LOCUS       NM_173095               1746 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily A
            member 1 (Kcna1), mRNA.
ACCESSION   NM_173095
VERSION     NM_173095.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Zhou,X., Guo,G., Yu,S. and Hu,R.
  TITLE     MiR-21-5p alleviates trigeminal neuralgia in rats through
            down-regulation of voltage-gated potassium channel Kv1.1
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 49 (1), 29-39 (2024)
   PUBMED   38615163
  REMARK    GeneRIF: MiR-21-5p alleviates trigeminal neuralgia in rats through
            down-regulation of voltage-gated potassium channel Kv1.1.
REFERENCE   2  (bases 1 to 1746)
  AUTHORS   Barrese,V., Wehbe,Z., Linden,A., McDowell,S., Forrester,E.,
            Povstyan,O., McCloskey,K.D. and Greenwood,I.A.
  TITLE     Key role for Kv11.1 (ether-a-go-go related gene) channels in rat
            bladder contractility
  JOURNAL   Physiol Rep 11 (3), e15583 (2023)
   PUBMED   36750122
  REMARK    GeneRIF: Key role for Kv11.1 (ether-a-go-go related gene) channels
            in rat bladder contractility.
REFERENCE   3  (bases 1 to 1746)
  AUTHORS   Langthaler,S., Lozanovic Sajic,J., Rienmuller,T., Weinberg,S.H. and
            Baumgartner,C.
  TITLE     Ion Channel Modeling beyond State of the Art: A Comparison with a
            System Theory-Based Model of the Shaker-Related Voltage-Gated
            Potassium Channel Kv1.1
  JOURNAL   Cells 11 (2), 239 (2022)
   PUBMED   35053355
  REMARK    GeneRIF: Ion Channel Modeling beyond State of the Art: A Comparison
            with a System Theory-Based Model of the Shaker-Related
            Voltage-Gated Potassium Channel Kv1.1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1746)
  AUTHORS   Hall,M.K., Weidner,D.A., Edwards,M.A. and Schwalbe,R.A.
  TITLE     Complex N-Glycans Influence the Spatial Arrangement of Voltage
            Gated Potassium Channels in Membranes of Neuronal-Derived Cells
  JOURNAL   PLoS One 10 (9), e0137138 (2015)
   PUBMED   26348848
  REMARK    GeneRIF: Our findings provide direct evidence that N-glycans of
            Kv3.1 splice variants contribute to the placement of these
            glycoproteins in the plasma membrane of neuronal-derived cells
            while those of Kv1.1 were absent.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1746)
  AUTHORS   Sosanya,N.M., Brager,D.H., Wolfe,S., Niere,F. and Raab-Graham,K.F.
  TITLE     Rapamycin reveals an mTOR-independent repression of Kv1.1
            expression during epileptogenesis
  JOURNAL   Neurobiol Dis 73, 96-105 (2015)
   PUBMED   25270294
  REMARK    GeneRIF: This stuidy demonstrated that kainic-acid induced status
            epilepticus there are two phases of Kv1.1 repression: (1) an
            initial mTOR-dependent repression of Kv1.1 that is followed by (2)
            a miR-129-5p persistent reduction of Kv1.1.
REFERENCE   6  (bases 1 to 1746)
  AUTHORS   Kim,E., Niethammer,M., Rothschild,A., Jan,Y.N. and Sheng,M.
  TITLE     Clustering of Shaker-type K+ channels by interaction with a family
            of membrane-associated guanylate kinases
  JOURNAL   Nature 378 (6552), 85-88 (1995)
   PUBMED   7477295
REFERENCE   7  (bases 1 to 1746)
  AUTHORS   Ivanina,T., Perets,T., Thornhill,W.B., Levin,G., Dascal,N. and
            Lotan,I.
  TITLE     Phosphorylation by protein kinase A of RCK1 K+ channels expressed
            in Xenopus oocytes
  JOURNAL   Biochemistry 33 (29), 8786-8792 (1994)
   PUBMED   8038169
REFERENCE   8  (bases 1 to 1746)
  AUTHORS   Stuhmer,W., Ruppersberg,J.P., Schroter,K.H., Sakmann,B.,
            Stocker,M., Giese,K.P., Perschke,A., Baumann,A. and Pongs,O.
  TITLE     Molecular basis of functional diversity of voltage-gated potassium
            channels in mammalian brain
  JOURNAL   EMBO J 8 (11), 3235-3244 (1989)
   PUBMED   2555158
REFERENCE   9  (bases 1 to 1746)
  AUTHORS   Christie,M.J., Adelman,J.P., Douglass,J. and North,R.A.
  TITLE     Expression of a cloned rat brain potassium channel in Xenopus
            oocytes
  JOURNAL   Science 244 (4901), 221-224 (1989)
   PUBMED   2539643
REFERENCE   10 (bases 1 to 1746)
  AUTHORS   Baumann,A., Grupe,A., Ackermann,A. and Pongs,O.
  TITLE     Structure of the voltage-dependent potassium channel is highly
            conserved from Drosophila to vertebrate central nervous systems
  JOURNAL   EMBO J 7 (8), 2457-2463 (1988)
   PUBMED   3191911
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M26161.1.
            
            On May 26, 2007 this sequence version replaced NM_173095.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M26161.1 [ECO:0000345]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1746
                     /gene="Kcna1"
                     /gene_synonym="Kcna; Kcpvd; Kv1.1"
                     /note="potassium voltage-gated channel subfamily A member
                     1"
                     /db_xref="GeneID:24520"
                     /db_xref="RGD:2949"
     exon            1..1746
                     /gene="Kcna1"
                     /gene_synonym="Kcna; Kcpvd; Kv1.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1522
                     /gene="Kcna1"
                     /gene_synonym="Kcna; Kcpvd; Kv1.1"
                     /note="potassium voltage gated channel shaker related
                     subfamily member 1; IA; RBKI; RCK1; potassium channel,
                     voltage gated shaker related subfamily A, member 1;
                     voltage-gated potassium channel subunit Kv1.1; potassium
                     (K+) channel protein voltage dependent"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily A
                     member 1"
                     /protein_id="NP_775118.1"
                     /db_xref="GeneID:24520"
                     /db_xref="RGD:2949"
                     /translation="MTVMSGENADEASAAPGHPQDGSYPRQADHDDHECCERVVINIS
                     GLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL
                     RRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYP
                     ESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTIHRIDNTTVIYTSNIFT
                     DPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQ
                     EGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLF
                     IGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLC
                     AIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTIS
                     KSEYMEIEEDMNNSIAHYRQANIRTGNCTATDQNCVNKSKLLTDV"
ORIGIN      
        1 tcctggcctc ctacccctgc accctgcatc catcatgacg gtgatgtcag gggagaatgc
       61 agacgaggct tcggccgctc caggtcaccc ccaggatggc agctacccaa ggcaggcgga
      121 ccacgacgac cacgaatgct gcgagcgcgt ggtgatcaac atctccgggc tgcgcttcga
      181 gacgcagctc aagactctgg cccagttccc caacacgctg ctgggcaacc cgaagaaacg
      241 catgcgctac tttgaccctc tgaggaatga gtacttcttt gaccgcaacc ggcccagctt
      301 cgatgccatc ctttattact accagtcggg ggggcgcctg cgcaggccgg tcaacgtgcc
      361 cctggacatg ttctccgagg agattaaatt ttacgagttg ggcgaggagg ccatggagaa
      421 gttccgggaa gatgagggct tcatcaagga agaggagcgc cccctacccg agaaggagta
      481 ccagcgccag gtgtggctgc tctttgagta tccggagagc tcaggacctg cacgggttat
      541 tgccattgta tccgtcatgg tcatcctcat ctccatagtc atcttttgcc tggagactct
      601 ccctgagctg aaggatgaca aggacttcac gggcaccatt caccgcatcg ataacaccac
      661 agtcatctac acttctaaca tcttcacaga ccctttcttc attgtggaaa ccttgtgtat
      721 catctggttc tcttttgagc tggtggtgcg cttcttcgcc tgccccagca agacagactt
      781 ctttaagaac atcatgaact tcatcgacat tgtggccatc atcccttatt tcattaccct
      841 gggcacagag atagctgagc aggaggggaa tcagaagggc gagcaggcca cttccctggc
      901 catcctcagg gtcatccgct tggtaagggt gttcagaatc ttcaaactct cccgccactc
      961 caagggcctt cagatcctgg gccagaccct caaagctagt atgagggagt tagggctgct
     1021 catctttttc ctcttcattg gcgtcatact gttttctagt gcagtgtact ttgcggaggc
     1081 ggaagaagct gagtcgcact tctccagtat ccccgatgct ttctggtggg cggtggtgtc
     1141 catgaccact gtgggatacg gtgacatgta ccctgtgaca attggaggca agatcgtggg
     1201 ctccttgtgt gccatcgctg gtgtgctgac aattgccctg cccgtacctg tcattgtgtc
     1261 caatttcaac tatttctacc accgagaaac tgagggggaa gagcaggctc agttgctcca
     1321 tgttagttct cctaacttag cctctgacag tgacctcagc cgccgcagct cctctactat
     1381 cagcaagtct gagtacatgg agatcgaaga ggacatgaac aatagcatag cccactacag
     1441 gcaggctaat atcagaactg gtaactgcac cgcaactgat caaaactgcg ttaataagag
     1501 caagctcctg accgatgttt aaaaaaagca ccaggcaagc aatcaaaagc ccccaaacaa
     1561 aacccttggc gactcctgtc ccactctgta gatactttac taaaaccgta gtctttgaat
     1621 gctttattta actggcaatg cactgttgca ttgtgaattt ggggggtggg caaacctgaa
     1681 gctttcaaga tcacatttaa aaaacaaaac caaccaaaca agcaaaaaga aaaaaaaaac
     1741 ccaaca
//
