LOCUS       NM_181081               3406 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus lysine acetyltransferase 7 (Kat7), transcript
            variant 1, mRNA.
ACCESSION   NM_181081
VERSION     NM_181081.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3406)
  AUTHORS   MacPherson,L., Anokye,J., Yeung,M.M., Lam,E.Y.N., Chan,Y.C.,
            Weng,C.F., Yeh,P., Knezevic,K., Butler,M.S., Hoegl,A., Chan,K.L.,
            Burr,M.L., Gearing,L.J., Willson,T., Liu,J., Choi,J., Yang,Y.,
            Bilardi,R.A., Falk,H., Nguyen,N., Stupple,P.A., Peat,T.S.,
            Zhang,M., de Silva,M., Carrasco-Pozo,C., Avery,V.M., Khoo,P.S.,
            Dolezal,O., Dennis,M.L., Nuttall,S., Surjadi,R., Newman,J., Ren,B.,
            Leaver,D.J., Sun,Y., Baell,J.B., Dovey,O., Vassiliou,G.S.,
            Grebien,F., Dawson,S.J., Street,I.P., Monahan,B.J., Burns,C.J.,
            Choudhary,C., Blewitt,M.E., Voss,A.K., Thomas,T. and Dawson,M.A.
  TITLE     HBO1 is required for the maintenance of leukaemia stem cells
  JOURNAL   Nature 577 (7789), 266-270 (2020)
   PUBMED   31827282
REFERENCE   2  (bases 1 to 3406)
  AUTHORS   Niida,H., Matsunuma,R., Horiguchi,R., Uchida,C., Nakazawa,Y.,
            Motegi,A., Nishimoto,K., Sakai,S., Ohhata,T., Kitagawa,K.,
            Moriwaki,S., Nishitani,H., Ui,A., Ogi,T. and Kitagawa,M.
  TITLE     Phosphorylated HBO1 at UV irradiated sites is essential for
            nucleotide excision repair
  JOURNAL   Nat Commun 8, 16102 (2017)
   PUBMED   28719581
  REMARK    Erratum:[Nat Commun. 2018 Apr 20;9:16214. doi:
            10.1038/ncomms16214.. PMID: 29676391]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3406)
  AUTHORS   Newman,D.M., Voss,A.K., Thomas,T. and Allan,R.S.
  TITLE     Essential role for the histone acetyltransferase KAT7 in T cell
            development, fitness, and survival
  JOURNAL   J Leukoc Biol 101 (4), 887-892 (2017)
   PUBMED   27733580
REFERENCE   4  (bases 1 to 3406)
  AUTHORS   Feng,Y., Vlassis,A., Roques,C., Lalonde,M.E., Gonzalez-Aguilera,C.,
            Lambert,J.P., Lee,S.B., Zhao,X., Alabert,C., Johansen,J.V.,
            Paquet,E., Yang,X.J., Gingras,A.C., Cote,J. and Groth,A.
  TITLE     BRPF3-HBO1 regulates replication origin activation and histone
            H3K14 acetylation
  JOURNAL   EMBO J 35 (2), 176-192 (2016)
   PUBMED   26620551
REFERENCE   5  (bases 1 to 3406)
  AUTHORS   Radhakrishnan,R., Li,Y., Xiang,S., Yuan,F., Yuan,Z., Telles,E.,
            Fang,J., Coppola,D., Shibata,D., Lane,W.S., Zhang,Y., Zhang,X. and
            Seto,E.
  TITLE     Histone deacetylase 10 regulates DNA mismatch repair and may
            involve the deacetylation of MutS homolog 2
  JOURNAL   J Biol Chem 290 (37), 22795-22804 (2015)
   PUBMED   26221039
REFERENCE   6  (bases 1 to 3406)
  AUTHORS   Kueh,A.J., Dixon,M.P., Voss,A.K. and Thomas,T.
  TITLE     HBO1 is required for H3K14 acetylation and normal transcriptional
            activity during embryonic development
  JOURNAL   Mol Cell Biol 31 (4), 845-860 (2011)
   PUBMED   21149574
REFERENCE   7  (bases 1 to 3406)
  AUTHORS   Peserico,A. and Simone,C.
  TITLE     Physical and functional HAT/HDAC interplay regulates protein
            acetylation balance
  JOURNAL   J Biomed Biotechnol 2011, 371832 (2011)
   PUBMED   21151613
  REMARK    Review article
REFERENCE   8  (bases 1 to 3406)
  AUTHORS   Wang,W.Z., Liu,H.O., Wu,Y.H., Hong,Y., Yang,J.W., Liu,Y.H.,
            Wu,W.B., Zhou,L., Sun,L.L., Xu,J.J., Yun,X.J. and Gu,J.X.
  TITLE     Estrogen receptor alpha (ERalpha) mediates 17beta-estradiol
            (E2)-activated expression of HBO1
  JOURNAL   J Exp Clin Cancer Res 29 (1), 140 (2010)
   PUBMED   21040551
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3406)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   10 (bases 1 to 3406)
  AUTHORS   Pasheva,E., Sarov,M., Bidjekov,K., Ugrinova,I., Sarg,B., Lindner,H.
            and Pashev,I.G.
  TITLE     In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of
            the acidic tail
  JOURNAL   Biochemistry 43 (10), 2935-2940 (2004)
   PUBMED   15005629
  REMARK    GeneRIF: Alteration of histone acetyltransferase CREB-binding
            protein acetylation of high mobility group box protein(HMGB)-1 and
            -2 and truncated forms lacking C-terminal tails is regarded as a
            mechanism by which the acidic tail modulates some properties of
            HMGBs.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 21, 2022 this sequence version replaced NM_181081.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY236854.1, SRR26643293.65560.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                JAXUCZ010000010.1  80751723-80751761   c
            40-187              JAXUCZ010000010.1  80748796-80748943   c
            188-364             JAXUCZ010000010.1  80745906-80746082   c
            365-604             JAXUCZ010000010.1  80742865-80743104   c
            605-687             JAXUCZ010000010.1  80737556-80737638   c
            688-777             JAXUCZ010000010.1  80734584-80734673   c
            778-876             JAXUCZ010000010.1  80732769-80732867   c
            877-987             JAXUCZ010000010.1  80729391-80729501   c
            988-1179            JAXUCZ010000010.1  80727239-80727430   c
            1180-1269           JAXUCZ010000010.1  80725262-80725351   c
            1270-1410           JAXUCZ010000010.1  80724941-80725081   c
            1411-1504           JAXUCZ010000010.1  80723847-80723940   c
            1505-1651           JAXUCZ010000010.1  80721430-80721576   c
            1652-1758           JAXUCZ010000010.1  80720515-80720621   c
            1759-3406           JAXUCZ010000010.1  80718335-80719982   c
FEATURES             Location/Qualifiers
     source          1..3406
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..3406
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /note="lysine acetyltransferase 7"
                     /db_xref="GeneID:303470"
                     /db_xref="RGD:727966"
     exon            1..39
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1860
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /EC_number="2.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone acetyltransferase MYST2; MYST protein 2; MOZ,
                     YBF2/SAS3, SAS2 and TIP60 protein 2; histone
                     acetyltransferase binding to ORC1; MYST-2; MYST histone
                     acetyltransferase 2; histone acetyltransferase KAT7; K
                     (lysine) acetyltransferase 7"
                     /codon_start=1
                     /product="histone acetyltransferase KAT7 isoform 1"
                     /protein_id="NP_851595.1"
                     /db_xref="GeneID:303470"
                     /db_xref="RGD:727966"
                     /translation="MAIGVKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVT
                     RSSARLSQSSQDSSPVRNLPSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSG
                     SETEQAVDFSDRETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSL
                     KDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSA
                     DECKVRAQSRDKQIEERMLSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGL
                     SKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEG
                     SNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWK
                     HPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEA
                     DNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSP
                     ERPLSDLGLISYRSYWKEVLLRYLHNFQGKEISIKEISQETAVNPVDIVSTLQALQML
                     KYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTPPKGT"
     exon            40..187
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            188..364
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            365..604
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..687
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            688..777
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..876
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..987
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1179
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1269
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1410
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1504
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1651
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1758
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..3406
                     /gene="Kat7"
                     /gene_synonym="Myst2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccgccct tccggataga gatggcgata ggtgtaaaga gaaatgcagg cagtagttca
       61 gatggaaccg aagattccga tttttctaca gatctcgagc atacagacag ttcagagagt
      121 gacggcacat cgcgccgatc tgcccgagtc acccgctctt cagccaggct aagccagagt
      181 tctcaagatt ccagccctgt tcgaaatttg ccatctttcg gcactgagga acccgcctat
      241 tctaccagaa gagtgactcg gagtcagcag cagcccacac cagtgactcc aaaaaagtac
      301 cccctccggc agactcgctc ctcgggctct gaaacggaac aggcggttga tttttcagat
      361 agagaaacta aaaatacagc tgatcatgat gagtcgccac ctcgaactcc gactggaaat
      421 gcaccttctt ctgagtctga catagacatc tccagtccca atgtgtctca tgatgagagc
      481 attgccaagg acatgtccct gaaggactca ggcagtgatc tctctcaccg ccccaagcgt
      541 cgtcgatttc acgaaagcta caatttcaac atgaagtgcc ctacgccggg ctgcaactct
      601 ctaggacatc ttacaggaaa gcacgagaga catttctcca tctcaggatg cccgctgtat
      661 cataacctct cggctgacga gtgcaaggtg agagcacaga gccgggataa gcagatagaa
      721 gagaggatgc tgtcccacag gcaagatgac aacaacaggc atgcaaccag gcaccaggca
      781 ccaacagaga gacagctgcg gtataaggaa aaagtggctg aactcaggaa gaaaagaaat
      841 tctggactga gcaaagagca gaaagagaaa tacatggaac acagacagac ctatgggaac
      901 actcgggagc ctctcttgga aaacctgacg agtgaatatg acttagatct tttccgaaga
      961 gcacaagccc gggcttctga ggatttggag aagttaaggc ttcaaggcca aatcacagag
     1021 ggaagcaaca tgattaaaac aattgctttt ggccgctacg agctggatac ttggtaccat
     1081 tctccctatc ctgaagaata tgcacgactg ggacgtctct acatgtgtga attctgctta
     1141 aaatacatga agagccaaac gattctccgc cgacacatgg ccaagtgtgt gtggaaacac
     1201 ccccctggtg atgagattta tcgcaaaggc tccatctctg tgtttgaagt agatggcaag
     1261 aaaaacaaga tctactgcca aaacctctgc cttttggcga agctttttct ggaccataag
     1321 accttatact acgatgtaga gcccttcctg ttctacgtta tgacagaagc agacaatact
     1381 ggctgccacc tgattggata tttttctaag gagaagaatt catttctcaa ctacaatgtc
     1441 tcctgtattc tcaccatgcc tcagtacatg agacagggct atgggaagat gctcattgac
     1501 ttcagttatt tactttccaa ggtagaagag aaagttggct ctccggaacg cccactgtca
     1561 gacctggggc ttataagcta ccgcagctac tggaaggaag tactgctccg gtacctgcac
     1621 aacttccagg gcaaggagat ctccatcaaa gaaattagcc aggaaacagc tgtgaatccc
     1681 gtggacattg tcagcactct gcaagccctt cagatgctca agtattggaa agggaagcac
     1741 ctagttttaa agagacagga cctgatagat gaatggatcg ccaaagaggc caaaaggtcc
     1801 aactccaaca aaaccatgga tccaagctgc ttaaaatgga cccctcccaa gggcacttaa
     1861 agtgacctgt cattctgagc cagcgagccc cagcagtaga aatccgtacc ctagggatct
     1921 gtctgtcatt tctgttgctc ttgtgattgg caagtatagt atcctctggg aaggccaccc
     1981 cctcagcact gttctggctc caacctgcgt gtacactgca gacactggtt ctgaggaact
     2041 gttgtttcgg cctcagtgag gttgcctgga tggatctgta ttaggctcga gtacagatcc
     2101 ctcgtagcac tgacccaagg agttgtgtta tggtactgta cctgtccagt cactggtccc
     2161 ctcttcatgc tctttaaccc cgtgaagttt gttgtgtcct gacctttgtg ctagtgcttt
     2221 ttcctgcctg gttaccagac ctccaaacat ggttgccacc aaagggccct ttccagttag
     2281 tcctcacaca ttcttcatga aggggtgggc aagaggcagt gcctgtgagt gtctgtgtgt
     2341 ctgctgggag ggtccgctca ccctgcattt catctcacag tcacttattt ttctcccttt
     2401 ttgtcaaaag acttaacttt gatcagggtc aggctgaccc agagctagga acgcctgaca
     2461 attcccaggg gttcacaggc cctggtccat ctgagtgagt cggtgaagtt taagaggtgg
     2521 tgatcctgtg ttttcctttg tatttactta tgggcactgg ggcagcatct tgctggtgga
     2581 aatgaatggg taattttttc cacagcagaa atgccccact ttttttctgc ccccttttat
     2641 gttggcagtt gccaaaatat tttaacaatc ttttttcatg ccacatcaag tgatcccgct
     2701 gtgggtcttt ccacactgcc ttcgccagcc tggtgtgggg cagctgtact ttccatgtaa
     2761 gttgcactga ttttgtccag agcttcctgg gagaagtgga aaatgtttga aatgacttgt
     2821 gtttctcagc ccgtgactca gcaagacaga gtggccgcac tgctacggtt cgcttccctt
     2881 tccaacagtg cctcccccag caggctgaag tgcttctgtc taagaactaa ctcatttccc
     2941 tttcgggact tgccaccatc atcctgttct ctgggttcct atttttggtg gtgttgagtg
     3001 aaggaagaaa tgtcccctct aatttctccc tgtcccagta tataacctgc tatcttgggg
     3061 cagcttttga tgtctgacat gtcacccttc ccaacttgtc tcctccagca ctgctgtctt
     3121 cacgtggcac cctctcacca caaccctaac tctggtcatt tgtgcctttc tcttgtcatc
     3181 tctgtacact actaatattc actgtgggtt ggagggagct gattttaagc atgttcagtg
     3241 gcggctcccc tccagtttca gtgtaactgt taaaatgtat ccaaaagccg cttcctgggg
     3301 gttttcttaa gggtaaaggc ctttcacgga tgctgagccc ttccccacac gtggtagaat
     3361 gtgctcttct gtatctactc aataaagcat gttctctgct catgtc
//
