LOCUS       NM_001107050            3059 bp    mRNA    linear   ROD 23-MAR-2024
DEFINITION  Rattus norvegicus lysine acetyltransferase 2A (Kat2a), mRNA.
ACCESSION   NM_001107050 XM_001081432 XM_239340
VERSION     NM_001107050.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3059)
  AUTHORS   Liu,Y., Zeng,J.M., Zhao,H., Ao,C.Y., Ao,L.H., Ban,J.Q. and Li,J.
  TITLE     Mechanism of KAT2A regulation of H3K36ac in manganese-induced
            oxidative damage to mitochondria in the nervous system and
            intervention by curcumin
  JOURNAL   Ecotoxicol Environ Saf 273, 116155 (2024)
   PUBMED   38417317
  REMARK    GeneRIF: Mechanism of KAT2A regulation of H3K36ac in
            manganese-induced oxidative damage to mitochondria in the nervous
            system and intervention by curcumin.
REFERENCE   2  (bases 1 to 3059)
  AUTHORS   Shi,S.M., Liu,T.T., Wei,X.Q., Sun,G.H., Yang,L. and Zhu,J.F.
  TITLE     GCN5 regulates ZBTB16 through acetylation, mediates osteogenic
            differentiation, and affects orthodontic tooth movement
  JOURNAL   Biochem Cell Biol 101 (3), 235-245 (2023)
   PUBMED   36786377
  REMARK    GeneRIF: GCN5 regulates ZBTB16 through acetylation, mediates
            osteogenic differentiation, and affects orthodontic tooth movement.
REFERENCE   3  (bases 1 to 3059)
  AUTHORS   Dong,Z., He,W., Lin,G., Chen,X., Cao,S., Guan,T., Sun,Y., Zhang,Y.,
            Qi,M., Guo,B., Zhou,Z., Zhuo,R., Wu,R., Liu,M. and Liu,Y.
  TITLE     Histone acetyltransferase KAT2A modulates neural stem cell
            differentiation and proliferation by inducing degradation of the
            transcription factor PAX6
  JOURNAL   J Biol Chem 299 (3), 103020 (2023)
   PUBMED   36791914
  REMARK    GeneRIF: Histone acetyltransferase KAT2A modulates neural stem cell
            differentiation and proliferation by inducing degradation of the
            transcription factor PAX6.
REFERENCE   4  (bases 1 to 3059)
  AUTHORS   Lin,G., Lin,H., Zhuo,R., He,W., Ma,C., Liu,Y. and Liu,M.
  TITLE     GCN5/KAT2A contributes to axon growth and neurogenesis
  JOURNAL   Neurosci Lett 784, 136742 (2022)
   PUBMED   35716963
  REMARK    GeneRIF: GCN5/KAT2A contributes to axon growth and neurogenesis.
REFERENCE   5  (bases 1 to 3059)
  AUTHORS   Li,J., Yan,C., Wang,Y., Chen,C., Yu,H., Liu,D., Huang,K. and Han,Y.
  TITLE     GCN5-mediated regulation of pathological cardiac hypertrophy via
            activation of the TAK1-JNK/p38 signaling pathway
  JOURNAL   Cell Death Dis 13 (4), 421 (2022)
   PUBMED   35490166
  REMARK    GeneRIF: GCN5-mediated regulation of pathological cardiac
            hypertrophy via activation of the TAK1-JNK/p38 signaling pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3059)
  AUTHORS   Wong,K., Zhang,J., Awasthi,S., Sharma,A., Rogers,L., Matlock,E.F.,
            Van Lint,C., Karpova,T., McNally,J. and Harrod,R.
  TITLE     Nerve growth factor receptor signaling induces histone
            acetyltransferase domain-dependent nuclear translocation of
            p300/CREB-binding protein-associated factor and hGCN5
            acetyltransferases
  JOURNAL   J Biol Chem 279 (53), 55667-55674 (2004)
   PUBMED   15496412
REFERENCE   7  (bases 1 to 3059)
  AUTHORS   Fulco,M., Schiltz,R.L., Iezzi,S., King,M.T., Zhao,P., Kashiwaya,Y.,
            Hoffman,E., Veech,R.L. and Sartorelli,V.
  TITLE     Sir2 regulates skeletal muscle differentiation as a potential
            sensor of the redox state
  JOURNAL   Mol Cell 12 (1), 51-62 (2003)
   PUBMED   12887892
  REMARK    Erratum:[Mol Cell. 2005 Nov 11;20(3):491]
REFERENCE   8  (bases 1 to 3059)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   9  (bases 1 to 3059)
  AUTHORS   Brand,M., Yamamoto,K., Staub,A. and Tora,L.
  TITLE     Identification of TATA-binding protein-free TAFII-containing
            complex subunits suggests a role in nucleosome acetylation and
            signal transduction
  JOURNAL   J Biol Chem 274 (26), 18285-18289 (1999)
   PUBMED   10373431
REFERENCE   10 (bases 1 to 3059)
  AUTHORS   Xu,W., Edmondson,D.G. and Roth,S.Y.
  TITLE     Mammalian GCN5 and P/CAF acetyltransferases have homologous
            amino-terminal domains important for recognition of nucleosomal
            substrates
  JOURNAL   Mol Cell Biol 18 (10), 5659-5669 (1998)
   PUBMED   9742083
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_239340.4, XM_001081432.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3059
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..3059
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /note="lysine acetyltransferase 2A"
                     /db_xref="GeneID:303539"
                     /db_xref="RGD:1307242"
     exon            1..378
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2553
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /EC_number="2.3.1.48"
                     /note="GCN5 general control of amino acid synthesis-like
                     2; general control of amino acid synthesis 5-like 2;
                     K(lysine) acetyltransferase 2A"
                     /codon_start=1
                     /product="histone acetyltransferase KAT2A"
                     /protein_id="NP_001100520.1"
                     /db_xref="GeneID:303539"
                     /db_xref="RGD:1307242"
                     /translation="MAEPSQAPNPAPAAQPRPLQSPAPAPTSTPAPSPASAPTPAPTP
                     APAPAPAAAPAGSTGTGGAGVGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEKLG
                     VFSACKANETCKCNGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVS
                     EDEINRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGS
                     PPFEKPNIEQGVLNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQ
                     SEDVATYKVNYTRWLCYCHVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRV
                     EKDKLVPEKRTLILTHFPKFLSMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPATVS
                     ATVVPSTPIFSPSMGGGSNSSLSLDSTGTEPMPGEKRKLPENLTLEDAKRLRVMGDIP
                     MELVNEVMLTITDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLTPKAN
                     RRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFRMFPTQ
                     GFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHSILYFLTYADEYAIGYFKKQGFSK
                     DIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQKEIIKKLIERKQAQIR
                     KVYPGLSCFKEGVRQIPVESVPGIRETGWKPLGKEKGKELKDPDQLYTTLKNLLAQIK
                     SHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIAN
                     CREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK"
     exon            379..502
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..648
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..738
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..920
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1112
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1219
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1330
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1467
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1676
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1803
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1914
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2058
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2173
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2210
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2274
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2359
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..3059
                     /gene="Kat2a"
                     /gene_synonym="Gcn5; Gcn5l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccatgcgg ccctagggct gggagcgcgg cgccgctccg ctgcggggga ggccatggcg
       61 gaaccttccc aggccccaaa cccggccccg gcagcgcagc cccggcccct tcagtccccg
      121 gcccctgccc caacttcgac tcctgcgccc agtccggctt cagcccccac tccggctcct
      181 actccggcac cagctcctgc cccagctgca gccccagccg ggagcacagg gactgggggg
      241 gccggggtag gaagtggagg ggatccggct cgacctggcc tgagccagca gcagcgcgct
      301 agccagagaa aggcgcaagt ccgggggctg ccgcgtgcca agaagcttga gaaactaggg
      361 gtcttctcag cttgcaaggc caatgaaacc tgcaagtgta atggctggaa aaaccccaag
      421 ccccccactg caccccgcat ggacctacag cagccagctg ctaacctgag cgagttgtgc
      481 cgcagctgtg agcacccctt ggcggaccat gtgtcccacc tggagaatgt gtcagaggat
      541 gagattaacc ggctcttggg aatggtagtg gatgtagaaa atctgttcat gtctgttcac
      601 aaggaagagg acacggacac caagcaggtc tatttctacc tcttcaagct cctgcggaaa
      661 tgcatcctgc aaatgacacg accagtggtg gagggatccc taggcagccc gccatttgag
      721 aagcctaaca tcgagcaggg tgttctgaac tttgtgcagt acaaatttag ccacctggcc
      781 ccccgggagc ggcagacaat gttcgagctc tcaaagatgt tcctgctctg ccttaactac
      841 tggaagctgg agacccctgc tcaattccgg cagcgatccc agtctgagga tgttgctacc
      901 tataaggtca attataccag atggctctgt tactgccacg tgcctcagag ctgcgacagc
      961 ctcccccgat atgagaccac ccatgtgttt ggccgaagcc ttctgcggtc catttttact
     1021 gtcacccgcc ggcagctact ggaaaaattt cgggtggaga aggacaaact ggtgcccgag
     1081 aagaggaccc tcatcctcac tcacttcccc aagttcctgt ccatgcttga ggaagagatc
     1141 tacggggcga attcccccat ctgggagtca ggcttcacca tgccaccttc ggaggggaca
     1201 cagctggtgc cccggccagc gactgtcagt gcaacagttg tacccagcac tcccatcttc
     1261 agtccttcca tgggcggagg cagcaacagc tccctgagcc tagattccac agggacagag
     1321 cccatgccag gagagaagag gaagcttcct gagaacctga ctctggagga tgctaagcgg
     1381 ctccgagtga tgggcgacat tcccatggag ctggtcaacg aggtcatgct gaccatcacc
     1441 gaccctgctg ccatgctggg gcccgagacg agcctgcttt cagccaacgc agctcgagat
     1501 gaaacagctc gcctggaaga gcgtcgaggg atcatcgaat tccacgtcat tggcaactct
     1561 ctgacgccca aggccaaccg gcgtgtgctg ctgtggcttg tggggctgca gaacgtcttc
     1621 tcccaccagc tgccacgaat gcccaaggaa tatattgccc gcctcgtctt tgacccgaag
     1681 cataagaccc tggccttgat caaggatggg cgggtcatcg gtgggatttg cttccgcatg
     1741 tttcccaccc agggcttcac ggaaatcgtc ttctgtgctg tcacctcaaa tgagcaggtc
     1801 aagggctatg gcacccacct gatgaatcac ctgaaggagt accacatcaa acacagcatc
     1861 ctgtacttcc tcacctacgc cgacgagtac gccatcggct acttcaagaa gcagggcttc
     1921 tccaaggaca tcaaggtgcc caagagccga tatctgggct acatcaagga ctatgaggga
     1981 gcgaccctga tggagtgtga gctgaacccc cgcatcccct acacagagct gtcccacatc
     2041 atcaagaagc agaaggagat catcaagaag ttgattgagc gcaaacaggc acagatccga
     2101 aaggtttacc ctggactcag ctgcttcaaa gaaggagtga ggcagatccc tgtggagagc
     2161 gtccctggca ttcgagagac aggctggaag ccactgggaa aggagaaggg caaggagctg
     2221 aaggaccctg accagctgta tacgaccctc aaaaacctgc tggctcagat caagtcacac
     2281 cccagtgcct ggcccttcat ggaacctgtg aagaagtcgg aggcccctga ctactacgag
     2341 gttatccgct tccccattga cctgaagacc atgacagaac ggttgcgcag ccgctactat
     2401 gtgacccgga agctctttgt agccgacctg cagcgggtca tcgccaactg ccgggagtac
     2461 aatcccccag acagcgaata ttgtcgctgc gccagtgccc tggagaagtt cttctacttc
     2521 aagctcaaag aaggagggct cattgacaag tagtgcccaa ctggggtctg cactgtccac
     2581 ctctgtctca tcagatccgt ttgggtgctc ccggaccccc tctccctgac tcagcgggag
     2641 aaactccagc caggggcccc aaatcttgca gactttggcc agcaggcact tactcccaag
     2701 cctgcagctc tcttcccacc ttcattgcat ccgacattag ggaggtgtct ggtctggggc
     2761 cagccccttg tagaatgtct ggtggccagg gaatgaactg ctagtcctta ccgagctatg
     2821 caggctgagc gtcctgagcc tggtccaggt gcctgtttcc cgggaccagg actattcagt
     2881 gaggagcctc gacgtgggaa cagctcagac tggaggaact atgaggggcc tcggctcgtc
     2941 ctacactgtt gtccacctgt cccccggggt tgggggcagg aggaccattc attccttggc
     3001 attaatccct tggagggaac aataaagctt tttttttttc cccctgtgtg attatttgg
//
