LOCUS       NP_076444                530 aa            linear   ROD 01-JUL-2024
DEFINITION  potassium voltage-gated channel subfamily A member 6 [Rattus
            norvegicus].
ACCESSION   NP_076444 XP_001067110 XP_575671
VERSION     NP_076444.1
DBSOURCE    REFSEQ: accession NM_023954.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 530)
  AUTHORS   Perumal,N., Yurugi,H., Dahm,K., Rajalingam,K., Grus,F.H.,
            Pfeiffer,N. and Manicam,C.
  TITLE     Proteome landscape and interactome of voltage-gated potassium
            channel 1.6 (Kv1.6) of the murine ophthalmic artery and neuroretina
  JOURNAL   Int J Biol Macromol 257 (Pt 1), 128464 (2024)
   PUBMED   38043654
  REMARK    GeneRIF: Proteome landscape and interactome of voltage-gated
            potassium channel 1.6 (Kv1.6) of the murine ophthalmic artery and
            neuroretina.
REFERENCE   2  (residues 1 to 530)
  AUTHORS   Zhu,J., Yan,J. and Thornhill,W.B.
  TITLE     The Kv1.3 potassium channel is localized to the cis-Golgi and Kv1.6
            is localized to the endoplasmic reticulum in rat astrocytes
  JOURNAL   FEBS J 281 (15), 3433-3445 (2014)
   PUBMED   24924920
  REMARK    GeneRIF: Kv1.6 is localized to the endoplasmic reticulum in rat
            astrocytes.
REFERENCE   3  (residues 1 to 530)
  AUTHORS   Iwasaki,S., Nakajima,T., Chihara,Y., Inoue,A., Fujimoto,C. and
            Yamasoba,T.
  TITLE     Developmental changes in the expression of Kappav1 potassium
            channels in rat vestibular ganglion cells
  JOURNAL   Brain Res 1429, 29-35 (2012)
   PUBMED   22079321
  REMARK    GeneRIF: down-regulation of the Kv1.6 protein and mRNA may be
            associated with maturation of excitable properties of primary
            vestibular neurons
REFERENCE   4  (residues 1 to 530)
  AUTHORS   Al-Sabi,A., Kaza,S., Le Berre,M., O'Hara,L., Bodeker,M., Wang,J.
            and Dolly,J.O.
  TITLE     Position-dependent attenuation by Kv1.6 of N-type inactivation of
            Kv1.4-containing channels
  JOURNAL   Biochem J 438 (2), 389-396 (2011)
   PUBMED   21352098
  REMARK    GeneRIF: N-type inactivation prevention (NIP) domain function was
            shown to require positioning of Kv1.6 adjacent to the Kv1.4
            subunit.
REFERENCE   5  (residues 1 to 530)
  AUTHORS   Fulton,S., Thibault,D., Mendez,J.A., Lahaie,N., Tirotta,E.,
            Borrelli,E., Bouvier,M., Tempel,B.L. and Trudeau,L.E.
  TITLE     Contribution of Kv1.2 voltage-gated potassium channel to D2
            autoreceptor regulation of axonal dopamine overflow
  JOURNAL   J Biol Chem 286 (11), 9360-9372 (2011)
   PUBMED   21233214
REFERENCE   6  (residues 1 to 530)
  AUTHORS   Soliven,B., Ma,L., Bae,H., Attali,B., Sobko,A. and Iwase,T.
  TITLE     PDGF upregulates delayed rectifier via Src family kinases and
            sphingosine kinase in oligodendroglial progenitors
  JOURNAL   Am J Physiol Cell Physiol 284 (1), C85-C93 (2003)
   PUBMED   12475761
REFERENCE   7  (residues 1 to 530)
  AUTHORS   Rhodes,K.J., Strassle,B.W., Monaghan,M.M., Bekele-Arcuri,Z.,
            Matos,M.F. and Trimmer,J.S.
  TITLE     Association and colocalization of the Kvbeta1 and Kvbeta2
            beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel
            complexes
  JOURNAL   J Neurosci 17 (21), 8246-8258 (1997)
   PUBMED   9334400
REFERENCE   8  (residues 1 to 530)
  AUTHORS   Kirsch,G.E., Drewe,J.A., Verma,S., Brown,A.M. and Joho,R.H.
  TITLE     Electrophysiological characterization of a new member of the RCK
            family of rat brain K+ channels
  JOURNAL   FEBS Lett 278 (1), 55-60 (1991)
   PUBMED   1993474
REFERENCE   9  (residues 1 to 530)
  AUTHORS   Swanson,R., Marshall,J., Smith,J.S., Williams,J.B., Boyle,M.B.,
            Folander,K., Luneau,C.J., Antanavage,J., Oliva,C., Buhrow,S.A. et
            al.
  TITLE     Cloning and expression of cDNA and genomic clones encoding three
            delayed rectifier potassium channels in rat brain
  JOURNAL   Neuron 4 (6), 929-939 (1990)
   PUBMED   2361015
REFERENCE   10 (residues 1 to 530)
  AUTHORS   Grupe,A., Schroter,K.H., Ruppersberg,J.P., Stocker,M., Drewes,T.,
            Beckh,S. and Pongs,O.
  TITLE     Cloning and expression of a human voltage-gated potassium channel.
            A novel member of the RCK potassium channel family
  JOURNAL   EMBO J 9 (6), 1749-1756 (1990)
   PUBMED   2347305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Jul 16, 2009 this sequence version replaced
            XP_575671.1, XP_001067110.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2513311.1,
                                           SRR26643298.25441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     Protein         1..530
                     /product="potassium voltage-gated channel subfamily A
                     member 6"
                     /note="kv2; RCK2; voltage-gated potassium channel subunit
                     Kv1.6; voltage-gated potassium channel subunit Kv2;
                     potassium channel-Kv2; potassium voltage gated channel,
                     shaker related subfamily, member 6; potassium channel,
                     voltage gated shaker related subfamily A, member 6"
                     /calculated_mol_wt=58654
     Region          1..35
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P17659.1)"
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61923; propagated from
                     UniProtKB/Swiss-Prot (P17659.1)"
     Region          41..170
                     /region_name="BTB_POZ_KCNA6"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in potassium
                     voltage-gated channel subfamily A member 6 (KCNA6);
                     cd18407"
                     /db_xref="CDD:349714"
     Site            order(41,74,77,79..80,82,84)
                     /site_type="other"
                     /note="putative beta subunit interface [polypeptide
                     binding]"
                     /db_xref="CDD:349714"
     Site            order(42,46,48..55,58,78,81,85,87..88,90..91,94,98,101,
                     105,107,111,115..116,119)
                     /site_type="other"
                     /note="putative tetramer interface [polypeptide binding]"
                     /db_xref="CDD:349714"
     Site            172..193
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P17659.1)"
     Region          203..239
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P17659.1)"
     Site            222
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P17659.1)"
     Region          258..469
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Site            264..285
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P17659.1)"
     Site            297..317
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P17659.1)"
     Site            339..359
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P17659.1)"
     Region          361..374
                     /region_name="S4-S5 linker.
                     /evidence=ECO:0000250|UniProtKB:P63142"
                     /note="propagated from UniProtKB/Swiss-Prot (P17659.1)"
     Site            375..396
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P17659.1)"
     Region          423..428
                     /region_name="Selectivity filter.
                     /evidence=ECO:0000250|UniProtKB:P63142"
                     /note="propagated from UniProtKB/Swiss-Prot (P17659.1)"
     Site            438..466
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P17659.1)"
     Site            512
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000305;
                     propagated from UniProtKB/Swiss-Prot (P17659.1)"
     Region          527..529
                     /region_name="PDZ-binding. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P17659.1)"
     Site            528
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKA. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P17659.1)"
     CDS             1..530
                     /gene="Kcna6"
                     /gene_synonym="Kv1.6"
                     /coded_by="NM_023954.2:1647..3239"
                     /db_xref="GeneID:64358"
                     /db_xref="RGD:62083"
ORIGIN      
        1 mrseksltla apgevrgpeg eqqdagefqe aeggggccss erlvinisgl ryetqlrtls
       61 lfpdtllgdp grrvrffdpl rneyffdrnr psfdailyyy qsggrlrrpv nvpldifmee
      121 irfyqlgdea laafredegc lpeggedekp lpsqpfqrqv wllfeypess gpargiaivs
      181 vlvilisivi fcletlpqfr adgrggsneg sgtrmspasr gsheeedede dsyafpgsip
      241 sgglgtggts sfstlggsff tdpfflvetl civwftfell vrfsacpska affrnimnii
      301 dlvaifpyfi tlgtelvqrh eqqpvsggsg qngqqamsla ilrvirlvrv frifklsrhs
      361 kglqilgktl qasmrelgll ifflfigvil fssavyfaea ddvdslfpsi pdafwwavvt
      421 mttvgygdmy pmtvggkivg slcaiagvlt ialpvpvivs nfnyfyhret eqeeqgqyth
      481 vtcgqptpdl katdnglgkp dfaeasrerr ssylptphra yaekrmltev
//
