LOCUS       NM_013186              11027 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily B
            member 1 (Kcnb1), mRNA.
ACCESSION   NM_013186
VERSION     NM_013186.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 11027)
  AUTHORS   Har,K., Lysenko,N.N., Dimitrova,D., Schluter,T., Zavaritskaya,O.,
            Kamkin,A.G., Mladenov,M., Grisk,O., Kohler,R., Gagov,H. and
            Schubert,R.
  TITLE     Kv2.1 Channels Prevent Vasomotion and Safeguard Myogenic Reactivity
            in Rat Small Superior Cerebellar Arteries
  JOURNAL   Cells 12 (15), 1989 (2023)
   PUBMED   37566068
  REMARK    GeneRIF: Kv2.1 Channels Prevent Vasomotion and Safeguard Myogenic
            Reactivity in Rat Small Superior Cerebellar Arteries.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11027)
  AUTHORS   Dallas,M.L., Al-Owais,M.M., Hettiarachchi,N.T., Vandiver,M.S.,
            Jarosz-Griffiths,H.H., Scragg,J.L., Boyle,J.P., Steele,D. and
            Peers,C.
  TITLE     Hydrogen sulfide regulates hippocampal neuron excitability via
            S-sulfhydration of Kv2.1
  JOURNAL   Sci Rep 11 (1), 8194 (2021)
   PUBMED   33854181
  REMARK    GeneRIF: Hydrogen sulfide regulates hippocampal neuron excitability
            via S-sulfhydration of Kv2.1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11027)
  AUTHORS   Hawkins,N.A., Misra,S.N., Jurado,M., Kang,S.K., Vierra,N.C.,
            Nguyen,K., Wren,L., George,A.L. Jr., Trimmer,J.S. and Kearney,J.A.
  TITLE     Epilepsy and neurobehavioral abnormalities in mice with a
            dominant-negative KCNB1 pathogenic variant
  JOURNAL   Neurobiol Dis 147, 105141 (2021)
   PUBMED   33132203
REFERENCE   4  (bases 1 to 11027)
  AUTHORS   Song,M.Y., Hwang,J.Y., Bae,E.J., Kim,S., Kang,H.M., Kim,Y.J.,
            Park,C. and Park,K.S.
  TITLE     Tyrosine Phosphorylation of the Kv2.1 Channel Contributes to Injury
            in Brain Ischemia
  JOURNAL   Int J Mol Sci 21 (24), 9538 (2020)
   PUBMED   33333928
  REMARK    GeneRIF: Tyrosine Phosphorylation of the Kv2.1 Channel Contributes
            to Injury in Brain Ischemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11027)
  AUTHORS   Wang,Y., Mo,X., Ping,C., Huang,Q., Zhang,H., Xie,C., Zhong,B.,
            Li,D. and Yao,J.
  TITLE     Site-specific contacts enable distinct modes of TRPV1 regulation by
            the potassium channel Kvbeta1 subunit
  JOURNAL   J Biol Chem 295 (50), 17337-17348 (2020)
   PUBMED   33060203
  REMARK    GeneRIF: Site-specific contacts enable distinct modes of TRPV1
            regulation by the potassium channel Kvbeta1 subunit.
REFERENCE   6  (bases 1 to 11027)
  AUTHORS   Swartz,K.J. and MacKinnon,R.
  TITLE     An inhibitor of the Kv2.1 potassium channel isolated from the venom
            of a Chilean tarantula
  JOURNAL   Neuron 15 (4), 941-949 (1995)
   PUBMED   7576642
REFERENCE   7  (bases 1 to 11027)
  AUTHORS   Drewe,J.A., Verma,S., Frech,G. and Joho,R.H.
  TITLE     Distinct spatial and temporal expression patterns of K+ channel
            mRNAs from different subfamilies
  JOURNAL   J Neurosci 12 (2), 538-548 (1992)
   PUBMED   1740690
REFERENCE   8  (bases 1 to 11027)
  AUTHORS   Taglialatela,M., Vandongen,A.M., Drewe,J.A., Joho,R.H., Brown,A.M.
            and Kirsch,G.E.
  TITLE     Patterns of internal and external tetraethylammonium block in four
            homologous K+ channels
  JOURNAL   Mol Pharmacol 40 (2), 299-307 (1991)
   PUBMED   1875913
REFERENCE   9  (bases 1 to 11027)
  AUTHORS   VanDongen,A.M., Frech,G.C., Drewe,J.A., Joho,R.H. and Brown,A.M.
  TITLE     Alteration and restoration of K+ channel function by deletions at
            the N- and C-termini
  JOURNAL   Neuron 5 (4), 433-443 (1990)
   PUBMED   2206531
REFERENCE   10 (bases 1 to 11027)
  AUTHORS   Frech,G.C., VanDongen,A.M., Schuster,G., Brown,A.M. and Joho,R.H.
  TITLE     A novel potassium channel with delayed rectifier properties
            isolated from rat brain by expression cloning
  JOURNAL   Nature 340 (6235), 642-645 (1989)
   PUBMED   2770868
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 12, 2021 this sequence version replaced NM_013186.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.14303.1,
                                           SRR26643285.14432.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117, SAMN12840129
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-761               JAXUCZ010000003.1  176331648-176332408 c
            762-11027           JAXUCZ010000003.1  176239285-176249550 c
FEATURES             Location/Qualifiers
     source          1..11027
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..11027
                     /gene="Kcnb1"
                     /gene_synonym="DRK1PC; Kcr1-1; Kv2.1; Shab"
                     /note="potassium voltage-gated channel subfamily B member
                     1"
                     /db_xref="GeneID:25736"
                     /db_xref="RGD:2954"
     exon            1..761
                     /gene="Kcnb1"
                     /gene_synonym="DRK1PC; Kcr1-1; Kv2.1; Shab"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2768
                     /gene="Kcnb1"
                     /gene_synonym="DRK1PC; Kcr1-1; Kv2.1; Shab"
                     /note="DRK1; potassium channel, voltage gated Shab-related
                     subfamily B, member 1; voltage-gated potassium channel
                     subunit Kv2.1; delayed rectifier potassium channel 1;
                     potassium channel Kv2.1; potassium voltage gated channel,
                     Shab-related subfamily, member 1"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily B
                     member 1"
                     /protein_id="NP_037318.2"
                     /db_xref="GeneID:25736"
                     /db_xref="RGD:2954"
                     /translation="MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEV
                     LWRTLDRLPRTRLGKLRDCNTHDSLLQVCDDYSLEDNEYFFDRHPGAFTSILNFYRTG
                     RLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREG
                     EEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLD
                     EFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVT
                     IFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLL
                     ILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKI
                     VGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNM
                     KDAFARSIEMMDIVVEKNGESIAKKDKVQDNHLSPNKWKWTKRALSETSSSKSFETKE
                     QGSPEKARSSSSPQHLNVQQLEDMYSKMAKTQSQPILNTKEMAPQSKPPEELEMSSMP
                     SPVAPLPARTEGVIDMRSMSSIDSFISCATDFPEATRFSHSPLASLSSKAGSSTAPEV
                     GWRGALGASGGRLTETNPIPETSRSGFFVESPRSSMKTNNPLKLRALKVNFVEGDPTP
                     LLPSLGLYHDPLRNRGGAAAAVAGLECASLLDKPVLSPESSIYTTASARTPPRSPEKH
                     TAIAFNFEAGVHHYIDTDTDDEGQLLYSVDSSPPKSLHGSTSPKFSTGARTEKNHFES
                     SPLPTSPKFLRPNCVYSSEGLTGKGPGAQEKCKLENHTPPDVHMLPGGGAHGSTRDQS
                     I"
     exon            762..11027
                     /gene="Kcnb1"
                     /gene_synonym="DRK1PC; Kcr1-1; Kv2.1; Shab"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgtgtccgc tttcgctttc tgcctcgcag ccgtcgggat ggaggtgaga cggtagccgt
       61 gacacccgcc ctcgcgcacc cctgcaccac agcggcctgc agagctcccc gccccccgcc
      121 cccgcggcag cgggccttgc cgtcgagtga cagcggcctg gggggcaggg ggggcggggg
      181 cggccagacc agcgatgccg gcgggcatga cgaagcatgg ctcgcgctcc accagctcgc
      241 tgccgcccga gcccatggag atcgtgcgca gcaaggcgtg ctcgcgccgg gtgcgcctca
      301 acgtcggggg cctggcgcac gaggtgctgt ggcgcactct ggaccgcctg ccccgcacgc
      361 ggctgggcaa gcttcgggac tgcaacacgc acgactccct gctccaggtg tgcgacgact
      421 acagccttga ggacaacgag tacttcttcg accgccaccc tggcgccttt acctccattc
      481 tcaatttcta ccgcaccggc cggctgcaca tgatggagga gatgtgcgcg ctgagcttca
      541 gccaggagct ggactactgg ggcatcgatg agatctacct ggagtcctgc tgccaggccc
      601 gctatcacca aaagaaggag cagatgaacg aggagctgaa gcgcgaggcc gagacgctgc
      661 gggagcggga gggcgaggag tttgacaaca cgtgctgtgc agagaagagg aagaaactct
      721 gggatctgct ggagaagccc aactcgtcgg tggccgccaa gatcctggcc atcatctcga
      781 tcatgttcat cgtcctgtcc accatcgctc tgtcactcaa cacgctgcct gagctgcaga
      841 gcctagacga gttcggccag agcacggata acccgcagct ggcgcacgtg gaggcggtgt
      901 gcatcgcatg gttcaccatg gagtacttgc tgaggttcct gtcctccccc aagaaatgga
      961 agttcttcaa gggccccctc aacgccattg acctactggc catcctgccc tactacgtca
     1021 ccatcttcct cacagaatcc aacaagagcg tgctgcagtt ccagaacgtg cgccgcgtgg
     1081 tccagatctt tcgcatcatg cgcatccttc ggatcctgaa gctggcccgt cactccactg
     1141 gcctgcagtc cttgggcttc accctgcgca gaagctacaa cgagctgggc ctgctcatcc
     1201 tcttcctcgc gatgggcatc atgatcttct ccagcctggt cttcttcgcg gagaaggatg
     1261 aggacgacac caagttcaaa agcatccccg cctctttctg gtgggctacc atcaccatga
     1321 caactgttgg ctatggagac atctacccga agactctcct ggggaaaatc gtgggggggc
     1381 tctgttgcat tgccggggtc ctggtgattg ctctccccat ccccatcatc gtcaataact
     1441 tctccgagtt ctacaaggag cagaagcgcc aggagaaagc catcaagcgg agggaggctc
     1501 tggagagagc caagaggaat ggcagcatcg tgtccatgaa catgaaggac gccttcgccc
     1561 ggagcatcga gatgatggac atcgtggtgg agaaaaatgg cgagagcata gctaagaagg
     1621 ataaagtgca agataatcac ctgtccccca acaagtggaa atggaccaag agggcactct
     1681 ccgagaccag ctccagtaag tcctttgaaa ccaaggagca gggatccccc gaaaaggcca
     1741 ggtcctcgtc tagtccacag cacttgaacg tccagcagct ggaagacatg tacagtaaga
     1801 tggccaagac acagtcccag cccatcctca acaccaagga gatggccccg cagagcaagc
     1861 ctccagagga gctggagatg agcagcatgc ccagccccgt ggcccctctg cccgcacgca
     1921 cggagggtgt catcgacatg cggagcatgt ccagcattga cagcttcatc agctgtgcca
     1981 cggacttccc tgaagccacc agattctccc acagtcctct ggcatccctc tccagcaagg
     2041 ctgggagcag cacagccccg gaggtgggct ggcggggggc tctgggtgcc agcggcggga
     2101 ggctcacgga gaccaacccc attcctgaga ccagccgctc tggtttcttc gtggagagtc
     2161 ccaggagttc catgaagacc aacaacccct tgaagctgcg agcgctcaag gtcaacttcg
     2221 tggagggcga ccccaccccg ctgctgccct ccctgggctt gtatcacgat cctcttagga
     2281 acagaggagg ggcagcggct gcagttgcgg gactggagtg tgcctccctc ttagacaagc
     2341 ccgtgctgag cccagagtcc tccatctaca ccacagcaag tgccaggacg ccccctcgct
     2401 cccctgagaa acacacagca atagcattca acttcgaggc gggagtccac cattacatag
     2461 acaccgacac agatgacgag ggtcagctgc tctacagcgt ggactccagc cctcccaaaa
     2521 gtctccacgg gagtaccagt cccaagttca gcactggagc tagaacggag aagaaccact
     2581 tcgagagctc ccccttgccc acctccccta agttcttaag gccgaactgt gtctactcct
     2641 cagaagggtt gactggaaaa ggccctgggg ctcaagagaa atgcaagctg gagaaccata
     2701 cccccccgga tgtgcacatg ctgcctgggg gaggagcaca cgggagcact agggatcaga
     2761 gtatctgagc tccctaccac agagggcatc tgcaggagaa atcaaggagg agggatgctt
     2821 ggcttgcctg ccactgagtt ctgcatgaac tccaaggccc ccaccaccac agagccccag
     2881 caagaggaga gaccccgaga gccatgacca atctgtggac actaactagc cacggggacc
     2941 acacctaaca acatcttcct gagatggccg gagcagagct gacagccacc actaagacct
     3001 agcctaggac acacactcct agtctcgtct ggaggctctc tcagcctctg gatacaccat
     3061 caccatctct caaggcttca gctgagatgg gtgttggagc gaggggttgc tagtgaaaga
     3121 gtgggctgcc caagaagtac tgggtgtcgg tctcctgtta ggagggtgca gaggaccctt
     3181 gatcatgagg gattctctgc tccgtcagcc acactcctag ggcattgtga tgcttacata
     3241 agcaagtggc tcaaatgatt cagtattctg tggtccctgg ggctttattc ggagactctg
     3301 tcggggtgag ctgacaattt agactcaatt ctttctgccc acctggccat ccaggaagtg
     3361 ttccgacggt tggcacgcag ccagggctgg cacaggaacg tgggttccaa acaacgctcg
     3421 tatggactga aaagatacgc aggcgtcaaa tatgcaaacg agatagatta tttaaggaga
     3481 ctgtgtgtga ctgaaaagca acattaaaaa ataataaatt tcattttcta catgaaaaaa
     3541 aaaaaagaaa aggaaaaaaa atccttcact gaactgccct gtgcagagtt gtgagtactt
     3601 tctgctgtag cggggaaaca cacctactct gagaggaagt tctttttttt tgtttgttcg
     3661 tttgtttgat tttcaatttt cttttgttgt tttttttggg ggggttgttt tgttttgttt
     3721 tttgtttcct gtggtattca agctaaaaaa tactaacaag ttaataaaaa aaagcacttt
     3781 atgtttttct aatctaggtt ctaccaggga cagtgtcaag atctcgcact ttaaaacaag
     3841 cactatttcc cgtgggccgc atgctggcac ttggggtatt acttgtgccc atttctggcc
     3901 acagtgggtc tgccgttacc acaccagagt ccggggcttt tctgtgaccc ccctcatccc
     3961 tcatgggaca ggagaggtcc tcagctctcg gggcagggct ctcttaaagt cctgcatata
     4021 agagacacag acgtctcaaa tgggcgcaga aagagttagg tgtcgggtgt cgtaccactc
     4081 tttcttgtca accggccatt gtgtgttcta tgttactgtc tgtcccgaaa gcccgacgct
     4141 ccttcctaca gccatctagg cagacggcac agccaaaagc aataagcacc cacgtgtatc
     4201 ccttgaggtt cccgtgtact tcctggtgtc agtcttcctg ttcaagtgtt gacctggcgt
     4261 tgtcccgcct gcctgtgacc cagtggcaca gtattgttgg cccctcgctc agtgacacca
     4321 gtctgcgcga tgctctcgtt atggcgatgt cgttggtcag cctgtctgtg gtacaacagg
     4381 gcactgtggt tttcttatga tggtgtgagt gggtaatgtc ccgaatgctg tagtgtcctc
     4441 ctccctgtcc tcagaacagt gatgggcgat ggcagtaatg tcacctgacc tcagtatcat
     4501 gtgtggctgg tcggcccggt agttcgatgg catgatccac ccgtcagcac atgcacatca
     4561 cgatgttctg ccttcttctc ttgtttccac ggctgaggcc aggccacctg ttacagatgc
     4621 tcaaagctca gaccaccacc cttaaacagc gcgttttcta cagttcatga catttctcag
     4681 catctccaaa gacctgggcc cccctccctc cagtgagcac agcttgggac ttggctgtgt
     4741 taatgaagaa gatgagacgt tggctctgcc tcattatccg tcctcagagc tttctcagag
     4801 cagaagcaaa ggggctgaga gctcgcctgg tcacctgtac cagcagcatc ctggaggcag
     4861 gaagcagggc gtgggcctcc atggccccct gctgagctca gcctggtgct gggggcctgt
     4921 tgccgtgacc atgaccgtga ccgtgggacc tttccgctga ccatctccca tgtctgtctt
     4981 ttgtgttgcc catcaatcac ccatcagcac aaatgtgaaa attcagggaa acaaacaaat
     5041 gcttttttga taaaaaagta aatagttgtg atttccgact cagatatttt tagagctatc
     5101 tgtaaaaact cctactgatg atatagtctt ctattttaca tatcaggaag taaacgcgtc
     5161 ttaacatagc catatatagc cagaaggaag ttatcgcccc tcccccttct ttaaaaccaa
     5221 ggcatttcat tggttggtta agccgatggc gggtgtacag tgtagaaatg attgctttct
     5281 tttttaagaa ccacttggtg cgactttcct tgtaaccaaa ggccccttct gccttgtgta
     5341 ggacctggct atccctccct cttgtgtttt gtctgacctt caagtagcat tatgcagaga
     5401 aaatgatgaa ttcagaataa tacccttcct agctgcacgg gcagagtccg acagaattcc
     5461 tatggagaca accatcatag cagtgtagac gatccataaa agttttctgt ttcggttttt
     5521 gtttggcttt ttctttcctt cacttataat tgtatgtact gtggaaatac agctcccccc
     5581 cccccaccgt gtgtaactca agttagaata ctataaattt tcctaccaac cctccatctg
     5641 ctaaaaagga acatagagtc tcatgccgcg tgtacctgac ccgggtatgt gtgtctacac
     5701 gcactgggaa accttgagtt gccaagatga agctgaatcc gaaagatggg tctcagccgt
     5761 gaagaaaaga gccagggtat ggaggcagag gccacttgaa cttggtggtc caactgatct
     5821 gacccaacca gagcaaaagg aagtaaggta cccaaatgac agtgggaact ggaggtggag
     5881 atctaacggt ccagttatga agtccacagg accatcaaga agccagctga acctgagttc
     5941 cagcaccaat cacaccatca gaaaaggcca ggcgtcagag cacccatcaa gctgggaaag
     6001 ccttactgtg gacaaggtga ggacaaccca gttcttttgc cttctcattt ttggatgcct
     6061 ccagagcaac aggtctgggg cgacagacct ctctctggga ttctacctta agcacattta
     6121 gatgggagag agagagagag agagagagag agagagagag agagagagag agagcgaata
     6181 aaagaggaga gacgatgtat tatcgaggag agaggagaca ccaaagtcat gaggaagcca
     6241 cccttaaccc tctccactca ccctgacagt ggctgggaat acgagttttt gtttttgtgt
     6301 ttttccctac tgagtctctc tcaccttctc ctcatctcct ctgtgttctg tagctgcagc
     6361 cttgtctctg tcccttctcc tgagaagatc cacatcccta aggaggaaac aagacgcaga
     6421 agcatcctct tctgtacaac tgtaatgtat tgtcgatatt tataattaca tatttgtctg
     6481 actctggtca tggctggaat gtctagtcca tgaacaaggg gatatttaaa ggtcatcaca
     6541 gacaagggtc cctaaagcca ggtctctcta tatagataga taagtatagg tatataaaca
     6601 gatctctttt ccttatttct ctgtcaactt gtctcatgta caatagccac aggctgcact
     6661 gaatcaaagt ggggaggaca cacagaaaag cttctagaac atggtccttt gggggcagac
     6721 tttgtgtatg gtctatctga gaggaagaag atggggtctc cgaggtcccc aaaaggacaa
     6781 tagaatgctc tagcctcagg catttcctaa cctattattg tttatctgac aaaccctgaa
     6841 tggctttcat gtcctaggcc agggccaccc aaaccagccc aggccacacc tggaaataag
     6901 agttacctcc gcattttccg ttgccatttt tctggctcta gaagcctcta taccctagga
     6961 tgtccgcaca tctcaagagt agtctatttt tttgttcaga taaaatatat acatatatgt
     7021 attttttagt atatttataa cagggcaatc gagtctgatt tcttttgtaa cagagtaata
     7081 ccttggggat cttattgttc atttgcatag ctggtcttct ctgcgctctc attccttccc
     7141 actgtccctt ctttcgtttt gttttgttct gtttgtttct gttggatccc agttgtctag
     7201 aaatggggaa agactggggt ttgatatcct ggcagacgga ggccctggaa atgggtgggt
     7261 gatgggggcc tgggagagca gctccatgtc tgtcctcatc aggtctgagt tccctggctg
     7321 tcactcttaa gaatccaggt gcgcaggagc aagccaggtg aagacaggtg cggttcgcac
     7381 ctgggctgcc gggagctcag acccttccct ccccaagtct taaaggactg gctttctggt
     7441 tcccagaaat attagaatca agacctacct gcaagcaaac ttgtctctga gctcaggaac
     7501 attcctgagt ccctcctggc cagactgtcc ccaagtccag catcctgctt cccagggcca
     7561 ccaactggat ccaaggacca gagtgtatgc aggctccagc aaacctcaga agaacattct
     7621 gtgtctccat aaccatttct catcgtctta ccaaaaacca gtggccagac agccttgtag
     7681 ctgaacgctg aggactgaca gcccaaagct gtgttctccc cacccagccc ctctcagcag
     7741 cgccaatgag agacttgaag cagtattttt ccagcttcta cttttccaag tctccagtcc
     7801 ttggtcagtc ctgaacatcc gtcggaaaca attttgagcc tagggacagg tggtggacag
     7861 actccacatg gagtgaaaag gctttgccga ccgtcaactt acacagggca acaagaaaag
     7921 ccaatcagat tgcctcctat gcccaaccag tcacctacct gcctcagctc tggactctga
     7981 gctctgccag ccccagagat ttgagtcaag ccagaacagc ctcatctcag gcagtgaaag
     8041 aatcccaaga ggatgctacc taaacacaaa tttaatattc tggtggttgg attttccctc
     8101 cttccccttg ggtttgttct gttttgtggt gttggggacc taactagggc cttggctgta
     8161 tcagacaagc gcgctcaacc ccgagctaca tctccagccc ctgaatgtat taattcggaa
     8221 tgtgattcta atccgttttt cccatcccta aaattcctgg taatctggtt tgttccagag
     8281 ctaaataaaa cagacaagat tttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     8341 tgtgtgtgac atatgcatgt gtgcaacttt tgcacaagaa caaaatttaa aattgctatc
     8401 ttgtttctga ggtttcctgc ccagataagt aaacactggc tgtcttccca agaaagacgg
     8461 ggtaccctcc taccttctct ccttgtccta gaatttctct tgaaatttcc aagaggtaac
     8521 ttgaacctag tttggaaggg gctgttagtc atttgagccc tcctctccat cgctatccct
     8581 acatctgtct ctctcagcca aggtcctgaa gaaatctaaa agccagtggg agagcatggg
     8641 tggggagttg gcccaaagaa gtagccactc aacaggagtt gtccatttca gctcaaagca
     8701 atgaagccct ttctcagcag ggtgggttat ctgctctcag atcacagtgc aagatgggta
     8761 aggggaatct agactctcca gtgtatcaca ggttttccct gggaggctgg ggaatgcacc
     8821 aatacgcctt ggcattaata caaaatggga ctggaagctc aaagcaattc tttcttgggg
     8881 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtccatggc cttcatgcac atgtgggtat
     8941 ctgcataggt gtcttgaaca ttctgggtcc aggttcaagc ctcatagaca aggacttaga
     9001 gcagagctac tgggacctca ggttatattg ccgggccagc ccaggaagcg ccacagcaga
     9061 caggctgccg cagaagactc agcatcctaa gcctgctctt gctatttttc tgaccctgtc
     9121 agcccattcc cagcggccta acaaggacca ctttagggaa gagatgcacg tcgcccttcc
     9181 cctggccagt aaagggccaa cttgaggtct cacctgtggt tggccaccgc atggtgcttc
     9241 agcccctccc cctatatcct gtgccctcaa agggactcaa tgatctatct ccccacaagc
     9301 cagccaccca ctgcccaagc aatcccaaat ggcgccattc caaaagggct gttttttttt
     9361 tcttattaaa taaaaagaaa cctaatcaag atcttcaaag gtctctgccc aagaaataaa
     9421 cccagaaaaa taaagacagc agaggtaatt aaaatccagc cttatcaggg aaacaaggct
     9481 tcagctgctt ccaagaggaa agcctgcact tccacatcca tctccaaaga gaatgctgtc
     9541 tgtctccact cagcacagag ctggtggttt tgaaaggcaa ggtagaccag taggccagaa
     9601 ttgcctgaac cattatcttc taaaactaaa ttaaatagaa actggtttat agattctcag
     9661 tccacagagg tgtttcccat gacacctcag ctgccagtta cagagtaaat gagagaaatg
     9721 tagggccacc caattctgtc ccacttagat gtgctccaag ccacacacat ataacccagg
     9781 cacttcctgc ctccctgggt gaaatttggt ttggatagac agggttgcac cacagaagag
     9841 accaccaagg actatcttaa cagcacagct tccagcctcc aggcttcccc aaggtttgaa
     9901 atgcccaaga ccatcgagca tccaagagcc agatgtggct acaggaaggg tagggcagct
     9961 gtcttctttc tctctgggcc catttggctt gagtccaagc taaaggacaa ggagtcccct
    10021 tttcctacac caggagctca tggccctctg ccaatgtgct gctggcacag agcggtcgtc
    10081 atccagcctg tgttttgggg tgagtgcatg tgagtatggt aagtgcttgg gcagacggtg
    10141 ctggattctc acctgactgg aggtgttgct agccaggaag gaaagagtgg aagtgtccct
    10201 ttgtctgaac tgtccccaca aatgccatct cttctatgac catattattt ggagtcacac
    10261 taatgcccac ggttgatgtt gggagcctca agctgatggg gtcatcatct actcaaaccc
    10321 tgaggctggc cagcactggc tttcttcctt ttctaattct tccttccttt gttctaattc
    10381 agttcccagg gaggtcacat ggagaccaca gtggctaccc agtagtccaa gccaagggtc
    10441 caaggtaggg ggtggtttat gggacttgac taggaaccta ggagccagtg tctatcaccg
    10501 ggtctcatta tctgaactgt aagaaccgat ggtccctcct ttcatctgag cccagaagcc
    10561 cccttaaaat gacaagcacc ccaatcccat cagcccagac tctctgtccc tcccagaacc
    10621 ccacaatgta aggtcagggt tcttctgcca gcaaagccat tctgactgcc ccacctttca
    10681 aggagaccaa gccaaccata ttagccataa tccaccaggg tcctcagtca ctcttcttgg
    10741 gttgtgttcc tgggtcctgt tcaaccttca tcagcccttc cggtccatgt gacaatgcac
    10801 atcggtgtgc gtgtgctcat acgtgcacaa gagtgcacac acaaggaaac caaccaaacc
    10861 ccaatgtcat cttctgcatg tggtgagatg gacttgtgac ccttgtgtga cctccggctg
    10921 ctgtcctgtc ttgtaaaaaa aaaaaagttc acatgtttaa gaattttcaa gcaaatggtc
    10981 ccttaatgaa gtctgcagcg ttcaaataaa agatacggag aaaacaa
//
