LOCUS       NM_019270               1954 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily A
            member 3 (Kcna3), mRNA.
ACCESSION   NM_019270
VERSION     NM_019270.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1954)
  AUTHORS   Yuan,X., Han,S., Manyande,A., Gao,F., Wang,J., Zhang,W. and Tian,X.
  TITLE     Spinal voltage-gated potassium channel Kv1.3 contributes to
            neuropathic pain via the promotion of microglial M1 polarization
            and activation of the NLRP3 inflammasome
  JOURNAL   Eur J Pain 27 (2), 289-302 (2023)
   PUBMED   36440534
  REMARK    GeneRIF: Spinal voltage-gated potassium channel Kv1.3 contributes
            to neuropathic pain via the promotion of microglial M1 polarization
            and activation of the NLRP3 inflammasome.
REFERENCE   2  (bases 1 to 1954)
  AUTHORS   Sole,L., Sastre,D., Colomer-Molera,M., Vallejo-Gracia,A.,
            Roig,S.R., Perez-Verdaguer,M., Lillo,P., Tamkun,M.M. and Felipe,A.
  TITLE     Functional Consequences of the Variable Stoichiometry of the
            Kv1.3-KCNE4 Complex
  JOURNAL   Cells 9 (5), 1128 (2020)
   PUBMED   32370164
  REMARK    GeneRIF: Functional Consequences of the Variable Stoichiometry of
            the Kv1.3-KCNE4 Complex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1954)
  AUTHORS   Tanner,M.R., Pennington,M.W., Chauhan,S.S., Laragione,T.,
            Gulko,P.S. and Beeton,C.
  TITLE     KCa1.1 and Kv1.3 channels regulate the interactions between
            fibroblast-like synoviocytes and T lymphocytes during rheumatoid
            arthritis
  JOURNAL   Arthritis Res Ther 21 (1), 6 (2019)
   PUBMED   30612588
  REMARK    GeneRIF: Interactions of fibroblast-like synoviocytes in
            collagen-induced arthritis are regulated by Kv1.3 and KCa1.1
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1954)
  AUTHORS   Bozic,I., Tesovic,K., Laketa,D., Adzic,M., Jakovljevic,M.,
            Bjelobaba,I., Savic,D., Nedeljkovic,N., Pekovic,S. and Lavrnja,I.
  TITLE     Voltage Gated Potassium Channel Kv1.3 Is Upregulated on Activated
            Astrocytes in Experimental Autoimmune Encephalomyelitis
  JOURNAL   Neurochem Res 43 (5), 1020-1034 (2018)
   PUBMED   29574670
  REMARK    GeneRIF: Kv1.3 may be a therapeutic target of interest for multiple
            sclerosis and add astrocytes to the list of cells whose activation
            would be suppressed by inhibiting Kv1.3 in inflammatory conditions
REFERENCE   5  (bases 1 to 1954)
  AUTHORS   Bergmann,R., Kubeil,M., Zarschler,K., Chhabra,S., Tajhya,R.B.,
            Beeton,C., Pennington,M.W., Bachmann,M., Norton,R.S. and Stephan,H.
  TITLE     Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A]
            in experimental rats
  JOURNAL   Sci Rep 7 (1), 3756 (2017)
   PUBMED   28623364
  REMARK    GeneRIF: The high stability and bioavailability, low normal-tissue
            uptake of [(64)Cu]Cu-NOTA-HsTX1[R14A], and accumulation in regions
            of up-regulated Kv channels both in vitro and in vivo demonstrate
            that HsTX1[R14A] represents a valuable lead for conditions
            treatable by blockade of the voltage-gated potassium channel Kv1.3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1954)
  AUTHORS   Holmes,T.C., Fadool,D.A. and Levitan,I.B.
  TITLE     Tyrosine phosphorylation of the Kv1.3 potassium channel
  JOURNAL   J Neurosci 16 (5), 1581-1590 (1996)
   PUBMED   8774427
REFERENCE   7  (bases 1 to 1954)
  AUTHORS   Kim,E., Niethammer,M., Rothschild,A., Jan,Y.N. and Sheng,M.
  TITLE     Clustering of Shaker-type K+ channels by interaction with a family
            of membrane-associated guanylate kinases
  JOURNAL   Nature 378 (6552), 85-88 (1995)
   PUBMED   7477295
REFERENCE   8  (bases 1 to 1954)
  AUTHORS   Douglass,J., Osborne,P.B., Cai,Y.C., Wilkinson,M., Christie,M.J.
            and Adelman,J.P.
  TITLE     Characterization and functional expression of a rat genomic DNA
            clone encoding a lymphocyte potassium channel
  JOURNAL   J Immunol 144 (12), 4841-4850 (1990)
   PUBMED   2351830
REFERENCE   9  (bases 1 to 1954)
  AUTHORS   Swanson,R., Marshall,J., Smith,J.S., Williams,J.B., Boyle,M.B.,
            Folander,K., Luneau,C.J., Antanavage,J., Oliva,C., Buhrow,S.A. et
            al.
  TITLE     Cloning and expression of cDNA and genomic clones encoding three
            delayed rectifier potassium channels in rat brain
  JOURNAL   Neuron 4 (6), 929-939 (1990)
   PUBMED   2361015
REFERENCE   10 (bases 1 to 1954)
  AUTHORS   Stuhmer,W., Ruppersberg,J.P., Schroter,K.H., Sakmann,B.,
            Stocker,M., Giese,K.P., Perschke,A., Baumann,A. and Pongs,O.
  TITLE     Molecular basis of functional diversity of voltage-gated potassium
            channels in mammalian brain
  JOURNAL   EMBO J 8 (11), 3235-3244 (1989)
   PUBMED   2555158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 3, 2022 this sequence version replaced NM_019270.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26643298.12865.1,
                                        SRR26643292.10409.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1954              JAXUCZ010000002.1  197320324-197322277
FEATURES             Location/Qualifiers
     source          1..1954
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1954
                     /gene="Kcna3"
                     /note="potassium voltage-gated channel subfamily A member
                     3"
                     /db_xref="GeneID:29731"
                     /db_xref="RGD:2951"
     exon            1..1954
                     /gene="Kcna3"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1832
                     /gene="Kcna3"
                     /note="KV3; RCK3; RGK5; voltage-gated potassium channel
                     subunit Kv1.3; voltage-gated potassium channel subunit
                     Kv3; potassium channel, voltage gated shaker related
                     subfamily A, member 3; potassium voltage-gated channel,
                     shaker-related subfamily, member 3"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily A
                     member 3"
                     /protein_id="NP_062143.3"
                     /db_xref="GeneID:29731"
                     /db_xref="RGD:2951"
                     /translation="MTVVPGDHLLEPEAAGGGGGDPPQGGCVSGGGCDRYEPLPPALP
                     AAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRN
                     RPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERP
                     LPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPAS
                     PSQDVFEAANNSTSGASSGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRN
                     IMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL
                     QILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTM
                     TTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYM
                     HVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTT
                     NNNPNSCVNIKKIFTDV"
ORIGIN      
        1 tgacagagcc tcgcggcagc cgcagcaaca ggcggcgggg ccgggctcgt ggggcagagg
       61 cggtggtggg gcggggagct ccaggaggag cgactcggag ctggccaccg ccagcaggga
      121 aggagagcat cgccgcctcc cgcgctcggc cgccgcagcc ctccgcccgc caccgcgccc
      181 accctgcgct ggaccccgcg ggcggcggcg cgcgcatcct gcagagccca ggctacgccg
      241 agctgccgcc agacatgacc gtggtgcccg gggaccacct gctggagcca gaagcggcgg
      301 gaggcggcgg cggggacccg cctcagggag gctgtgtcag tggcggcggc tgcgaccgct
      361 acgaaccgct gccgcccgcg ctgcccgccg cgggcgagca ggattgctgc ggggagcgcg
      421 tggtcatcaa catctccggg ctgcgcttcg agacacagct caagaccctc tgccagttcc
      481 ctgagacgct gctaggcgac cccaagcggc gcatgcgata cttcgacccg ctccgcaatg
      541 agtacttctt cgaccgcaac agacccagct tcgacgccat cctctactac taccagtccg
      601 ggggccgcat ccgccggccg gtcaacgtgc ccatcgacat cttctccgag gagatccgct
      661 tctaccaact gggtgaggag gctatggaga agttccgtga ggacgagggc ttcctgcggg
      721 aggaggagcg acctctgccc cgccgtgact tccagcgcca ggtgtggctg ctcttcgaat
      781 accccgagag ctccgggccg gcccggggca ttgccatcgt gtcagtgctg gtcattctca
      841 tctccattgt catcttctgc ttggagacac tacccgagtt tcgcgacgag aaggactatc
      901 ccgcctctcc gtcgcaggac gtgtttgagg ctgccaacaa cagcacgtcg ggggcctcct
      961 ctggagcctc cagcttctcg gaccccttct tcgtagtgga gaccctgtgc atcatctggt
     1021 tctcctttga gctgctggtg cgattctttg cttgccccag taaagccacc ttctccagaa
     1081 atatcatgaa cctgatagac attgtagcca tcatccctta ttttattact ctgggcactg
     1141 agctggctga gcgacagggt aatgggcagc aggctatgtc actggccatc ctgagggtca
     1201 tccgcctagt aagggtcttc cgcatcttca agctctcccg ccattctaag gggctgcaga
     1261 tcctgggaca gacactgaag gcttccatgc gagagctggg gctgctcatt ttcttccttt
     1321 tcattggggt catccttttc tccagtgcag tctactttgc tgaggcagac gacccttctt
     1381 cgggttttaa cagtatcccg gatgccttct ggtgggccgt ggtaaccatg acaactgtcg
     1441 gttatggtga tatgcaccca gtgaccatag gaggcaagat tgtgggctct ctttgtgcca
     1501 tcgcaggtgt cttgaccatt gcattgccgg ttcctgtgat tgtttccaac ttcaattact
     1561 tctaccaccg ggagacagaa ggggaagagc aagcccagta catgcacgtg ggaagctgcc
     1621 agcacctctc ctcttcagca gaggagctcc gaaaagcccg gagtaactcc actctgagta
     1681 agtcggagta tatggtgatc gaagaggggg gtatgaacca cagcgccttc ccccagaccc
     1741 ccttcaaaac gggcaactcc actgccactt gcaccaccaa caataatccc aactcctgtg
     1801 tcaacatcaa aaagatattc actgatgtct aatagatgat acgattgcca ttctgtgccc
     1861 agtattgtgt ggaacatgcc cccttggtct gtgtatgccc ttgatttata catttccaga
     1921 ccattcatca aggaaagtac atgaagaagt ggaa
//
