LOCUS       NM_012970               2329 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily A
            member 2 (Kcna2), mRNA.
ACCESSION   NM_012970
VERSION     NM_012970.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2329)
  AUTHORS   Peng,Y., Zhang,Q., Cheng,H., Yan,G. and Xing,C.
  TITLE     Upregulation of ubiquitin conjugating enzyme E2B (Ube2b)
            ameliorates neuropathic pain by regulating Kcna2 (potassium
            voltage-gated channel subfamily A member 2) in primary afferent
            neurons
  JOURNAL   Bioengineered 12 (1), 7470-7480 (2021)
   PUBMED   34632937
  REMARK    GeneRIF: Upregulation of ubiquitin conjugating enzyme E2B (Ube2b)
            ameliorates neuropathic pain by regulating Kcna2 (potassium
            voltage-gated channel subfamily A member 2) in primary afferent
            neurons.
REFERENCE   2  (bases 1 to 2329)
  AUTHORS   Zhang,J., Rong,L., Shao,J., Zhang,Y., Liu,Y., Zhao,S., Li,L.,
            Yu,W., Zhang,M., Ren,X., Zhao,Q., Zhu,C., Luo,H., Zang,W. and
            Cao,J.
  TITLE     Epigenetic restoration of voltage-gated potassium channel Kv1.2
            alleviates nerve injury-induced neuropathic pain
  JOURNAL   J Neurochem 156 (3), 367-378 (2021)
   PUBMED   32621322
  REMARK    GeneRIF: Epigenetic restoration of voltage-gated potassium channel
            Kv1.2 alleviates nerve injury-induced neuropathic pain.
            Erratum:[J Neurochem. 2022 Mar;160(6):675. doi: 10.1111/jnc.15584..
            PMID: 35288944]
REFERENCE   3  (bases 1 to 2329)
  AUTHORS   Lee,J., Kang,M., Kim,S. and Chang,I.
  TITLE     Structural and molecular insight into the pH-induced
            low-permeability of the voltage-gated potassium channel Kv1.2
            through dewetting of the water cavity
  JOURNAL   PLoS Comput Biol 16 (4), e1007405 (2020)
   PUBMED   32315300
  REMARK    GeneRIF: two residues E327 and H418 in the proximity of the water
            cavity of Kv1.2 play crucial roles as a pH switch
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2329)
  AUTHORS   Zhao,Q., Wang,Q., Xu,J., Wang,J. and Deng,X.
  TITLE     [Expression of KCNA2 in the dorsal root ganglia of rats with
            osteoarthritis pain induced by monoiodoacetate]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 39 (5), 579-585 (2019)
   PUBMED   31140423
  REMARK    GeneRIF: The expression of KCNA2 is decreased in the DRG neurons of
            rats with OA pain likely as a result of enhanced methylation of
            Kcna2 promoter region
REFERENCE   5  (bases 1 to 2329)
  AUTHORS   Long,Q.Q., Wang,H., Gao,W., Fan,Y., Li,Y.F., Ma,Y., Yang,Y.,
            Shi,H.J., Chen,B.R., Meng,H.Y., Wang,Q.M., Wang,F., Wang,Z.M. and
            Wang,L.S.
  TITLE     Long Noncoding RNA Kcna2 Antisense RNA Contributes to Ventricular
            Arrhythmias via Silencing Kcna2 in Rats With Congestive Heart
            Failure
  JOURNAL   J Am Heart Assoc 6 (12), e005965 (2017)
   PUBMED   29263036
  REMARK    GeneRIF: Ventricular Kcna2 AS expression increases in rats with CHF
            and contributes to reduced IKs, prolonged APs, and the occurrence
            of ventricular arrhythmias by silencing Kcna2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2329)
  AUTHORS   Kim,E., Niethammer,M., Rothschild,A., Jan,Y.N. and Sheng,M.
  TITLE     Clustering of Shaker-type K+ channels by interaction with a family
            of membrane-associated guanylate kinases
  JOURNAL   Nature 378 (6552), 85-88 (1995)
   PUBMED   7477295
REFERENCE   7  (bases 1 to 2329)
  AUTHORS   Wang,H., Kunkel,D.D., Schwartzkroin,P.A. and Tempel,B.L.
  TITLE     Localization of Kv1.1 and Kv1.2, two K channel proteins, to
            synaptic terminals, somata, and dendrites in the mouse brain
  JOURNAL   J Neurosci 14 (8), 4588-4599 (1994)
   PUBMED   8046438
REFERENCE   8  (bases 1 to 2329)
  AUTHORS   Paulmichl,M., Nasmith,P., Hellmiss,R., Reed,K., Boyle,W.A.,
            Nerbonne,J.M., Peralta,E.G. and Clapham,D.E.
  TITLE     Cloning and expression of a rat cardiac delayed rectifier potassium
            channel
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7892-7895 (1991)
   PUBMED   1715584
REFERENCE   9  (bases 1 to 2329)
  AUTHORS   Stuhmer,W., Ruppersberg,J.P., Schroter,K.H., Sakmann,B.,
            Stocker,M., Giese,K.P., Perschke,A., Baumann,A. and Pongs,O.
  TITLE     Molecular basis of functional diversity of voltage-gated potassium
            channels in mammalian brain
  JOURNAL   EMBO J 8 (11), 3235-3244 (1989)
   PUBMED   2555158
REFERENCE   10 (bases 1 to 2329)
  AUTHORS   McKinnon,D.
  TITLE     Isolation of a cDNA clone coding for a putative second potassium
            channel indicates the existence of a gene family
  JOURNAL   J Biol Chem 264 (14), 8230-8236 (1989)
   PUBMED   2722779
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012970.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04731.1, SRR26643298.12868.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                JAXUCZ010000002.1  197393530-197393627
            99-423              JAXUCZ010000002.1  197395031-197395355
            424-2329            JAXUCZ010000002.1  197395778-197397683
FEATURES             Location/Qualifiers
     source          1..2329
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2329
                     /gene="Kcna2"
                     /gene_synonym="BK2; NGK1"
                     /note="potassium voltage-gated channel subfamily A member
                     2"
                     /db_xref="GeneID:25468"
                     /db_xref="RGD:2950"
     exon            1..98
                     /gene="Kcna2"
                     /gene_synonym="BK2; NGK1"
                     /inference="alignment:Splign:2.1.0"
     exon            99..423
                     /gene="Kcna2"
                     /gene_synonym="BK2; NGK1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..2329
                     /gene="Kcna2"
                     /gene_synonym="BK2; NGK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             587..2086
                     /gene="Kcna2"
                     /gene_synonym="BK2; NGK1"
                     /note="RAK; RBK2; RCK5; voltage-gated potassium channel
                     subunit Kv1.2; Potassium (K+) channel protein alpha 2,
                     voltage dependent; potassium voltage-gated channel,
                     shaker-related subfamily, member 2; potassium channel,
                     voltage gated shaker related subfamily A, member 2;
                     Potassium voltage gated channel shaker related subfamily
                     member 2"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily A
                     member 2"
                     /protein_id="NP_037102.1"
                     /db_xref="GeneID:25468"
                     /db_xref="RGD:2950"
                     /translation="MTVATGDPVDEAAALPGHPQDTYDPEADHECCERVVINISGLRF
                     ETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPV
                     NVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSG
                     PARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGGGVTFHTYSNSTIGYQQSTSF
                     TDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAE
                     KPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFF
                     LFIGVILFSSAVYFAEADERDSQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGS
                     LCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSA
                     STISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV"
ORIGIN      
        1 gcaccccgcc gccacaaccg ccaccgcccc gctgtccggg ttctgcctgc cctgtctatc
       61 acccaggaac atggaggctc gggtacccat ctgcaagggc aacgtcacac ctcctgagga
      121 cagccaggag gactctggct tttgctgagc tgtgcatctt acctccttcc ttccaaaggc
      181 ttcagaccca agctccactc tcctcaagtc gtgcgctgtg cccctggcta agcatctcac
      241 tgtccctcaa gccccatcca gtcctagagc acacctcgag gacctgccct cctgctcaga
      301 atgactcacc attatttcca gctcaagtga gaagatgtga cggggactga gctgcctatt
      361 tgtgtatctg tggcatcaga tctgctcttc aaggaagaga acctcaggct cctgcctggc
      421 cagccaaagg aggctgtgac tccaactcac agaaggctct gggtctttcc tacaggagcg
      481 cagactaatg cttctgtgtt tcctggggcc cagttaccag caccctgagt tccctgctgc
      541 aggcagctgg aaggcataaa ataaagcaca ctcctcagcc ccaattatga cagtggctac
      601 cggagaccca gtggatgagg ctgctgccct ccctgggcac cctcaagaca cctatgaccc
      661 agaggcagac cacgagtgct gtgagagagt ggtgattaac atctcaggcc tgcggttcga
      721 gactcagcta aagaccttag cccagttccc agagaccctc ttaggagacc ccaagaaacg
      781 gatgaggtac tttgatcccc tccgaaatga gtactttttt gatcgcaacc gccctagctt
      841 tgatgccatt ttgtactact accagtctgg gggcaggttg aggcgacctg tgaatgtgcc
      901 cttagatatc ttctctgaag aaatccggtt ttatgagcta ggagaagagg caatggagat
      961 gtttcgggag gatgaaggct acatcaagga agaagaacgt cccctgcctg aaaatgagtt
     1021 tcagagacag gtgtggcttc tctttgaata ccctgagagc tcagggccgg ccaggatcat
     1081 agccattgta tctgtgatgg tcattctgat ctcgatcgtc agcttctgtc tggaaacctt
     1141 gcccatcttc cgggatgaga acgaggacat gcatggtggt ggggtgacct tccacaccta
     1201 ttccaacagc accattgggt accagcagtc cacctccttc accgaccctt tcttcatcgt
     1261 agagactctc tgcatcatct ggttctcctt tgagtttctg gttagattct ttgcctgtcc
     1321 cagcaaagct ggcttcttca ccaacatcat gaacatcatt gacattgtgg ctatcatccc
     1381 ttactttatc accctgggga cagagttagc tgagaagcca gaggacgccc agcaaggcca
     1441 gcaggccatg tcactggcca ttctccgtgt catccggttg gtaagagtct ttaggatttt
     1501 caagttgtcc agacactcca aaggtctgca gattctaggt cagaccctca aagccagcat
     1561 gagggaattg ggcctcctga tattcttcct cttcattggg gtcatcctct tctctagtgc
     1621 tgtctatttt gcagaagctg atgagcgaga ttcccagttc cccagcatcc cggatgcctt
     1681 ctggtgggca gtcgtctcca tgacaactgt aggctatgga gacatggttc caactaccat
     1741 tgggggaaag atagtgggtt ctctgtgtgc aattgcaggt gtgttaacca ttgccttacc
     1801 agtccctgtc atagtgtcta atttcaacta cttctaccac cgggagacag agggagagga
     1861 gcaggcccag tacttgcaag tgacaagttg tccaaagatc ccgtcctccc ctgacctaaa
     1921 gaaaagtaga agtgcctcta ccataagtaa gtctgattac atggagatac aggagggagt
     1981 aaacaacagt aatgaggact ttagagagga gaacttaaaa acagccaact gtaccttggc
     2041 taacacaaac tatgtgaata ttaccaaaat gttaactgat gtctgattga aacctattaa
     2101 tgtactcaca gctcaacagg actaatgcag atattgcata atagcctgca ttgtagtcag
     2161 tgttctacag tgtgcatctg gttctgcatg gaaagcaata gtcgtgcaag tgacttttga
     2221 tcttttgatt tttgatttag aacacagaat atttatcatg gctttcatga aatctttatc
     2281 accgacttac aggtttccaa agatgagagt cacccatgga gccagcatc
//
