LOCUS       NM_023954               6696 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily A
            member 6 (Kcna6), mRNA.
ACCESSION   NM_023954 XM_001067110 XM_575671
VERSION     NM_023954.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6696)
  AUTHORS   Perumal,N., Yurugi,H., Dahm,K., Rajalingam,K., Grus,F.H.,
            Pfeiffer,N. and Manicam,C.
  TITLE     Proteome landscape and interactome of voltage-gated potassium
            channel 1.6 (Kv1.6) of the murine ophthalmic artery and neuroretina
  JOURNAL   Int J Biol Macromol 257 (Pt 1), 128464 (2024)
   PUBMED   38043654
  REMARK    GeneRIF: Proteome landscape and interactome of voltage-gated
            potassium channel 1.6 (Kv1.6) of the murine ophthalmic artery and
            neuroretina.
REFERENCE   2  (bases 1 to 6696)
  AUTHORS   Zhu,J., Yan,J. and Thornhill,W.B.
  TITLE     The Kv1.3 potassium channel is localized to the cis-Golgi and Kv1.6
            is localized to the endoplasmic reticulum in rat astrocytes
  JOURNAL   FEBS J 281 (15), 3433-3445 (2014)
   PUBMED   24924920
  REMARK    GeneRIF: Kv1.6 is localized to the endoplasmic reticulum in rat
            astrocytes.
REFERENCE   3  (bases 1 to 6696)
  AUTHORS   Iwasaki,S., Nakajima,T., Chihara,Y., Inoue,A., Fujimoto,C. and
            Yamasoba,T.
  TITLE     Developmental changes in the expression of Kappav1 potassium
            channels in rat vestibular ganglion cells
  JOURNAL   Brain Res 1429, 29-35 (2012)
   PUBMED   22079321
  REMARK    GeneRIF: down-regulation of the Kv1.6 protein and mRNA may be
            associated with maturation of excitable properties of primary
            vestibular neurons
REFERENCE   4  (bases 1 to 6696)
  AUTHORS   Al-Sabi,A., Kaza,S., Le Berre,M., O'Hara,L., Bodeker,M., Wang,J.
            and Dolly,J.O.
  TITLE     Position-dependent attenuation by Kv1.6 of N-type inactivation of
            Kv1.4-containing channels
  JOURNAL   Biochem J 438 (2), 389-396 (2011)
   PUBMED   21352098
  REMARK    GeneRIF: N-type inactivation prevention (NIP) domain function was
            shown to require positioning of Kv1.6 adjacent to the Kv1.4
            subunit.
REFERENCE   5  (bases 1 to 6696)
  AUTHORS   Fulton,S., Thibault,D., Mendez,J.A., Lahaie,N., Tirotta,E.,
            Borrelli,E., Bouvier,M., Tempel,B.L. and Trudeau,L.E.
  TITLE     Contribution of Kv1.2 voltage-gated potassium channel to D2
            autoreceptor regulation of axonal dopamine overflow
  JOURNAL   J Biol Chem 286 (11), 9360-9372 (2011)
   PUBMED   21233214
REFERENCE   6  (bases 1 to 6696)
  AUTHORS   Soliven,B., Ma,L., Bae,H., Attali,B., Sobko,A. and Iwase,T.
  TITLE     PDGF upregulates delayed rectifier via Src family kinases and
            sphingosine kinase in oligodendroglial progenitors
  JOURNAL   Am J Physiol Cell Physiol 284 (1), C85-C93 (2003)
   PUBMED   12475761
REFERENCE   7  (bases 1 to 6696)
  AUTHORS   Rhodes,K.J., Strassle,B.W., Monaghan,M.M., Bekele-Arcuri,Z.,
            Matos,M.F. and Trimmer,J.S.
  TITLE     Association and colocalization of the Kvbeta1 and Kvbeta2
            beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel
            complexes
  JOURNAL   J Neurosci 17 (21), 8246-8258 (1997)
   PUBMED   9334400
REFERENCE   8  (bases 1 to 6696)
  AUTHORS   Kirsch,G.E., Drewe,J.A., Verma,S., Brown,A.M. and Joho,R.H.
  TITLE     Electrophysiological characterization of a new member of the RCK
            family of rat brain K+ channels
  JOURNAL   FEBS Lett 278 (1), 55-60 (1991)
   PUBMED   1993474
REFERENCE   9  (bases 1 to 6696)
  AUTHORS   Swanson,R., Marshall,J., Smith,J.S., Williams,J.B., Boyle,M.B.,
            Folander,K., Luneau,C.J., Antanavage,J., Oliva,C., Buhrow,S.A. et
            al.
  TITLE     Cloning and expression of cDNA and genomic clones encoding three
            delayed rectifier potassium channels in rat brain
  JOURNAL   Neuron 4 (6), 929-939 (1990)
   PUBMED   2361015
REFERENCE   10 (bases 1 to 6696)
  AUTHORS   Grupe,A., Schroter,K.H., Ruppersberg,J.P., Stocker,M., Drewes,T.,
            Beckh,S. and Pongs,O.
  TITLE     Cloning and expression of a human voltage-gated potassium channel.
            A novel member of the RCK potassium channel family
  JOURNAL   EMBO J 9 (6), 1749-1756 (1990)
   PUBMED   2347305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 30, 2020 this sequence version replaced NM_023954.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2513311.1,
                                           SRR26643298.25441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6369              JAXUCZ010000004.1  161255984-161262352 c
            6370-6696           JAXUCZ010000004.1  161229103-161229429 c
FEATURES             Location/Qualifiers
     source          1..6696
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..6696
                     /gene="Kcna6"
                     /gene_synonym="Kv1.6"
                     /note="potassium voltage-gated channel subfamily A member
                     6"
                     /db_xref="GeneID:64358"
                     /db_xref="RGD:62083"
     exon            1..6369
                     /gene="Kcna6"
                     /gene_synonym="Kv1.6"
                     /inference="alignment:Splign:2.1.0"
     CDS             1647..3239
                     /gene="Kcna6"
                     /gene_synonym="Kv1.6"
                     /note="kv2; RCK2; voltage-gated potassium channel subunit
                     Kv1.6; voltage-gated potassium channel subunit Kv2;
                     potassium channel-Kv2; potassium voltage gated channel,
                     shaker related subfamily, member 6; potassium channel,
                     voltage gated shaker related subfamily A, member 6"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily A
                     member 6"
                     /protein_id="NP_076444.1"
                     /db_xref="GeneID:64358"
                     /db_xref="RGD:62083"
                     /translation="MRSEKSLTLAAPGEVRGPEGEQQDAGEFQEAEGGGGCCSSERLV
                     INISGLRYETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQS
                     GGRLRRPVNVPLDIFMEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQV
                     WLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRADGRGGSNEGSGTRMSPA
                     SRGSHEEEDEDEDSYAFPGSIPSGGLGTGGTSSFSTLGGSFFTDPFFLVETLCIVWFT
                     FELLVRFSACPSKAAFFRNIMNIIDLVAIFPYFITLGTELVQRHEQQPVSGGSGQNGQ
                     QAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFS
                     SAVYFAEADDVDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLT
                     IALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQPTPDLKATDNGLGKPDFAEASRE
                     RRSSYLPTPHRAYAEKRMLTEV"
     exon            6370..6696
                     /gene="Kcna6"
                     /gene_synonym="Kv1.6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttagatggct gtattgttta ttgacattgt attgtacctc ctttttgttt atccttccct
       61 cccctttctc gacatagata aatgtaaatt gcacaatctt ttcttttttt ctttcccccc
      121 tagggaggct tggagcaaag attcctggct gccattcctt tatatagtgt ttcttcagta
      181 acatagcctc ctggtgcttt atcatggaga tgatggtgga tgtcttctgg acaccatgag
      241 aggacggttt cctactcact gggcatgaac aggtttttcc tgccctctta ctttcactat
      301 gccttgaagg tgagattcgg ccttgccttt ccaggttgta gaagtgagag tctgttgggg
      361 aattaacact gggacacagc cgagatggaa agctctcaag acatttaaaa atacttcacc
      421 ccccccaacc cccagtagag gttgaaactg gcaaatgtgt cttcgtggat atagaaaaca
      481 tgggtccccc gcccgccacc cccccagtaa acagcgtttg aggggtcagg tgctgagtat
      541 agcttattgg gcagggtgtg tggggggcta gcgtgtgatt tcttttttga tgaaatacac
      601 tgcgtaggtc agcccggtga acagaaatga gaggagacga tttgtggagg atggagtggg
      661 tgtgttatta ggatactgcg gcttggttgg ggtgggggtg ggggtggggg cgtgcgtgtg
      721 aatgtgagaa agcaagaggc atgccaggag agcgcgggaa agattaccgg gaaggcaagt
      781 gtgcatctct ctctctctct ctccagcatc caggcttgct gcagccccta gctgggtaag
      841 gggtgtgatg tgagagtggg gtgggagggg gcagcaggcg gggcctgcca cgtcacttgg
      901 agagtgtgtt aaggaggaag ggcagagctg agagctgagc ctgctgctgc tgttgctgct
      961 gctgctgttg ctgctgcttg ctgttgctgc tgctgctggg gctgctgcgg gtgcgggcaa
     1021 ggattgatgc ggtggggagg tgggtctctg cgctccggcg cccgggcagg cccagggcgg
     1081 ttccgaggcc tgtagaacag ctcctgggaa gaaggtggcg gctgcaatcg cgaccttggc
     1141 cagacctagt tcgtggtgga cgtagggcgg aggcggaggc cgagcccggg caggagtctt
     1201 tggcgagcca gagggaggcg catctggcgc ttcggtacca gcggcagcct tgtgagtctt
     1261 gtgaggctgg agaagcgcag caggacctgg tgagagctag caagtctgga gggcggacct
     1321 gtgggtcccg agcccagttt taggcaccac cgagagctaa gccaagcgtc ttttcgggca
     1381 gccagtttca cgcgcgcgac agtttgcggg ttccaggcat ctcagaaatc ttgagcacgg
     1441 aggcgcggct actgagagcc agagccacat cccagaccta gcctggcaga gagaccagct
     1501 gcagggttca ccgacctaac cgccaggtca gagcacgggc cccaccctaa aggagggcgc
     1561 agccggagct gggaagccgg tgccgcgctc cggagctcgt gtcgtgggcg ccgtcctagt
     1621 ggcggggagc gcaccgccga ggtgacatga gatcggagaa atccctgacg ctggcggcgc
     1681 cgggggaggt ccgtgggccg gagggggagc aacaggatgc gggtgagttc caggaggccg
     1741 agggcggcgg cggctgctgt agtagtgaga ggctggtgat caacatctct gggctgcgct
     1801 acgagacgca gctgcgcacc ttgtcgctgt tccctgacac gctgctagga gaccctggcc
     1861 gcagagtccg cttctttgac cccttgagga atgagtactt ctttgaccgc aaccgaccca
     1921 gcttcgacgc tatcctttat tactaccagt cggggggtcg cctgcgcagg ccggttaacg
     1981 tgccccttga catctttatg gaagagattc gcttctatca gttgggagat gaagccctgg
     2041 cggccttccg ggaggatgag ggttgcctgc ccgaaggtgg tgaggatgag aagccactcc
     2101 cctcccagcc tttccagcga caggtctggc tcctctttga gtatccggag agttctgggc
     2161 ccgcccgagg cattgccatc gtctcagtgt tggtcatcct catctccatt gtcatctttt
     2221 gcctggagac cttgcctcag ttccgtgcag atgggcgcgg tggaagcaac gaggggagtg
     2281 ggacccgcat gtccccggcc tccaggggga gccacgagga ggaagatgaa gacgaggatt
     2341 cctatgcatt tcctggtagc attccctctg gggggttggg gaccggagga acttcttcat
     2401 ttagtactct cgggggttcc ttcttcacag accccttctt cctggtggaa actctgtgta
     2461 tcgtctggtt cacctttgag ctcctggtgc gcttctctgc ctgtcccagc aaggcggcct
     2521 tctttcgcaa tatcatgaac atcattgact tggtggccat cttcccctac tttatcaccc
     2581 tgggcaccga gctagtgcaa cgtcacgagc agcagcctgt gagtggtggc agtggtcaga
     2641 atgggcagca ggccatgtcc ctagccatcc tcagggtgat ccgcctggtc cgggtgtttc
     2701 ggatcttcaa gctctcccgc cactccaagg ggttgcagat cctgggtaag accttgcaag
     2761 catccatgcg ggagctcggg ctactcatct tcttcctctt cattggagtc atcctcttct
     2821 ccagcgctgt ctacttcgca gaggcagatg acgttgactc gctcttccct agcatcccag
     2881 atgccttttg gtgggctgtg gttacaatga ccacagtagg ttatggggac atgtacccca
     2941 tgacggtggg aggcaagatt gtgggctcac tgtgtgccat tgctggggtc ctcaccattg
     3001 cattaccggt accggtcatt gtctccaatt tcaactactt ctaccaccga gagacggagc
     3061 aggaggaaca aggccagtat acccacgtca cttgtgggca gcctacaccg gacctgaagg
     3121 caacggacaa tgggcttggc aaacctgact ttgcggaggc ttcacgggaa cggcggtcca
     3181 gctaccttcc aactccacat cgagcttatg cagagaaaag gatgctcacc gaggtttgat
     3241 ggatgcgggc aggcctgcag gaaaacagga gctctgagca agtcatctct caggcttcct
     3301 tctcatgctc actactcccg ccttagctcc agaggacctc gaacccccgc cccgccccct
     3361 cccgtacaca gtacacggca tcctggacca aatatctgga ctatagactg ttgctcgctc
     3421 ctcgcagcat tcgaggtttc tccatcttag tgacattttt ggaaatttca acggtgccac
     3481 ccaatcatgc ccatcagtca cgtgaatgag atgcacattt ctgactgacc ttccctcaag
     3541 actgagttct catgcctggg tcttgtaata tctctaggaa tggtgacacc aatagaatag
     3601 gaagcagcta cactcaggtc ccttctttag agtcctttgc tttgggtcat gcgccttcct
     3661 tagcttctgg tcacgtggtc actggcagac tctggactat ggaagatttc agcttgccgt
     3721 tttggtgctc tctccagctt ctggctggta gagctattag ctgcccggct ttgaaagtta
     3781 tccacagcta aatttggatg gaattagaga aaatactacc caactggatt atttgaagga
     3841 cacgagggtc agttctagat caatgggggc cagtggacct ctcagttgtg atctgtcaca
     3901 ggagaccaca gcaggggggt ctacagtaga cctcaccacc cagattccct gactcccttg
     3961 agcttccaag aaggcacctt ctcagagcca agttcttttt gtgtgcaagc gccttggtgt
     4021 gaggaggaac tggaaaacag aaccacggag acaggagaaa agcctgacca gagccgaagg
     4081 actggctgga ccacacatct gaagcgaggt gccccttagc agagactgtc aacttagaac
     4141 aggcagaggg accctgctgc agtcagcagc caattctccg agattagccc agatctctct
     4201 aaggtatcct cttcccttct ccctgggaac ctgacctagg attgcagatt gtttttataa
     4261 agcaaacctc agctctaacc tacagacagg tgagttcaca catcgaatgc cagcagagct
     4321 tttctcttat gctgcggcaa cagcctttgg ttgggagcca ggaaagggca cggctatgtt
     4381 gttggcagcc tctgttctgc tgagtcaagc aaacgttggt ctgctctgct cttcctttgg
     4441 agctgcattc ggcctgctct aactgctaag gtaactcggt ggttcccact tggaccaagc
     4501 catcttctac cattgtgaaa tcactgccac cctcccagct gcccactgcc ccctccctcc
     4561 cataacattg ccatttagtt ttgcctttga taaactgtga cacactgttc tcagttctca
     4621 tgggtacagt tctgaaactc aaaggactgt taacatgttt ttaattttat attgatgctt
     4681 taaagttctt caaagagaat gctttttcaa aagattttcc tgaagagcaa cttagtaagg
     4741 agagtgacat tgattactgg cttgagaggc cactgtggct ccagggagtg acagatcaca
     4801 gtctgagttt tgccacagct ttacagggta actctggtgt cacggtccct cattgtgcct
     4861 cagtttcttc cacccgttaa atgagaacat taaagtcttc ccctccctac ctcatggggg
     4921 aattatcaat aaactcaccc aggaaggtgg ggaagatgct atgcaagtgt atgaattata
     4981 gtaatggctt tgagttttcg ttcattatac tgcctgccta tctctcaaag gcaaggcctt
     5041 tcccccagaa atttccactg tggatccaaa gcctaagact aggtcattgt agaccaacag
     5101 ctttctaagt ctctccttgg tattttgggc ttgggtcttc atcctttctt tcacccttca
     5161 gaatggacta tattcttgtg gtagacttgg tggccagaag tcatttcctt ggaggcttga
     5221 cttctccaag cctgcagcag agtaaaagac tgagatgttt aagactccgg agatctattc
     5281 caaggccagt aagaaagtat tttgtttcca gtgattttag ttgttaggag cccaccccag
     5341 tgaccaaagg gaggccccca gctgaggatg gatgagggga tatgtgtgca tggatctctc
     5401 tctctctgtg tatatattgt caccctcatc actatccctg tctttatgca aacattgcct
     5461 tttcaagtca gaacatgcct gaaagtaaaa ggtttgtgga gagccaggct ctccagggac
     5521 tctggttgct gtagcaacct tccagactgt tctctctact gatttgggta tcaaggggga
     5581 acagactaca tatcccagct tctcatatgg gaacacctcc aatctatcga tttaggcatt
     5641 ggcagaacta aagcaaggac tcaggacctt tgacaacgtg ggggaagtag attctcaaca
     5701 cttcctgcct agacatttct tcctggctct ttatctggtc actgaagctg ccacatctta
     5761 ccccgattct tcagaaactt gaatgcttag aaactgccca actctgccaa caccaatgtc
     5821 aggttttcaa aaggagacct cagagagggg tacaaaaggt cctctccgta gcagtcagac
     5881 tgggccttga ggacacagag gacaccagtc tggggtgtca tggtattctc atctcagatg
     5941 caggctcttc ccagctctaa gagagatcga gaagaatgga actcctccct cccagggagc
     6001 agcattgctc ctgacgaaaa ttatggaagc gattcttaag atgtcagaca gaaactgaga
     6061 ggccgtgact caatctagct tttgtgaaga gttttgtcca gtgagctctc cctgcttctg
     6121 agcctccctg tggatgacgt aaccttggca tccagagaga acgtgtacca ccgtgtgctg
     6181 cctcagcagc tggaatagca tcacagctgc ctgagaaggt ggggttcaag ccatctcaat
     6241 gactgactta agccagtggg ggctcccaga ggacgcccta ggactgccag tttctgcttg
     6301 ggatgaggac attcctcctg cctagcatcc tagaggagca aggaacagct ggccttcctt
     6361 gcctctgagg gctgtgctgc tcgtggtcac tctggaaaac ctgtgcatcc aaagaccttt
     6421 aacttctctg gaggatgaga ccccacgcct cctcactgaa taactcagcc tggcagcccc
     6481 tggcggcctt ccgcaagcac tgactgggaa ggaaaaggct gagacggggg attctggatg
     6541 ttgcggtggg gccataggaa ggcggggaga gctgctggcc tgatcgaagg agaaagggtg
     6601 ttaggatgat gtgggatcat gtgtgctgca gagccgccca ggcaggcact cgctggctgg
     6661 ggaagagtaa ctaataaata aatgacagtc tcagag
//
