LOCUS       NM_139217               2441 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily C
            member 2 (Kcnc2), transcript variant b, mRNA.
ACCESSION   NM_139217
VERSION     NM_139217.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2441)
  AUTHORS   Huang,C.Y., Chu,D., Hwang,W.C. and Tsaur,M.L.
  TITLE     Coexpression of high-voltage-activated ion channels Kv3.4 and
            Cav1.2 in pioneer axons during pathfinding in the developing rat
            forebrain
  JOURNAL   J Comp Neurol 520 (16), 3650-3672 (2012)
   PUBMED   22473424
REFERENCE   2  (bases 1 to 2441)
  AUTHORS   Kanda,V.A., Lewis,A., Xu,X. and Abbott,G.W.
  TITLE     KCNE1 and KCNE2 provide a checkpoint governing voltage-gated
            potassium channel alpha-subunit composition
  JOURNAL   Biophys J 101 (6), 1364-1375 (2011)
   PUBMED   21943417
REFERENCE   3  (bases 1 to 2441)
  AUTHORS   Tavian,D., De Giorgio,A. and Granato,A.
  TITLE     Selective underexpression of Kv3.2 and Kv3.4 channels in the cortex
            of rats exposed to ethanol during early postnatal life
  JOURNAL   Neurol Sci 32 (4), 571-577 (2011)
   PUBMED   21234782
REFERENCE   4  (bases 1 to 2441)
  AUTHORS   Wang,Z., Wong,N.C., Cheng,Y., Kehl,S.J. and Fedida,D.
  TITLE     Control of voltage-gated K+ channel permeability to NMDG+ by a
            residue at the outer pore
  JOURNAL   J Gen Physiol 133 (4), 361-374 (2009)
   PUBMED   19332619
  REMARK    GeneRIF: In the absence of potassium ion, significant
            N-methyl-D-glucamine (NMDG)-positive currents could be recorded
            from human embryonic kidney cells expressing Kv3.1 or Kv3.2b
            channels and Kv1.5 Arg487Tyr/Val, but not wild-type channels.
REFERENCE   5  (bases 1 to 2441)
  AUTHORS   Grabert,J. and Wahle,P.
  TITLE     Neuronal activity and TrkB ligands influence Kv3.1b and Kv3.2
            expression in developing cortical interneurons
  JOURNAL   Neuroscience 156 (3), 618-629 (2008)
   PUBMED   18775767
REFERENCE   6  (bases 1 to 2441)
  AUTHORS   Rettig,J., Wunder,F., Stocker,M., Lichtinghagen,R., Mastiaux,F.,
            Beckh,S., Kues,W., Pedarzani,P., Schroter,K.H., Ruppersberg,J.P. et
            al.
  TITLE     Characterization of a Shaw-related potassium channel family in rat
            brain
  JOURNAL   EMBO J 11 (7), 2473-2486 (1992)
   PUBMED   1378392
REFERENCE   7  (bases 1 to 2441)
  AUTHORS   Rudy,B., Kentros,C., Weiser,M., Fruhling,D., Serodio,P., Vega-Saenz
            de Miera,E., Ellisman,M.H., Pollock,J.A. and Baker,H.
  TITLE     Region-specific expression of a K+ channel gene in brain
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4603-4607 (1992)
   PUBMED   1374908
REFERENCE   8  (bases 1 to 2441)
  AUTHORS   Luneau,C., Wiedmann,R., Smith,J.S. and Williams,J.B.
  TITLE     Shaw-like rat brain potassium channel cDNA's with divergent 3' ends
  JOURNAL   FEBS Lett 288 (1-2), 163-167 (1991)
   PUBMED   1879548
REFERENCE   9  (bases 1 to 2441)
  AUTHORS   McCormack,T., Vega-Saenz de Miera,E.C. and Rudy,B.
  TITLE     Molecular cloning of a member of a third class of Shaker-family K+
            channel genes in mammals
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 4060 (1991)
   PUBMED   2023956
  REMARK    Correction to:[Proc Natl Acad Sci U S A. 1990 Jul;87(13):5227-31.
            doi: 10.1073/pnas.87.13.5227.. PMID: 2367536]
REFERENCE   10 (bases 1 to 2441)
  AUTHORS   McCormack,T., Vega-Saenz de Miera,E.C. and Rudy,B.
  TITLE     Molecular cloning of a member of a third class of Shaker-family K+
            channel genes in mammals
  JOURNAL   Proc Natl Acad Sci U S A 87 (13), 5227-5231 (1990)
   PUBMED   2367536
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1991 May 1;88(9):4060. doi:
            10.1073/pnas.88.9.4060-b.. PMID: 2023956]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M59211.1.
            
            Transcript Variant: This variant (b) encodes the longer isoform
            (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M59211.1, M84203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2441
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2441
                     /gene="Kcnc2"
                     /gene_synonym="KShIIIA; Kv3.2"
                     /note="potassium voltage-gated channel subfamily C member
                     2"
                     /db_xref="GeneID:246153"
                     /db_xref="RGD:628829"
     exon            1..723
                     /gene="Kcnc2"
                     /gene_synonym="KShIIIA; Kv3.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1953
                     /gene="Kcnc2"
                     /gene_synonym="KShIIIA; Kv3.2"
                     /note="isoform b is encoded by transcript variant b;
                     voltage-gated potassium channel subunit Kv3.2; potassium
                     voltage gated channel, Shaw-related subfamily, member 2;
                     shaw-like potassium channel; potassium channel
                     voltage-gated Shaw-related subfamily C member 2;
                     voltage-gated potassium channel KCNC2"
                     /codon_start=1
                     /product="voltage-gated potassium channel KCNC2 isoform b"
                     /protein_id="NP_631963.1"
                     /db_xref="GeneID:246153"
                     /db_xref="RGD:628829"
                     /translation="MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPQG
                     DCLTAAGDKLQPLPPPLSPPPRPPPLSPVPSGCFEGGAGNCSSHGGNGSDHPGGGREF
                     FFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHR
                     DAEEALDIFETPDLIGGDPGDDEDLGGKRLGIEDAAGLGGPDGKSGRWRKLQPRMWAL
                     FEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSAVLQYEI
                     ETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSG
                     LSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG
                     VLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSG
                     MLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPLASSPTF
                     CKTELNMACNSTQSDTCLGKENRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSSTR
                     DKNRRGETCFLLTTGDYTCASDGGIRKGYEKSRSLNNIAGLAGNALRLSPVTSPYNSP
                     CPLRRSRSPIPSIL"
     exon            724..1651
                     /gene="Kcnc2"
                     /gene_synonym="KShIIIA; Kv3.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1816
                     /gene="Kcnc2"
                     /gene_synonym="KShIIIA; Kv3.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2441
                     /gene="Kcnc2"
                     /gene_synonym="KShIIIA; Kv3.2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgttcgcct tccctagtca tgtctgagcc acagagatgg gcaagatcga gaacaacgag
       61 agggtgatcc tcaatgtcgg aggcaccagg cacgaaacct accgcagcac tctcaagacc
      121 cttcctggaa ctcgcctggc ccttctcgcc tcctctgaac ctcagggcga ctgcctgact
      181 gctgcgggtg acaagctgca gccgctgccc cctccgctgt ctccaccgcc gcgaccgcct
      241 cccttgtccc ctgtccccag cggctgcttc gagggcggcg caggcaactg cagttcgcac
      301 ggtggcaatg gcagcgacca ccctggggga ggccgcgaat tcttcttcga tcgccaccca
      361 ggagtcttcg cctatgtgct caactactac cgcacgggca agctgcactg ccccgccgac
      421 gtgtgtggac cgctcttcga ggaagagctg gcattctggg gcatcgatga gaccgacgtg
      481 gagccctgct gctggatgac ctacaggcag caccgggacg cggaggaggc cctggatatc
      541 ttcgagacac ccgacctcat cggaggcgac cctggtgatg atgaggacct agggggcaag
      601 agactgggca ttgaggatgc tgcggggctg ggaggacccg atggcaagtc tggccgctgg
      661 aggaagctgc agcctcgcat gtgggctctc tttgaggacc cctattcatc cagagccgct
      721 aggtttattg cttttgcttc tctgttcttc attttggttt ccatcacaac cttttgcctg
      781 gagacacacg aagctttcaa tattgttaaa aacaagacag agccagtcat caacggcacc
      841 agcgctgttc tccagtatga aatcgaaacg gatcctgcct tgacatatgt ggaaggagtg
      901 tgtgtggtgt ggtttacttt tgaattttta gtccgtattg ttttctcgcc caataaactt
      961 gagttcatca aaaatctatt gaacatcatt gactttgtgg ccatcctccc cttctactta
     1021 gaggtgggac tcagcgggct gtcttccaaa gcggctaaag atgtgctcgg ctttctcagg
     1081 gtggttaggt ttgtgaggat cctgagaatc ttcaagctta cccgccattt cgtaggtctg
     1141 agagtgctcg gacacactct tcgtgcgagc accaatgaat ttttgttgct gatcatcttt
     1201 ctggctctgg gagttttgat attcgctacg atgatctact acgctgagcg agtaggggct
     1261 caacctaatg atccctcagc gagtgagcac acacagttca aaaacatccc cattggtttc
     1321 tggtgggctg tggtgaccat gactacctta ggctatgggg atatgtaccc ccaaacatgg
     1381 tcagggatgt tggtgggggc cttgtgtgct ctggctggag tgctgaccat agctatgcct
     1441 gtgcccgtca ttgtcaacaa ttttgggatg tactactcct tggcaatggc gaagcagaaa
     1501 cttccaagaa aaagaaagaa gcacattcct cctgcccctc tggcaagctc acctacattt
     1561 tgcaagacag aattaaacat ggcttgtaac agtacccaga gtgacacatg tctgggcaaa
     1621 gaaaaccggc ttctggaaca taacagatca gtgttatcag gtgacgacag tacaggaagt
     1681 gagccgccat tatcacctcc ggaaaggctc cccatcagac gctctagtac cagagacaaa
     1741 aacagaagag gggaaacatg tttcctgttg acgacaggtg attacacgtg cgcttctgat
     1801 ggaggaatca ggaaaggata tgaaaaatcc cgaagcttaa acaacatagc gggcttggca
     1861 ggcaatgctc tgagactctc tccagtaaca tccccctaca actctccgtg tcctctgagg
     1921 cgctctcggt ctcccatccc atctatcttg taaaccaaac tgcaccaatc ggctaaattc
     1981 tatcactaca actcctgtcc accctgtact ggaaacaatt aactatagag tttctccagg
     2041 ctccattaag aacagtgtag atcctgcatg acattactat tcgaagtcag aaatgctact
     2101 cgagtagcta gaacatcttt tcctggcttt aaagatggcc taaagtagtg ctgctactca
     2161 gtaagagttg cccaatttcc tttcgctata cggtgaccaa tagcgtcaga tattggccag
     2221 tgcacgaatg cataagcaaa tcttcaggga gatattcttt aatagtgtgc ttctaaatgc
     2281 caaccacttc actggacctt cctttcttgt gactgactcc aacccattct gaagatgtct
     2341 gggatcctat ctagatcgta taaaccatga ctttggtcag ctcgtttgca tggaccatct
     2401 tgcctgtatc acctgaatac agtgtgtagc gtcctggtac c
//
