LOCUS       NM_001005872            1975 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Rattus norvegicus lysine acetyltransferase 5 (Kat5), mRNA.
ACCESSION   NM_001005872 XM_341995
VERSION     NM_001005872.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1975)
  AUTHORS   Cheng,X., Ma,X., Zhu,Q., Song,D., Ding,X., Li,L., Jiang,X.,
            Wang,X., Tian,R., Su,H., Shen,Z., Chen,S., Liu,T., Gong,W., Liu,W.
            and Sun,Q.
  TITLE     Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in
            Regulation of Autophagosome Maturation and Lipid Metabolism
  JOURNAL   Mol Cell 73 (4), 788-802 (2019)
   PUBMED   30704899
REFERENCE   2  (bases 1 to 1975)
  AUTHORS   Xu,S., Panikker,P., Iqbal,S. and Elefant,F.
  TITLE     Tip60 HAT Action Mediates Environmental Enrichment Induced
            Cognitive Restoration
  JOURNAL   PLoS One 11 (7), e0159623 (2016)
   PUBMED   27454757
  REMARK    GeneRIF: Our results implicate Tip60 as a critical mediator of
            EE-induced benefits, and provide broad insights into synergistic
            behavioral and epigenetic based therapeutic approaches for
            treatment of cognitive disorder.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1975)
  AUTHORS   Obri,A., Ouararhni,K., Papin,C., Diebold,M.L., Padmanabhan,K.,
            Marek,M., Stoll,I., Roy,L., Reilly,P.T., Mak,T.W., Dimitrov,S.,
            Romier,C. and Hamiche,A.
  TITLE     ANP32E is a histone chaperone that removes H2A.Z from chromatin
  JOURNAL   Nature 505 (7485), 648-653 (2014)
   PUBMED   24463511
REFERENCE   4  (bases 1 to 1975)
  AUTHORS   Mahajan,M.A. and Stanley,F.M.
  TITLE     Insulin-activated Elk-1 recruits the TIP60/NuA4 complex to increase
            prolactin gene transcription
  JOURNAL   Mol Cell Endocrinol 382 (1), 159-169 (2014)
   PUBMED   24075908
  REMARK    GeneRIF: insulin activates prolactin gene transcription by
            activating Elk-1 that recruits the NuA4 complex to the promoter.
REFERENCE   5  (bases 1 to 1975)
  AUTHORS   Xiao,J., Liu,C., Li,G., Peng,S., Hu,J., Qu,L., Lv,P., Zhang,Y.,
            Ma,D. and Chen,Y.
  TITLE     PDCD5 negatively regulates autoimmunity by upregulating FOXP3(+)
            regulatory T cells and suppressing Th17 and Th1 responses
  JOURNAL   J Autoimmun 47, 34-44 (2013)
   PUBMED   24012345
REFERENCE   6  (bases 1 to 1975)
  AUTHORS   Kioussi,C., Briata,P., Baek,S.H., Rose,D.W., Hamblet,N.S.,
            Herman,T., Ohgi,K.A., Lin,C., Gleiberman,A., Wang,J., Brault,V.,
            Ruiz-Lozano,P., Nguyen,H.D., Kemler,R., Glass,C.K.,
            Wynshaw-Boris,A. and Rosenfeld,M.G.
  TITLE     Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway
            mediating cell-type-specific proliferation during development
  JOURNAL   Cell 111 (5), 673-685 (2002)
   PUBMED   12464179
REFERENCE   7  (bases 1 to 1975)
  AUTHORS   Prendergast,M.A., Rogers,D.T., Mulholland,P.J., Littleton,J.M.,
            Wilkins,L.H. Jr., Self,R.L. and Nath,A.
  TITLE     Neurotoxic effects of the human immunodeficiency virus type-1
            transcription factor Tat require function of a polyamine
            sensitive-site on the N-methyl-D-aspartate receptor
  JOURNAL   Brain Res 954 (2), 300-307 (2002)
   PUBMED   12414113
  REMARK    GeneRIF: The neurotoxic effects of HIV-1 Tat are mediated, in part,
            by direct interactions with a polyamine-sensitive site on the NMDA
            receptor.
REFERENCE   8  (bases 1 to 1975)
  AUTHORS   Cao,X. and Sudhof,T.C.
  TITLE     A transcriptionally [correction of transcriptively] active complex
            of APP with Fe65 and histone acetyltransferase Tip60
  JOURNAL   Science 293 (5527), 115-120 (2001)
   PUBMED   11441186
  REMARK    Erratum:[Science 2001 Aug 24;293(5534):1436]
REFERENCE   9  (bases 1 to 1975)
  AUTHORS   Sheridan,A.M., Force,T., Yoon,H.J., O'Leary,E., Choukroun,G.,
            Taheri,M.R. and Bonventre,J.V.
  TITLE     PLIP, a novel splice variant of Tip60, interacts with group IV
            cytosolic phospholipase A(2), induces apoptosis, and potentiates
            prostaglandin production
  JOURNAL   Mol Cell Biol 21 (14), 4470-4481 (2001)
   PUBMED   11416127
REFERENCE   10 (bases 1 to 1975)
  AUTHORS   Ikura,T., Ogryzko,V.V., Grigoriev,M., Groisman,R., Wang,J.,
            Horikoshi,M., Scully,R., Qin,J. and Nakatani,Y.
  TITLE     Involvement of the TIP60 histone acetylase complex in DNA repair
            and apoptosis
  JOURNAL   Cell 102 (4), 463-473 (2000)
   PUBMED   10966108
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083879.1.
            
            On Oct 25, 2004 this sequence version replaced XM_341995.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083879.1, SRR8487227.338122.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1975
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1975
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /note="lysine acetyltransferase 5"
                     /db_xref="GeneID:192218"
                     /db_xref="RGD:621061"
     exon            1..17
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1547
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /EC_number="2.3.1.48"
                     /note="60 kDa Tat-interactive protein; histone
                     acetyltransferase HTATIP; protein lactyltransferase KAT5;
                     HIV-1 tat interactive protein, homolog; HIV-1 Tat
                     interactive protein, 60 kD; K(lysine) acetyltransferase 5;
                     protein acetyltransferase KAT5; protein
                     crotonyltransferase KAT5; protein
                     2-hydroxyisobutyryltransferase KAT5"
                     /codon_start=1
                     /product="histone acetyltransferase KAT5"
                     /protein_id="NP_001005872.1"
                     /db_xref="GeneID:192218"
                     /db_xref="RGD:621061"
                     /translation="MAEVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFY
                     VHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQAS
                     GKTLPIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPV
                     PSETAPASVFPQNGSARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVS
                     DRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCL
                     QRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTD
                     PFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYEL
                     SKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSI
                     KKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWS
                     KRGKW"
     exon            18..84
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /inference="alignment:Splign:2.1.0"
     exon            85..153
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /inference="alignment:Splign:2.1.0"
     exon            154..290
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /inference="alignment:Splign:2.1.0"
     exon            291..446
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /inference="alignment:Splign:2.1.0"
     exon            447..521
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /inference="alignment:Splign:2.1.0"
     exon            522..596
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /inference="alignment:Splign:2.1.0"
     exon            597..845
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /inference="alignment:Splign:2.1.0"
     exon            846..935
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1076
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1170
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1330
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1412
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1948
                     /gene="Kat5"
                     /gene_synonym="Htatip; Htatip1; Tip60"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagatggc ggaggtgggg gagataatcg agggctgccg cctgcccgtg ctgcggcgca
       61 accaggacaa cgaagatgag tggcccctgg ctgagatcct gagcgtgaag gacatcagtg
      121 gccggaagct tttctatgtc cattacattg atttcaacaa acgtctggat gaatgggtga
      181 ctcacgagcg gctggactta aagaagatcc aatttcccaa gaaagaagcc aagacaccta
      241 ccaagaacgg acttcctggg tcccgccccg gctctcccga aagagaggtg ccggcctccg
      301 cccaggccag cgggaagacc ttgccaatcc cggtccagat cacactccgc ttcaacctgc
      361 ccaaggagcg ggaggccatt ccaggtggcg agcctgacca gccgctctcc tccagctcct
      421 gcctgcaacc caaccaccgc tcaacgaaac ggaaggtgga ggtggtttca ccagcaactc
      481 cagtgcccag cgagacagcc ccagcttcag ttttccccca gaatggatca gcccgtaggg
      541 cagtggcagc acagccagga cggaagcgga aatctaattg cctgggcact gatgaggatt
      601 ctcaggacag ctcagatgga ataccgtcag caccacgcat gactggcagt ttggtgtctg
      661 accggagcca cgacgacatt gtcacccgga tgaagaacat tgagtgtatt gagcttggcc
      721 ggcaccgcct caagccgtgg tacttctccc cgtaccctca agagcttacc acgctacctg
      781 tcctctacct gtgcgaattt tgcctcaaat atggccgtag cctcaagtgt ctgcagcgcc
      841 acttgaccaa atgtgatctt cgacaccctc caggcaatga aatttaccgc aagggcacca
      901 tctccttttt tgagattgat gggcggaaaa acaagagtta ctcacaaaac ctgtgtcttc
      961 tggccaagtg tttcctcgac cacaagacat tgtactatga cacagacccc ttccttttct
     1021 atgtaatgac ggagtatgac tgcaagggct tccacatcgt gggctacttc tccaaggaaa
     1081 aggagtccac agaagattac aatgtggcct gcatcttgac tctgccacct tatcagcgcc
     1141 ggggctatgg aaagctgctt attgagttca gctatgaact ctcgaaagta gaagggaaga
     1201 caggaactcc tgagaaaccc ctgtcagatc ttggccttct atcctaccga agttactggt
     1261 cccaaaccat cttggagatc ctgatggggc tgaagtcgga gagtggggag agaccacaga
     1321 tcaccatcaa tgagatcagt gaaatcacta gtatcaagaa agaagatgtc atttccacac
     1381 tgcagtatct caatctcatc aattactaca agggccagta tatcctcact ctgtcagaag
     1441 acatcgtgga tgggcatgag cgggctatgc tcaagcggct ccttcgaatt gactccaagt
     1501 gtctgcactt cactcccaaa gactggagca agagaggaaa gtggtgacac acacactctc
     1561 actgcaacac cgcgaaagcc agctgaacac ggctgtcatc ctgtcgtatc ccattcgagc
     1621 ttcgaagagt catgcaaagg gagacaggcc aaaggacaga cccaaaagaa gaagaggcct
     1681 aggaggggcc aactagtggc cagtaccaaa gcgagctcag gtctaggccg actccaagga
     1741 tagctggctt gttggctcag gtccgctctg aacacaggga ccagggggac ccaggcagct
     1801 gtgtacacta aggcgggtgg ggagcatctg tacaggactg gtgactgtaa aaatttcttt
     1861 tgtaaaggag gagctggagg gtggggtggg cgctggttgc aaagttctgg ccctccctgc
     1921 ccccagaaat aaattgtttt tataggcaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
