LOCUS       NM_001415110            4318 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily C
            member 4 (Kcnc4), transcript variant 1, mRNA.
ACCESSION   NM_001415110 XM_039103130
VERSION     NM_001415110.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4318)
  AUTHORS   Zemel,B.M., Zhi,L., Brown,E.V., Tymanskyj,S.R., Liang,Q. and
            Covarrubias,M.
  TITLE     PKCepsilon associates with the Kv3.4 channel to promote its
            expression in a kinase activity-dependent manner
  JOURNAL   FASEB J 35 (1), e21241 (2021)
   PUBMED   33368632
  REMARK    GeneRIF: PKCepsilon associates with the Kv3.4 channel to promote
            its expression in a kinase activity-dependent manner.
REFERENCE   2  (bases 1 to 4318)
  AUTHORS   Ritter,D.M., Zemel,B.M., Lepore,A.C. and Covarrubias,M.
  TITLE     Kv3.4 channel function and dysfunction in nociceptors
  JOURNAL   Channels (Austin) 9 (4), 209-217 (2015)
   PUBMED   26039360
  REMARK    GeneRIF: Data indicate ubiquitous expression of Kv3.4 potassium
            channel protein in nociceptors.
            Erratum:[doi: 10.1523/JNEUROSCI.1594-14.2015]
REFERENCE   3  (bases 1 to 4318)
  AUTHORS   Huang,C.Y., Chu,D., Hwang,W.C. and Tsaur,M.L.
  TITLE     Coexpression of high-voltage-activated ion channels Kv3.4 and
            Cav1.2 in pioneer axons during pathfinding in the developing rat
            forebrain
  JOURNAL   J Comp Neurol 520 (16), 3650-3672 (2012)
   PUBMED   22473424
REFERENCE   4  (bases 1 to 4318)
  AUTHORS   Kanda,V.A., Lewis,A., Xu,X. and Abbott,G.W.
  TITLE     KCNE1 and KCNE2 provide a checkpoint governing voltage-gated
            potassium channel alpha-subunit composition
  JOURNAL   Biophys J 101 (6), 1364-1375 (2011)
   PUBMED   21943417
REFERENCE   5  (bases 1 to 4318)
  AUTHORS   Kanda,V.A., Lewis,A., Xu,X. and Abbott,G.W.
  TITLE     KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type
            voltage-gated potassium channels
  JOURNAL   Biophys J 101 (6), 1354-1363 (2011)
   PUBMED   21943416
REFERENCE   6  (bases 1 to 4318)
  AUTHORS   Baranauskas,G., Tkatch,T., Nagata,K., Yeh,J.Z. and Surmeier,D.J.
  TITLE     Kv3.4 subunits enhance the repolarizing efficiency of Kv3.1
            channels in fast-spiking neurons
  JOURNAL   Nat Neurosci 6 (3), 258-266 (2003)
   PUBMED   12592408
REFERENCE   7  (bases 1 to 4318)
  AUTHORS   Antz,C., Bauer,T., Kalbacher,H., Frank,R., Covarrubias,M.,
            Kalbitzer,H.R., Ruppersberg,J.P., Baukrowitz,T. and Fakler,B.
  TITLE     Control of K+ channel gating by protein phosphorylation: structural
            switches of the inactivation gate
  JOURNAL   Nat Struct Biol 6 (2), 146-150 (1999)
   PUBMED   10048926
REFERENCE   8  (bases 1 to 4318)
  AUTHORS   Antz,C., Geyer,M., Fakler,B., Schott,M.K., Guy,H.R., Frank,R.,
            Ruppersberg,J.P. and Kalbitzer,H.R.
  TITLE     NMR structure of inactivation gates from mammalian
            voltage-dependent potassium channels
  JOURNAL   Nature 385 (6613), 272-275 (1997)
   PUBMED   9000078
REFERENCE   9  (bases 1 to 4318)
  AUTHORS   Rettig,J., Wunder,F., Stocker,M., Lichtinghagen,R., Mastiaux,F.,
            Beckh,S., Kues,W., Pedarzani,P., Schroter,K.H., Ruppersberg,J.P. et
            al.
  TITLE     Characterization of a Shaw-related potassium channel family in rat
            brain
  JOURNAL   EMBO J 11 (7), 2473-2486 (1992)
   PUBMED   1378392
REFERENCE   10 (bases 1 to 4318)
  AUTHORS   Schroter,K.H., Ruppersberg,J.P., Wunder,F., Rettig,J., Stocker,M.
            and Pongs,O.
  TITLE     Cloning and functional expression of a TEA-sensitive A-type
            potassium channel from rat brain
  JOURNAL   FEBS Lett 278 (2), 211-216 (1991)
   PUBMED   1840526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 21, 2022 this sequence version replaced XM_039103130.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.12908.1,
                                           SRR26643295.10739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840122 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2091              JAXUCZ010000002.1  197786343-197788433 c
            2092-3028           JAXUCZ010000002.1  197776027-197776963 c
            3029-3232           JAXUCZ010000002.1  197773932-197774135 c
            3233-4318           JAXUCZ010000002.1  197766650-197767735 c
FEATURES             Location/Qualifiers
     source          1..4318
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4318
                     /gene="Kcnc4"
                     /note="potassium voltage-gated channel subfamily C member
                     4"
                     /db_xref="GeneID:684516"
                     /db_xref="RGD:1589169"
     exon            1..2091
                     /gene="Kcnc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1411..3294
                     /gene="Kcnc4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potassium voltage-gated channel subfamily C member 4
                     (Voltage-gated potassium channel subunit Kv3.4) (Raw3);
                     raw3; voltage-gated potassium channel subunit Kv3.4;
                     potassium voltage gated channel, Shaw-related subfamily,
                     member 4; potassium channel, voltage gated Shaw-related
                     subfamily C, member 4; voltage-gated potassium channel
                     KCNC4"
                     /codon_start=1
                     /product="voltage-gated potassium channel KCNC4 isoform 1"
                     /protein_id="NP_001402039.1"
                     /db_xref="GeneID:684516"
                     /db_xref="RGD:1589169"
                     /translation="MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGG
                     TRHETYRSTLRTLPGTRLAWLADPDGGGRPESDGGGAGSSGSSGGGGGCEFFFDRHPG
                     VFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALD
                     IFESPDGGGGGAGPGDEAGDDERELALQRLGPHEGGSGPGAGSGGCRGWQPRMWALFE
                     DPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIHRVGNITSVRFRREV
                     ETEPILTYIEGVCVMWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSG
                     LSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG
                     VLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSG
                     MLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPPQLESPIY
                     CKSEETSPRDSTYSDTSPPAREEGMVERKRADSKQNGDANAVLSDEEGAGLTQPLASA
                     PTPEERRALRRSGTRDRNKKAAACFLLSAGDYACADGSVRKETCQDALSSNYAHAEVL
                     TLS"
     exon            2092..3028
                     /gene="Kcnc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3232
                     /gene="Kcnc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..4318
                     /gene="Kcnc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actggctgct agcgggttac gcgcctccgc tgggctggga tgcgcggatg aaggctgagc
       61 tttgctgccg gagctccgca acgccccagg tctgccttgc gccttgccgc gcccaccccg
      121 ccccccggag ggcgcgcccg ggtcaagcga ggccgagagg aaaaggcgcc acttggagcg
      181 tcgcatcctc tgtcatcgcg ggagggagtc gcagaaacct ctgagcccca ttcctctggc
      241 gcccaggcgc tcccatccct agaccacctc gcgcccgccc ctagcaagga gccaaggccg
      301 gcgccccgcc cggagatggg cagacgcgca gatggcgcgg ctcccggcgc cgccagatcg
      361 caggaacccg gcgccggggc gctgcgctga ggctccctct tggagcggcc tcggaagcct
      421 gcaggtgtcc ttgaccattc ggccaccgcc cgggacactc ctccgccagc actgggtgcc
      481 tggctcttca gagcagcccc gccctccagg ctctgcgccg cgcaggacgc cccgtctgaa
      541 tccccccctc cccgtcccgg cgcggccccc gcagcgctgc acccagcccc gcgcagctcc
      601 cggccgcgga cgcaggaccc aggctcgctg cagcgggcgc gcttgttttc ctgtcgcctg
      661 gtcctgcgca gctcccaccc gctggtccgt ctcgctcggc tcagccccgc ccgccatcgg
      721 tgctccgcgc tggatttatg aatgggggca acaggccaca tgcccgccac cgccgcctcg
      781 aattgaccgc acactgcccg gccccgcaga gctctggcta ccgtaagaac atccgcctgg
      841 ccccggtagc cactccgaag acttgttgct gttacgctgc tgcctccgcc gctgccgccg
      901 cccggagaaa ccctgccgcg tccaggctcg ccgggttcta ggagccaaaa ggtggcccgt
      961 gtgagtgtga gcgagcgagc gcgctgcgga ccctggcagt gctctgggac tgtgcgcttc
     1021 tctgtctttc tggggttggg gggggcgtgt ccccggcccg gagcatcctt gtgcttgcct
     1081 caaccttctg agaccccgga ccccttggat tgagtcctcg accctggtct tcacctcctg
     1141 cctcccctag gttcttcctg ccaaatccca accacctgtg caccacaaaa agccaactct
     1201 tcctgctccg agccccgggg gggtggggtg ggggggaggc aggggcagag ccactctgca
     1261 gaaggggccg ccaccacctc ctgcctcctc ctcctccacc acctcctcct ccttctcgtc
     1321 tcctccccct ccccgttctg acgctgcctc cttgggaagg gtgtttggag ggcagcggcc
     1381 gccccaagcc ggagccccgc agcgcttctt atgatcagct cggtgtgtgt ctcctcctac
     1441 cgcgggcgca agtcggggaa caagcctccg tccaaaacat gtctgaagga ggagatggcc
     1501 aagggcgagg cgtcggagaa gatcatcatc aacgtgggcg gcacgcgaca tgagacctac
     1561 cgcagcaccc tgcgcaccct accgggcacc cgccttgcct ggctggcgga tcccgacggc
     1621 gggggtcggc cagagtcgga tggcggcggt gcaggcagca gcggcagcag cggcggcggc
     1681 gggggctgtg agttcttctt tgatcggcac ccgggtgttt ttgcctatgt gctcaactac
     1741 taccgcacgg gcaagctgca ttgccccgca gacgtctgtg ggcctctctt tgaggaagag
     1801 ctcactttct ggggtatcga tgagacagat gtggaaccct gctgctggat gacctaccgg
     1861 cagcaccgcg atgctgaaga ggcactggac atcttcgaga gcccggacgg gggcgggggt
     1921 ggcgcagggc ccggcgacga ggctggagac gatgagcggg agttggcctt gcagcgcctg
     1981 ggcccccatg aaggaggctc tggccctggt gctgggtccg ggggttgccg tggctggcag
     2041 ccccgaatgt gggcgctctt cgaggatccg tactcatccc gggcggccag ggtggtagcc
     2101 tttgcctctc tcttcttcat cttggtctcc attaccacct tctgcctgga gacccacgag
     2161 gccttcaaca ttgaccgaaa tgtgacggag atccaccggg tagggaatat caccagcgtg
     2221 cgcttccggc gggaggtaga aacagaaccc attcttacct acatcgaggg cgtgtgcgtg
     2281 atgtggttca ctctagagtt cctggttcgc attgtgtgct gccctgatac gttggacttt
     2341 gtcaagaacc tgctcaacat catcgacttt gtggccatct tgccctttta cctggaggtg
     2401 ggattgagtg gcctgtcatc caaggcagct cgagatgtgc tgggtttcct gcgtgtggtg
     2461 cgctttgtac gcatcctgcg gatcttcaag ctcacacgcc actttgtggg gctgcgtgtg
     2521 ctcggccaca cactccgggc cagcaccaac gagttcctgc tgcttatcat cttcctggcc
     2581 ctgggtgtgc tcatctttgc caccatgatc tattatgctg agcgaatcgg ggccaggcca
     2641 tctgacccac ggggcaatga ccacaccgac ttcaagaaca tccccatcgg tttctggtgg
     2701 gctgtggtca ccatgacaac gcttggctat ggggacatgt atcctaagac atggtcagga
     2761 atgctggtgg gtgcgctgtg tgcactggct ggtgtgctaa ccattgccat gcctgtgcct
     2821 gtcatcgtca ataactttgg tatgtactac tccctggcta tggccaagca gaagcttccc
     2881 aagaaacgaa agaagcatgt accacggcca ccccagcttg agtcacccat ttactgcaag
     2941 tctgaggaga cttcaccccg ggacagcacc tacagtgaca ccagcccccc tgcccgggaa
     3001 gagggtatgg tcgagaggaa acgagcagac tccaagcaga atggtgacgc taatgcggtg
     3061 ctgtccgatg aggagggagc tggcctcacc cagcccctgg cctcggcccc cacccctgaa
     3121 gagcgtcgag ccctgagacg ctcaggcaca cgggacagaa acaagaaggc agctgcctgc
     3181 ttcctgctca gtgctgggga ctatgcctgt gctgatggca gtgtccggaa agagacctgc
     3241 caagacgccc tctcgtccaa ctatgcccat gctgaagtcc tcaccctctc ttagagcggc
     3301 accaacgtga gaaagacaga cagacagaaa gccagaggct taggaaaact ctggaaccca
     3361 ggcacgaatc ttttgctggg aaagatatcc ttgtttgcac aagactggtg gaaaaatctc
     3421 ccatgcaact ctcagggccc agagccatct gggtctgata ctctgttcta ctgtacattg
     3481 aagagacata tatgcacata tagtatctat attcatacat actatatact cttgtgtgta
     3541 gtgcacgtgc tactggtggt ctgtcttcat cgttaggcta tgtctcccaa gtcctctgcc
     3601 caccctgttt ccccaccccc tcttccttca tggattgttt cttctgacca tgtttttgga
     3661 gtgtcccagg agaggtatac ctgggacctg cccctccagc tgggtggtcc caggctgctc
     3721 tcacttgggg gtgtcccctg ccagcaggtg gcctgctgaa gtcagttgaa ggcacgattg
     3781 cccttctggg gtcactgctt cactagccca accccacccc agattggggt tctacctccc
     3841 accccacacc ccagtttggg gggcactttt gcagcctctg tcactccttc cggcgcccct
     3901 tctgtgtcgg tgacagaggg gagtttcatt tcttttgtgc gtctcctttg tccatttctt
     3961 ttcaaagatg ctgctgggca gatggaaggg atctgtttgc ccatctggct caggggtctg
     4021 agaaggggac accttgggca agaggagacc agctgcaata ctgtacttcc tggccagtgg
     4081 ccagaggatg cgtgcaatag cagaggccag gtgacccctt cagccttggc ctctgcccct
     4141 ccctcggccc ttcctgccca cccttggtat tggtcagtcc ttttctaaag ctgtcccctt
     4201 gtgtgtgtct gaggcacgcc taggctgggc ccactgtgcc ctgtctgcat gccctccact
     4261 gtcatgctgt gctcgagtac caataaagac atctgagtgt cctgctgctc ctctgtga
//
