LOCUS       NM_054000               3230 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily B
            member 2 (Kcnb2), mRNA.
ACCESSION   NM_054000
VERSION     NM_054000.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3230)
  AUTHORS   Kirmiz,M., Palacio,S., Thapa,P., King,A.N., Sack,J.T. and
            Trimmer,J.S.
  TITLE     Remodeling neuronal ER-PM junctions is a conserved nonconducting
            function of Kv2 plasma membrane ion channels
  JOURNAL   Mol Biol Cell 29 (20), 2410-2432 (2018)
   PUBMED   30091655
  REMARK    GeneRIF: these findings demonstrate a conserved in vivo function
            for Kv2 family members in remodeling neuronal endoplasmic
            reticulum-plasma membrane junctions.
REFERENCE   2  (bases 1 to 3230)
  AUTHORS   Chen,G., Zhang,F., Xue,W., Wu,R., Xu,H., Wang,K. and Zhu,J.
  TITLE     An association study revealed substantial effects of dominance,
            epistasis and substance dependence co-morbidity on alcohol
            dependence symptom count
  JOURNAL   Addict Biol 22 (6), 1475-1485 (2017)
   PUBMED   27151647
REFERENCE   3  (bases 1 to 3230)
  AUTHORS   Bishop,H.I., Guan,D., Bocksteins,E., Parajuli,L.K., Murray,K.D.,
            Cobb,M.M., Misonou,H., Zito,K., Foehring,R.C. and Trimmer,J.S.
  TITLE     Distinct Cell- and Layer-Specific Expression Patterns and
            Independent Regulation of Kv2 Channel Subtypes in Cortical
            Pyramidal Neurons
  JOURNAL   J Neurosci 35 (44), 14922-14942 (2015)
   PUBMED   26538660
  REMARK    GeneRIF: The Kv2 family members, Kv2.1 and Kv2.2, are expresssed in
            distinct cortical layers and pyramidal cell types.
REFERENCE   4  (bases 1 to 3230)
  AUTHORS   Tsantoulas,C., Zhu,L., Yip,P., Grist,J., Michael,G.J. and
            McMahon,S.B.
  TITLE     Kv2 dysfunction after peripheral axotomy enhances sensory neuron
            responsiveness to sustained input
  JOURNAL   Exp Neurol 251, 115-126 (2014)
   PUBMED   24252178
  REMARK    GeneRIF: From histological assessment illustrates that the Kv2.1
            and Kv.2 subunits are widely expressed in a mixture of DRG neurons
            and appear enriched in the myelinated neuron population.
REFERENCE   5  (bases 1 to 3230)
  AUTHORS   Jensen,M.V., Haldeman,J.M., Zhang,H., Lu,D., Huising,M.O.,
            Vale,W.W., Hohmeier,H.E., Rosenberg,P. and Newgard,C.B.
  TITLE     Control of voltage-gated potassium channel Kv2.2 expression by
            pyruvate-isocitrate cycling regulates glucose-stimulated insulin
            secretion
  JOURNAL   J Biol Chem 288 (32), 23128-23140 (2013)
   PUBMED   23788641
  REMARK    GeneRIF: a model in which a key function of the pyruvate-isocitrate
            cycle is to maintain levels of Kv2.2 expression sufficient to allow
            it to serve as a negative regulator of Kv channel activity.
REFERENCE   6  (bases 1 to 3230)
  AUTHORS   Kihira,Y., Hermanstyne,T.O. and Misonou,H.
  TITLE     Formation of heteromeric Kv2 channels in mammalian brain neurons
  JOURNAL   J Biol Chem 285 (20), 15048-15055 (2010)
   PUBMED   20202934
REFERENCE   7  (bases 1 to 3230)
  AUTHORS   Guan,D., Tkatch,T., Surmeier,D.J., Armstrong,W.E. and Foehring,R.C.
  TITLE     Kv2 subunits underlie slowly inactivating potassium current in rat
            neocortical pyramidal neurons
  JOURNAL   J Physiol 581 (Pt 3), 941-960 (2007)
   PUBMED   17379638
  REMARK    GeneRIF: Kv2.2 subunits make a minor contribution to slowly
            inactivating potassium currents in neocortical pyramidal neurons.
REFERENCE   8  (bases 1 to 3230)
  AUTHORS   Salinas,M., Duprat,F., Heurteaux,C., Hugnot,J.P. and Lazdunski,M.
  TITLE     New modulatory alpha subunits for mammalian Shab K+ channels
  JOURNAL   J Biol Chem 272 (39), 24371-24379 (1997)
   PUBMED   9305895
REFERENCE   9  (bases 1 to 3230)
  AUTHORS   Hwang,P.M., Fotuhi,M., Bredt,D.S., Cunningham,A.M. and Snyder,S.H.
  TITLE     Contrasting immunohistochemical localizations in rat brain of two
            novel K+ channels of the Shab subfamily
  JOURNAL   J Neurosci 13 (4), 1569-1576 (1993)
   PUBMED   8463836
REFERENCE   10 (bases 1 to 3230)
  AUTHORS   Hwang,P.M., Glatt,C.E., Bredt,D.S., Yellen,G. and Snyder,S.H.
  TITLE     A novel K+ channel with unique localizations in mammalian brain:
            molecular cloning and characterization
  JOURNAL   Neuron 8 (3), 473-481 (1992)
   PUBMED   1550672
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473984.1.
            
            On Jan 12, 2008 this sequence version replaced NM_054000.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M77482.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3230
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..3230
                     /gene="Kcnb2"
                     /gene_synonym="Kv2.2"
                     /note="potassium voltage-gated channel subfamily B member
                     2"
                     /db_xref="GeneID:117105"
                     /db_xref="RGD:621349"
     exon            1..234
                     /gene="Kcnb2"
                     /gene_synonym="Kv2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            235..902
                     /gene="Kcnb2"
                     /gene_synonym="Kv2.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..3047
                     /gene="Kcnb2"
                     /gene_synonym="Kv2.2"
                     /note="CDRK; voltage-gated potassium channel subunit
                     Kv2.2; potassium voltage gated channel, Shab-related
                     subfamily, member 2; potassium channel, voltage gated
                     Shab-related subfamily B, member 2"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily B
                     member 2"
                     /protein_id="NP_446452.2"
                     /db_xref="GeneID:117105"
                     /db_xref="RGD:621349"
                     /translation="MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGL
                     NHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNF
                     YRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMR
                     EREGEEFDNTCCPEKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPEL
                     QENDEFGQPSDNRKLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILP
                     YYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNE
                     LGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTL
                     LGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIV
                     SMNLKDAFARSMELIDVAVEKAGESANIKDSVDDNHLSPSRWKWARKALSETSSNKSY
                     ENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQTHSHPNPDCQEQPER
                     PSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPP
                     SASHLQMKFPTDLPGMDEHQRVRAPPFLTLSRDKGPAAREAALDYAPIDITVNLDAGA
                     SHGPLQPDSASDSPKSSLKGSNPLKSRSLKVNFQENRGSAPQTPPSTARPLPVTTADF
                     PLTTPQHMSTILLEEALPQGQRPLPGADVSAHCQGPSKGLSPRVPKQKLFPFSSRERR
                     SFTEIDTGEDEDFLDLQRPRPDKQADPSPNCLADKPGEARDPLREEGCVGSSSPQNTD
                     HNCRQDIYQAVGEVKKDSSQEGYKMENHLFAPEIHSNPGDTGYCPTRETSM"
     exon            903..3230
                     /gene="Kcnb2"
                     /gene_synonym="Kv2.2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgcgaacc ggagtgaggg atgtaaagaa gggagaagga aagctgccag gagctccagc
       61 cagtcgggga gaccctcctc tctgtggagg ggagggggat ttccagcgac acatcattgg
      121 cgaaagggac ctttgcagga gaggagtcct ctgagggaac agggaagccc acagccccct
      181 gtggcacagg agccagagct gctgcccgag cggagctggg tccgtgggag ctagctgatg
      241 tggcaatgcc tgttccagtg gaatcctgct tcaggtgacc tcctttctaa ggaccctagc
      301 tctgtggctc tgtccagttc aaaatggcag aaaaggcacc tcctggcttg aacagaaaaa
      361 catccaggtc aacactttct cttcctccag aaccagtgga cattatccga agcaaaacat
      421 gctctcggag agttaagatc aacgtagggg gccttaacca cgaagtcctg tggagaactc
      481 tggacaggct acccaggacg cgcctgggga agctccgaga ctgtaacacg cacgagagtc
      541 tcctggaggt gtgcgatgac tacaacctta atgagaatga gtatttcttc gaccgccatc
      601 ctggagcctt cacatctatt ctgaacttct accggacggg aaagctccac atgatggaag
      661 aaatgtgtgc cctctccttt ggccaagagc ttgattactg gggcatcgat gagatctacc
      721 tagagtcctg ctgccaagcc agataccatc agaagaagga gcagatgaac gaagaactta
      781 gaagggaggc agagaccatg cgtgagcgcg agggggagga gtttgataac acctgctgcc
      841 cagagaaaag gaagaaactt tgggacttgc tggagaagcc gaactcatcc gtggcggcaa
      901 agatcctggc catcgtgtct atcctgttca tcgtcctttc caccattgct ctgtctctca
      961 acacacttcc ggagctgcaa gaaaacgatg aatttgggca acccagtgac aaccggaagt
     1021 tggcgcacgt agaggctgtg tgcattgctt ggtttaccat ggagtacctt ttacgattcc
     1081 tgtcctcacc aaataaatgg aaattcttta aaggcccact gaatgtcatt gacctcctgg
     1141 ccatcttgcc atactatgta accatcttcc tcaccgagtc caacaaaagt gtgctgcagt
     1201 tccagaatgt gagacgcgtg gtccagatct ttcgaatcat gcgcatcctc aggatcctga
     1261 aactcgccag acactcgacg ggcctgcagt ctctgggttt caccctcagg cggagttaca
     1321 atgagttggg tttattaata ctgtttctgg ccatgggaat aatgatattt tccagtttgg
     1381 tgtttttcgc tgagaaagat gaagatgcta caaagttcac cagtatccct gcatcatttt
     1441 ggtgggctac catcaccatg accactgtgg gctatggtga catttaccct aaaacactgt
     1501 tagggaaaat tgtgggtggc ctttgctgca ttgcaggagt cctggttatt gcccttccta
     1561 tccccatcat tgtgaacaat ttctctgagt tctataagga acaaaaacgc caggagaaag
     1621 ctattaaaag gagagaggct cttgaaagag ccaaaagaaa tggaagcatc gtttctatga
     1681 acttaaagga tgcctttgct agaagtatgg aactgatcga cgtggccgtg gagaaggctg
     1741 gagagtcggc caatatcaag gactccgtgg atgataacca cctgtctcca agccggtgga
     1801 agtgggccag aaaggcgctg tcggaaacaa gctccaacaa gtcttacgag aataagtacc
     1861 aggaggttag ccaaaaagac tcccacgaac agctgaacaa cacttcttcc tccagcccac
     1921 agcatctgag cgcccagaag ctggagatgc tatacaatga aatcaccaag acacagactc
     1981 attcccaccc gaacccagac tgccaagaac agccagagag gccatctgcc tatgaggagg
     2041 agatagaaat ggaagaggtg gtctgcccac aggagcagct ggctgtggca cagaccgagg
     2101 tcatcgtgga catgaagagc acctccagca ttgacagctt caccagctgt gccactgact
     2161 tcacggagac tgagaggtca cccctgccac caccctctgc ctctcacttg cagatgaagt
     2221 tccccaccga cctcccagga atggatgagc accaaagagt cagggcacct ccattcctaa
     2281 cactaagcag agataagggg cctgctgcca gggaggctgc actggattat gccccaattg
     2341 acataactgt gaacctcgat gctggggctt cccatggtcc tttgcaacct gacagtgcca
     2401 gcgacagccc caagagctcg ctgaaaggga gcaaccccct caagtctaga tccctaaaag
     2461 tgaactttca ggaaaacaga ggcagtgcac cccagacccc acccagcaca gccaggccac
     2521 tgccagtaac cacagctgac tttccgctca ccacccccca gcacatgagt accattcttc
     2581 tagaagaagc cctcccccag ggacagagac ccttgccggg ggctgatgtt tcagcacact
     2641 gtcagggacc atccaaaggt ctatccccac gagttcccaa gcaaaaactg tttcctttct
     2701 cttctagaga aaggaggagc ttcactgaaa tagacactgg agaagacgaa gacttcttgg
     2761 acctccaaag gccaagacca gacaagcaag cagatcccag ccccaactgc ttagcagata
     2821 agcctggaga ggccagagac cctttaagag aagagggctg tgtgggttcc tcctctcccc
     2881 agaacacaga ccacaactgt aggcaagaca tttaccaggc tgtgggtgaa gtcaaaaagg
     2941 acagtagtca agaagggtac aagatggaga accacttgtt tgccccagaa attcattcta
     3001 acccaggaga cacaggttat tgccccactc gtgagaccag catgtgacta gttataaaag
     3061 caataaaaga aaaagactca tttcttaaaa atgcattaaa atgccgtgaa ctaaaatatg
     3121 agaaaccccg ccccctaata ccagtgcata aaatgttatt tttgcatggc atgaacagct
     3181 tagtttaagg attgtttaaa taaagagttg agactgcatt ttgtaacaaa
//
