LOCUS       NM_012972               2957 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily A
            member 5 (Kcna5), mRNA.
ACCESSION   NM_012972
VERSION     NM_012972.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2957)
  AUTHORS   Lv,Y., Fu,L., Zhang,Z., Gu,W., Luo,X., Zhong,Y., Xu,S., Wang,Y.,
            Yan,L., Li,M. and Du,L.
  TITLE     Increased Expression of MicroRNA-206 Inhibits Potassium
            Voltage-Gated Channel Subfamily A Member 5 in Pulmonary Arterial
            Smooth Muscle Cells and Is Related to Exaggerated Pulmonary Artery
            Hypertension Following Intrauterine Growth Retardation in Rats
  JOURNAL   J Am Heart Assoc 8 (2), e010456 (2019)
   PUBMED   30636484
  REMARK    GeneRIF: expression of Kv1.5 and 4-aminopyridine (Kv channel
            special inhibitor)-sensitive Kv current were correlated with the
            inhibition of miR-206 in PA rings of IUGR - CH rats and cultured
            IUGR PASMC s exposed to hypoxia. Thus, miR-206 may be a trigger for
            induction of exaggerated CH-pulmonary artery hypertension of IUGR
            via Kv1.5.
REFERENCE   2  (bases 1 to 2957)
  AUTHORS   Kidd,M.W., Bulley,S. and Jaggar,J.H.
  TITLE     Angiotensin II reduces the surface abundance of KV 1.5 channels in
            arterial myocytes to stimulate vasoconstriction
  JOURNAL   J Physiol 595 (5), 1607-1618 (2017)
   PUBMED   27958660
  REMARK    GeneRIF: Ang II selectively stimulates degradation of KV1.5
            channels to reduce functional KV1.5 channel surface abundance in
            mesenteric artery myocytes
REFERENCE   3  (bases 1 to 2957)
  AUTHORS   Zimmer,J., Takahashi,T., Hofmann,A.D. and Puri,P.
  TITLE     Imbalance of NFATc2 and KV1.5 Expression in Rat Pulmonary
            Vasculature of Nitrofen-Induced Congenital Diaphragmatic Hernia
  JOURNAL   Eur J Pediatr Surg 27 (1), 68-73 (2017)
   PUBMED   27522126
  REMARK    GeneRIF: This study demonstrates for the first time an altered gene
            and protein expression of NFATc2 and KV1.5 in the pulmonary
            vasculature of nitrofen-induced congenital diaphragmatic hernia.
            Upregulation of NFATc2 with concomitant downregulation of KV1.5
            channels may contribute to abnormal vascular remodeling.
REFERENCE   4  (bases 1 to 2957)
  AUTHORS   Lu,G., Xu,C., Tang,K., Zhang,J., Li,Q., Peng,L., Wang,Y., Huang,Z.
            and Gao,X.
  TITLE     H2S inhibits angiotensin II-induced atrial Kv1.5 upregulation by
            attenuating Nox4-mediated ROS generation during atrial fibrillation
  JOURNAL   Biochem Biophys Res Commun 483 (1), 534-540 (2017)
   PUBMED   28011270
  REMARK    GeneRIF: H2S downregulates Ang II-induced atrial Kv1.5 expression
            by attenuating Nox4-related ROS-triggered P-Smad2/3 and P-ERK 1/2
            activation during atrial fibrillation
REFERENCE   5  (bases 1 to 2957)
  AUTHORS   Moral-Sanz,J., Mahmoud,A.D., Ross,F.A., Eldstrom,J., Fedida,D.,
            Hardie,D.G. and Evans,A.M.
  TITLE     AMP-activated protein kinase inhibits Kv 1.5 channel currents of
            pulmonary arterial myocytes in response to hypoxia and inhibition
            of mitochondrial oxidative phosphorylation
  JOURNAL   J Physiol 594 (17), 4901-4915 (2016)
   PUBMED   27062501
  REMARK    GeneRIF: AMPK selectively inhibits Kv1.5 in pulmonary arterial
            myocytes
REFERENCE   6  (bases 1 to 2957)
  AUTHORS   Mays,D.J., Foose,J.M., Philipson,L.H. and Tamkun,M.M.
  TITLE     Localization of the Kv1.5 K+ channel protein in explanted cardiac
            tissue
  JOURNAL   J Clin Invest 96 (1), 282-292 (1995)
   PUBMED   7615797
REFERENCE   7  (bases 1 to 2957)
  AUTHORS   Attali,B., Lesage,F., Ziliani,P., Guillemare,E., Honore,E.,
            Waldmann,R., Hugnot,J.P., Mattei,M.G., Lazdunski,M. and Barhanin,J.
  TITLE     Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed
            rectifier K+ channel
  JOURNAL   J Biol Chem 268 (32), 24283-24289 (1993)
   PUBMED   8226976
REFERENCE   8  (bases 1 to 2957)
  AUTHORS   Roberds,S.L. and Tamkun,M.M.
  TITLE     Cloning and tissue-specific expression of five voltage-gated
            potassium channel cDNAs expressed in rat heart
  JOURNAL   Proc Natl Acad Sci U S A 88 (5), 1798-1802 (1991)
   PUBMED   1705709
REFERENCE   9  (bases 1 to 2957)
  AUTHORS   Philipson,L.H., Hice,R.E., Schaefer,K., LaMendola,J., Bell,G.I.,
            Nelson,D.J. and Steiner,D.F.
  TITLE     Sequence and functional expression in Xenopus oocytes of a human
            insulinoma and islet potassium channel
  JOURNAL   Proc Natl Acad Sci U S A 88 (1), 53-57 (1991)
   PUBMED   1986382
REFERENCE   10 (bases 1 to 2957)
  AUTHORS   Swanson,R., Marshall,J., Smith,J.S., Williams,J.B., Boyle,M.B.,
            Folander,K., Luneau,C.J., Antanavage,J., Oliva,C., Buhrow,S.A. et
            al.
  TITLE     Cloning and expression of cDNA and genomic clones encoding three
            delayed rectifier potassium channels in rat brain
  JOURNAL   Neuron 4 (6), 929-939 (1990)
   PUBMED   2361015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 20, 2021 this sequence version replaced NM_012972.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26360172.921971.1,
                                        SRR26360190.988747.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2957              JAXUCZ010000004.1  161040853-161043809 c
FEATURES             Location/Qualifiers
     source          1..2957
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2957
                     /gene="Kcna5"
                     /gene_synonym="Kv1; Kv1.5"
                     /note="potassium voltage-gated channel subfamily A member
                     5"
                     /db_xref="GeneID:25470"
                     /db_xref="RGD:2953"
     exon            1..2957
                     /gene="Kcna5"
                     /gene_synonym="Kv1; Kv1.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..2172
                     /gene="Kcna5"
                     /gene_synonym="Kv1; Kv1.5"
                     /note="RK4; RCK7; voltage-gated potassium channel subunit
                     Kv1.5; Potassium (K+) channel protein alpha 5; potassium
                     voltage-gated channel, shaker-related subfamily, member 5;
                     potassium channel, voltage gated shaker related subfamily
                     A, member 5"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily A
                     member 5"
                     /protein_id="NP_037104.1"
                     /db_xref="GeneID:25470"
                     /db_xref="RGD:2953"
                     /translation="MEISLVPLENGSAMTLRGGGEAGASCVQTPRGECGCPPTSGLNN
                     QSKETLLRGRTTLEDANQGGRPLPPMAQELPQPRRLSAEDEEGEGDPGLGTVEEDQAP
                     QDAGSLHHQRVLINISGLRFETQLGTLAQFPNTLLGDPAKRLHYFDPLRNEYFFDRNR
                     PSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPL
                     PRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHP
                     PVPPQPPAPAPGINGSVSGALSSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRF
                     FACPSKAEFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGQNGQQAMSLAILRVIR
                     LVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNHG
                     SHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNF
                     NYFYHRETDHEEQAALKEEQGNQRRESGLDTGGQRKVSCSKASFCKTGGSLESSDSIR
                     RGSCPLEKCHLKAKSNVDLRRSLYALCLDTSRETDL"
ORIGIN      
        1 actctccgac tccgtcccca aaggagaaac gggaggggga ggaggagagg agggagccac
       61 agagggcgga ggccggggag ctcagccaga gaggggctgc tggaggttgc atctgctgga
      121 aggaggtttt tcccgctgcc tggtaaccag ctgccagaac actgagaggg agagagagag
      181 gcagggagca ggggcagcag cttcttgacg tcaggaccag ccaaggatcg ggccagctac
      241 cccggccagc ctagagtcag cggggccctc ggctggagag gagacctacg cgaggcttgg
      301 agcgtgagtt gggggtgtgg gaaccggttg tctggggcgc agcatgcccc ctgcccccgg
      361 accatggaga tctccctggt gcccctggag aatggcagtg ccatgaccct cagaggagga
      421 ggggaggcag gggcaagctg tgtgcagacc cccaggggag agtgtgggtg ccctccgacg
      481 tctggactca ataatcagtc caaagaaaca ctgttgaggg ggcgcacaac gctcgaggat
      541 gcgaaccagg gtggacggcc tttgccccct atggctcagg agctgccaca acctagaagg
      601 ctatctgctg aggatgagga gggagaaggc gaccctggcc tgggcacagt ggaggaggac
      661 caggctcctc aggatgcagg gtcactccat caccagcgag tcctcataaa catctccggg
      721 ttgcgtttcg agacgcagct gggcaccctg gcacagtttc ccaacaccct cctgggggac
      781 ccagccaagc gcctgcacta cttcgacccc ttgagaaatg aatacttctt cgaccgcaac
      841 cggcccagct tcgatggcat tttgtactac taccagtctg ggggccgcct gcgcaggccc
      901 gtcaatgtct ccctggatgt gtttgcagat gagatccgct tttaccagct gggggacgag
      961 gccatggagc gcttccggga ggatgagggc ttcatcaagg aagaggagaa gcccctgccc
     1021 cgcaacgagt tccagcgcca ggtatggctt atcttcgaat acccagaaag ctctgggtcc
     1081 gcaagagcca tcgccatagt gtcggtcctg gtcattctca tctctatcat caccttctgc
     1141 ctggagactc tgcctgagtt cagggatgag cgggagctgc tacgccatcc cccagtgccg
     1201 ccccagcccc cagcccctgc ccctgggatc aatggcagcg tctctggagc actttcctct
     1261 ggccctacgg tggctccact cttgcctagg acactggccg atccattctt catcgtggag
     1321 accacatgtg tgatctggtt cacttttgag ttgctcgtgc gcttctttgc ctgccccagc
     1381 aaggcagaat tctctcggaa tatcatgaac atcatcgatg tcgtggccat cttcccctac
     1441 tttatcaccc tgggcaccga gctggcagag caacaaccag ggggaggggg tcagaatggg
     1501 cagcaggcca tgtccctagc catcctcagg gtgatccgcc tggtgcgggt gtttcggatc
     1561 ttcaagctct cccgccactc caagggactg cagatcctgg gtaagacctt gcaagcatcc
     1621 atgcgggaac tcgggctact catcttcttc ctcttcattg gagtcatcct cttctccagc
     1681 gctgtctact tcgcagaggc agacaatcac gggtcccatt tctctagtat cccagatgcc
     1741 ttctggtggg cagtagtcac tatgaccact gtaggctatg gagacatgag acccatcact
     1801 gtagggggca agatcgtggg ttcactgtgc gccatagctg gggtcctcac cattgccctg
     1861 cctgtccccg tcatcgtctc caactttaat tacttctatc atcgggagac agaccacgag
     1921 gagcaggctg ccctgaagga agaacaaggc aaccagaggc gggagtctgg gctggacaca
     1981 gggggtcaac ggaaggtcag ctgcagcaag gcctcctttt gcaagactgg gggttccctg
     2041 gagagttctg acagtatcag aaggggtagc tgtcctctag aaaagtgtca cctcaaggcc
     2101 aagagcaacg tggacttgcg gaggtccctg tatgccctct gtctggacac tagccgtgaa
     2161 acagatttgt aaagagagat ccaggcagac tggcaccagt gaagctggcc acaggggtgc
     2221 cccttgagcc tgggcatctg ctttacacca ccgagtattt aagcccacct ggtcacccac
     2281 cgatgtctgc ctttctttca cccttctcac cttcctgccc tctaacttcc ccattttaac
     2341 tcctctttcc ataaccccca gggtcgccta tttttaacaa gtatgacatt ccatgacgca
     2401 ggagccgttg aagtgctgag ccctcactgg aagatggatg cattcatagc cagttttcta
     2461 cacccagcag agggataatc aaacaaattt gactttaaaa agcttagatc ccaagagaat
     2521 ccatagcatt ccctacccgt gttccaaatt tactttacat gggattacat ttgtgtatgg
     2581 gcaaatatta tttttatggc cgatgactgc attttgtaca gcagtgcaca tgaagaatat
     2641 ttgggtgtgc tcttaagata tactttgaat tatgaaagtg ttgggggggt caccatttcc
     2701 tgggacactc agggacaaag accctaaaag agttgttcag gtttctgtgt tctcaagctt
     2761 cttattattc tgggatgtac tattggtgct tctggtctag gagagagaat gttctagaag
     2821 accagcaaat ctaatcttgt gactgtcttc acagaagcat tttaaggatg ttggaagaag
     2881 gatttggaga attcatgctt ttcgttttaa taccaggaaa taaaatgtga ctgtcgggca
     2941 agtattagtt tgcctac
//
