LOCUS       NM_012971               3127 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily A
            member 4 (Kcna4), mRNA.
ACCESSION   NM_012971
VERSION     NM_012971.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3127)
  AUTHORS   O'Donovan,B., Adeluyi,A., Anderson,E.L., Cole,R.D., Turner,J.R. and
            Ortinski,P.I.
  TITLE     Altered gating of Kv1.4 in the nucleus accumbens suppresses
            motivation for reward
  JOURNAL   Elife 8, e47870 (2019)
   PUBMED   31487241
  REMARK    GeneRIF: Neuronal and behavioral outputs associated with low
            motivation were linked to faster inactivation of a voltage-gated
            potassium channel, Kv1.4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3127)
  AUTHORS   Gomez,B., Zhu,J., Recio-Pinto,E. and Thornhill,W.B.
  TITLE     Amino Acid Properties of Trafficking Determinants in the Outer
            Pore-Forming Region of Kv1 Potassium Channels in Cell Lines
  JOURNAL   Cell Biochem Biophys 75 (1), 25-33 (2017)
   PUBMED   28054303
  REMARK    GeneRIF: Four prolines and four lysines in a Kv1.4 homotetramer
            might provide a binding site for a putative endoplasmic
            reticulum-export molecule to ensure high cell surface protein
            expression of the channel.
REFERENCE   3  (bases 1 to 3127)
  AUTHORS   Xie,C., Su,H., Guo,T., Yan,Y., Peng,X., Cao,R., Wang,Y., Chen,P.,
            Wang,X. and Liang,S.
  TITLE     Synaptotagmin I delays the fast inactivation of Kv1.4 channel
            through interaction with its N-terminus
  JOURNAL   Mol Brain 7, 4 (2014)
   PUBMED   24423395
  REMARK    GeneRIF: synaptotagmin I is an interacting protein of Kv1.4
            channel.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3127)
  AUTHORS   Sahoo,N., Goradia,N., Ohlenschlager,O., Schonherr,R., Friedrich,M.,
            Plass,W., Kappl,R., Hoshi,T. and Heinemann,S.H.
  TITLE     Heme impairs the ball-and-chain inactivation of potassium channels
  JOURNAL   Proc Natl Acad Sci U S A 110 (42), E4036-E4044 (2013)
   PUBMED   24082096
  REMARK    GeneRIF: Kv1.4 K(+) channels are potently regulated by
            intracellular free heme; heme binds to the N-terminal inactivation
            domain and thereby impairs the inactivation process
REFERENCE   5  (bases 1 to 3127)
  AUTHORS   Feng,X., Zhou,Y.L., Meng,X., Qi,F.H., Chen,W., Jiang,X. and Xu,G.Y.
  TITLE     Hydrogen sulfide increases excitability through suppression of
            sustained potassium channel currents of rat trigeminal ganglion
            neurons
  JOURNAL   Mol Pain 9, 4 (2013)
   PUBMED   23413915
  REMARK    GeneRIF: Endogenous H2S generating enzyme
            cystathionine-beta-synthetase was co-localized well with Kv1.1 and
            Kv1.4 in trigeminal ganglion neurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3127)
  AUTHORS   Kim,E., Niethammer,M., Rothschild,A., Jan,Y.N. and Sheng,M.
  TITLE     Clustering of Shaker-type K+ channels by interaction with a family
            of membrane-associated guanylate kinases
  JOURNAL   Nature 378 (6552), 85-88 (1995)
   PUBMED   7477295
REFERENCE   7  (bases 1 to 3127)
  AUTHORS   Sheng,M., Liao,Y.J., Jan,Y.N. and Jan,L.Y.
  TITLE     Presynaptic A-current based on heteromultimeric K+ channels
            detected in vivo
  JOURNAL   Nature 365 (6441), 72-75 (1993)
   PUBMED   8361540
REFERENCE   8  (bases 1 to 3127)
  AUTHORS   Po,S., Roberds,S., Snyders,D.J., Tamkun,M.M. and Bennett,P.B.
  TITLE     Heteromultimeric assembly of human potassium channels. Molecular
            basis of a transient outward current?
  JOURNAL   Circ Res 72 (6), 1326-1336 (1993)
   PUBMED   8495559
REFERENCE   9  (bases 1 to 3127)
  AUTHORS   Tseng-Crank,J.C., Tseng,G.N., Schwartz,A. and Tanouye,M.A.
  TITLE     Molecular cloning and functional expression of a potassium channel
            cDNA isolated from a rat cardiac library
  JOURNAL   FEBS Lett 268 (1), 63-68 (1990)
   PUBMED   2384173
REFERENCE   10 (bases 1 to 3127)
  AUTHORS   Stuhmer,W., Ruppersberg,J.P., Schroter,K.H., Sakmann,B.,
            Stocker,M., Giese,K.P., Perschke,A., Baumann,A. and Pongs,O.
  TITLE     Molecular basis of functional diversity of voltage-gated potassium
            channels in mammalian brain
  JOURNAL   EMBO J 8 (11), 3235-3244 (1989)
   PUBMED   2555158
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Jul 16, 2024 this sequence was replaced by
            NM_012971.4.
            
            On Nov 27, 2020 this sequence version replaced NM_012971.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M32867.1, SRR26360194.2380600.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3127              JAXUCZ010000003.1  114215336-114218462
FEATURES             Location/Qualifiers
     source          1..3127
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q33"
     gene            1..3127
                     /gene="Kcna4"
                     /gene_synonym="KCHAN; Kv1.4; Kv4; RHK1; RK3"
                     /note="potassium voltage-gated channel subfamily A member
                     4"
                     /db_xref="GeneID:25469"
                     /db_xref="RGD:2952"
     exon            1..3127
                     /gene="Kcna4"
                     /gene_synonym="KCHAN; Kv1.4; Kv4; RHK1; RK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2042
                     /gene="Kcna4"
                     /gene_synonym="KCHAN; Kv1.4; Kv4; RHK1; RK3"
                     /note="RCK4; voltage-gated potassium channel subunit
                     Kv1.4; potassium voltage-gated channel, shaker-related
                     subfamily, member 4; potassium channel, voltage gated
                     shaker related subfamily A, member 4"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily A
                     member 4"
                     /protein_id="NP_037103.2"
                     /db_xref="GeneID:25469"
                     /db_xref="RGD:2952"
                     /translation="MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAV
                     AAATAAVEGTGGSGGGPHHHHQTRGAYSSHDPQGSRGSRRRRRQRTEKKKLHHRQSSF
                     PHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEEDHGDGCSYTDLLPQD
                     DGGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRN
                     EYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGF
                     VREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFR
                     DDRDLIMALSAGGHSRLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCF
                     ACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLV
                     RVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTH
                     FQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNY
                     FYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLC
                     GKEEKCQGKGDDSETDKNNCSNAKAVETDV"
ORIGIN      
        1 ggtaagaaaa taagctgccc tatttttctt tcttcttctc ttacaactgg aaccagccat
       61 ttccccaaac taccaccatg gaggtggcaa tggtgagtgc cgagagctca gggtgcaaca
      121 gccacatgcc ttatggttat gctgcccagg ccagggctcg agagagggag agacttgctc
      181 actccagggc agctgcagct gctgctgttg cagctgccac ggctgcggtg gaaggcactg
      241 gaggttctgg tggaggcccc caccatcatc atcagacacg tggggcctac tcctcccatg
      301 atcctcaagg aagccgaggt agtcggagga ggaggcgaca gcgaactgag aagaagaaac
      361 tccaccacag gcagagcagt tttcctcatt gctcagacct gatgcccagt ggctctgaag
      421 agaagatcct tagggagctg agcgaggagg aggaagacga ggaggaggaa gaggaggagg
      481 aagaggaggg aaggttttac tatagtgaag aggaccatgg ggatgggtgt tcctacactg
      541 acctactgcc acaggatgat gggggtggcg gcggctacag ttcagtccgc tacagtgact
      601 gttgtgaacg cgtggtaata aatgtgtctg gtctacgctt cgaaacccaa atgaaaactt
      661 tggctcagtt tccagaaact ctgttgggag accctgagaa gaggactcag tacttcgacc
      721 ctttgcgcaa tgagtatttt tttgatagga accgtcccag ctttgatgcc attttgtatt
      781 attaccagtc aggaggccgc ctgaagaggc cagtcaatgt cccctttgat atcttcactg
      841 aggaggtgaa gttctatcag ttgggagagg aagccctgct caagttccgt gaggatgagg
      901 gctttgtgag agaagaggag gacagggctc tgccagaaaa tgaatttaaa aaacagattt
      961 ggcttctctt tgaatatccc gagagttcca gccctgccag gggcatagcc atcgtatctg
     1021 tcctggtcat cttaatctct attgtcatat tttgcctgga aaccttgcct gagttcaggg
     1081 atgataggga cctcatcatg gccctcagcg caggtggaca cagcagatta ttgaatgaca
     1141 cctcggcacc ccacctggag aactcagggc acacaatatt caatgaccct ttcttcattg
     1201 tggagacagt atgtatcgtg tggttttcct ttgagtttgt ggttcgatgc tttgcttgtc
     1261 ccagtcaagc actcttcttc aaaaacatca tgaacatcat tgatatcgtc tccattttgc
     1321 cttacttcat cactctgggc accgatctgg cccagcagca ggggggtggc aacggccagc
     1381 agcagcaggc tatgtccttt gccatcctca ggatcatccg tctggtccga gtgttccgga
     1441 tcttcaagct ctccagacac tccaagggcc tgcagatcct gggccacacc ctaagagcca
     1501 gcatgcgtga actgggcctt cttatctttt tcctcttcat cggggtcatc ctcttttcca
     1561 gcgctgtgta ttttgcagag gcagatgaac ctaccaccca tttccaaagc attccagatg
     1621 cgttttggtg ggctgtggta accatgacaa ctgtgggcta cggggacatg aagcccatca
     1681 cagtgggagg aaagattgtg gggtccctgt gtgccattgc gggtgtctta accattgctt
     1741 tgcccgtgcc ggtgattgtg tctaacttta actatttcta ccacagagag actgaaaacg
     1801 aagaacagac ccagctgacc caaaacgcag tcagttgccc atacctacct tctaatttgc
     1861 tcaagaaatt tcggagctct acttcttctt ccctggggga caagtcagag tatctagaga
     1921 tggaagaagg ggtcaaggag tctttatgtg gaaaggaaga gaagtgtcag ggaaaggggg
     1981 atgacagcga gacagataaa aacaactgtt ctaatgcaaa ggctgtggag actgatgtgt
     2041 gaatctcttt ccccacctgc cgctgccgcc cgcccagctc cgaatatatt catacataaa
     2101 gaatgcagtt atgaaaatga gatatgcact gcatacagta atacactgct taatggcgat
     2161 acatggcata attgtggcga aacgtgtatt gcatatcaaa taagtgatgc atcttggaga
     2221 agagggaggc attaaaaaca gcagatctat ctttatattt tttaatagaa tgcaagaatt
     2281 ttgcacataa tgggaaaatg ttaatagtaa aggtggtccc gaggagagtg agtgtgtgtg
     2341 agagagtgag agagtgtgtg gccatgggag tgtaagtaaa ttgtcaacat tgttgggaat
     2401 tgtgccgtga tgggaaaagt tggcattctg aagtatttac tatgtaagaa ctaatgaact
     2461 tgagcagtct tttaccagtg ttttaataac atctcctatg tctttggatt ctgtagttgt
     2521 tttctagaaa ttgtaagaat tactgtgtag aaaaaagaga aagtaaatta tttaatagaa
     2581 tataggtcac aatttaatct tggatttaat taaagtttat ttttaactgg aaattaactt
     2641 ttgaaaaggc tgcaggggcc tttagaaatt gattatattt tgttattaat tttggggaga
     2701 tatactagca aatgcctaat gttctggagg aaatgtaaca agttttgttc acaggtctta
     2761 agactggaat ttttttttct tttgcactac tttctatgct gaagcccgag agagacttca
     2821 tactgtgaat gtttactaac gcaccaatca gttcaatgac aatcattgga agaatggttt
     2881 cttcgtctca tttattgttc ttttcatttt gtgagactaa tgagcacaca gataacagca
     2941 cacgattcct gctttaaaat ctgaacaacc gatctacaaa gggactacga agtaacgttc
     3001 agcagccgaa tctttcaaaa ttggtttgtt acaatgatgc ttcagaaacc atactatttt
     3061 caatactctt ctgcctttta agtccagaat aatttaacca aagttattgc atgcacagaa
     3121 agaattc
//
