LOCUS       NM_053997               5268 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily C
            member 3 (Kcnc3), mRNA.
ACCESSION   NM_053997
VERSION     NM_053997.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5268)
  AUTHORS   Duarri,A., Nibbeling,E.A., Fokkens,M.R., Meijer,M., Boerrigter,M.,
            Verschuuren-Bemelmans,C.C., Kremer,B.P., van de Warrenburg,B.P.,
            Dooijes,D., Boddeke,E., Sinke,R.J. and Verbeek,D.S.
  TITLE     Functional analysis helps to define KCNC3 mutational spectrum in
            Dutch ataxia cases
  JOURNAL   PLoS One 10 (3), e0116599 (2015)
   PUBMED   25756792
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5268)
  AUTHORS   Gallego-Iradi,C., Bickford,J.S., Khare,S., Hall,A., Nick,J.A.,
            Salmasinia,D., Wawrowsky,K., Bannykh,S., Huynh,D.P.,
            Rincon-Limas,D.E., Pulst,S.M., Nick,H.S., Fernandez-Funez,P. and
            Waters,M.F.
  TITLE     KCNC3(R420H), a K(+) channel mutation causative in spinocerebellar
            ataxia 13 displays aberrant intracellular trafficking
  JOURNAL   Neurobiol Dis 71, 270-279 (2014)
   PUBMED   25152487
REFERENCE   3  (bases 1 to 5268)
  AUTHORS   Zhao,J., Zhu,J. and Thornhill,W.B.
  TITLE     Spinocerebellar ataxia-13 Kv3.3 potassium channels:
            arginine-to-histidine mutations affect both functional and protein
            expression on the cell surface
  JOURNAL   Biochem J 454 (2), 259-265 (2013)
   PUBMED   23734863
REFERENCE   4  (bases 1 to 5268)
  AUTHORS   Huang,C.Y., Chu,D., Hwang,W.C. and Tsaur,M.L.
  TITLE     Coexpression of high-voltage-activated ion channels Kv3.4 and
            Cav1.2 in pioneer axons during pathfinding in the developing rat
            forebrain
  JOURNAL   J Comp Neurol 520 (16), 3650-3672 (2012)
   PUBMED   22473424
REFERENCE   5  (bases 1 to 5268)
  AUTHORS   Figueroa,K.P., Waters,M.F., Garibyan,V., Bird,T.D., Gomez,C.M.,
            Ranum,L.P., Minassian,N.A., Papazian,D.M. and Pulst,S.M.
  TITLE     Frequency of KCNC3 DNA variants as causes of spinocerebellar ataxia
            13 (SCA13)
  JOURNAL   PLoS One 6 (3), e17811 (2011)
   PUBMED   21479265
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5268)
  AUTHORS   Brooke,R.E., Atkinson,L., Edwards,I., Parson,S.H. and Deuchars,J.
  TITLE     Immunohistochemical localisation of the voltage gated potassium ion
            channel subunit Kv3.3 in the rat medulla oblongata and thoracic
            spinal cord
  JOURNAL   Brain Res 1070 (1), 101-115 (2006)
   PUBMED   16403474
  REMARK    GeneRIF: Role for Kv3.3 subunits in regulating neuronal
            excitability and in the modulation of excitatory and inhibitory
            synaptic transmission in the medulla oblongata and spinal cord.
            (Kv3.3)
REFERENCE   7  (bases 1 to 5268)
  AUTHORS   Brooke,R.E., Moores,T.S., Morris,N.P., Parson,S.H. and Deuchars,J.
  TITLE     Kv3 voltage-gated potassium channels regulate neurotransmitter
            release from mouse motor nerve terminals
  JOURNAL   Eur J Neurosci 20 (12), 3313-3321 (2004)
   PUBMED   15610163
REFERENCE   8  (bases 1 to 5268)
  AUTHORS   Shevchenko,T., Teruyama,R. and Armstrong,W.E.
  TITLE     High-threshold, Kv3-like potassium currents in magnocellular
            neurosecretory neurons and their role in spike repolarization
  JOURNAL   J Neurophysiol 92 (5), 3043-3055 (2004)
   PUBMED   15240761
  REMARK    GeneRIF: Kv3-like currents may be important for maintaining spike
            width and calcium influx within acceptable limits during repetitive
            firing.
REFERENCE   9  (bases 1 to 5268)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   10 (bases 1 to 5268)
  AUTHORS   Vega-Saenz de Miera,E., Moreno,H., Fruhling,D., Kentros,C. and
            Rudy,B.
  TITLE     Cloning of ShIII (Shaw-like) cDNAs encoding a novel
            high-voltage-activating, TEA-sensitive, type-A K+ channel
  JOURNAL   Proc Biol Sci 248 (1321), 9-18 (1992)
   PUBMED   1381835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053997.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY179603.1, SRR26360176.2040312.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1096              JAXUCZ010000001.1  104217472-104218567
            1097-2204           JAXUCZ010000001.1  104221951-104223058
            2205-2396           JAXUCZ010000001.1  104225139-104225330
            2397-5268           JAXUCZ010000001.1  104228806-104231677
FEATURES             Location/Qualifiers
     source          1..5268
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5268
                     /gene="Kcnc3"
                     /gene_synonym="KShIIID; Kv3.3"
                     /note="potassium voltage-gated channel subfamily C member
                     3"
                     /db_xref="GeneID:117101"
                     /db_xref="RGD:621358"
     exon            1..1096
                     /gene="Kcnc3"
                     /gene_synonym="KShIIID; Kv3.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..2533
                     /gene="Kcnc3"
                     /gene_synonym="KShIIID; Kv3.3"
                     /note="voltage-gated potassium channel subunit Kv3.3;
                     potassium voltage gated channel, Shaw-related subfamily,
                     member 3; potassium channel, voltage gated Shaw-related
                     subfamily C, member 3"
                     /codon_start=1
                     /product="voltage-gated potassium channel KCNC3"
                     /protein_id="NP_446449.2"
                     /db_xref="GeneID:117101"
                     /db_xref="RGD:621358"
                     /translation="MLSSVCVWSFSGRQGTRKQHSQPAPTPQPPESSPPPLLPPPQQQ
                     CAQPGTAASPAGAPLSCGPGGRRAEPCSGLPAVAMGRHGGGGGDSGKIVINVGGVRHE
                     TYRSTLRTLPGTRLAGLTEPEAAARFDYDPGTDEFFFDRHPGVFAYVLNYYRTGKLHC
                     PADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDSSGNANANAG
                     GAHDAGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPAGGPGGAGGTWWRRWQPR
                     VWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAP
                     PENITNVEVETEPFLTYVEGVCVVWFTFEFLMRVTFCPDKVEFLKSSLNIIDCVAILP
                     FYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFL
                     LLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYG
                     DMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPR
                     PPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVAGAYPPGPHTHPGL
                     LRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIETNRADPRPNGDPAAAALAHEDCPAID
                     QPAMSPEDKSPITPGSRGRYSRDRACFLVTDYAPSPDGSIRKGYEKSRSLSSIVGLSG
                     VSLRLAPLATPPGSPRATRRAPPTLPSIL"
     exon            1097..2204
                     /gene="Kcnc3"
                     /gene_synonym="KShIIID; Kv3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2396
                     /gene="Kcnc3"
                     /gene_synonym="KShIIID; Kv3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..5268
                     /gene="Kcnc3"
                     /gene_synonym="KShIIID; Kv3.3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagctttttg tgcaatccca cctcctctag ctaggcttgg ttagagtctg cctagccgtg
       61 gccccgccca ctccatcagt ccaatcagct cgtgttctcc ctccacctgc ccaatcactc
      121 cctccccatc cattcatcgc ctcctcctgc ccaatcacat ctgcttctct accaaggctc
      181 cgcccccaag accctgcccc cctcagcccc gcctccctgt ccaatgctca gctcagtgtg
      241 cgtctggtcg ttcagcgggc gccaggggac ccgcaagcag cattctcagc cggcgccaac
      301 gccgcagccg cctgagtcct caccgccgcc tctgctaccg ccgccgcagc agcagtgcgc
      361 tcagcccggc accgccgcct ccccggcggg tgccccgctt tcctgtgggc ctgggggccg
      421 gcgcgccgag ccatgctccg ggctgccggc ggtggccatg gggcggcacg gcggcggcgg
      481 cggcgacagc ggtaagatcg tgatcaacgt gggcggcgtg cgccatgaga cgtaccgctc
      541 cacgttgcgc accctaccgg ggacccggct ggccgggctg accgagcccg aggcggccgc
      601 gcgctttgac tacgacccgg gcacggacga gttcttcttt gaccgtcacc cgggcgtctt
      661 cgcctacgtg ctcaactact accgcaccgg caagctgcac tgcccggccg acgtgtgcgg
      721 gccgctcttc gaggaggagc tgggcttctg gggcatagac gagacggacg tggaggcctg
      781 ctgctggatg acctaccgcc agcaccgtga tgccgaagag gcactggact ccttcgaggc
      841 tccggactcc tcgggcaacg ccaacgccaa cgccggaggc gcccatgatg cgggcctgga
      901 cgacgaggcg ggcgcaggag gtggcggcct ggacggggca ggcggcgagc tcaagcgtct
      961 gtgttttcag gacgcgggcg gaggtgccgg aggacctgcc ggaggcccgg gcggcgcggg
     1021 cggcacgtgg tggaggcgct ggcagccccg cgtgtgggcg ctttttgagg acccctactc
     1081 gtcgcgggcc gccaggtacg tggccttcgc ctccctattc tttatcctca tctccatcac
     1141 caccttctgc ctggagacac acgagggctt catccacatc agcaacaaga cggtgacgca
     1201 ggcctctcca atccctgggg ctcccccgga gaatatcacc aatgtggagg tggagacgga
     1261 accctttttg acctacgtgg aaggcgtgtg tgtggtctgg ttcacctttg agtttctcat
     1321 gcgggtcacc ttctgcccgg ataaggtgga gtttctcaaa agcagtctta acatcatcga
     1381 ctgtgtagcc atcttgccct tctacttgga agtgggcctg tcaggtctca gctccaaagc
     1441 tgccaaggac gtgctgggct tcctgcgcgt cgtccgcttc gtgcgcatcc tccgtatctt
     1501 caagctgacc cgccattttg tgggcctgcg ggtcctgggc cacacgctcc gtgccagcac
     1561 caacgagttc ttgttactca ttattttcct ggctctgggg gtcctcatct ttgccaccat
     1621 gatctactat gccgagcgca tcggggccga tcctgatgac atcctgggct ccaaccacac
     1681 ctacttcaag aacatcccca tcggcttctg gtgggctgtg gtcaccatga ccacactggg
     1741 ctatggtgac atgtacccca agacatggtc tgggatgctg gtcggggcac tgtgtgccct
     1801 ggctggtgtg ctgaccattg ccatgccggt gcccgtcatt gtcaacaact tcggcatgta
     1861 ctattcactg gctatggcca agcagaaatt gccaaagaag aaaaacaaac atatccccag
     1921 gcccccgcag cctggctcac ccaactactg caagcccgat cccccgcctc cgcccccacc
     1981 acacccccac cacggcagcg gtggcatcag cccaccaccg cccatcaccc ctccttccat
     2041 gggggtgact gtggctgggg cttacccacc tggaccccac acgcaccccg ggctgcttag
     2101 gggtggtgct gggggactgg gaattatggg attgcctcct ctgccagccc ctggtgagcc
     2161 ctgcccactg gctcaagaag aggtgattga aaccaacagg gcagaccccc gtcccaatgg
     2221 agaccctgca gcagctgcac tggctcatga ggactgcccc gccattgacc agccagccat
     2281 gtctccagaa gacaagagcc cgatcactcc cggaagccgg ggtcgctaca gccgggaccg
     2341 agcttgcttc cttgtcacag actatgcccc ttcccccgat ggctccatcc gaaaaggtta
     2401 cgagaagtcc cgcagcctga gcagcattgt gggcctgagc ggggtgtccc tgcgcctcgc
     2461 gcccctcgcc accccccctg gctctccccg ggccacgcgc cgagctcccc cgaccctgcc
     2521 ctccatcctc tagcgctgtc ctcccccctg tggggggact gggggtgatg ggaaggtgaa
     2581 aaggagctgg gagaaggggt ggggaaaggg ttatttaaaa aaaaaagtta ataatatgca
     2641 aaagatgatg ccagcagaca cccccggggc ctctcactcc ccatatagta gagaacccag
     2701 gatagagggg gcggggccgg agcctgtacc cccacaactc cctccccttt ccccccccaa
     2761 aaaatgcaaa cctcaggtct ccatgagcca taggacaccc ctcccatcga ctcctgtaaa
     2821 taactaaaag ccgattccat cttggggcac ccactccagt ttgcatgcct ctccgacccc
     2881 cctcttcagc aataagccgc caggagctgc gtgcagagag ttggagggga ggctgctggg
     2941 agcctctggg gtcggggcta gcattttagg ggtcttcctg gataccccgc caaaaggcaa
     3001 cccacccacc actaattgat tcaggaaaaa caaaaacctc taggaacacg taggaaaagg
     3061 aagacaggtt aatcagctgc aaccccgagg agctcagcgt gggggtgggg gtggggttct
     3121 gccagctgct cttgggcttg gaggacgcca gctggtgcat tccacccacg cccgcctcca
     3181 gagatctgct ccctctattc gctgcatgga cttggccctc caggcccaga accctctcta
     3241 cccattgcag tctccactct atcccaatgt gagactagta ccctagactt acggagatag
     3301 aacctggcac cctgcactcc cataccccac ggactccggc gccccacact tcccacctcc
     3361 atcactccat cccccactgg cctggactgc accacagagt tcttccaccc tttccttgca
     3421 ccccagctca cttccagcca ttggggttct gacagtcctc aagaccctga catatctaga
     3481 cacccccata tcctcaagcc tcccccaacc ccagacagcc ccaaccctct gatatcacat
     3541 ttctctgtcc tgggcgcctc tgacgcaaga ccttccggga caagctctga ttccagggag
     3601 ctcccacccc attccagcat cgctgtctag gcagccccct cctctacgct tccccccccc
     3661 ccatggtgcc aaaacacatt ttcttcatgg ccaccagagt ttcccagagc gtgggactcc
     3721 cgttccctct tcgcatgctg aactttgcag agtgcacaga cgaccaagtg ttttaaaatt
     3781 gtgtactctt cgcaagctca tacccggctg gtgcgtcctg gcagcgtagc agttgggcgt
     3841 tgccattgaa agcaagtcaa ggacaggatg ggacccaatg ctaaaagcgc tggcttaatg
     3901 tgctaaggtc ccagggttca atctccagca atccctcttt gcccgaccgg tgggaaaaga
     3961 ggacacgccc acctcggcta ggatcttagc ctgcccttcc cagcttcctt gcccaccgcg
     4021 tgccacattc gcgggtggaa aactttctca aatctcgtct tggctccagg atgctacctc
     4081 ccctaagccc agagaccaca ctggtcccag aatccttagt gaacttcccc ttttggagct
     4141 gggtggtcgg cagaattagc aatcccttgt tcccaccgcc tcagggaaac ctcccgctgt
     4201 caccagagtt gtcggtgggg gtgtccttgg gcccaattct tgatgcaaca attcctatgc
     4261 aagggacatt ttgagtccct cccgcactcc ccgccttccc tcgggacctt aaaccctggt
     4321 gagacagggg ttgaggagtg gggtgggatc tggtaggggc agggcaaagg gctaggggac
     4381 tctagacacc agggtatggg gtgaggactc ctaatattgc caaaggattc aacttattta
     4441 aacaacccct attacccccc cccccgtccc tcaaaagagc gaatggggcg gggaaagggg
     4501 taagagtcct ttttgaaggg taccaaccac ttcccactgt ttcaccctgt gctctccagt
     4561 cccctacaca tatccagctt tttagttaag catttttaaa aagctacagt tcattataaa
     4621 cgtctacaaa acgtgatttt tgcccctcca catttcccaa tttaccaaac agtgtgggat
     4681 tcggggaggg agagccagtc ctggtctccc ttttccccac ggccgccagg gtgcctgcaa
     4741 ctgcacgcat gcgctgcatg acgcgccccc ccacatacac acgcatgcgt cgcgcacccc
     4801 tcctgcgctg gggggggacg cacggacttg ggggcggggc gatggggagg aatgattggc
     4861 agaggggaag ggggtttttc tgagctcaat ggctcctctc cttccccaca cactcaacag
     4921 caataagttt ctctacttca agtgggcgga cgggcctagc ctgacctggc gcgggagggg
     4981 ctggccaagg ggcgctctca gggatggggg cgggtcctga gtctggggga ggggaggtct
     5041 gcaactctgg tgctaatggc gggtcttcct ggcccacccg caggcaggga ggaaggagtc
     5101 ggcaggctcc tcccccaagc ctcccccacg cccacccagg gtgcatgaac cacccacgca
     5161 gaagctgccg catgtcaacc ctccccccaa caaagaaaca gtgtcatgcc cctccccacc
     5221 tgccctccca ctccccagcc caataaatga ttccttttca tttacaaa
//
