LOCUS       NM_017304               1590 bp    mRNA    linear   ROD 03-FEB-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily A
            regulatory beta subunit 2 (Kcnab2), mRNA.
ACCESSION   NM_017304
VERSION     NM_017304.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1590)
  AUTHORS   Alka,K., Dolly,J.O., Ryan,B.J. and Henehan,G.T.
  TITLE     New inhibitors of the Kvbeta2 subunit from mammalian Kv1 potassium
            channels
  JOURNAL   Int J Biochem Cell Biol 55, 35-39 (2014)
   PUBMED   25066316
  REMARK    GeneRIF: Data suggest that potassium channel Kvbeta2 inhibitors
            could serve as tools to decipher the role of Kvbeta2 in vivo and,
            eventually, inform the development of novel therapeutics.
REFERENCE   2  (bases 1 to 1590)
  AUTHORS   Proepper,C., Putz,S., Russell,R., Boeckers,T.M. and Liebau,S.
  TITLE     The Kvbeta2 subunit of voltage-gated potassium channels is
            interacting with ProSAP2/Shank3 in the PSD
  JOURNAL   Neuroscience 261, 133-143 (2014)
   PUBMED   24211303
  REMARK    GeneRIF: Article reports a newly identified protein-protein
            interaction between the PSD-protein ProSAP2/Shank3 and the
            voltage-gated potassium channel subunit Kvbeta2
REFERENCE   3  (bases 1 to 1590)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   4  (bases 1 to 1590)
  AUTHORS   Ovsepian,S.V., Steuber,V., Le Berre,M., O'Hara,L., O'Leary,V.B. and
            Dolly,J.O.
  TITLE     A defined heteromeric KV1 channel stabilizes the intrinsic
            pacemaking and regulates the output of deep cerebellar nuclear
            neurons to thalamic targets
  JOURNAL   J Physiol 591 (7), 1771-1791 (2013)
   PUBMED   23318870
REFERENCE   5  (bases 1 to 1590)
  AUTHORS   Vacher,H., Yang,J.W., Cerda,O., Autillo-Touati,A., Dargent,B. and
            Trimmer,J.S.
  TITLE     Cdk-mediated phosphorylation of the Kvbeta2 auxiliary subunit
            regulates Kv1 channel axonal targeting
  JOURNAL   J Cell Biol 192 (5), 813-824 (2011)
   PUBMED   21357749
REFERENCE   6  (bases 1 to 1590)
  AUTHORS   Rhodes,K.J., Strassle,B.W., Monaghan,M.M., Bekele-Arcuri,Z.,
            Matos,M.F. and Trimmer,J.S.
  TITLE     Association and colocalization of the Kvbeta1 and Kvbeta2
            beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel
            complexes
  JOURNAL   J Neurosci 17 (21), 8246-8258 (1997)
   PUBMED   9334400
REFERENCE   7  (bases 1 to 1590)
  AUTHORS   Rhodes,K.J., Monaghan,M.M., Barrezueta,N.X., Nawoschik,S.,
            Bekele-Arcuri,Z., Matos,M.F., Nakahira,K., Schechter,L.E. and
            Trimmer,J.S.
  TITLE     Voltage-gated K+ channel beta subunits: expression and distribution
            of Kv beta 1 and Kv beta 2 in adult rat brain
  JOURNAL   J Neurosci 16 (16), 4846-4860 (1996)
   PUBMED   8756417
REFERENCE   8  (bases 1 to 1590)
  AUTHORS   Shi,G., Nakahira,K., Hammond,S., Rhodes,K.J., Schechter,L.E. and
            Trimmer,J.S.
  TITLE     Beta subunits promote K+ channel surface expression through effects
            early in biosynthesis
  JOURNAL   Neuron 16 (4), 843-852 (1996)
   PUBMED   8608002
REFERENCE   9  (bases 1 to 1590)
  AUTHORS   McCormack,K., McCormack,T., Tanouye,M., Rudy,B. and Stuhmer,W.
  TITLE     Alternative splicing of the human Shaker K+ channel beta 1 gene and
            functional expression of the beta 2 gene product
  JOURNAL   FEBS Lett 370 (1-2), 32-36 (1995)
   PUBMED   7649300
REFERENCE   10 (bases 1 to 1590)
  AUTHORS   Rettig,J., Heinemann,S.H., Wunder,F., Lorra,C., Parcej,D.N.,
            Dolly,J.O. and Pongs,O.
  TITLE     Inactivation properties of voltage-gated K+ channels altered by
            presence of beta-subunit
  JOURNAL   Nature 369 (6478), 289-294 (1994)
   PUBMED   8183366
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X76724.1.
            
            [WARNING] On Apr 26, 2024 this sequence was replaced by
            NM_017304.3.
            
            On Apr 20, 2007 this sequence version replaced NM_017304.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X76724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1590              X76724.1           111-1700
FEATURES             Location/Qualifiers
     source          1..1590
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1590
                     /gene="Kcnab2"
                     /note="potassium voltage-gated channel subfamily A
                     regulatory beta subunit 2"
                     /db_xref="GeneID:29738"
                     /db_xref="RGD:61828"
     exon            1..430
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..559
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..1586
                     /gene="Kcnab2"
                     /note="kv-beta-2; K(+) channel subunit beta-2; potassium
                     voltage-gated channel, shaker-related subfamily, beta
                     member 2; potassium channel, voltage gated shaker-related
                     subfamily A regulatory beta subunit 2; potassium channel,
                     voltage gated subfamily A regulatory beta subunit 2"
                     /codon_start=1
                     /product="voltage-gated potassium channel subunit beta-2"
                     /protein_id="NP_059000.1"
                     /db_xref="GeneID:29738"
                     /db_xref="RGD:61828"
                     /translation="MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGK
                     SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNI
                     IKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP
                     DPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYH
                     MFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDK
                     ILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENI
                     GAIQVLPKLSSSIVHEIDSILGNKPYSKKDYRS"
     exon            560..601
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..645
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     exon            646..683
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     exon            684..763
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..808
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..853
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     exon            854..897
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     exon            898..984
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1070
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1191
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1286
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1407
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1496
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1590
                     /gene="Kcnab2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcgtgga tccagtgctg gtccaggggg tcgcccaatc cgccgccacc cacgcgagga
       61 gtcccgacct gagggatacc gctcactcag cacagaaccc gccccgcgtc acttttacgt
      121 caaggtagcg cggccaatga gagccagagt tcaatgattc tgactctacg cgcgcggacc
      181 aatcgacgca tcggcgggag ctgcaggatt tgcatggact ccgaaggcca ctgccaatga
      241 gactgtgact ggcgtgaatc atagccaata ataggatgct aggggcgtgg ccgcgggcgt
      301 cccacgaggt aaagatgctg cgggcggaac ctgccggagc aagcgggatt cgggggtgct
      361 gaagtcgcaa gggcagggcg ggaaggaaga tccggaacgg ggcgtgggat ccggagctgg
      421 aggcccccag gatttcccct ctgtgaaaag acacgctgat ctagataagt gaggccggcc
      481 ccatgtatcc ggaatcaacc acggggtctc cagctcgact ctccctgcgg cagacaggct
      541 cccccgggat gatctacagt actcggtatg ggagtcccaa aagacagctc cagttttaca
      601 ggaatctggg caaatctggc cttcgggtct cctgcctggg gcttggaaca tgggtgacct
      661 tcggaggcca gatcacagat gagatggcag agcacctaat gaccttggcc tatgacaatg
      721 gcatcaacct gttcgatacg gcggaggtct acgcagctgg caaggctgaa gtggtattag
      781 ggaacatcat taagaagaag gggtggagac ggtccagcct tgtcatcacc accaagatct
      841 tctggggcgg aaaggcagag accgagagag gcctttcccg gaagcacata atcgaaggac
      901 tgaaagcttc cctggagagg ctgcagctgg agtacgtgga tgtggttttt gccaaccgcc
      961 cagaccccaa cacacccatg gaagagactg tgcgggccat gacccatgtc atcaaccaag
     1021 ggatggccat gtactggggc acatcacgct ggagctccat ggagatcatg gaggcctact
     1081 cggtggctcg gcagttcaac ctgatcccgc ccatctgcga gcaagcggaa taccacatgt
     1141 tccagaggga gaaggtagag gtccagctgc cagagctgtt ccacaagata ggagtaggtg
     1201 ccatgacctg gtcccctctg gcctgcggca ttgtctcagg gaagtatgac agtggcatcc
     1261 caccctactc cagagcctct ctgaagggct accagtggtt gaaggacaag atcctgagtg
     1321 aggagggtcg ccgccagcaa gccaaactga aggaactgca ggccattgca gagcgcctag
     1381 gctgcaccct cccacagctg gccatagcct ggtgcctgag gaacgagggc gtcagctccg
     1441 tgctcctggg tgcttccaat gcagaacaac ttatggagaa cattggagca atacaggtcc
     1501 ttccaaaatt gtcgtcctcc atcgtccacg agatcgacag cattctgggc aataaaccct
     1561 acagcaaaaa ggactataga tcctaagtca
//
