LOCUS       NM_001107947            3703 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus KN motif and ankyrin repeat domains 4 (Kank4),
            mRNA.
ACCESSION   NM_001107947 XM_001059919 XM_233215
VERSION     NM_001107947.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3703)
  AUTHORS   Gee,H.Y., Zhang,F., Ashraf,S., Kohl,S., Sadowski,C.E.,
            Vega-Warner,V., Zhou,W., Lovric,S., Fang,H., Nettleton,M.,
            Zhu,J.Y., Hoefele,J., Weber,L.T., Podracka,L., Boor,A.,
            Fehrenbach,H., Innis,J.W., Washburn,J., Levy,S., Lifton,R.P.,
            Otto,E.A., Han,Z. and Hildebrandt,F.
  TITLE     KANK deficiency leads to podocyte dysfunction and nephrotic
            syndrome
  JOURNAL   J Clin Invest 125 (6), 2375-2384 (2015)
   PUBMED   25961457
  REMARK    GeneRIF: In rats, KANK1, KANK2, and KANK4 all localized to
            podocytes in glomeruli, and KANK1 partially colocalized with
            synaptopodin.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473998.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_233215.4, XM_001059919.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3703
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..3703
                     /gene="Kank4"
                     /gene_synonym="BC060737"
                     /note="KN motif and ankyrin repeat domains 4"
                     /db_xref="GeneID:313385"
                     /db_xref="RGD:1307635"
     exon            1..41
                     /gene="Kank4"
                     /gene_synonym="BC060737"
                     /inference="alignment:Splign:2.1.0"
     exon            42..108
                     /gene="Kank4"
                     /gene_synonym="BC060737"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..3125
                     /gene="Kank4"
                     /gene_synonym="BC060737"
                     /codon_start=1
                     /product="KN motif and ankyrin repeat domain-containing
                     protein 4"
                     /protein_id="NP_001101417.1"
                     /db_xref="GeneID:313385"
                     /db_xref="RGD:1307635"
                     /translation="MEKMDAKDQSPQGDEEKEPPKSYPYSVETPYGFHLDLDFLKYVD
                     DIEKGHTIKRIPIHRRAKQAKFSTLPRNFSLPNSGDRSHAAPPQQNWSPVVPRKISLG
                     TQEQSQSVPLGDLPQATVHGNELSYHRKALLAKDTRQVEAGSLEDAGSGRPQLLRASS
                     MPATLPQNQAPEVPNLTSGPSALLVLPPLQDEGSVRDGTFDPAEGLMGFQAAAQSTDR
                     AVEELEPAIPEPVWEGAEPEEGDIKAASHLSQPAPSSSVQNVSVDLEEVDIQHHTRTA
                     DLALSPGSSTPSPPPLPSPIPENELSLEEIELNISEIPPPPPIEVDVRSVGVRVTEES
                     LGLVETATSSISSLKSQVLDLEDKLSGRTEELAQVRAALEQQEEETKAREQRIQELEC
                     TVAHLEEKLSQEKASDALDRTDAMVNTDPLRELIPRESQDKNIGVNLLSTPVPECWAS
                     RAEKNGFPWVQTNHKQSYPSPEEPALPPQLSLPRGPEQILASSLCSCLSMELRIEEEV
                     SEQERDPDGGAGSLSREAGGSPWSRRESAPVIREEASSQLPGAERPGRPASSPQDATI
                     GQYVKKIQELLHEQWNCLEHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQA
                     PEPKESPVPPSSTPPPPPEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYE
                     TTSSEDTSGEDSSPEDLSDSETEKKQDCSEPREDRDMHLSCEAGQGVSKGTGNSGHMS
                     EPRKGVSHMKAERYKPSEEFLNACQALSQHLPEAGATNKQLLRQSLNTISQEWFRVSS
                     RKLSSPEAVAACLLEVQPQSPHLLKLLVNLADRSGNTALHYSVSHSNFAIAKLLLDTG
                     VCNVDHQNKAGYTAVMITPLASPKTKEDMAVVWKLLREGNVNIQATQGGQTALMLGVS
                     HDREDMVQALLSCKADVNLQDHDGSSALMLACHQGNADLVRLLLAHADCNSNLTDKAG
                     QTALSIVLNSPAHVEIAELLRAHSEQGRSLGLKELQKN"
     exon            109..2019
                     /gene="Kank4"
                     /gene_synonym="BC060737"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2131
                     /gene="Kank4"
                     /gene_synonym="BC060737"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2350
                     /gene="Kank4"
                     /gene_synonym="BC060737"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2438
                     /gene="Kank4"
                     /gene_synonym="BC060737"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2658
                     /gene="Kank4"
                     /gene_synonym="BC060737"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2801
                     /gene="Kank4"
                     /gene_synonym="BC060737"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..3002
                     /gene="Kank4"
                     /gene_synonym="BC060737"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3703
                     /gene="Kank4"
                     /gene_synonym="BC060737"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgctcctc gcttccagcc agaaccccgc ggctccccaa gaactctcca cgaatcacgc
       61 agactccgtg gatgtggagt acctgagaga cgatggagaa gatggacgcc aaggaccagt
      121 cccctcaggg ggatgaagag aaagagcctc caaagagcta cccctactct gtggagaccc
      181 catatggctt tcatttggac ttggactttc tcaaatacgt ggatgacatt gagaagggac
      241 acaccatcaa aaggattcct atccacagga gagccaagca ggctaagttt agtactctgc
      301 cccgaaactt cagccttccc aacagtgggg accgctccca tgctgctcct ccccagcaga
      361 actggtctcc tgtggtaccc agaaagatat ccctggggac ccaggagcaa tcccagtcag
      421 tcccactggg tgatctcccc caggccacag tgcacggcaa tgagctgagt taccacagga
      481 aggccctctt ggcaaaggac accaggcagg tggaggctgg ttctctggag gatgctggga
      541 gtggacggcc ccagttgttg agagcatcca gcatgcccgc tacactgccg caaaaccagg
      601 cccccgaagt gcccaacctg acctcaggcc cttctgcact tcttgtcctc cctcctctcc
      661 aggatgaagg cagtgtccgg gatggtacct ttgaccctgc agaagggctc atgggtttcc
      721 aagcagcggc ccagtcaaca gacagagcgg tggaagaact ggagccagca atcccagagc
      781 cggtctggga gggggctgaa ccagaagaag gtgacatcaa ggctgcaagt cacctctctc
      841 agccggctcc ttcctcctca gttcagaatg tctcagtgga tctagaggag gtagacattc
      901 agcaccatac tagaacagca gacctggcgt tatcacctgg ctcctccact cccagccctc
      961 cccctctgcc gtcccccatc cctgagaacg agctctccct ggaggaaatt gagctcaata
     1021 tcagtgagat cccgccccct ccacccatag aagtggatgt gaggagtgtc ggtgtccggg
     1081 taacagagga gagcctgggc ctggtggaga ctgctaccag cagcatctcc agtctgaaaa
     1141 gtcaggtcct ggacctagag gacaaattgt cagggagaac tgaagagctc gcccaggtca
     1201 gagctgccct tgagcagcag gaagaagaga ccaaggctag ggagcagagg attcaagagt
     1261 tggagtgtac cgtggcccat ttagaagaaa agcttagtca agagaaggcc agtgacgctc
     1321 tggacaggac tgacgccatg gtgaacactg accccctccg tgagctcatc cctagagagt
     1381 cacaggacaa gaacatcggg gtcaacctgc tgagcacccc agttcctgaa tgctgggcat
     1441 cgagagcaga aaagaatggc ttcccatggg tccaaactaa tcacaagcaa agctatccga
     1501 gccccgaaga acccgcactg ccaccccaac tgtcactgcc aagggggcct gagcagatcc
     1561 tcgcctcatc cttatgtagc tgcctctcca tggaactccg gattgaagag gaggtttctg
     1621 aacaggagag agacccagac gggggagctg ggagcttgag cagggaagca ggaggctctc
     1681 cctggagcag aagagaatct gctccagtga tcagggagga ggccagctca caactcccag
     1741 gggcagagcg tccaggaagg ccagcaagtt ccccacaaga cgccacaatc gggcagtatg
     1801 tcaagaagat ccaagagcta ctgcatgagc agtggaactg cctggagcac gggtacccgg
     1861 agctggccag cgccatcaag cagcctgcct ccaagctcag cagcatccag aaccagctgc
     1921 tcagttccct taacctgttg ctctctgcct actcagctca ggctccagag cccaaggaat
     1981 cccctgttcc gccctcctcc acccctcccc cacctccaga gatctctccg tcgaccagcc
     2041 ttaaatccat aatgaaaaag aaagactatg gcttccgtgc aggaggtaat gggaccaaaa
     2101 agaaccttca gtttgttggg gttaacggtg gctatgagac cacatctagc gaggacacca
     2161 gtggggaaga cagctcccct gaggacttgt ctgacagtga gaccgagaag aaacaagact
     2221 gctcagagcc cagggaggac agagacatgc atctcagctg tgaggccggg cagggagtct
     2281 ccaaaggcac cggtaactca ggccacatga gtgagccgag gaagggagtc tctcacatga
     2341 aggccgagag atataaaccc tcagaggagt ttcttaacgc atgccaggca ctgagccagc
     2401 acctgccgga agccggggcc accaacaagc agctcctgag gcaaagcttg aataccatca
     2461 gtcaggagtg gttccgcgtg tccagccgga agttatctag ccccgaggcc gtggccgcct
     2521 gcctccttga ggtccagcct cagtctccac atcttctgaa gctacttgtc aacttggctg
     2581 accgaagcgg gaacacagcc cttcactaca gtgtgtcgca ctccaacttc gccattgcca
     2641 agcttctgct ggacacaggt gtctgcaatg tggatcatca gaacaaagct ggctacactg
     2701 ctgtgatgat cactcccttg gcttctccaa agacaaaaga agacatggcg gtcgtctgga
     2761 agctcttacg agaagggaac gtgaacatac aagcaactca gggaggccag actgcactga
     2821 tgttaggagt cagccacgac cgggaggaca tggtgcaagc gctactgagc tgcaaggcgg
     2881 acgtcaacct gcaggaccat gatggatcgt cggccctcat gctggcctgt caccaaggca
     2941 acgcggacct ggtgcgactg ctcctggcac acgcagactg caacagcaac ctgactgaca
     3001 aggccggcca aacagctttg tccatcgttc tgaattcacc tgcccacgtg gaaatcgcag
     3061 agcttctgag ggcccactcg gagcagggca ggtccctggg gctgaaggag ctgcagaaga
     3121 attagcagcc aagaacaaaa ggttcctttg ctggactccc cccctgccct tagagagggc
     3181 tggggtcaca gccagagggc caccattcaa gacagaaact atgtcaaata tgcacaatac
     3241 attcccggca tacagttctg ctcattagga tgcttggtag tgtttgtctt aggccaaacc
     3301 ccccaaacta catgaggtcc agagcagggt gcgaggtgca gagtgcaggc tgcagtggag
     3361 tcacccagaa attcaaaaca gcttcagctt tgaattcctc acgatgttgt ctttgcagcc
     3421 ctgtgtagca agcacgtagg taagggcaca ctcgcacagt agaaaaagca atacttttta
     3481 catggagttt taaagggcac cgtctttttg tttttaatca agtatgtata caaatatgtc
     3541 ccagtgaata tgcatgtcta gagagaatgg caggagtcta aattcaggta aaggaggact
     3601 aagcccagtg atgtcagtgc caggctgtga cacttctgag taccccaggg gttcccatcc
     3661 cctctatgga agtaagcaga aaaccaatcc aatgataaat act
//
