LOCUS       NM_017303               3496 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily A
            regulatory beta subunit 1 (Kcnab1), mRNA.
ACCESSION   NM_017303 XM_345220
VERSION     NM_017303.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3496)
  AUTHORS   Cho,I.H., Panzera,L.C., Chin,M., Alpizar,S.A., Olveda,G.E.,
            Hill,R.A. and Hoppa,M.B.
  TITLE     The potassium channel subunit Kvbeta1 serves as a major control
            point for synaptic facilitation
  JOURNAL   Proc Natl Acad Sci U S A 117 (47), 29937-29947 (2020)
   PUBMED   33168717
  REMARK    GeneRIF: The potassium channel subunit Kvbeta1 serves as a major
            control point for synaptic facilitation.
REFERENCE   2  (bases 1 to 3496)
  AUTHORS   Busolin,G., Malacrida,S., Bisulli,F., Striano,P., Di
            Bonaventura,C., Egeo,G., Pasini,E., Cianci,V., Ferlazzo,E.,
            Bianchi,A., Coppola,G., Elia,M., Mecarelli,O., Gobbi,G.,
            Casellato,S., Marchini,M., Binelli,S., Freri,E., Granata,T.,
            Posar,A., Parmeggiani,A., Vigliano,P., Boniver,C., Aguglia,U.,
            Striano,S., Tinuper,P., Giallonardo,A.T., Michelucci,R. and
            Nobile,C.
  TITLE     Association of intronic variants of the KCNAB1 gene with lateral
            temporal epilepsy
  JOURNAL   Epilepsy Res 94 (1-2), 110-116 (2011)
   PUBMED   21333500
REFERENCE   3  (bases 1 to 3496)
  AUTHORS   Bunse,S., Locovei,S., Schmidt,M., Qiu,F., Zoidl,G., Dahl,G. and
            Dermietzel,R.
  TITLE     The potassium channel subunit Kvbeta3 interacts with pannexin 1 and
            attenuates its sensitivity to changes in redox potentials
  JOURNAL   FEBS J 276 (21), 6258-6270 (2009)
   PUBMED   19780818
  REMARK    GeneRIF: The potassium channel subunit Kvbeta3 interacts with
            pannexin 1 and attenuates its sensitivity to changes in redox
            potentials.
REFERENCE   4  (bases 1 to 3496)
  AUTHORS   Pan,Y., Weng,J., Kabaleeswaran,V., Li,H., Cao,Y., Bhosle,R.C. and
            Zhou,M.
  TITLE     Cortisone dissociates the Shaker family K+ channels from their beta
            subunits
  JOURNAL   Nat Chem Biol 4 (11), 708-714 (2008)
   PUBMED   18806782
REFERENCE   5  (bases 1 to 3496)
  AUTHORS   Bukiya,A.N., McMillan,J., Parrill,A.L. and Dopico,A.M.
  TITLE     Structural determinants of monohydroxylated bile acids to activate
            beta 1 subunit-containing BK channels
  JOURNAL   J Lipid Res 49 (11), 2441-2451 (2008)
   PUBMED   18650555
  REMARK    GeneRIF: A structural model of fatty acid (lithocholate) insertion
            and docking onto specific Kcnab1 transmembrane domain 2 interface
            regions is postulated that explains the differential efficacy of
            bile acids on large channel activity.
REFERENCE   6  (bases 1 to 3496)
  AUTHORS   Rhodes,K.J., Monaghan,M.M., Barrezueta,N.X., Nawoschik,S.,
            Bekele-Arcuri,Z., Matos,M.F., Nakahira,K., Schechter,L.E. and
            Trimmer,J.S.
  TITLE     Voltage-gated K+ channel beta subunits: expression and distribution
            of Kv beta 1 and Kv beta 2 in adult rat brain
  JOURNAL   J Neurosci 16 (16), 4846-4860 (1996)
   PUBMED   8756417
REFERENCE   7  (bases 1 to 3496)
  AUTHORS   Morales,M.J., Castellino,R.C., Crews,A.L., Rasmusson,R.L. and
            Strauss,H.C.
  TITLE     A novel beta subunit increases rate of inactivation of specific
            voltage-gated potassium channel alpha subunits
  JOURNAL   J Biol Chem 270 (11), 6272-6277 (1995)
   PUBMED   7890764
REFERENCE   8  (bases 1 to 3496)
  AUTHORS   Majumder,K., De Biasi,M., Wang,Z. and Wible,B.A.
  TITLE     Molecular cloning and functional expression of a novel potassium
            channel beta-subunit from human atrium
  JOURNAL   FEBS Lett 361 (1), 13-16 (1995)
   PUBMED   7890032
REFERENCE   9  (bases 1 to 3496)
  AUTHORS   Rettig,J., Heinemann,S.H., Wunder,F., Lorra,C., Parcej,D.N.,
            Dolly,J.O. and Pongs,O.
  TITLE     Inactivation properties of voltage-gated K+ channels altered by
            presence of beta-subunit
  JOURNAL   Nature 369 (6478), 289-294 (1994)
   PUBMED   8183366
REFERENCE   10 (bases 1 to 3496)
  AUTHORS   Scott,V.E., Rettig,J., Parcej,D.N., Keen,J.N., Findlay,J.B.,
            Pongs,O. and Dolly,J.O.
  TITLE     Primary structure of a beta subunit of alpha-dendrotoxin-sensitive
            K+ channels from bovine brain
  JOURNAL   Proc Natl Acad Sci U S A 91 (5), 1637-1641 (1994)
   PUBMED   8127858
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 2, 2021 this sequence version replaced NM_017303.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089219.1, X70662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-878               JAXUCZ010000002.1  151614551-151615428
            879-922             JAXUCZ010000002.1  151798683-151798726
            923-960             JAXUCZ010000002.1  151825991-151826028
            961-1040            JAXUCZ010000002.1  151829274-151829353
            1041-1085           JAXUCZ010000002.1  151831169-151831213
            1086-1130           JAXUCZ010000002.1  151833670-151833714
            1131-1174           JAXUCZ010000002.1  151835657-151835700
            1175-1261           JAXUCZ010000002.1  151860607-151860693
            1262-1347           JAXUCZ010000002.1  151897041-151897126
            1348-1468           JAXUCZ010000002.1  151897575-151897695
            1469-1563           JAXUCZ010000002.1  151898774-151898868
            1564-1684           JAXUCZ010000002.1  151905815-151905935
            1685-1773           JAXUCZ010000002.1  151908890-151908978
            1774-3496           JAXUCZ010000002.1  151911914-151913636
FEATURES             Location/Qualifiers
     source          1..3496
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..3496
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /note="potassium voltage-gated channel subfamily A
                     regulatory beta subunit 1"
                     /db_xref="GeneID:29737"
                     /db_xref="RGD:61827"
     exon            1..878
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /inference="alignment:Splign:2.1.0"
     CDS             658..1863
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /note="voltage-gated potassium channel beta subunit;
                     potassium channel, voltage gated subfamily A regulatory
                     beta subunit 1; kv-beta-1; K(+) channel subunit beta-1;
                     potassium voltage-gated channel, shaker-related subfamily,
                     beta member 1; potassium voltage-gated channel subfamily A
                     member regulatory beta subunit 1; Kvbeta1.1; Kvbeta1.2;
                     Kvbeta1.3; potassium channel, voltage-gated shaker related
                     subfamily A regulatory beta subunit 1"
                     /codon_start=1
                     /product="voltage-gated potassium channel subunit beta-1"
                     /protein_id="NP_058999.1"
                     /db_xref="GeneID:29737"
                     /db_xref="RGD:61827"
                     /translation="MQVSIACTEHNLKSRNGEDRLLSKQSSTAPNVVNAARAKFRTVA
                     IIARSLGTFTPQHHISLKESTAKQTGMKYRNLGKSGLRVSCLGLGTWVTFGGQISDEV
                     AERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAE
                     TERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMY
                     WGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMT
                     WSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLG
                     CTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILRNK
                     PYSKKDYRS"
     exon            879..922
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /inference="alignment:Splign:2.1.0"
     exon            923..960
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1040
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1085
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1130
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1174
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1261
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1347
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1468
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1563
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1684
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1773
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..3496
                     /gene="Kcnab1"
                     /gene_synonym="KvBeta3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttgtccg aggatgagtg gggaggggtc ttgagaagcc tccacctccg catcctccga
       61 agttccggag ggaggtagtt gacaggcaga gtggatggag accacgggtc cgcggggccc
      121 tgcttgctgt tagctgcttc ttgggatgct cctctccagt tgagcctcct gcctgtgatc
      181 cagagggtgc tggcagcgcg tcttgcggta tgcctgcgtt gctttgagcc agcgcccaga
      241 aaccagccct ctgcattcag gcacctcgga ctggctccag gcagggctgt gtgcagtcac
      301 catgaatgct cagctctagg cttctgcacc agcctcctga ccacatggat ctggctgttt
      361 aatcagccga gatcacaacc tgggaagatt ggggacgctg atatgcgctc cagctgctga
      421 gacaacttcc agcttggctg tttacttctt tgggtcccag ggactctgtc ctacacctca
      481 gcctctcctg ccactgtgtg tgggttctga agtcagctgc tgggactcct ccgaaggcat
      541 ccaggaaggg gggcaagagg ggttaaaaga cagccgaaat cccctccaac tgctcaccct
      601 ctgccgaccg cctgtgctgt ggggttctga gaggaccttg cgctgtccgg ggaagcaatg
      661 caagtctcca tagcctgcac agagcacaat ttgaagagtc gaaatggtga ggaccgactt
      721 ctgagcaagc agagctccac cgcccccaat gtggtgaacg cagcccgggc caaattccgc
      781 actgtcgcta tcatcgctcg cagcctgggg accttcaccc ctcagcatca catttctctc
      841 aaagagtcca ctgcaaagca gactggcatg aaatatagga atcttgggaa atcaggactc
      901 agagtttcgt gcttgggtct tggaacatgg gtgacattcg gaggtcaaat ttcagatgag
      961 gttgctgaac ggctgatgac aattgcctat gagagtggag ttaatctctt cgacactgca
     1021 gaagtctatg ctgctgggaa ggctgaggtg attctgggga gcatcatcaa gaagaaaggc
     1081 tggaggaggt caagcttggt catcacaacc aaactctact ggggtggaaa agccgaaaca
     1141 gaaagaggat tgtcaagaaa gcacatcatt gaaggactga aaggctccct ccagaggctg
     1201 caactggaat atgtggacgt ggtctttgca aatcgcccag acagcaacac ccccatggaa
     1261 gaaatcgttc gagccatgac gcacgtgatc aaccaaggca tggcaatgta ctggggcacc
     1321 tcgaggtgga gcgcgatgga gatcatggaa gcctactctg tcgcgcggca gttcaacatg
     1381 atcccgcctg tctgtgagca agctgagtat catcttttcc agagagaaaa ggtggaggtc
     1441 cagctgccag agctctacca taaaataggg gttggtgcaa tgacatggtc tccacttgct
     1501 tgtggaatta tttcaggaaa atatggaaat ggggtgccag aaagttctag agcttcactg
     1561 aagtgctacc agtggttgaa ggaaaggatt gtaagtgaag aagggagaaa acagcaaaac
     1621 aagctgaaag acctctctcc aattgctgaa cgcctgggat gcacactacc tcagctggct
     1681 gtggcatggt gcctgagaaa cgagggtgtg agctctgtgc tgctgggatc atccactcct
     1741 gaacaactca ttgaaaacct tggtgccatt caggtcctcc ctaagatgac atcacatgtg
     1801 gtaaatgaga ttgataacat attgcgcaac aagccctaca gcaaaaagga ctatagatcc
     1861 taaggcaatg catgagccac ttaagctgca tgagtaaatc ctggtgggta ggcggtgcag
     1921 aacggcctta ccagccactc ttttcaatca cttagcagct tgctgctcaa cctctagtgt
     1981 cccaggattc tctgaggtct ctctgctgtt gctaccactg tgcaccctga attctgaaca
     2041 catctgaaaa ttcacaagcc agaaaatcca ttctattttc ttatcttgga ctggtcccct
     2101 ctcctggcat tggtctgtgt acctcatgtt tttgcaatgg aaagaatatt ggggtagggg
     2161 aatctattat cttcagaagg ctgtacatat atattttttt caaaagaaca aaattcacaa
     2221 gatacagtgt atgacctgca taggaaacag gatagcctca ctctttagtc ttgcttggga
     2281 gaacaaacag aattaattta cttttttttt aatatttcat attcacacta gcaagtttta
     2341 tgtcatctgt aattcaaata aaacttctag gtatttactt tcactacctt gaaagttatg
     2401 ttgttgcctg gccctgtaca atttaagtgg ggtgtctctc agggttctaa catatccatt
     2461 tacatagagt tataaaggca tgaccacccc aatctttact agatacacaa tgctaattta
     2521 taaaagggtt atagtgctat ggaaacagct ttaaataaaa tgttgtgttc atttttttac
     2581 tttctattaa aacctgcata tacgttcaat tgcttgtagg cacaatttct gttaagttta
     2641 aatgtttgag ctttaaaaat acatacatgc tcagttttgt aattaaacct ataaataccc
     2701 agaaagggaa gtgtcagttt accactggga cattattata caatgcttgg tattttctga
     2761 agagttatta acatgaaaac aaatcataga caatgtaaaa agaaaaatgt ttttctcatt
     2821 cctcagcaca tgctagatga attaacttgc ccaaagaaaa agcaaaatat tcaagaagct
     2881 cctgattcta aatgtaccac acactacacc gtatgcatga aagttctttg catggaataa
     2941 aggggcttag ctttgcactc agaatctgag atatacttag ccctgcctct acaggttaat
     3001 tcccctcact atcccacttg agaagaactg taagactata ctgtgtgggt atctgtaaat
     3061 aaggataaaa cacaaagggt ttttgttgtt gttttgtttt ctgtaaaggt tgggtcattt
     3121 tctaactcta tttgtctatc tatagatgaa caacatccta cttcatctag ttagcaagtt
     3181 cttcatcact ttaagattta cacaagaaat atatgaactt aaaataattt tcagtcatgt
     3241 accacataac catgttgtac atcttaaact atcagtgaaa gataccaaga atcatgattg
     3301 ttactaccta gactccagta ggcaacttgg aagtttcacc catgagtatc tgattaatga
     3361 tggagctgaa ttaactttcc aactattcat tgtaaattta atccactgaa ctgtatgtat
     3421 aaatgagtgg agtgctgtct aaatgaaaat caattcattt gcttagagta ataaaggcat
     3481 ctgcaatctc atagta
//
