 gcttcttcat tgcggtctcg gtgatcacca acgtggtgga gacggtgcca tgcggcacgg
      721 tgcctgggag caaggaactg ccgtgtggag agcgctactc cgtggctttc ttctgcctgg
      781 acactgcgtg tgtcatgatc ttcacggtgg agtacctcct ccgactcttc gcggcaccca
      841 gcaggtaccg cttcatccgc agtgtgatga gcatcatcga cgtggtggcc atcatgccct
      901 attacattgg cctggtcatg accaacaacg aggacgtgtc cggggcattt gtcacactcc
      961 gggtcttccg cgtcttcagg atcttcaagt tctcccgaca ttcccagggc ctacggatcc
     1021 taggctacac cctgaagagc tgtgcctcag aactaggctt tcttctcttc tccctcacca
     1081 tggccatcat catctttgcc actgtgatgt tttatgctga gaagggctcc tccgccagca
     1141 agttcacaag catccctgcg tctttctggt acaccatagt caccatgaca acactggggt
     1201 atggagacat ggtgcctaag acaattgctg ggaagatatt tggctccatc tgctccctaa
     1261 gcggcgtcct ggtcattgct ctgccagtcc ccgtcatagt ctccaacttt agcaggatct
     1321 accatcagaa ccagagagca gataaacgca gggcacagaa gaaggcccgc cttgccagaa
     1381 tccgtgtggc caaaacaggg agctccaatg cctacctgca cagcaagcgc aatggactcc
     1441 tcaatgaagc tctggagctg accggcaccc cagaagagga gcacatgggc aagaccacgt
     1501 cactcatcga gagccagcac caccacctgc tacactgctt agaaaagacc actgggttat
     1561 cctatcttgt ggatgatccc ctgttgtctg tacgaacctc caccatcaag aaccacgagt
     1621 ttattgatga gcagatgttt gagcagaact gcatggagag ctcaatgcag aactacccat
     1681 ccaccagaag cccttctctg tccagccact cgggcctcac caccacctgc tgctcccgcc
     1741 gtagcaagaa gaccacgcac ctgcccaact ccaacctgcc ggccacccgc ctgcgcagca
     1801 tgcaagagct cagcaccatc cacatccagg gcagtgagca gccctccctc accactagtc
     1861 gctccagcct taatttgaaa gcagacgacg gactgagacc aaactgcaaa acatcccaga
     1921 ttacaacagc catcatcagc atccctactc ccccagctct aaccccagag ggagaaagtc
     1981 ggccaccccc tgccagccca ggtcccaaca cgaacattcc ttccataacc agcaatgttg
     2041 tcaaggtctc tgccttgtaa aaacactgga cagagggcct gagggggtag tggggagtaa
     2101 agggggctgg catgttggtg ggtggccact gggaccactc cctcccacta tttctgcctg
     2161 ccccattgca cctccagcac tgagacttgt gcctggaagg gaaaggaaac agcaaagggt
     2221 acccaaggat ccccctgctg gagtggacat agccctgtga cattgcatct tactggggcc
     2281 agaggaaggg agggggtggg taggggattg gccattaggg ggtgcaggct gcttgcctgg
     2341 acagggcctg gtgggggtac ctcagaccaa ataacagttg tttctggaga ccccagtgag
     2401 gaaaacacaa gaccaagagc agcccagagg ccgagtcgtc acatgcaaac aggaagaaat
     2461 tataacactg tgtatttaag cacctttttc aaggatctta atggataata tttattcatg
     2521 ggaaaaggtg gaaaacaaaa tcatcaatgg atattcgtga aatgtttttc tccacgaacc
     2581 caacaccttt aaaccaaaac aatgcatttt gtgaggttgg tttttatttt tcttctttta
     2641 tagcaaaagc ttttaggctc aaagtcagtt actgctgagt tctctcccca ttccctggat
     2701 gggtgaggtc accttagccg ggccctcact gcccagctga cctgcacaga actgtcaagc
     2761 aaccacacag caaaccttct gctccgttgg tccgtccgtc tcctttgtct ctgtacctat
     2821 ctgcttcacc ttggctgttt ctgtgtccaa ccatctgtct cgccgtggac agtaaatcct
     2881 tctccgtcac tgccaagtac tgcagacttg tgcctggggt caggccgagt gaatgccaat
     2941 acagaaaaga aaggaagcca gtgggctgag tttaagggtg aggtaagtct atattatgaa
     3001 cagaggtgct tcccttttaa ttggaaccac ttatctttgc agtttaggtg ggggggtggt
     3061 cttgaaattg aaatcagcaa cctcagaaag cagttgtttc tgctatgccc caatgaagac
     3121 agaagcacca agaagctccc acagttccag agcgccttgc tgtgtaccct cctttaggat
     3181 ccaccatgaa gtccatgcgg agctctgcca agaggcttca tgagcatctt caagtgagga
     3241 ggatgggagg agaccctggc ttaccaccca aggcggttcc taaatagaac tgtgaaagtt
     3301 aagcttgtgt atctcatgaa gaatgtttca aagcaagaaa gcaagcaaga ggctctagat
     3361 gatcattgcc tggtctaaaa gatgccttga ggtctgagcc ctcatctctg aagatagcta
     3421 atgtgtggaa ccactgatga cctccacaca aatgagggag tgcagattat atcctgaaaa
     3481 tgtggatatg tttgttcaag ttatttgcag ggtagtgggc ctgggaaaca gtgtttctgg
     3541 aatcttccta atcattttca ccacttcaca gcagagcaag tgagcctcag ggttagtgac
     3601 aagagtcctt tcctgccctt ctcaacccca aatactctat tgcagtctct gaagcctagg
     3661 atctgaggca catgagctgt ttggaatttc ttacccattc tacagctgtt taaaataaag
     3721 ataagctgtt catttacagc tcaaactctc tctacccact acagccatct agatgagttt
     3781 taactagaca gcggttaacc tgaggacact catggggctt cctggttcca gccccagtga
     3841 ccctgaatgc agaggagtcc tggtgttttg aagcggtacc aaaccagaaa gtggctagaa
     3901 gggtggaaga aaggggccct tccttccatg tttgtctccc tgtcttcatc ctcagtggcc
     3961 cgacagtcct ttctcctaga cctggcctca agatttcccc ttataggaat ggagtggttc
     4021 ttccaatcta gtaacttcag acatatttta gcagccaagg catagagcca agctagaccc
     4081 aattttagca ggtaggccaa gtagtagaag agaatcttcc ttttgaagag tggatcatgg
     4141 aacaaaggaa tgtctagttg catgataagc cctaagagct gagtggaata aggagaagag
     4201 ttgaaaagga acacttgaat tctcatacaa accaccgttc tatttcagaa caagtcgtta
     4261 gagagttaga ataatggctg cttcaaccaa ggatctccat gtcacttgaa cagtgcacca
     4321 acgcagcata ctgtgcttct catgaaaaga aatatatttt aaaacctgca cctccaaaat
     4381 tccattttta ctgacttcag agacctgaat cttgtgttgt ttctatttca tctccaaagc
     4441 ccatatcatg ccagctccta aaaataatca ttaaactgtc tgcattttca ttcccccatt
     4501 ttagtcttga caagagataa ggaacccaac tcacctatgc tcaaagatac caacccaaga
     4561 aaacagctca cagccatatc tgctaaaggg gattcacggg gaagcacagc ggcaaaactt
     4621 cgatcaactt agtaaatctg attcatcagc tagtaaggca acaaccagga taccacgttc
     4681 ttctggagac caagagctct ctgatgcaat gactcacggt gtacaaacca tgttagggta
     4741 tcagtaaatt ccccactcca ccactccatt caaccttact tagcattggt gatgaaaaaa
     4801 agaaaaggac aaaaaaaaaa aaaagactaa gactacactc aaataataaa tgaaaataac
     4861 ttggaaaata cagtattgag catatgagaa attaaaagac taattcattt tacagtgtag
     4921 aaagctaaga tgcagagaag ttgataccat caaggcaata tagtctttaa ggatagaata
     4981 gggaccagag cacaagactc tttggctact ggtctaatgt ggtttggttt ggtttggttt
     5041 tgaggttttt catcacacct cttgcctcac agagctacta tgttggagaa gaaccatcaa
     5101 agttgccatg tcataaggag acactcatgt gtaaatgtca acatgacttg atatagctct
     5161 tggaaatcac ctgactgtac tagtacaaat tataaactta gaaacagtgt ttcttgtgta
     5221 gagccagcca tgggtgatca cttctctaag aagtagatga acaagcgaat gcccaagatc
     5281 tttcaggcaa acgtttgact ttctcaatga ggaggaggct tggacgatga catttcaaag
     5341 catactattg cttctcacta caatctgtga agaagtcacc ttagtaaatt tttgattcag
     5401 agagaagaaa tgggcacaaa gaagctggat gcctcactca aggtttcaca gcacgcgagt
     5461 ggcaaaatta tgatttgatc caagacgtgg gtcctgggag tgtcttctat atcctgctcc
     5521 attgctctaa ggcttgctca tttttaaaag ccagatttca agagtgttga ttaggggaag
     5581 gaagcattcc tgaattagca ggacctcctg aaatacacca ttattctgtc ctcattccca
     5641 gttttcctaa ctagtctcaa gctcaggact aactgtacag aacctctttc aaaagaccag
     5701 tagatagtct caacagttga acattcctag tgtatgacca cattgatcag atgttaagga
     5761 agtggtggat gatgtcaact ctgcagttga cagaagtcac atacagaact gtggaggact
     5821 ttatacagtt gttttctctg cagttcagga tcgtgacctt ttcttgtccg aaagcaagta
     5881 gggaaagtac ctgggagcat tatatgccta gatcattttc cttgtctttt taaaaatagc
     5941 agtagtgact gaaattgaac tagcattaga tttgaaattg ttaatggatt ctagtgattc
     6001 aggctccctc atttcaatta ctaggtaact aagtaaggca gaaggatccc aatactgttc
     6061 atttgaagta atagcttccc tttcatgcta gctagcatgg taaccaccat aagaggaaca
     6121 ggagacactt ttatatttcc tctaaagaat tctcattact tgcaaagctt taaagtgatg
     6181 ggataaagga aaaacagtca tgacccatga cacttggagg ccaaacagta tcaggaaaag
     6241 cattagaacc aagggaaagt ggctttgaaa caaaatggct ttttaaaggg gttccttgtg
     6301 ggtcttgttt tttattcagg atattctacg tttctcatca aatgttggaa tgacatttat
     6361 cttagcaggt tcttaaactg tgctggctga taacacatta gccagtgcag ggcacagacc
     6421 caagtcctag gggactcctt ggaccaatgg actattttac aaaccaggga ggtgggaggg
     6481 atggtatatt tttgataacc agacattcca atgttttcct tagaggtcat gcgctcccat
     6541 taatgttctt gtggaaaaca tcaagtgtgt tcttttctat tttcgtataa ttattgggct
     6601 ttgcttacca acatcacact ggcaaagaaa tacattgtat aaaactgcag gaagacaaat
     6661 gtgaaaactt tctgtgggga aaaagctctt aagtttcttg tcttctttga aactgtagtg
     6721 caaatgttat aacatgcata tcatttacag tattgagtcc tgtgccactg ctgtacctga
     6781 tgtatccaac ctggattaaa caaactatgt gccacaag
//
