LOCUS       NM_001017378            1558 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus lysine acetyltransferase 8 (Kat8), mRNA.
ACCESSION   NM_001017378 XM_226893
VERSION     NM_001017378.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1558)
  AUTHORS   Li,L., Ghorbani,M., Weisz-Hubshman,M., Rousseau,J., Thiffault,I.,
            Schnur,R.E., Breen,C., Oegema,R., Weiss,M.M., Waisfisz,Q.,
            Welner,S., Kingston,H., Hills,J.A., Boon,E.M., Basel-Salmon,L.,
            Konen,O., Goldberg-Stern,H., Bazak,L., Tzur,S., Jin,J., Bi,X.,
            Bruccoleri,M., McWalter,K., Cho,M.T., Scarano,M., Schaefer,G.B.,
            Brooks,S.S., Hughes,S.S., van Gassen,K.L.I., van Hagen,J.M.,
            Pandita,T.K., Agrawal,P.B., Campeau,P.M. and Yang,X.J.
  TITLE     Lysine acetyltransferase 8 is involved in cerebral development and
            syndromic intellectual disability
  JOURNAL   J Clin Invest 130 (3), 1431-1445 (2020)
   PUBMED   31794431
REFERENCE   2  (bases 1 to 1558)
  AUTHORS   Qiao,W., Zhang,W., Gai,Y., Zhao,L. and Fan,J.
  TITLE     The histone acetyltransferase MOF overexpression blunts cardiac
            hypertrophy by targeting ROS in mice
  JOURNAL   Biochem Biophys Res Commun 448 (4), 379-384 (2014)
   PUBMED   24802406
REFERENCE   3  (bases 1 to 1558)
  AUTHORS   Fullgrabe,J., Lynch-Day,M.A., Heldring,N., Li,W., Struijk,R.B.,
            Ma,Q., Hermanson,O., Rosenfeld,M.G., Klionsky,D.J. and Joseph,B.
  TITLE     The histone H4 lysine 16 acetyltransferase hMOF regulates the
            outcome of autophagy
  JOURNAL   Nature 500 (7463), 468-471 (2013)
   PUBMED   23863932
  REMARK    Erratum:[Nature. 2017 Mar 30;543(7647):742. doi:
            10.1038/nature22027.. PMID: 28297710]
REFERENCE   4  (bases 1 to 1558)
  AUTHORS   Wang,Y., Zhang,R., Wu,D., Lu,Z., Sun,W., Cai,Y., Wang,C. and Jin,J.
  TITLE     Epigenetic change in kidney tumor: downregulation of histone
            acetyltransferase MYST1 in human renal cell carcinoma
  JOURNAL   J Exp Clin Cancer Res 32 (1), 8 (2013)
   PUBMED   23394073
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1558)
  AUTHORS   Patani,N., Jiang,W.G., Newbold,R.F. and Mokbel,K.
  TITLE     Histone-modifier gene expression profiles are associated with
            pathological and clinical outcomes in human breast cancer
  JOURNAL   Anticancer Res 31 (12), 4115-4125 (2011)
   PUBMED   22199269
REFERENCE   6  (bases 1 to 1558)
  AUTHORS   Kruse,J.P. and Gu,W.
  TITLE     Modes of p53 regulation
  JOURNAL   Cell 137 (4), 609-622 (2009)
   PUBMED   19450511
  REMARK    Review article
REFERENCE   7  (bases 1 to 1558)
  AUTHORS   Dou,Y., Milne,T.A., Tackett,A.J., Smith,E.R., Fukuda,A.,
            Wysocka,J., Allis,C.D., Chait,B.T., Hess,J.L. and Roeder,R.G.
  TITLE     Physical association and coordinate function of the H3 K4
            methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
  JOURNAL   Cell 121 (6), 873-885 (2005)
   PUBMED   15960975
REFERENCE   8  (bases 1 to 1558)
  AUTHORS   Craig,J.M., Earle,E., Canham,P., Wong,L.H., Anderson,M. and
            Choo,K.H.
  TITLE     Analysis of mammalian proteins involved in chromatin modification
            reveals new metaphase centromeric proteins and distinct chromosomal
            distribution patterns
  JOURNAL   Hum Mol Genet 12 (23), 3109-3121 (2003)
   PUBMED   14519686
REFERENCE   9  (bases 1 to 1558)
  AUTHORS   Pelletier,N., Champagne,N., Stifani,S. and Yang,X.J.
  TITLE     MOZ and MORF histone acetyltransferases interact with the
            Runt-domain transcription factor Runx2
  JOURNAL   Oncogene 21 (17), 2729-2740 (2002)
   PUBMED   11965546
REFERENCE   10 (bases 1 to 1558)
  AUTHORS   Kitabayashi,I., Aikawa,Y., Nguyen,L.A., Yokoyama,A. and Ohki,M.
  TITLE     Activation of AML1-mediated transcription by MOZ and inhibition by
            the MOZ-CBP fusion protein
  JOURNAL   EMBO J 20 (24), 7184-7196 (2001)
   PUBMED   11742995
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083891.1.
            
            On Apr 22, 2005 this sequence version replaced XM_226893.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1558
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..1558
                     /gene="Kat8"
                     /gene_synonym="Myst1"
                     /note="lysine acetyltransferase 8"
                     /db_xref="GeneID:310194"
                     /db_xref="RGD:1311512"
     exon            1..216
                     /gene="Kat8"
                     /gene_synonym="Myst1"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1382
                     /gene="Kat8"
                     /gene_synonym="Myst1"
                     /EC_number="2.3.1.48"
                     /note="probable histone acetyltransferase MYST1; MYST
                     protein 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; K
                     (lysine) acetyltransferase 8; MYST-1; MYST histone
                     acetyltransferase 1; protein acetyltransferase KAT8;
                     protein propionyltransferase KAT8"
                     /codon_start=1
                     /product="histone acetyltransferase KAT8"
                     /protein_id="NP_001017378.1"
                     /db_xref="GeneID:310194"
                     /db_xref="RGD:1311512"
                     /translation="MAAQGATAAVAATTSGIVGEGEPGPGENTSVEGPARSPGRVSPP
                     TPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDE
                     WVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMD
                     PTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMK
                     FEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTL
                     YFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIA
                     FSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSIT
                     QNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKH
                     KQVKLSKK"
     exon            217..291
                     /gene="Kat8"
                     /gene_synonym="Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..467
                     /gene="Kat8"
                     /gene_synonym="Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..521
                     /gene="Kat8"
                     /gene_synonym="Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            522..686
                     /gene="Kat8"
                     /gene_synonym="Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..776
                     /gene="Kat8"
                     /gene_synonym="Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..917
                     /gene="Kat8"
                     /gene_synonym="Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1011
                     /gene="Kat8"
                     /gene_synonym="Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1162
                     /gene="Kat8"
                     /gene_synonym="Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1317
                     /gene="Kat8"
                     /gene_synonym="Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1509
                     /gene="Kat8"
                     /gene_synonym="Myst1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcaatggc ggcacaggga gcaacagccg ctgttgctgc aacaacttca ggaattgtag
       61 gggagggaga gcccggtccg ggggaaaata catcggtcga ggggcctgcc cgatccccgg
      121 gccgggtctc tccgccgact ccggcgcgtg gcgaaccaga agtcaccgtg gagatcggag
      181 aaacgtacct gtgccggcgg cccgacagca cctggcattc agcagaagtg atccagtctc
      241 gagtgaatga ccaagagggc cgagaagaat tctatgttca ttatgtgggc tttaacaggc
      301 gactggacga atgggtggac aagaaccgac ttgctctgac taagacagtg aaggatgccg
      361 tgcagaagaa ttctgagaag tacctgagtg agctggcgga gcagcctgag cgcaagatca
      421 ctcgaaacca aaaacgaaag catgatgaga tcaaccatgt acagaagacc tatgcagaga
      481 tggaccccac cacagcagcc ttggaaaagg agcatgaggc gatcaccaaa gtgaagtatg
      541 tagacaagat ccacattggc aactacgaaa ttgatgcctg gtatttctca cctttcccgg
      601 aggactatgg gaagcagccc aagctttggc tctgcgagta ctgcctcaag tacatgaagt
      661 tcgagaagag ctaccgcttc cacctgggcc agtgccagtg gcggcagccc ccagggaagg
      721 agatctatcg aaagagcaac atctctgtgt atgaagtgga tggcaaagac cataagatat
      781 attgtcagaa cctgtgtttg ctggccaagc ttttcctgga ccacaagacc ttgtattttg
      841 atgtggagcc ctttgtcttt tacattttga cagaagtaga taggcaaggg gctcacattg
      901 ttggctactt ttctaaggag aaggaatccc ctgatggaaa caacgtggcc tgcatcctga
      961 ccctgcctcc ctaccagcgg cgtggctatg ggaagtttct cattgccttc agttatgagc
     1021 tttctaagct tgagagtact gtaggctccc cagagaagcc actgagtgac ctgggcaaac
     1081 tcagttacag aagctactgg tcatgggtct tgctggagat ccttcgagac ttccggggca
     1141 cattgtctat caaagatctt agccagatga ccagcatcac ccagaatgac atcatcagca
     1201 ccctgcagtc cctcaacatg gtcaagtact ggaagggcca gcatgtgatc tgtgtcacac
     1261 ctaagctagt agaagaacat ctcaaaagtg cccagtataa gaagccacct atcacagtgg
     1321 actctgtctg cctcaagtgg gcacccccga agcacaaaca agtcaagctc tccaagaagt
     1381 gaatggcctg tgcccttctt tggatctgtg tttcctggcc tctaacctgt aaatatgtgt
     1441 acagacctgt tttgtgtcat ttattaataa agcaaattct gctggtgtgc tggacttcgg
     1501 aggcaggaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
