LOCUS       NM_012856               3975 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily C
            member 1 (Kcnc1), mRNA.
ACCESSION   NM_012856 XM_001080128 XM_001080138
VERSION     NM_012856.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3975)
  AUTHORS   Vicente,P.C., Kim,J.Y., Ha,J.J., Song,M.Y., Lee,H.K., Kim,D.H.,
            Choi,J.S. and Park,K.S.
  TITLE     Identification and characterization of site-specific
            N-glycosylation in the potassium channel Kv3.1b
  JOURNAL   J Cell Physiol 233 (1), 549-558 (2018)
   PUBMED   28322444
  REMARK    GeneRIF: Trafficking-dependent roles of the Kv3.1b potassium
            channel are dependent on N229 site-specific glycosylation and
            N-glycan structure, and operate through a mechanism whereby
            specific N-glycan structures regulate cell surface expression.
REFERENCE   2  (bases 1 to 3975)
  AUTHORS   Soares,D., Goldrick,I., Lemon,R.N., Kraskov,A., Greensmith,L. and
            Kalmar,B.
  TITLE     Expression of Kv3.1b potassium channel is widespread in macaque
            motor cortex pyramidal cells: A histological comparison between rat
            and macaque
  JOURNAL   J Comp Neurol 525 (9), 2164-2174 (2017)
   PUBMED   28213922
  REMARK    GeneRIF: This study demonstrated that Kv3.1b potassium channel
            expression in motor cortex pyramidal cells.
REFERENCE   3  (bases 1 to 3975)
  AUTHORS   Hall,M.K., Weidner,D.A., Edwards,M.A. and Schwalbe,R.A.
  TITLE     Complex N-Glycans Influence the Spatial Arrangement of Voltage
            Gated Potassium Channels in Membranes of Neuronal-Derived Cells
  JOURNAL   PLoS One 10 (9), e0137138 (2015)
   PUBMED   26348848
  REMARK    GeneRIF: Our findings provide direct evidence that N-glycans of
            Kv3.1 splice variants contribute to the placement of these
            glycoproteins in the plasma membrane of neuronal-derived cells
            while those of Kv1.1 were absent.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3975)
  AUTHORS   Bae,S.H., Kim,D.H., Shin,S.K., Choi,J.S. and Park,K.S.
  TITLE     Src regulates membrane trafficking of the Kv3.1b channel
  JOURNAL   FEBS Lett 588 (1), 86-91 (2014)
   PUBMED   24291260
  REMARK    GeneRIF: Results indicate that Src kinase may play an important
            role in regulating membrane trafficking of Kv3.1b channels.
REFERENCE   5  (bases 1 to 3975)
  AUTHORS   Zhao,J., Zhu,J. and Thornhill,W.B.
  TITLE     Spinocerebellar ataxia-13 Kv3.3 potassium channels:
            arginine-to-histidine mutations affect both functional and protein
            expression on the cell surface
  JOURNAL   Biochem J 454 (2), 259-265 (2013)
   PUBMED   23734863
REFERENCE   6  (bases 1 to 3975)
  AUTHORS   Kanemasa,T., Gan,L., Perney,T.M., Wang,L.Y. and Kaczmarek,L.K.
  TITLE     Electrophysiological and pharmacological characterization of a
            mammalian Shaw channel expressed in NIH 3T3 fibroblasts
  JOURNAL   J Neurophysiol 74 (1), 207-217 (1995)
   PUBMED   7472324
REFERENCE   7  (bases 1 to 3975)
  AUTHORS   Denamur,E. and Chehab,F.F.
  TITLE     Analysis of the mouse and rat CFTR promoter regions
  JOURNAL   Hum Mol Genet 3 (7), 1089-1094 (1994)
   PUBMED   7526924
REFERENCE   8  (bases 1 to 3975)
  AUTHORS   Perney,T.M., Marshall,J., Martin,K.A., Hockfield,S. and
            Kaczmarek,L.K.
  TITLE     Expression of the mRNAs for the Kv3.1 potassium channel gene in the
            adult and developing rat brain
  JOURNAL   J Neurophysiol 68 (3), 756-766 (1992)
   PUBMED   1432046
REFERENCE   9  (bases 1 to 3975)
  AUTHORS   Rettig,J., Wunder,F., Stocker,M., Lichtinghagen,R., Mastiaux,F.,
            Beckh,S., Kues,W., Pedarzani,P., Schroter,K.H., Ruppersberg,J.P. et
            al.
  TITLE     Characterization of a Shaw-related potassium channel family in rat
            brain
  JOURNAL   EMBO J 11 (7), 2473-2486 (1992)
   PUBMED   1378392
REFERENCE   10 (bases 1 to 3975)
  AUTHORS   Luneau,C.J., Williams,J.B., Marshall,J., Levitan,E.S., Oliva,C.,
            Smith,J.S., Antanavage,J., Folander,K., Stein,R.B., Swanson,R. et
            al.
  TITLE     Alternative splicing contributes to K+ channel diversity in the
            mammalian central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3932-3936 (1991)
   PUBMED   2023941
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000033.1.
            
            [WARNING] On Mar 27, 2024 this sequence was replaced by
            NM_012856.3.
            
            On Nov 27, 2020 this sequence version replaced NM_012856.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M68880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132287, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1731              JACYVU010000033.1  20779907-20781637
            1732-2665           JACYVU010000033.1  20810368-20811301
            2666-2854           JACYVU010000033.1  20818458-20818646
            2855-3975           JACYVU010000033.1  20820578-20821698
FEATURES             Location/Qualifiers
     source          1..3975
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3975
                     /gene="Kcnc1"
                     /gene_synonym="KShIIIB; Kv3.1; Kv4; NGK2-KV4"
                     /note="potassium voltage-gated channel subfamily C member
                     1"
                     /db_xref="GeneID:25327"
                     /db_xref="RGD:2955"
     exon            1..1731
                     /gene="Kcnc1"
                     /gene_synonym="KShIIIB; Kv3.1; Kv4; NGK2-KV4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1162..2919
                     /gene="Kcnc1"
                     /gene_synonym="KShIIIB; Kv3.1; Kv4; NGK2-KV4"
                     /note="NGK2; RAW2; Potassium channel gene 1 (alternative
                     splicing product described in Luneau et al 1991);
                     potassium voltage gated channel, Shaw-related subfamily,
                     member 1; voltage-gated potassium channel subunit Kv3.1;
                     voltage-gated potassium channel subunit Kv4; potassium
                     channel, voltage gated Shaw-related subfamily C, member 1"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily C
                     member 1"
                     /protein_id="NP_036988.1"
                     /db_xref="GeneID:25327"
                     /db_xref="RGD:2955"
                     /translation="MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHS
                     HFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVE
                     PCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDS
                     PDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPI
                     VNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKN
                     SLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVL
                     GHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFW
                     WAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQ
                     KLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRADSKLNGE
                     VAKAALANEDCPHIDQALTPDEGLPFTRSGTRERYGPCFLLSTGEYACPPGGGMRKDL
                     CKESPVIAKYMPTEAVRVT"
     exon            1732..2665
                     /gene="Kcnc1"
                     /gene_synonym="KShIIIB; Kv3.1; Kv4; NGK2-KV4"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2854
                     /gene="Kcnc1"
                     /gene_synonym="KShIIIB; Kv3.1; Kv4; NGK2-KV4"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..3975
                     /gene="Kcnc1"
                     /gene_synonym="KShIIIB; Kv3.1; Kv4; NGK2-KV4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacgagcaa gcgagcaggc agcggagcag cagcccggag gcagcagcgg cggcggtggt
       61 ggcggcagtg gccgctccgc gcctcgcctc cctggcctcg ccagcctcgt tgcgccgcgc
      121 ccggacctgc cacccccgcc taccgggccc gacctcggca gcgcccctcg catcggctgc
      181 cagcgccacc cgccctccca gagcagtgag cggagtgcgg ggcgcagaaa caccggagcc
      241 agtgcccgcc agccccgcca agcaaaacgg gctgagagaa cctacgctcg gcccagcgcg
      301 gctccacagc cgtccgggag ctgtcccttc agcaccgccg cggaagcctg agtcccagcg
      361 cagcccagcg gaacccctga cccagcccga gcgcaccagg cgctgcgctt agcggcagcc
      421 ccgcggggag cacccttgtg cccctaccca ggggacctgc catctcctcc gggaggcggg
      481 gagaaggaac gaggagggag gtcgggcagc ttcacccgcc accgagggga gtaggcagac
      541 aagcaaggag atccgaaggg gatcggtcac gcagggagga gagcaagccg catccgtccc
      601 caccgcaccg ggagcgcgct gcggcgacca ccgcagagcc aagcgcggat ttctcgtaac
      661 cccctctttc ctagcagggg ctggtctatc ggtccggccc ccgaaacgga gcagctgacc
      721 ttcccctaaa aagctttgtg tcgatttctc catttttccc gctgagatgg taccgggagc
      781 ccggcccccc catcatctct cccctcctcc cgggcctcgc cgctgagcgc cgccccactc
      841 ccttcctccc tccctcttta cctccctcct ctcttccact gcctcctccg cagccaggcc
      901 agctccctct cacactaggc gccttaaaga ccctaaggag cccgcgcaca cacccctgga
      961 cccgcacctg actgacagct ccccctgagg gggcttggct cgttggttgg ggtgggtggc
     1021 cagagccgcg gtcctctgtg ccccccgacg gctgggggga ggggggaaga ggccctgcgc
     1081 ccccctcccc gtcgccaact ccccctggcg gcagctccca tgggtgtcgc tgggccgcgc
     1141 catgcctaag ggggcgccgc gatgggccaa ggggacgaga gcgagcgcat cgtgatcaac
     1201 gtgggcggca cgcgccacca gacgtaccgc tcgacgctgc gcacgctgcc cggcacgcgg
     1261 cttgcctggc tggcggagcc ggacgcccac agccacttcg actatgaccc gcgcgctgac
     1321 gagttcttct tcgaccgcca cccgggcgtc ttcgctcaca tcctgaacta ttaccgcacc
     1381 ggcaagctac actgcccggc cgacgtgtgc gggccgctct acgaggagga gctggccttc
     1441 tggggcatcg acgagacgga cgtggagccc tgctgctgga tgacgtatcg ccagcaccgc
     1501 gacgctgagg aggcgctgga cagctttggt ggcgcgccct tggacaacag cgccgacgac
     1561 gcggacgccg acggccccgg cgactcgggc gacggcgagg acgagctgga gatgaccaag
     1621 agattggcgc tcagtgactc cccagatggc cggcctggcg gcttctggcg ccgctggcag
     1681 ccacgcatct gggcactgtt cgaggacccc tactcatccc gctatgcgcg gtacgtggcc
     1741 tttgcctccc tcttcttcat cctggtctcc atcacaacct tctgtctgga gacccacgag
     1801 cgcttcaacc ccatcgtgaa caagacagaa attgagaacg ttcgaaatgg cacacaagtg
     1861 cggtactacc gggaagcgga gacggaggcc ttcctcacct acatcgaggg tgtctgcgtg
     1921 gtctggttca ccttcgagtt cctcatgcgt gttgtcttct gtcccaacaa ggtggagttc
     1981 atcaagaact ccctcaatat cattgacttc gtggccatcc tccccttcta cctggaggtg
     2041 ggcctaagtg gcctgtcctc caaagctgcc aaggacgtgc taggcttcct gcgcgtcgtg
     2101 cgcttcgtgc gcatcctccg tatcttcaag ctgacccgcc attttgtggg cctgcgggtc
     2161 ctgggccaca cgctccgtgc cagcaccaac gagttcctgc tgcttatcat cttcctggcc
     2221 ctgggtgtgc tcatctttgc caccatgatc tactatgctg agaggatagg ggcacagccc
     2281 aatgacccca gcgccagcga acacacacac tttaaaaata tccccatcgg cttctggtgg
     2341 gctgtggtca ccatgacgac actgggctat ggagacatgt atcctcagac gtggtctggg
     2401 atgttggtgg gagcactgtg cgccctggct ggtgtgctga ccattgccat gccggtgccc
     2461 gtcatcgtga acaattttgg gatgtactac tctttagcca tggctaagca gaaactacca
     2521 aagaaaaaaa agaagcatat tccgcggcca ccacagctgg gatctcccaa ttattgtaaa
     2581 tctgtcgtaa actctccaca ccacagtact cagagtgaca catgtccgct ggcccaggaa
     2641 gaaattttag aaattaacag agcagattcc aaactgaatg gggaggtggc gaaggccgcg
     2701 ctggcgaacg aagactgccc ccacatagac caggccctca ctcccgatga gggcctgccc
     2761 tttacccgct cgggcacccg cgagagatac ggaccctgct tcctcttatc aaccggggag
     2821 tacgcgtgcc cgcctggtgg aggaatgaga aaggatcttt gcaaagaaag ccctgtcatt
     2881 gctaagtata tgccgacaga ggctgtgaga gtgacttgac caggcggctt ggccgaggac
     2941 actggtggct attaagcatc tgggtggacc tgcagcccct cctcaccctc ggacagagta
     3001 aattcacgcc atgcaggttt gccggacgag tccgagtggc cccgggcatt gtactaagac
     3061 ggacgtagct ttttctacgg cccacggtaa ctgaccgtag aggattcgcc cttctttctt
     3121 ttgattttct ttttctttct tttttttttt tttagaagtt accttttatt tggggagggg
     3181 gggtcaaggg gagccttagc atgacttgca tgaagttaaa cagaaaaccc agctaaacca
     3241 accccaccag cccctgctgt gactgtatgc tcactctaac caccaccgag aaccagagaa
     3301 aagcaagagt ctcttatttc ttccagcatt ctttgacacg tagtgtcgga gtcaaactgt
     3361 gacggcgctt ggtagaaccc tgtacatttc cgggagtggg tgcggggggg ggggggaggt
     3421 cagggactaa ggatggggcc aggggagtgg attgcttttt tgtacacgag acccagagga
     3481 aaggtcccaa aaaggcagtc agtcatcggt cacattgacc tcaccttcat agctcacctc
     3541 tcgctcggaa aaccaagaac tatgctccga ataggattgt ggaaattcac actgccaccc
     3601 tcttccacct ccgtttggca tgcttgcgac ccaatggacc tctccccaag accccgacag
     3661 cggctagttt aggtcaattc tctcatcttg gtgtgtagct ccagtgtgac caagtttcat
     3721 aacaaattgt tcatagttac accacatgga ttttccaatg tcattttaaa gccaggatgt
     3781 agagtccctc cagttcagga ccaccagagg ggcgcctccc ctccaccttt actaaggcga
     3841 aaaccgacac tgtatgcaat ttagtacttc agagctcaaa gaaaaaaaaa aaaagaaaaa
     3901 aaaagaaaaa agaaaaactg catgcccaat gttatgcaaa gagattcgag catgaaataa
     3961 attttgtaac atggt
//
