LOCUS       NM_031730               4018 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily D
            member 2 (Kcnd2), mRNA.
ACCESSION   NM_031730
VERSION     NM_031730.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4018)
  AUTHORS   Ye,W., Zhao,H., Dai,Y., Wang,Y., Lo,Y.H., Jan,L.Y. and Lee,C.H.
  TITLE     Activation and closed-state inactivation mechanisms of the human
            voltage-gated KV4 channel complexes
  JOURNAL   Mol Cell 82 (13), 2427-2442 (2022)
   PUBMED   35597238
REFERENCE   2  (bases 1 to 4018)
  AUTHORS   Shimaoka,T., Wang,Y., Morishima,M., Miyamoto,S. and Ono,K.
  TITLE     Magnesium Deficiency Causes Transcriptional Downregulation of
            Kir2.1 and Kv4.2 Channels in Cardiomyocytes Resulting in QT
            Interval Prolongation
  JOURNAL   Circ J 84 (8), 1244-1253 (2020)
   PUBMED   32554946
  REMARK    GeneRIF: Magnesium Deficiency Causes Transcriptional Downregulation
            of Kir2.1 and Kv4.2 Channels in Cardiomyocytes Resulting in QT
            Interval Prolongation.
REFERENCE   3  (bases 1 to 4018)
  AUTHORS   Alday,A., Ahyayauch,H., Fernandez-Lopez,V., Echeazarra,L.,
            Urrutia,J., Casis,O. and Gallego,M.
  TITLE     CaMKII Modulates the Cardiac Transient Outward K+ Current through
            its Association with Kv4 Channels in Non-Caveolar Membrane Rafts
  JOURNAL   Cell Physiol Biochem 54 (1), 27-39 (2020)
   PUBMED   31935048
  REMARK    GeneRIF: Immunogold staining and electron microscopy of heart
            vibrosections was performed to localize Kv4.2/Kv4.3 and
            Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) proteins.
            Patch-Clamp recordings in control conditions and after lipid raft
            or caveolae disruption show that the CaMKII-Kv4 channel complex
            must associate in non-caveolar lipid rafts to be functional.
REFERENCE   4  (bases 1 to 4018)
  AUTHORS   Kashino,Y., Obara,Y., Okamoto,Y., Saneyoshi,T., Hayashi,Y. and
            Ishii,K.
  TITLE     ERK5 Phosphorylates Kv4.2 and Inhibits Inactivation of the A-Type
            Current in PC12 Cells
  JOURNAL   Int J Mol Sci 19 (7), 2008 (2018)
   PUBMED   29996472
  REMARK    GeneRIF: Study revealed that ERK5 signaling promotes
            phosphorylation of Kv4.2 and inhibits the inactivation of the
            A-type current for the enhancement of membrane excitability in PC12
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4018)
  AUTHORS   Liu,X., Shi,S., Yang,H., Qu,C., Chen,Y., Liang,J. and Yang,B.
  TITLE     The activation of N-methyl-d-aspartate receptors downregulates
            transient outward potassium and L-type calcium currents in rat
            models of depression
  JOURNAL   Am J Physiol Cell Physiol 313 (2), C187-C196 (2017)
   PUBMED   28566490
  REMARK    GeneRIF: NMDA reduced both currents in a concentration-dependent
            manner, whereas there was no significant impact on the currents
            when perfused with MK-801. MDD rats exhibited significantly more
            fibrosis areas in heart tissue and reduced expression of Kv4.2,
            Kv4.3, and Cav1.2.
REFERENCE   6  (bases 1 to 4018)
  AUTHORS   Alonso,G. and Widmer,H.
  TITLE     Clustering of KV4.2 potassium channels in postsynaptic membrane of
            rat supraoptic neurons: an ultrastructural study
  JOURNAL   Neuroscience 77 (3), 617-621 (1997)
   PUBMED   9070739
REFERENCE   7  (bases 1 to 4018)
  AUTHORS   Sanguinetti,M.C., Johnson,J.H., Hammerland,L.G., Kelbaugh,P.R.,
            Volkmann,R.A., Saccomano,N.A. and Mueller,A.L.
  TITLE     Heteropodatoxins: peptides isolated from spider venom that block
            Kv4.2 potassium channels
  JOURNAL   Mol Pharmacol 51 (3), 491-498 (1997)
   PUBMED   9058605
REFERENCE   8  (bases 1 to 4018)
  AUTHORS   Blair,T.A., Roberds,S.L., Tamkun,M.M. and Hartshorne,R.P.
  TITLE     Functional characterization of RK5, a voltage-gated K+ channel
            cloned from the rat cardiovascular system
  JOURNAL   FEBS Lett 295 (1-3), 211-213 (1991)
   PUBMED   1722463
REFERENCE   9  (bases 1 to 4018)
  AUTHORS   Baldwin,T.J., Tsaur,M.L., Lopez,G.A., Jan,Y.N. and Jan,L.Y.
  TITLE     Characterization of a mammalian cDNA for an inactivating
            voltage-sensitive K+ channel
  JOURNAL   Neuron 7 (3), 471-483 (1991)
   PUBMED   1840649
REFERENCE   10 (bases 1 to 4018)
  AUTHORS   Roberds,S.L. and Tamkun,M.M.
  TITLE     Cloning and tissue-specific expression of five voltage-gated
            potassium channel cDNAs expressed in rat heart
  JOURNAL   Proc Natl Acad Sci U S A 88 (5), 1798-1802 (1991)
   PUBMED   1705709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1, M59980.1, CO393575.1 and CB790894.1.
            
            On Oct 4, 2005 this sequence version replaced NM_031730.1.
            
            Sequence Note: This RefSeq record was created using sequences from
            two different strains, BN/SsNHsdMCW and Sprague-Dawley, because no
            single transcript from the same strain was available for the full
            length of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M59980.1, SRR26643298.21975.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               JAXUCZ010000004.1  50742485-50742828
            345-1725            M59980.1           24-1404
            1726-2119           CO393575.1         287-680
            2120-2416           CB790894.1         91-387
            2417-4018           JAXUCZ010000004.1  51241939-51243540
FEATURES             Location/Qualifiers
     source          1..4018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..4018
                     /gene="Kcnd2"
                     /gene_synonym="Kv4.2; RK5; Shal1"
                     /note="potassium voltage-gated channel subfamily D member
                     2"
                     /db_xref="GeneID:65180"
                     /db_xref="RGD:68393"
     exon            1..1668
                     /gene="Kcnd2"
                     /gene_synonym="Kv4.2; RK5; Shal1"
                     /inference="alignment:Splign:2.1.0"
     CDS             554..2446
                     /gene="Kcnd2"
                     /gene_synonym="Kv4.2; RK5; Shal1"
                     /note="potassium voltage gated channel, Shal-related
                     family, member 2; potassium channel, voltage-gated
                     Shal-related subfamily D, member 2; voltage-gated
                     potassium channel subunit Kv4.2; potassium voltage-gated
                     channel, Shal-related subfamily, member 2"
                     /codon_start=1
                     /product="A-type voltage-gated potassium channel KCND2"
                     /protein_id="NP_113918.2"
                     /db_xref="GeneID:65180"
                     /db_xref="RGD:68393"
                     /translation="MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIV
                     LNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTG
                     KLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDNTGES
                     ALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKE
                     LPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIG
                     LVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMA
                     IIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSL
                     SGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRN
                     GLLSNQLQSSEDEPAFVSKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVAT
                     VNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRIPNANVSGSHRGSVQELSTIQIRCVER
                     TPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIPTPPVTTPEGDDRPESPEYSGGNI
                     VRVSAL"
     exon            1669..1831
                     /gene="Kcnd2"
                     /gene_synonym="Kv4.2; RK5; Shal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1927
                     /gene="Kcnd2"
                     /gene_synonym="Kv4.2; RK5; Shal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2020
                     /gene="Kcnd2"
                     /gene_synonym="Kv4.2; RK5; Shal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2268
                     /gene="Kcnd2"
                     /gene_synonym="Kv4.2; RK5; Shal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..4018
                     /gene="Kcnd2"
                     /gene_synonym="Kv4.2; RK5; Shal1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcggctg tgaccgcatt tctggagcta caacaacagg tcgtcttttt gagacgcctt
       61 tggcgggaag gaccacttca gcagaagggg aaggtgaaaa ggttctttct tttaagagac
      121 taccactggt tgactttccc tgtttcctct cacctgctct atataccgac cctgtatcaa
      181 ccagactgta tcaggggaga agtgaagaca cctgtttgaa gcaaggctgt ctctaaagtc
      241 acctgtgcgt ttagatgtgc caggaggtgc cctggtccaa ctgttggcag agctttgttt
      301 aggctctatg gagagagatt tttaggtcac tgtatttttt ttttctctct tagtattcca
      361 aatacttgtc tgtgagagaa atctggcttt ttgggtactg tgacttcacc tgcgccacct
      421 tggaataacc gtgttcctgt gagccgtgtt ccccagtgtt ttgtctgagg tgaagaagtg
      481 gggcattttg ttactttcat tgtgttactt tgggtgaccc ctgatcactc ttgtgacctc
      541 tacttcagac aacatggcag ccggtgttgc agcatggcta ccctttgcca gggcagccgc
      601 cattgggtgg atgcctgttg cctccgggcc tatgccagct cccccaaggc aggagagaaa
      661 aaggactcag gacgctctaa ttgtgctgaa cgtgagtggc acccgtttcc agacatggca
      721 agacaccctg gaacgatacc cagacactct gctgggcagt tccgagagag actttttcta
      781 ccacccagag acccaacaat atttctttga ccgtgaccca gacatcttcc gccacatcct
      841 caacttctac cgcacgggga agcttcacta tccccgccat gagtgcatct cggcttatga
      901 tgaagaattg gccttctttg gcctcatccc agaaattatt ggcgactgct gttatgagga
      961 gtacaaggac cgcaggcggg agaatgcaga gcgcctccag gatgatgcag acactgacaa
     1021 tacaggagag agtgctctgc ccaccatgac tgctaggcag agggtctgga gggcctttga
     1081 gaacccccac accagcacca tggccctggt gttctactat gtgaccgggt tcttcattgc
     1141 cgtctcagtc atcgcgaatg tggtggaaac agttccatgt gggtctagcc caggccacat
     1201 aaaagaactg ccttgtgggg aaaggtatgc agtggccttc ttctgcttgg ataccgcctg
     1261 tgtcatgatc tttacggttg agtacttgct acgcctggcc gcagcgccta gtcgttaccg
     1321 ttttgtgcgc agtgtcatga gtatcatcga tgtggtggcc atcctaccct attacattgg
     1381 gctggtgatg acagacaatg aggatgtcag tggcgccttt gtcacactcc gagtctttcg
     1441 agtcttcagg atctttaagt tttcccgcca ctctcaaggc ctgcgtatac tggggtacac
     1501 actgaagagc tgtgcgtcag aactgggctt cttgctcttt tccctcacaa tggctatcat
     1561 cattttcgct acggttatgt tctacgcaga gaagggctct tcagcaagca agttcaccag
     1621 catccctgca gccttctggt acaccatcgt caccatgaca acactggggt atggcgacat
     1681 ggtaccaaaa accatagcag ggaagatttt cgggtctatc tgctctctga gcggagtctt
     1741 ggtcatcgcg ctacccgtgc ctgtgatcgt gtctaacttc agtcggatct accaccaaaa
     1801 ccaacgagcg gacaaacgaa gggcacagaa gaaagcgagg ctggccagga tccgggcagc
     1861 caaaagtgga agtgcaaatg cctacatgca gagcaagcgg aatgggttac tgagcaacca
     1921 actgcagtcc tcggaggatg aaccggcctt cgttagcaaa tctggatcca gcttcgagac
     1981 acaacaccac cacctgcttc actgcctgga gaaaaccacg aaccatgagt ttgtggatga
     2041 acaagtcttt gaagaaagct gcatggaagt ggccactgtt aatcgccctt caagtcacag
     2101 cccctccctc tcttcccaac aaggagtcac cagcacttgc tgctcacgga gacacaaaaa
     2161 aactttccga atcccaaatg ccaatgtgtc aggaagtcat agaggcagcg tgcaagaact
     2221 cagtacaatt cagatcagat gtgtggagag aactccacta tccaacagcc gatccagctt
     2281 aaatgccaaa atggaagagt gtgtcaaact aaactgtgaa caaccttacg tgaccacagc
     2341 aataattagc attccaacac ctccagtaac caccccagaa ggcgacgaca ggcccgagtc
     2401 tcctgagtat tcgggaggaa acatcgtcag ggtgtctgct ttgtaagaca attggcacag
     2461 gtctgagagc atgggagccc tgactatgga aagaatctaa aggagaagaa agaagaaata
     2521 acaacccctt tttgcatatt aagacagcca agcaagaagg ttggcgatga gacaaaaaaa
     2581 ataaaaatga agatatcaga gatgaagatg tgaattaaac cactgaaagg catttctaga
     2641 cagcattcga ccggaccaca gagggtgcca ctgtggctct ttgactttgt gaatgagcac
     2701 aatgaaatgc catctgttga tgcctcttat gatcagaact cttttttaat aaaacaaata
     2761 aaatgaatct ttggacataa tgtgccagtt gaatgcaaaa caaaaaaatt atggaaaaca
     2821 ttttgataaa aatttttcct gttgacaacc atgaacattg gctctggtga agactactgt
     2881 cgatgagaaa actcacagga tccatttgtg tggactgaag gaaaccatcc taatgcatgc
     2941 tagaattctt tggagcagtg atctcagttt ccttatgtcg tcttcagaat aggcatgaca
     3001 aactctacct gtagaaaggg gaaatttctg tgcacttaca atgagctgac tgcccaggtt
     3061 ctatggttgg gctgtgcaaa taaactcctt ttagcactgc agtgtttctc atggggatgc
     3121 acactagtaa aatctaaagt gttcggatag ttcagtatta attattgttt aaccttgcac
     3181 ctggtcattg ttataactgc aataattcat tctatatctg ttgtatcagg aatcaggatt
     3241 ttctttcata tccatagatt catagataca gttagagcca cattcacaga aacattcctg
     3301 ctgtggccgg gttttaggtg acttcttaat ccgaaactat tgtgtcataa atgttttttg
     3361 gtagtattct ttggtccact gtattcctgt gacccagtgc attatctgtc cctggatctc
     3421 tctagtgtct ttctactggg cttacccatt aatgacagga ttagtgttta ctgtagttat
     3481 aaaacaaaag attcctgcct ttgtatctcc caaccagatg ttacaaaaag actgtcatca
     3541 atccccttga taaaaactag agtaaaggag ttgacatgaa atatctctag tgttttcact
     3601 acttatagaa aatccagacc ctacaaacac ccatatgggt tttgggaagg agttagatgg
     3661 tactttaaaa aaacaaaaaa tcacaggatg ggtgatttca gaatctaatt caatgtatta
     3721 ttttgcttca gatcttcaat acattttgag atcaactgaa atgcagaggt aaactgaagt
     3781 gctttgtgta ccaatatttg atgagagcat gcttttaatg acatccaagg aagcaacaat
     3841 gtatcttaga agagtctagt gtatcacaag gcacaaagtt ctctgcaaaa aatcaagaag
     3901 aaggagtgtg atgaagttga ccactatgta catttaagtg aaaagtcttg ctaccttttc
     3961 acccttgaat atccgcagat gtgtctgcac gtgatggtgt aaaaataaaa ataaaaaa
//
