LOCUS       NM_001004217            1852 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus katanin catalytic subunit A1 (Katna1), mRNA.
ACCESSION   NM_001004217 XM_214787
VERSION     NM_001004217.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1852)
  AUTHORS   Buijs,R.R., Hummel,J.J.A., Burute,M., Pan,X., Cao,Y., Stucchi,R.,
            Altelaar,M., Akhmanova,A., Kapitein,L.C. and Hoogenraad,C.C.
  TITLE     WDR47 protects neuronal microtubule minus ends from
            katanin-mediated severing
  JOURNAL   Cell Rep 36 (2), 109371 (2021)
   PUBMED   34260930
  REMARK    GeneRIF: WDR47 protects neuronal microtubule minus ends from
            katanin-mediated severing.
REFERENCE   2  (bases 1 to 1852)
  AUTHORS   Tan,D., Zhang,H., Deng,J., Liu,J., Wen,J., Li,L., Wang,X., Pan,M.,
            Hu,X. and Guo,J.
  TITLE     RhoA-GTPase Modulates Neurite Outgrowth by Regulating the
            Expression of Spastin and p60-Katanin
  JOURNAL   Cells 9 (1), 230 (2020)
   PUBMED   31963385
  REMARK    GeneRIF: RhoA-GTPase Modulates Neurite Outgrowth by Regulating the
            Expression of Spastin and p60-Katanin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1852)
  AUTHORS   Cheung,K., Senese,S., Kuang,J., Bui,N., Ongpipattanakul,C.,
            Gholkar,A., Cohn,W., Capri,J., Whitelegge,J.P. and Torres,J.Z.
  TITLE     Proteomic Analysis of the Mammalian Katanin Family of
            Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1
            (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing
  JOURNAL   Mol Cell Proteomics 15 (5), 1658-1669 (2016)
   PUBMED   26929214
REFERENCE   4  (bases 1 to 1852)
  AUTHORS   Matsuo,M., Shimodaira,T., Kasama,T., Hata,Y., Echigo,A., Okabe,M.,
            Arai,K., Makino,Y., Niwa,S., Saya,H. and Kishimoto,T.
  TITLE     Katanin p60 contributes to microtubule instability around the
            midbody and facilitates cytokinesis in rat cells
  JOURNAL   PLoS One 8 (11), e80392 (2013)
   PUBMED   24303010
  REMARK    GeneRIF: Katanin p60 contributes to microtubule instability around
            the midbody and facilitates cytokinesis in rat cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1852)
  AUTHORS   Lacroix,B., van Dijk,J., Gold,N.D., Guizetti,J.,
            Aldrian-Herrada,G., Rogowski,K., Gerlich,D.W. and Janke,C.
  TITLE     Tubulin polyglutamylation stimulates spastin-mediated microtubule
            severing
  JOURNAL   J Cell Biol 189 (6), 945-954 (2010)
   PUBMED   20530212
REFERENCE   6  (bases 1 to 1852)
  AUTHORS   Yu,W., Solowska,J.M., Qiang,L., Karabay,A., Baird,D. and Baas,P.W.
  TITLE     Regulation of microtubule severing by katanin subunits during
            neuronal development
  JOURNAL   J Neurosci 25 (23), 5573-5583 (2005)
   PUBMED   15944385
  REMARK    GeneRIF: the ratio of P60 to P80 varies markedly in different
            tissues, at different phases of development, and regionally within
            the neuron. Suggested that the effects on neuronal morphology are
            dependent on the degree of microtubule severing and loss of polymer
REFERENCE   7  (bases 1 to 1852)
  AUTHORS   Karabay,A., Yu,W., Solowska,J.M., Baird,D.H. and Baas,P.W.
  TITLE     Axonal growth is sensitive to the levels of katanin, a protein that
            severs microtubules
  JOURNAL   J Neurosci 24 (25), 5778-5788 (2004)
   PUBMED   15215300
REFERENCE   8  (bases 1 to 1852)
  AUTHORS   McNally,K.P., Bazirgan,O.A. and McNally,F.J.
  TITLE     Two domains of p80 katanin regulate microtubule severing and
            spindle pole targeting by p60 katanin
  JOURNAL   J Cell Sci 113 (Pt 9), 1623-1633 (2000)
   PUBMED   10751153
REFERENCE   9  (bases 1 to 1852)
  AUTHORS   Syu,L.J. and Saltiel,A.R.
  TITLE     Lipotransin: a novel docking protein for hormone-sensitive lipase
  JOURNAL   Mol Cell 4 (1), 109-115 (1999)
   PUBMED   10445032
REFERENCE   10 (bases 1 to 1852)
  AUTHORS   Ahmad,F.J., Yu,W., McNally,F.J. and Baas,P.W.
  TITLE     An essential role for katanin in severing microtubules in the
            neuron
  JOURNAL   J Cell Biol 145 (2), 305-315 (1999)
   PUBMED   10209026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC097929.1 and BI302698.1.
            
            On Aug 11, 2009 this sequence version replaced NM_001004217.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1833              BC097929.1         1-1833
            1834-1852           BI302698.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1852
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..1852
                     /gene="Katna1"
                     /note="katanin catalytic subunit A1"
                     /db_xref="GeneID:292464"
                     /db_xref="RGD:1303062"
     exon            1..183
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..358
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1672
                     /gene="Katna1"
                     /EC_number="5.6.1.1"
                     /note="microtubule severing protein; katanin p60 subunit A
                     1; p60 katanin; katanin p60 subunit A1"
                     /codon_start=1
                     /product="katanin p60 ATPase-containing subunit A1"
                     /protein_id="NP_001004217.2"
                     /db_xref="GeneID:292464"
                     /db_xref="RGD:1303062"
                     /translation="MSMSLLMITENVKLAREYALLGNYDSAMVYYQGVLDQINKYLYS
                     VKDTHLHQKWQQVWQEINVEAKHVKEIMKTLESFKLDSTSLKAAQHELPSSEGEVWSL
                     PVPVERRPLPGPRKRQSTQHSDPKPHSNRPGAVVRAHRPSAQSLHSDRGKAVRSREKK
                     EQSKGREEKNKLPAAVTEPEANKFDSTGYDKDLVEALERDIISQNPNVRWYDIADLVE
                     AKKLLQEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVS
                     SSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAE
                     LLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREEL
                     LRISLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNL
                     SREEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIVEFGSC"
     exon            359..516
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..697
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..819
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..925
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1084
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1211
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1346
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1473
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1835
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggaggag gacccagtaa gaggggcttg ccgggtttga tttcaagttg gcagcgacca
       61 agaactgcgg tgcccgcggg cctcgaccgt gcggctcgcg gagctccgag cgagacgccg
      121 cggcccgggc ctcattcccc gccacgcggc ggacagcgtg tcctggagcc tgggctgcac
      181 cagcttacgg atgagcatga gtcttctaat gattactgag aatgtaaaat tggctcgtga
      241 gtatgcattg ctgggaaact atgactctgc aatggtctat tatcagggag ttcttgacca
      301 aattaacaag tatctatact cagtcaaaga tacacacctc catcagaaat ggcaacaggt
      361 ttggcaggaa ataaacgtgg aagctaagca tgttaaggag atcatgaaaa cactggagag
      421 ctttaaactg gacagcactt ctttgaaagc tgcacagcat gagcttccgt cctcggaagg
      481 agaagtctgg tctttgccgg tacctgttga aaggagaccc ttaccaggac ctaggaagcg
      541 ccagtctact cagcacagtg accctaagcc acacagtaac cggccaggcg cagtcgtcag
      601 agctcatcga ccatctgcac agagtctgca cagcgacaga ggcaaagctg ttcgtagtcg
      661 tgaaaagaaa gagcagagta agggcagaga ggaaaagaac aaattacctg ctgcagttac
      721 agaaccagag gcaaataaat ttgatagcac ggggtatgac aaggacttag tagaagcttt
      781 ggaaagagat ataatttctc agaatcccaa cgttcggtgg tatgatattg ctgatttagt
      841 agaagctaaa aagttgcttc aggaagcagt ggtgttacca atgtggatgc cagaattctt
      901 taagggcatt aggagaccat ggaaaggtgt gctgatggtt ggcccacctg gcactggaaa
      961 gaccctcctt gctaaagcag ttgccacaga atgcaagaca acgttcttca atgtctcttc
     1021 atccactctg acttccaaat acagaggaga gtctgagaag cttgtccgtc ttctgtttga
     1081 aatggctcgg ttttactccc cagctaccat atttattgat gagatagatt ccatctgcag
     1141 ccgccgagga acttctgaag agcatgaagc aagccgaagg gtgaaagctg agctgctggt
     1201 tcagatggat ggtgttggag gtgcctcaga aaatgacgac ccttccaaga tggtcatggt
     1261 tctggcggcc actaatttcc catgggacat agatgaggct ttaaggcgtc gtctggagaa
     1321 aagaatctat attccgttac catcagcaaa aggcagagaa gaactgttaa gaataagtct
     1381 acgagagctg gaattggctg atgatgttaa ccttgcaagc atagcagaaa acatggaagg
     1441 ctactcaggt gcagacatta ccaatgtatg cagggatgcg tccttgatgg ccatgagacg
     1501 ccgtattgag ggtctaaccc cagaagaaat ccggaacctt tcaagagaag aaatgcacat
     1561 gcctaccacc atggaggatt ttgaaatggc tttaaagaag gtctccaaat cagtatcagc
     1621 tgcagacatt gagagatacg agaaatggat agttgagttt ggatcatgct agctaagttc
     1681 tcacatgtaa actgtgagaa atctgcctta agtctttgaa aataattaaa tgtagtattt
     1741 cagtgcattg agtgccatat ttttttgaac tttgataatg gtgtgatatt taaattcttt
     1801 ctggtgctta ataaagacaa tatttttaaa ctgcaaaaaa aaaaaaaaaa aa
//
